Transcriptional Regulation of Channelopathies in Genetic and Acquired Epilepsies.

Abstract:

:Epilepsy is a common neurological disorder characterized by recurrent uncontrolled seizures and has an idiopathic "genetic" etiology or a symptomatic "acquired" component. Genetic studies have revealed that many epilepsy susceptibility genes encode ion channels, including voltage-gated sodium, potassium and calcium channels. The high prevalence of ion channels in epilepsy pathogenesis led to the causative concept of "ion channelopathies," which can be elicited by specific mutations in the coding or promoter regions of genes in genetic epilepsies. Intriguingly, expression changes of the same ion channel genes by augmentation of specific transcription factors (TFs) early after an insult can underlie acquired epilepsies. In this study, we review how the transcriptional regulation of ion channels in both genetic and acquired epilepsies can be controlled, and compare these epilepsy "ion channelopathies" with other neurodevelopmental disorders.

journal_name

Front Cell Neurosci

authors

van Loo KMJ,Becker AJ

doi

10.3389/fncel.2019.00587

subject

Has Abstract

pub_date

2020-01-14 00:00:00

pages

587

issn

1662-5102

journal_volume

13

pub_type

杂志文章,评审
  • Rethinking schizophrenia in the context of normal neurodevelopment.

    abstract::The schizophrenia brain is differentiated from the normal brain by subtle changes, with significant overlap in measures between normal and disease states. For the past 25 years, schizophrenia has increasingly been considered a neurodevelopmental disorder. This frame of reference challenges biological researchers to co...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2013.00060

    authors: Catts VS,Fung SJ,Long LE,Joshi D,Vercammen A,Allen KM,Fillman SG,Rothmond DA,Sinclair D,Tiwari Y,Tsai SY,Weickert TW,Shannon Weickert C

    更新日期:2013-05-15 00:00:00

  • Purkinje Cell-Specific Knockout of Tyrosine Hydroxylase Impairs Cognitive Behaviors.

    abstract::Tyrosine hydroxylase (Th) expression has previously been reported in Purkinje cells (PCs) of rodents and humans, but its role in the regulation of behavior is not understood. Catecholamines are well known for facilitating cognitive behaviors and are expressed in many regions of the brain. Here, we investigated a possi...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2020.00228

    authors: Locke TM,Fujita H,Hunker A,Johanson SS,Darvas M,du Lac S,Zweifel LS,Carlson ES

    更新日期:2020-07-29 00:00:00

  • Multiple Kinases Involved in the Nicotinic Modulation of Gamma Oscillations in the Rat Hippocampal CA3 Area.

    abstract::Neuronal synchronization at gamma band frequency (20-80 Hz, γ oscillations) is closely associated with higher brain function, such as learning, memory and attention. Nicotinic acetylcholine receptors (nAChRs) are highly expressed in the hippocampus, and modulate hippocampal γ oscillations, but the intracellular mechan...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2017.00057

    authors: Wang J,He X,Guo F,Cheng X,Wang Y,Wang X,Feng Z,Vreugdenhil M,Lu C

    更新日期:2017-03-06 00:00:00

  • Synaptic vesicle tethering and the CaV2.2 distal C-terminal.

    abstract::Evidence that synaptic vesicles (SVs) can be gated by a single voltage sensitive calcium channel (CaV2.2) predict a molecular linking mechanism or "tether" (Stanley, 1993). Recent studies have proposed that the SV binds to the distal C-terminal on the CaV2.2 calcium channel (Kaeser et al., 2011; Wong et al., 2013) whi...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2014.00071

    authors: Wong FK,Nath AR,Chen RH,Gardezi SR,Li Q,Stanley EF

    更新日期:2014-03-07 00:00:00

  • Systematic Analysis of mRNA and miRNA Expression of 3D-Cultured Neural Stem Cells (NSCs) in Spaceflight.

    abstract::Recently, with the development of the space program there are growing concerns about the influence of spaceflight on tissue engineering. The purpose of this study was thus to determine the variations of neural stem cells (NSCs) during spaceflight. RNA-Sequencing (RNA-Seq) based transcriptomic profiling of NSCs identif...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2017.00434

    authors: Cui Y,Han J,Xiao Z,Qi Y,Zhao Y,Chen B,Fang Y,Liu S,Wu X,Dai J

    更新日期:2018-01-11 00:00:00

  • LRRK2: an éminence grise of Wnt-mediated neurogenesis?

    abstract::The importance of leucine-rich repeat kinase 2 (LRRK2) to mature neurons is well-established, since mutations in PARK8, the gene encoding LRRK2, are the most common known cause of Parkinson's disease. Nonetheless, despite the LRRK2 knockout mouse having no overt neurodevelopmental defect, numerous lines of in vitro da...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2013.00082

    authors: Berwick DC,Harvey K

    更新日期:2013-05-31 00:00:00

  • Legal but lethal: functional protein aggregation at the verge of toxicity.

