Morphological and functional aspects of progenitors perturbed in cortical malformations.

abstract：:Recent advances in fast volumetric imaging have enabled rapid generation of large amounts of multi-dimensional functional data. While many computer frameworks exist for data storage and analysis of the multi-gigabyte Ca2+ imaging experiments in neurons, they are less useful for analyzing Ca2+ dynamics in astrocytes, w...

journal_title：Frontiers in cellular neuroscience

authors： Savtchouk I,Carriero G,Volterra A

更新日期：2018-04-13 00:00:00

abstract：:Traumatic spinal cord injury (SCI) leads to disruption of sensory, motor and autonomic function, and triggers structural, physiological and biochemical changes that cause reorganization of existing circuits that affect functional recovery. Propriospinal neurons (PN) appear to be very plastic within the inhibitory micr...

journal_title：Frontiers in cellular neuroscience

authors： Michael FM,Patel SP,Rabchevsky AG

更新日期：2019-11-08 00:00:00

abstract：:Cerebral ischemic stroke is regarded as one of the most serious diseases in the human central nervous system. The secondary ischemia and reperfusion (I/R) injury increased the difficulty of treatment. Moreover, the latent molecular regulating mechanism in I/R injury is still unclear. Based on our previous clinical stu...

journal_title：Frontiers in cellular neuroscience

authors： Yu S,Yu M,Bu Z,He P,Feng J

更新日期：2020-07-15 00:00:00

abstract：:Microglia, the immune competent cells of the central nervous system (CNS), normally exist in a resting state characterized by a ramified morphology with many processes, and become activated to amoeboid morphology in response to brain injury, infection, and a variety of neuroinflammatory stimuli. Many studies focused o...

journal_title：Frontiers in cellular neuroscience

authors： Fan Y,Chen Z,Pathak JL,Carneiro AMD,Chung CY

更新日期：2018-09-11 00:00:00

abstract：:[This corrects the article on p. 56 in vol. 11, PMID: 28303091.]. ...

journal_title：Frontiers in cellular neuroscience

authors： Owens R,Grabert K,Davies CL,Alfieri A,Antel JP,Healy LM,McColl BW

更新日期：2017-08-24 00:00:00

abstract：:Intrastriatal transplantation of fetal human ventral mesencephalic dopaminergic neurons is an experimental therapy for patients suffering from Parkinson's disease. The success of this approach depends on several host brain parameters including neurotrophic factors and growth inhibitors that guide survival and integrat...

journal_title：Frontiers in cellular neuroscience

authors： Seiler S,Di Santo S,Andereggen L,Widmer HR

更新日期：2017-05-26 00:00:00

abstract：:Autism is a neurodevelopmental disorder marked by social skills and communication deficits and interfering repetitive behavior. Intellectual disability often accompanies autism. In addition to behavioral deficits, autism is characterized by neuropathology and brain overgrowth. Increased intracranial volume often accom...

journal_title：Frontiers in cellular neuroscience

authors： Lahiri DK,Sokol DK,Erickson C,Ray B,Ho CY,Maloney B

更新日期：2013-06-21 00:00:00

abstract：:Understanding non-stationary neuronal activity as seen in vivo requires estimation of both excitatory and inhibitory synaptic conductances from a single trial of recording. For this purpose, we propose a new intracellular recording method, called "firing clamp." Synaptic conductances are estimated from the characteris...

journal_title：Frontiers in cellular neuroscience

authors： Chizhov AV,Malinina E,Druzin M,Graham LJ,Johansson S

更新日期：2014-03-27 00:00:00

abstract：:Ischemic stroke can induce rapid activation of the microglia. It has been reported that the microglia's survival is dependent on colony-stimulating factor 1 receptor (CSF1R) signaling and that pharmacological inhibition of CSF1R leads to morphological changes in the microglia in the healthy brain. However, the impact ...

journal_title：Frontiers in cellular neuroscience

authors： Hou B,Jiang C,Wang D,Wang G,Wang Z,Zhu M,Kang Y,Su J,Wei P,Ren H,Ju F

更新日期：2020-10-16 00:00:00

abstract：:The pannexin family of channels consists of three members-pannexin-1 (Panx1), pannexin-2 (Panx2), and pannexin-3 (Panx3) that enable the exchange of metabolites and signaling molecules between intracellular and extracellular compartments. Pannexin-mediated release of intracellular ATP into the extracellular space has ...

journal_title：Frontiers in cellular neuroscience

authors： Horton SM,Luna Lopez C,Blevins E,Howarth H,Weisberg J,Shestopalov VI,Makarenkova HP,Shah SB

