Studying Axon-Astrocyte Functional Interactions by 3D Two-Photon Ca2+ Imaging: A Practical Guide to Experiments and "Big Data" Analysis.

abstract：:Alzheimer disease is characterized by a progressive cognitive deficit and may be associated with an aberrant hyperexcitability of the neuronal network. Notoginsenoside R1 (R1), a major activity ingredient from Panax notoginseng, has demonstrated favorable changes in neuronal plasticity and induced neuroprotective effe...

journal_title：Frontiers in cellular neuroscience

authors： Hu T,Li S,Liang WQ,Li SS,Lu MN,Chen B,Zhang L,Mao R,Ding WH,Gao WW,Chen SW,XiYang YB,Zhang J,Wang XY

更新日期：2020-09-04 00:00:00

abstract：BACKGROUND:Amyotrophic lateral sclerosis (ALS) is an incurable fatal motoneuron disease with a lifetime risk of approximately 1:400. It is characterized by progressive weakness, muscle wasting, and death ensuing 3-5 years after diagnosis. Granulocyte-colony stimulating factor (G-CSF) is a drug candidate for ALS, with e...

journal_title：Frontiers in cellular neuroscience

authors： Henriques A,Kastner S,Chatzikonstantinou E,Pitzer C,Plaas C,Kirsch F,Wafzig O,Krüger C,Spoelgen R,Gonzalez De Aguilar JL,Gretz N,Schneider A

更新日期：2015-01-20 00:00:00

abstract：:Epilepsy is a common neurological disorder characterized by recurrent uncontrolled seizures and has an idiopathic "genetic" etiology or a symptomatic "acquired" component. Genetic studies have revealed that many epilepsy susceptibility genes encode ion channels, including voltage-gated sodium, potassium and calcium ch...

journal_title：Frontiers in cellular neuroscience

authors： van Loo KMJ,Becker AJ

更新日期：2020-01-14 00:00:00

abstract：:Germinal matrix hemorrhage (GMH) is a serious complication in extremely preterm infants associated with neurological deficits and mortality. The purpose of the present study was to develop and characterize a grade III and IV GMH model in postnatal day 5 (P5) rats, the equivalent of preterm human brain maturation. P5 W...

journal_title：Frontiers in cellular neuroscience

authors： Jinnai M,Koning G,Singh-Mallah G,Jonsdotter A,Leverin AL,Svedin P,Nair S,Takeda S,Wang X,Mallard C,Ek CJ,Rocha-Ferreira E,Hagberg H

更新日期：2020-12-03 00:00:00

abstract：:The extracellular matrix (ECM) is known to play important roles in regulating neuronal recovery from injury. The ECM can also impact physiological synaptic plasticity, although this process is less well understood. To understand the impact of the ECM on synaptic function and remodeling in vivo, we examined ECM composi...

journal_title：Frontiers in cellular neuroscience

authors： Kelly EA,Russo AS,Jackson CD,Lamantia CE,Majewska AK

更新日期：2015-09-22 00:00:00

abstract：:Members of the Shank family of multidomain proteins (Shank1, Shank2, and Shank3) are core components of the postsynaptic density (PSD) of excitatory synapses. At synaptic sites Shanks serve as scaffolding molecules that cluster neurotransmitter receptors as well as cell adhesion molecules attaching them to the actin c...

journal_title：Frontiers in cellular neuroscience

authors： Heise C,Schroeder JC,Schoen M,Halbedl S,Reim D,Woelfle S,Kreutz MR,Schmeisser MJ,Boeckers TM

更新日期：2016-04-26 00:00:00

abstract：:Functionally related neurons assemble into connected networks that process and transmit electrochemical information. To do this in a coordinated manner, the number and strength of synaptic connections is tightly regulated. Synapse function relies on the microtubule (MT) cytoskeleton, the dynamics of which are in turn ...

journal_title：Frontiers in cellular neuroscience

authors： Verstraelen P,Detrez JR,Verschuuren M,Kuijlaars J,Nuydens R,Timmermans JP,De Vos WH

更新日期：2017-06-22 00:00:00

abstract：:The complex and elaborate architecture of a neuron poses a great challenge to the cellular machinery which localizes proteins and organelles, such as mitochondria, to necessary locations. Proper mitochondrial localization in neurons is particularly important as this organelle provides energy and metabolites essential ...

journal_title：Frontiers in cellular neuroscience

authors： Mandal A,Drerup CM

更新日期：2019-08-09 00:00:00

abstract：:Chronic pain is accompanied with long-term sensory, affective and cognitive disturbances. What are the mechanisms that mediate the long-term consequences of painful experiences and embed them in the genome? We hypothesize that alterations in DNA methylation, an enzymatic covalent modification of cytosine bases in DNA,...

journal_title：Frontiers in cellular neuroscience

authors： Alvarado S,Tajerian M,Suderman M,Machnes Z,Pierfelice S,Millecamps M,Stone LS,Szyf M

更新日期：2015-03-24 00:00:00

abstract：:Analysis of presynaptic protein expression in glutamatergic and GABAergic central synapses performed in several laboratories and with different techniques is unveiling a complex scenario, largely because each presynaptic protein exists in several isoforms. The interpretation of these findings is generally based on the...