    abstract::Many neurodegenerative disorders are linked to irreversible protein aggregation, a process that usually comes along with toxicity and serious cellular damage. However, it is emerging that protein aggregation can also serve for physiological purposes, as impressively shown for prions. While the aggregation of this prot...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fncel.2015.00045

    authors: Falsone A,Falsone SF

    更新日期:2015-02-18 00:00:00

  • Disruption of Slc4a10 augments neuronal excitability and modulates synaptic short-term plasticity.

    abstract::Slc4a10 is a Na(+)-coupled Cl(-)-HCO3 (-) exchanger, which is expressed in principal and inhibitory neurons as well as in choroid plexus epithelial cells of the brain. Slc4a10 knockout (KO) mice have collapsed brain ventricles and display an increased seizure threshold, while heterozygous deletions in man have been as...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2015.00223

    authors: Sinning A,Liebmann L,Hübner CA

    更新日期:2015-06-16 00:00:00

  • Distribution of nitric oxide-producing cells along spinal cord in urodeles.

    abstract::Nitric oxide is a unique neurotransmitter, which participates in many physiological and pathological processes in the organism. There are little data about the neuronal nitric oxide synthase immunoreactivity in the spinal cord of amphibians. In this respect, the present study aims to investigate the distribution of ni...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2014.00299

    authors: Mahmoud MA,Fahmy GH,Moftah MZ,Sabry I

    更新日期:2014-09-25 00:00:00

  • GABA(A) Receptor β3 Subunit Expression Regulates Tonic Current in Developing Striatopallidal Medium Spiny Neurons.

    abstract::The striatum is a key structure for movement control, but the mechanisms that dictate the output of distinct subpopulations of medium spiny projection neurons (MSNs), striatonigral projecting and dopamine D1 receptor- (D1+) or striatopallidal projecting and dopamine D2 receptor- (D2+) expressing neurons, remains poorl...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2011.00015

    authors: Janssen MJ,Yasuda RP,Vicini S

    更新日期:2011-07-28 00:00:00

  • Corrigendum: Imaging Calcium in Hippocampal Presynaptic Terminals With a Ratiometric Calcium Sensor in a Novel Transgenic Mouse.

    abstract::[This corrects the article DOI: 10.3389/fncel.2018.00209.]. ...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章,已发布勘误

    doi:10.3389/fncel.2019.00194

    authors: Al-Osta I,Mucha M,Pereda D,Piqué-Gili M,Okorocha AE,Thomas R,Hartell NA

    更新日期:2019-05-15 00:00:00

  • HAX-1 Protects Glioblastoma Cells from Apoptosis through the Akt1 Pathway.

    abstract::Glioblastoma is the most common malignant tumor in central nervous system (CNS), and it is still insurmountable and has a poor prognosis. The proliferation and survival mechanism of glioma cells needs to be explored further for the development of glioma treatment. Hematopoietic-substrate-1 associated protein X-1 (HAX-...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2017.00420

    authors: Deng X,Song L,Zhao W,Wei Y,Guo XB

    更新日期:2017-12-21 00:00:00

  • Ca2+ Regulates the Kinetics of Synaptic Vesicle Fusion at the Afferent Inner Hair Cell Synapse.

    abstract::The early auditory pathway processes information at high rates and with utmost temporal fidelity. Consequently, the synapses in the auditory pathway are highly specialized to meet the extraordinary requirements on signal transmission. The calyceal synapses in the auditory brainstem feature more than a hundred active z...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2018.00364

    authors: Huang CH,Moser T

    更新日期:2018-10-17 00:00:00

  • Overexpression of Isoforms of Nitric Oxide Synthase 1 Adaptor Protein, Encoded by a Risk Gene for Schizophrenia, Alters Actin Dynamics and Synaptic Function.

    abstract::Proper communication between neurons depends upon appropriate patterning of dendrites and correct distribution and structure of spines. Schizophrenia is a neuropsychiatric disorder characterized by alterations in dendrite branching and spine density. Nitric oxide synthase 1 adaptor protein (NOS1AP), a risk gene for sc...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2016.00006

    authors: Hernandez K,Swiatkowski P,Patel MV,Liang C,Dudzinski NR,Brzustowicz LM,Firestein BL

    更新日期:2016-02-02 00:00:00

  • Dyslipidemic Diet Induces Mobilization of Peripheral Neutrophils and Monocytes That Exacerbate Hemorrhagic Brain Injury and Neuroinflammation.