更新日期：2017-11-22 00:00:00

abstract：:The use of human pluripotent stem cells (PSCs) for cell therapy faces a number of challenges that are progressively answered by results from clinical trials and experimental research. Among these is the control of differentiation before transplantation and the prediction of cell fate after administration into the huma...

journal_title：Frontiers in cellular neuroscience

authors： Benchoua A,Onteniente B

更新日期：2012-01-27 00:00:00

abstract：:The complex and elaborate architecture of a neuron poses a great challenge to the cellular machinery which localizes proteins and organelles, such as mitochondria, to necessary locations. Proper mitochondrial localization in neurons is particularly important as this organelle provides energy and metabolites essential ...

journal_title：Frontiers in cellular neuroscience

authors： Mandal A,Drerup CM

更新日期：2019-08-09 00:00:00

abstract：:Limited axon regeneration in the injured adult mammalian central nervous system (CNS) usually results in irreversible functional deficits. Both the presence of extrinsic inhibitory molecules at the injury site and the intrinsically low capacity of adult neurons to grow axons are responsible for the diminished capacity...

journal_title：Frontiers in cellular neuroscience

authors： Ribas VT,Costa MR

更新日期：2017-08-07 00:00:00

abstract：:Maturation of neuronal and synaptic functions during early life is essential for the development of neuronal circuits and behaviors. In newborns synaptic transmission at excitatory synapses is primarily mediated by N-methyl-D-aspartate receptors (NMDARs), and NMDAR-mediated signaling plays an important role in synapti...

journal_title：Frontiers in cellular neuroscience

authors： Hou G,Zhang ZW

更新日期：2017-11-07 00:00:00

abstract：:In recent years several evidence demonstrated that some features of hippocampal biology, like neurogenesis, synaptic transmission, learning, and memory performances are deeply modulated by social, motor, and sensorial experiences. Fractalkine/CX(3)CL1 is a transmembrane chemokine abundantly expressed in the brain by n...

journal_title：Frontiers in cellular neuroscience

authors： Maggi L,Scianni M,Branchi I,D'Andrea I,Lauro C,Limatola C

更新日期：2011-10-19 00:00:00

abstract：:Neurological disorders are prevalent worldwide. Cerebrovascular diseases (CVDs), which account for 55% of all neurological diseases, are the leading cause of permanent disability, cognitive and motor disorders and dementia. Stroke affects the function and structure of blood-brain barrier, the loss of cerebral blood fl...

journal_title：Frontiers in cellular neuroscience

authors： Posada-Duque RA,Barreto GE,Cardona-Gomez GP

更新日期：2014-08-14 00:00:00

abstract：:Increased expression of S100B and its specific receptor for advanced glycation end products (RAGE) has been described in patients with multiple sclerosis (MS), being associated with an active demyelinating process. We previously showed that a direct neutralization of S100B reduces lysophosphatidylcholine (LPC)-induced...

journal_title：Frontiers in cellular neuroscience

authors： Santos G,Barateiro A,Brites D,Fernandes A

更新日期：2020-09-04 00:00:00

abstract：:Nanobodies are single domain antibodies derived from llama heavy-chain only antibodies (HCAbs). They represent a new generation of biologicals with unique properties: nanobodies show excellent tissue distribution, high temperature and pH stability, are easy to produce recombinantly and can readily be converted into di...

journal_title：Frontiers in cellular neuroscience

authors： Rissiek B,Koch-Nolte F,Magnus T

更新日期：2014-10-21 00:00:00

abstract：:Propofol is a widely used anesthetic in the clinic while several studies have demonstrated that propofol exposure may cause neurotoxicity in the developing brain. However, the effects of early propofol exposure on cerebellar development are not well understood. Propofol (30 or 60 mg/kg) was administered to mice on pos...

journal_title：Frontiers in cellular neuroscience

authors： Xiao R,Yu D,Li X,Huang J,Jing S,Bao X,Yang T,Fan X

更新日期：2017-11-22 00:00:00

abstract：:Hippocampal inhibitory interneurons exhibit a large diversity of dendritic Ca2+ mechanisms that are involved in the induction of Hebbian and anti-Hebbian synaptic plasticity. High resolution imaging techniques allowed examining somatic Ca2+ signals and, accordingly, the recruitment of hippocampal interneurons in awake...