journal_title：Frontiers in cellular neuroscience

authors： Bragina L,Fattorini G,Giovedì S,Bosco F,Benfenati F,Conti F

更新日期：2013-02-04 00:00:00

abstract：:IN ADULT MAMMALS, UNDER PHYSIOLOGICAL CONDITIONS, NEUROGENESIS, THE PROCESS OF GENERATING NEW FUNCTIONAL NEURONS FROM PRECURSOR CELLS, OCCURS MAINLY IN TWO BRAIN AREAS: the subgranular zone in the dentate gyrus of the hippocampus, and the subventricular zone (SVZ) lining the walls of the brain lateral ventricles. Taki...

journal_title：Frontiers in cellular neuroscience

authors： Falcão AM,Marques F,Novais A,Sousa N,Palha JA,Sousa JC

更新日期：2012-08-09 00:00:00

abstract：:Alterations in NGF/TrkA signaling have been suggested to underlie the selective degeneration of the cholinergic basal forebrain neurons occurring in vivo in AD (Counts and Mufson, 2005; Mufson et al., 2008; Niewiadomska et al., 2011) and significant reduction of cognitive decline along with an improvement of cholinerg...

journal_title：Frontiers in cellular neuroscience

authors： Latina V,Caioli S,Zona C,Ciotti MT,Amadoro G,Calissano P

更新日期：2017-03-15 00:00:00

abstract：:Brain neurons, to support their neurotransmitter functions, require a several times higher supply of glucose than non-excitable cells. Pyruvate, the end product of glycolysis, through pyruvate dehydrogenase complex reaction, is a principal source of acetyl-CoA, which is a direct energy substrate in all brain cells. Se...

journal_title：Frontiers in cellular neuroscience

authors： Ronowska A,Szutowicz A,Bielarczyk H,Gul-Hinc S,Klimaszewska-Łata J,Dyś A,Zyśk M,Jankowska-Kulawy A

更新日期：2018-07-10 00:00:00

abstract：:Degenerative retinopathies are the leading causes of irreversible visual impairment in the elderly, affecting hundreds of millions of patients. Müller glia cells (MGC), the main type of glia found in the vertebrate retina, can resume proliferation in the rodent adult injured retina but contribute weakly to tissue repa...

journal_title：Frontiers in cellular neuroscience

authors： Guimarães RPM,Landeira BS,Coelho DM,Golbert DCF,Silveira MS,Linden R,de Melo Reis RA,Costa MR

更新日期：2018-11-12 00:00:00

abstract：:During the last decades it became increasingly evident that electrical synapses are capable of activity-dependent plasticity. However, measuring the actual strength of electrical transmission remains difficult. Usually changes in coupling strength can only be inferred indirectly from measures such as the coupling coef...

journal_title：Frontiers in cellular neuroscience

authors： Welzel G,Schuster S

更新日期：2019-02-12 00:00:00

abstract：:Local circuit and long-range GABAergic projections provide powerful inhibitory control over the operation of hippocampal inhibitory circuits, yet little is known about the input- and target-specific organization of interacting inhibitory networks in relation to their specific functions. Using a combination of two-phot...

journal_title：Frontiers in cellular neuroscience

authors： Chamberland S,Salesse C,Topolnik D,Topolnik L

更新日期：2010-10-15 00:00:00

abstract：:Fatty acids (FAs) are typically associated with structural and metabolic roles, as they can be stored as triglycerides, degraded by β-oxidation or used in phospholipids' synthesis, the main components of biological membranes. It has been shown that these lipids exhibit also regulatory functions in different cell types...

journal_title：Frontiers in cellular neuroscience

authors： Falomir-Lockhart LJ,Cavazzutti GF,Giménez E,Toscani AM

更新日期：2019-04-24 00:00:00

abstract：:Up to 15 years ago, bibliographic searches based on keywords such as "photoreceptor degeneration, inner retina" or "photoreceptor degeneration, second order neurons" returned only a handful of papers, as the field was dominated by the general assumption that retinal degeneration had direct effects on the sole populati...

journal_title：Frontiers in cellular neuroscience

authors： Strettoi E

更新日期：2015-12-23 00:00:00

abstract：:Gonadotropin releasing hormone-1 (GnRH-1) neurons play a pivotal role in controlling pubertal onset and fertility once they reach their hypothalamic location. During embryonic development, GnRH-1 neurons migrate from the nasal area to the hypothalamus where they modulate gonadotropin release from the pituitary gland. ...

journal_title：Frontiers in cellular neuroscience

authors： Taroc EZM,Lin JM,Tulloch AJ,Jaworski A,Forni PE

更新日期：2019-03-01 00:00:00

abstract：:Neurotrophin receptors use endosomal pathways for signaling in neurons. However, how neurotrophins regulate the endosomal system for proper signaling is unknown. Rabs are monomeric GTPases that act as molecular switches to regulate membrane trafficking by binding a wide range of effectors. Among the Rab GTPases, Rab5 ...