    abstract::Background: Non-alcoholic fatty liver disease (NAFLD) is a common liver condition characterized by a significant accumulation of lipids in the liver without excessive alcohol consumption. Accumulating evidence suggests a significantly increased risk of intracerebral hemorrhage (ICH) in NAFLD patients. However, it rema...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2020.00154

    authors: Li X,Cheng X,Wang X,Liu Q,Ma H,Li M

    更新日期:2020-06-08 00:00:00

  • Enhanced Synaptic Activity and Epileptiform Events in the Embryonic KCC2 Deficient Hippocampus.

    abstract::The neuronal potassium-chloride co-transporter 2 [indicated thereafter as KCC2 (for protein) and Kcc2 (for gene)] is thought to play an important role in the post natal excitatory to inhibitory switch of GABA actions in the rodent hippocampus. Here, by studying hippocampi of wild-type (Kcc2(+/+)) and Kcc2 deficient (K...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2011.00023

    authors: Khalilov I,Chazal G,Chudotvorova I,Pellegrino C,Corby S,Ferrand N,Gubkina O,Nardou R,Tyzio R,Yamamoto S,Jentsch TJ,Hübner CA,Gaiarsa JL,Ben-Ari Y,Medina I

    更新日期:2011-11-01 00:00:00

  • AMPA Receptors Are Involved in Store-Operated Calcium Entry and Interact with STIM Proteins in Rat Primary Cortical Neurons.

    abstract::The process of store-operated calcium entry (SOCE) leads to refilling the endoplasmic reticulum (ER) with calcium ions (Ca2+) after their release into the cytoplasm. Interactions between (ER)-located Ca2+ sensors (stromal interaction molecule 1 [STIM1] and STIM2) and plasma membrane-located Ca2+ channel-forming protei...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2016.00251

    authors: Gruszczynska-Biegala J,Sladowska M,Kuznicki J

    更新日期:2016-10-25 00:00:00

  • G Protein-Coupled Receptor Heteromers as Putative Pharmacotherapeutic Targets in Autism.

    abstract::A major challenge in the development of pharmacotherapies for autism is the failure to identify pathophysiological mechanisms that could be targetable. The majority of developing strategies mainly aim at restoring the brain excitatory/inhibitory imbalance described in autism, by targeting glutamate or GABA receptors. ...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fncel.2020.588662

    authors: DelaCuesta-Barrutia J,Peñagarikano O,Erdozain AM

    更新日期:2020-10-30 00:00:00

  • AF-6 Protects Against Dopaminergic Dysfunction and Mitochondrial Abnormalities in Drosophila Models of Parkinson's Disease.

    abstract::Afadin 6 (AF-6) is an F-actin binding multidomain-containing scaffolding protein that is known for its function in cell-cell adhesion. Interestingly, besides this well documented role, we recently found that AF-6 is a Parkin-interacting protein that augments Parkin/PINK1-mediated mitophagy. Notably, mutations in Parki...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2017.00241

    authors: Basil AH,Sim JPL,Lim GGY,Lin S,Chan HY,Engelender S,Lim KL

    更新日期:2017-08-10 00:00:00

  • Experience-Dependent Changes in Myelin Basic Protein Expression in Adult Visual and Somatosensory Cortex.

    abstract::An experience-driven increase in oligodendrocytes and myelin in the somatosensory cortex (S1) has emerged as a new marker of adult cortical plasticity. That finding contrasts with the view that myelin is a structural brake on plasticity, and that contributes to ending the critical period (CP) in the visual cortex (V1)...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2020.00056

    authors: Murphy KM,Mancini SJ,Clayworth KV,Arbabi K,Beshara S

    更新日期:2020-03-17 00:00:00

  • Studying Axon-Astrocyte Functional Interactions by 3D Two-Photon Ca2+ Imaging: A Practical Guide to Experiments and "Big Data" Analysis.

    abstract::Recent advances in fast volumetric imaging have enabled rapid generation of large amounts of multi-dimensional functional data. While many computer frameworks exist for data storage and analysis of the multi-gigabyte Ca2+ imaging experiments in neurons, they are less useful for analyzing Ca2+ dynamics in astrocytes, w...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2018.00098

    authors: Savtchouk I,Carriero G,Volterra A

    更新日期:2018-04-13 00:00:00

  • Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasia.

    abstract::Cortical dysplasia is associated with intractable epilepsy and developmental delay in young children. Recent work with the rat freeze-induced focal cortical dysplasia (FCD) model has demonstrated that hyperexcitability in the dysplastic cortex is due in part to higher levels of extracellular glutamate. Astrocyte gluta...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2014.00425

    authors: Campbell SL,Hablitz JJ,Olsen ML

    更新日期:2014-12-17 00:00:00

  • Effects of bone marrow mesenchymal stem cells (BM-MSCs) on rat pial microvascular remodeling after transient middle cerebral artery occlusion.