journal_title：Frontiers in cellular neuroscience

authors： Francavilla R,Villette V,Martel O,Topolnik L

更新日期：2019-03-15 00:00:00

abstract：:Gamma aminobutric acid (GABA) is the major inhibitory neurotransmitter in the adult brain and mechanisms of GABAergic inhibition have been intensely investigated in the past decades. Recent studies provided evidence for an important role of astrocytes in shaping GABAergic currents. One of the most obvious, but yet poo...

journal_title：Frontiers in cellular neuroscience

authors： Kaczor P,Rakus D,Mozrzymas JW

更新日期：2015-04-09 00:00:00

abstract：:Gene knockout by homologous recombination is a popular method to study gene functions in the mouse in vivo. However, its lack of temporal control has limited the interpretation of knockout studies because the complete elimination of a gene product often alters developmental processes, and can induce severe malformatio...

journal_title：Frontiers in cellular neuroscience

authors： Heitz F,Johansson T,Baumgärtel K,Gecaj R,Pelczar P,Mansuy IM

更新日期：2014-03-19 00:00:00

abstract：:It has been estimated that 20% of pregnant women suffer from depression and it is well-documented that maternal depression can have long-lasting effects on the child. Currently, common treatment for maternal depression has been the selective serotonin reuptake inhibitor medications (SSRIs) which are used by 2-3% of pr...

journal_title：Frontiers in cellular neuroscience

authors： Olivier JD,Akerud H,Kaihola H,Pawluski JL,Skalkidou A,Högberg U,Sundström-Poromaa I

更新日期：2013-05-21 00:00:00

abstract：:GABA transporters belong to a large family of neurotransmitter:sodium symporters. They are widely expressed throughout the brain, with different levels of expression in different brain regions. GABA transporters are present in neurons and in astrocytes and their activity is crucial to regulate the extracellular concen...

journal_title：Frontiers in cellular neuroscience

authors： Scimemi A

更新日期：2014-06-17 00:00:00

abstract：:The immune system provides protection in the CNS via resident microglial cells and those that traffic into it in the course of pathological challenges. These populations of cells are key players in modulating immune functions that are involved in disease outcomes. In this review, we briefly summarize and highlight the...

journal_title：Frontiers in cellular neuroscience

authors： Fani Maleki A,Rivest S

更新日期：2019-07-31 00:00:00

abstract：:Cortical dysplasia is associated with intractable epilepsy and developmental delay in young children. Recent work with the rat freeze-induced focal cortical dysplasia (FCD) model has demonstrated that hyperexcitability in the dysplastic cortex is due in part to higher levels of extracellular glutamate. Astrocyte gluta...

journal_title：Frontiers in cellular neuroscience

authors： Campbell SL,Hablitz JJ,Olsen ML

更新日期：2014-12-17 00:00:00

abstract：:MicroRNA (miR)-210 is the most consistently and predominantly up-regulated miR in response to hypoxia in multiple cancer cells. The roles of miR-210 in rat adrenal gland pheochromocytoma (PC-12) cells remain unknown. We aimed to explore the possible effect of miR-210 in neonatal brain injury. We explored the potential...

journal_title：Frontiers in cellular neuroscience

authors： Luan Y,Zhang X,Zhang Y,Dong Y

更新日期：2017-09-22 00:00:00

abstract：:Epilepsy is a common neurological disorder characterized by recurrent uncontrolled seizures and has an idiopathic "genetic" etiology or a symptomatic "acquired" component. Genetic studies have revealed that many epilepsy susceptibility genes encode ion channels, including voltage-gated sodium, potassium and calcium ch...

journal_title：Frontiers in cellular neuroscience

authors： van Loo KMJ,Becker AJ

更新日期：2020-01-14 00:00:00

abstract：:Outer Hair Cells (OHCs) in the mammalian cochlea display a unique type of voltage-induced mechanical movement termed electromotility, which amplifies auditory signals and contributes to the sensitivity and frequency selectivity of mammalian hearing. Electromotility occurs in the OHC lateral wall, but it is not fully u...

journal_title：Frontiers in cellular neuroscience

authors： Triffo WJ,Palsdottir H,Song J,Morgan DG,McDonald KL,Auer M,Raphael RM

更新日期：2019-12-20 00:00:00

abstract：:Neurotrophin receptors use endosomal pathways for signaling in neurons. However, how neurotrophins regulate the endosomal system for proper signaling is unknown. Rabs are monomeric GTPases that act as molecular switches to regulate membrane trafficking by binding a wide range of effectors. Among the Rab GTPases, Rab5 ...

journal_title：Frontiers in cellular neuroscience

authors： Moya-Alvarado G,Gonzalez A,Stuardo N,Bronfman FC

更新日期：2018-12-17 00:00:00