Abstract:
:Hippocampal inhibitory interneurons exhibit a large diversity of dendritic Ca2+ mechanisms that are involved in the induction of Hebbian and anti-Hebbian synaptic plasticity. High resolution imaging techniques allowed examining somatic Ca2+ signals and, accordingly, the recruitment of hippocampal interneurons in awake behaving animals. However, little is still known about dendritic Ca2+ activity in interneurons during different behavioral states. Here, we used two-photon Ca2+ imaging in mouse hippocampal CA1 interneurons to reveal Ca2+ signal patterns in interneuron dendrites during animal locomotion and immobility. Despite overall variability in dendritic Ca2+ transients (CaTs) across different cells and dendritic branches, we report consistent behavior state-dependent organization of Ca2+ signaling in interneurons. As such, spreading regenerative CaTs dominated in dendrites during locomotion, whereas both spreading and localized Ca2+ signals were seen during immobility. Thus, these data indicate that while animal locomotion is associated with widespread Ca2+ elevations in interneuron dendrites that may reflect regenerative activity, local CaTs that may be related to synaptic activity become apparent during animal quiet state.
journal_name
Front Cell Neuroscijournal_title
Frontiers in cellular neuroscienceauthors
Francavilla R,Villette V,Martel O,Topolnik Ldoi
10.3389/fncel.2019.00098subject
Has Abstractpub_date
2019-03-15 00:00:00pages
98issn
1662-5102journal_volume
13pub_type
杂志文章abstract::Regulatory T cells (Tregs) play an anti-inflammatory effect to protect against ischemic stroke. Plasmacytoid dendritic cells (pDCs) can induce regulatory T cells tolerance in sterile-inflammation conditions. However, whether and how pDCs-mediated Tregs response play a part in the pathology of ischemic stroke remains u...
journal_title:Frontiers in cellular neuroscience
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journal_title:Frontiers in cellular neuroscience
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journal_title:Frontiers in cellular neuroscience
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journal_title:Frontiers in cellular neuroscience
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journal_title:Frontiers in cellular neuroscience
pub_type: 杂志文章
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journal_title:Frontiers in cellular neuroscience
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journal_title:Frontiers in cellular neuroscience
pub_type: 杂志文章,评审
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journal_title:Frontiers in cellular neuroscience
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journal_title:Frontiers in cellular neuroscience
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journal_title:Frontiers in cellular neuroscience
pub_type: 杂志文章
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journal_title:Frontiers in cellular neuroscience
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doi:10.3389/fncel.2020.00114
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journal_title:Frontiers in cellular neuroscience
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doi:10.3389/fncel.2014.00071
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journal_title:Frontiers in cellular neuroscience
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journal_title:Frontiers in cellular neuroscience
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journal_title:Frontiers in cellular neuroscience
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