    abstract::Previous studies have shown that the pial microcirculation remodeling improves neurological outcome after middle cerebral artery occlusion (MCAO), accompanied by higher expression of vascular endothelial growth factor (VEGF) and endothelial nitric oxide synthase (eNOS), modulating in vivo angiogenesis. This study was ...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2015.00329

    authors: Lapi D,Vagnani S,Sapio D,Mastantuono T,Boscia F,Pignataro G,Penna C,Pagliaro P,Colantuoni A

    更新日期:2015-08-25 00:00:00

  • Fatty Acid Signaling Mechanisms in Neural Cells: Fatty Acid Receptors.

    abstract::Fatty acids (FAs) are typically associated with structural and metabolic roles, as they can be stored as triglycerides, degraded by β-oxidation or used in phospholipids' synthesis, the main components of biological membranes. It has been shown that these lipids exhibit also regulatory functions in different cell types...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fncel.2019.00162

    authors: Falomir-Lockhart LJ,Cavazzutti GF,Giménez E,Toscani AM

    更新日期:2019-04-24 00:00:00

  • Spatiotemporal Differences in Gene Expression Between Motor and Sensory Autografts and Their Effect on Femoral Nerve Regeneration in the Rat.

    abstract::To improve the outcome after autologous nerve grafting in the clinic, it is important to understand the limiting variables such as distinct phenotypes of motor and sensory Schwann cells. This study investigated the properties of phenotypically different autografts in a 6 mm femoral nerve defect model in the rat, where...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2019.00182

    authors: Hercher D,Kerbl M,Schuh CMAP,Heinzel J,Gal L,Stainer M,Schmidhammer R,Hausner T,Redl H,Nógrádi A,Hacobian A

    更新日期:2019-05-08 00:00:00

  • Neuropathic Pain Causes Pyramidal Neuronal Hyperactivity in the Anterior Cingulate Cortex.

    abstract::The anterior cingulate cortex (ACC) is thought to be important for acute pain perception as well as the development of chronic pain after peripheral nerve injury. Nevertheless, how ACC neurons respond to sensory stimulation under chronic pain states is not well understood. Here, we used an in vivo two-photon imaging t...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2018.00107

    authors: Zhao R,Zhou H,Huang L,Xie Z,Wang J,Gan WB,Yang G

    更新日期:2018-04-20 00:00:00

  • Morphological and functional aspects of progenitors perturbed in cortical malformations.

    abstract::In this review, we discuss molecular and cellular mechanisms important for the function of neuronal progenitors during development, revealed by their perturbation in different cortical malformations. We focus on a class of neuronal progenitors, radial glial cells (RGCs), which are renowned for their unique morphologic...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fncel.2015.00030

    authors: Bizzotto S,Francis F

    更新日期:2015-02-12 00:00:00

  • Long-Term Stress Disrupts the Structural and Functional Integrity of GABAergic Neuronal Networks in the Medial Prefrontal Cortex of Rats.

    abstract::Clinical and experimental data suggest that fronto-cortical GABAergic deficits contribute to the pathophysiology of major depressive disorder (MDD). To further test this hypothesis, we used a well characterized rat model for depression and examined the effect of stress on GABAergic neuron numbers and GABA-mediated syn...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2018.00148

    authors: Czéh B,Vardya I,Varga Z,Febbraro F,Csabai D,Martis LS,Højgaard K,Henningsen K,Bouzinova EV,Miseta A,Jensen K,Wiborg O

    更新日期:2018-06-20 00:00:00

  • Electrophysiological Effects of Ghrelin in the Hypothalamic Paraventricular Nucleus Neurons.

    abstract::The paraventricular nucleus (PVN) is involved in the control of sympathetic tone and the secretion of hormones, both functions known to be influenced by ghrelin, suggesting direct effect of ghrelin in this nucleus. However, the effects of ghrelin on the excitability of different PVN neuronal populations have not been ...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2018.00275

    authors: Dos-Santos RC,Grover HM,Reis LC,Ferguson AV,Mecawi AS

    更新日期:2018-08-24 00:00:00

  • Enhanced Expression of Secreted α-Klotho in the Hippocampus Alters Nesting Behavior and Memory Formation in Mice.

    abstract::The klotho gene family consists of α-, β-, and γ-Klotho, which encode type I single-pass transmembrane proteins with large extracellular domains. α-Klotho exists as a full-length membrane-bound and as a soluble form after cleavage of the extracellular domain. Due to gene splicing, a short extracellular Klotho form can...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2019.00133

    authors: Li D,Jing D,Liu Z,Chen Y,Huang F,Behnisch T

    更新日期:2019-04-02 00:00:00