journal_title：Frontiers in cellular neuroscience

authors： Moya-Alvarado G,Gonzalez A,Stuardo N,Bronfman FC

更新日期：2018-12-17 00:00:00

abstract：:The cerebellar cortex is remarkable for its organizational regularity, out of which task-related neural networks should emerge. In Purkinje cells, both complex and simple spike network patterns are evident in sensorimotor behavior. However, task-related patterns of activity in the granule cell layer (GCL) have been le...

journal_title：Frontiers in cellular neuroscience

authors： Courtemanche R,Chabaud P,Lamarre Y

更新日期：2009-07-20 00:00:00

abstract：:A fundamental interest in circuit analysis is to parse out the synaptic inputs underlying a behavioral experience. Toward this aim, we have devised an unbiased strategy that specifically labels the afferent inputs that are activated by a defined stimulus in an activity-dependent manner. We validated this strategy in f...

journal_title：Frontiers in cellular neuroscience

authors： Krauth N,Khalil V,Jariwala M,Mermet-Joret N,Vestergaard AK,Capogna M,Nabavi S

更新日期：2020-05-12 00:00:00

abstract：:Neurons must establish and stabilize connections made with diverse targets, each with distinct demands and functional characteristics. At Drosophila neuromuscular junctions (NMJs), synaptic strength remains stable in a manipulation that simultaneously induces hypo-innervation on one target and hyper-innervation on the...

journal_title：Frontiers in cellular neuroscience

authors： Goel P,Nishimura S,Chetlapalli K,Li X,Chen C,Dickman D

更新日期：2020-06-26 00:00:00

abstract：:Ion channel receptors are a vital component of nervous system signaling, allowing rapid and direct conversion of a chemical neurotransmitter message to an electrical current. In recent decades, it has become apparent that ionotropic receptors are regulated by protein-protein interactions with other ion channels, G-pro...

journal_title：Frontiers in cellular neuroscience

authors： Li S,Wong AH,Liu F

更新日期：2014-05-09 00:00:00

abstract：:Amyloid peptide is able to promote the activation of microglia and astrocytes in Alzheimer's disease (AD), and this stimulates the production of pro-inflammatory cytokines. Inflammation contributes to the process of neurodegeneration and therefore is a key factor in the development of AD. Some of the most important pr...

journal_title：Frontiers in cellular neuroscience

authors： Toral-Rios D,Franco-Bocanegra D,Rosas-Carrasco O,Mena-Barranco F,Carvajal-García R,Meraz-Ríos MA,Campos-Peña V

更新日期：2015-05-18 00:00:00

abstract：:Microglial activation is a key pathogenic process at the onset of Alzheimer's disease (AD). Identifying regulators of microglial activation bears great potential in elucidating causes and mechanisms of AD and determining candidates for early intervention. Previous studies demonstrate abnormal elevation of glutaminase ...

journal_title：Frontiers in cellular neuroscience

authors： Gao G,Zhao S,Xia X,Li C,Li C,Ji C,Sheng S,Tang Y,Zhu J,Wang Y,Huang Y,Zheng JC

更新日期：2019-06-28 00:00:00

abstract：:Endoplasmic reticulum (ER) stress and protein misfolding are associated with various neurodegenerative diseases. ER stress activates unfolded protein response (UPR), an adaptative response. However, severe ER stress can induce cell death. Here we show that the E3 ubiquitin ligase and co-chaperone Carboxyl Terminus HSP...

journal_title：Frontiers in cellular neuroscience

authors： Cabral Miranda F,Adão-Novaes J,Hauswirth WW,Linden R,Petrs-Silva H,Chiarini LB

更新日期：2015-01-09 00:00:00

abstract：:Autoreactive T cells that infiltrate into the central nervous system (CNS) are believed to have a significant role in mediating the pathology of neuroinflammatory diseases like multiple sclerosis. Their interaction with microglia and astrocytes in the CNS is crucial for the regulation of neuroinflammatory processes. O...

journal_title：Frontiers in cellular neuroscience

authors： Prajeeth CK,Dittrich-Breiholz O,Talbot SR,Robert PA,Huehn J,Stangel M

更新日期：2018-10-10 00:00:00

abstract：:After damage, axons in the peripheral nervous system (PNS) regenerate and regrow following a process termed Wallerian degeneration, but the regenerative process is often incomplete and usually the system does not reach full recovery. Key steps to the creation of a permissive environment for axonal regrowth are the tra...

journal_title：Frontiers in cellular neuroscience

authors： Pellegatta M,Taveggia C

更新日期：2019-03-20 00:00:00

abstract：:Sections from the middle frontal gyrus (Brodmann area 46) of autopsy-confirmed Alzheimer's disease (AD) patients and non-demented subjects were examined for the prevalence of hallmark AD pathology, including amyloid-β (Aβ) plaques, phosphorylated tau (pTau) tangles, neuroinflammation and synaptic loss (n = 7 subjects/...

journal_title：Frontiers in cellular neuroscience

authors： Metaxas A,Thygesen C,Briting SRR,Landau AM,Darvesh S,Finsen B

更新日期：2019-12-05 00:00:00