Structure, function, and plasticity of GABA transporters.

abstract：:Climbing fiber (CF) triggered complex spikes (CS) are massive depolarization bursts in the cerebellar Purkinje cell (PC), showing several high frequency spikelet components (±600 Hz). Since its early observations, the CS is known to vary in shape. In this study we describe CS waveforms, extracellularly recorded in awa...

journal_title：Frontiers in cellular neuroscience

authors： Warnaar P,Couto J,Negrello M,Junker M,Smilgin A,Ignashchenkova A,Giugliano M,Thier P,De Schutter E

更新日期：2015-04-13 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fncel.2019.00150.]. ...

journal_title：Frontiers in cellular neuroscience

authors： Chen Q,Qiao Y,Xu XJ,You X,Tao Y

更新日期：2019-08-22 00:00:00

abstract：:Microglia are activated after neuronal injury and in neurodegenerative diseases, and trigger neuroinflammation in the central nervous system (CNS). Microglia-derived neuroinflammation has both beneficial and detrimental effects on neurons. Because the timing and magnitude of microglial activation is thought to be a cr...

journal_title：Frontiers in cellular neuroscience

authors： Konishi H,Kiyama H

更新日期：2018-08-06 00:00:00

abstract：:Soon after its discovery, microRNA-9 (miR-9) attracted the attention of neurobiologists, since it is one of the most highly expressed microRNAs in the developing and adult vertebrate brain. Functional analyses in different vertebrate species have revealed a prominent role of this microRNA in balancing proliferation in...

journal_title：Frontiers in cellular neuroscience

authors： Coolen M,Katz S,Bally-Cuif L

更新日期：2013-11-20 00:00:00

abstract：:Prenatal exposure to the antiepileptic drug valproic acid (VPA) induces autism spectrum disorder (ASD) in humans and autistic-like behaviors in rodents, which makes it a good model to study the neural underpinnings of ASD. Rats prenatally exposed to VPA show profound deficits in the social domain. The altered social b...

journal_title：Frontiers in cellular neuroscience

authors： Schiavi S,Iezzi D,Manduca A,Leone S,Melancia F,Carbone C,Petrella M,Mannaioni G,Masi A,Trezza V

更新日期：2019-10-25 00:00:00

abstract：:Neurodegenerative disorders such as Parkinson's (PD) and Huntington's disease (HD) are characterized by a selective detrimental impact on neurons in a specific brain area. Currently, these diseases have no cures, although some promising trials of therapies that may be able to slow the loss of brain cells are underway....

journal_title：Frontiers in cellular neuroscience

authors： Salado-Manzano C,Perpiña U,Straccia M,Molina-Ruiz FJ,Cozzi E,Rosser AE,Canals JM

更新日期：2020-08-11 00:00:00

abstract：:Increasing evidence suggest that astrocytes significantly modulate neuronal function at the level of the tripartite synapse both in physiological and pathophysiological conditions. The global control of the astrocytic syncytium over neuronal networks, however, is still less recognized. Here we examined astrocytic sign...

journal_title：Frontiers in cellular neuroscience

authors： Kékesi O,Ioja E,Szabó Z,Kardos J,Héja L

更新日期：2015-06-18 00:00:00

abstract：:Nanobodies are single domain antibodies derived from llama heavy-chain only antibodies (HCAbs). They represent a new generation of biologicals with unique properties: nanobodies show excellent tissue distribution, high temperature and pH stability, are easy to produce recombinantly and can readily be converted into di...

journal_title：Frontiers in cellular neuroscience

authors： Rissiek B,Koch-Nolte F,Magnus T

更新日期：2014-10-21 00:00:00

abstract：:Stressors, during early life or adulthood, can alter steroid-sensitive behaviors, such as exploration, anxiety, and/or cognitive processes. We investigated if exposure to acute stressors in adulthood may alter behavioral and neuroendocrine responses of male rats that were exposed to gestational stress or not. We hypot...

journal_title：Frontiers in cellular neuroscience

authors： Walf AA,Frye CA

更新日期：2012-12-18 00:00:00

abstract：:Several cytokines and chemokines are now known to play normal physiological roles in the brain where they act as key regulators of communication between neurons, glia, and microglia. In particular, cytokines and chemokines can affect cardinal cellular and molecular processes of hippocampal-dependent long-term memory c...

journal_title：Frontiers in cellular neuroscience

authors： Sheridan GK,Wdowicz A,Pickering M,Watters O,Halley P,O'Sullivan NC,Mooney C,O'Connell DJ,O'Connor JJ,Murphy KJ

更新日期：2014-08-12 00:00:00

abstract：:IN ADULT MAMMALS, UNDER PHYSIOLOGICAL CONDITIONS, NEUROGENESIS, THE PROCESS OF GENERATING NEW FUNCTIONAL NEURONS FROM PRECURSOR CELLS, OCCURS MAINLY IN TWO BRAIN AREAS: the subgranular zone in the dentate gyrus of the hippocampus, and the subventricular zone (SVZ) lining the walls of the brain lateral ventricles. Taki...

journal_title：Frontiers in cellular neuroscience

authors： Falcão AM,Marques F,Novais A,Sousa N,Palha JA,Sousa JC

更新日期：2012-08-09 00:00:00

abstract：:The main olfactory epithelium (MOE) functions to detect odor molecules, provide an epithelial surface barrier, and remove xenobiotics from inhaled air. Mechanisms coordinating the activities of different cell types within the MOE to maintain these functions are poorly understood. Previously, we showed that superficial...

journal_title：Frontiers in cellular neuroscience

authors： Fu Z,Ogura T,Luo W,Lin W

更新日期：2018-03-20 00:00:00

abstract：:Fragile X Syndrome (FXS) is caused by a deficiency in Fragile X Mental Retardation Protein (FMRP) leading to global sensorial abnormalities, among which visual defects represent a critical part. These visual defects are associated with cerebral neuron immaturity especially in the primary visual cortex. However, we rec...

journal_title：Frontiers in cellular neuroscience

authors： Perche O,Felgerolle C,Ardourel M,Bazinet A,Pâris A,Rossignol R,Meyer-Dilhet G,Mausset-Bonnefont AL,Hébert B,Laurenceau D,Montécot-Dubourg C,Menuet A,Bizot JC,Pichon J,Ranchon-Cole I,Briault S

更新日期：2018-04-06 00:00:00

abstract：:Amyloid beta (Aβ) is a peptide cleaved from amyloid precursor protein that contributes to the formation of senile plaques in Alzheimer's disease (AD). The relationship between Aβ and astrocyte proliferation in AD remains controversial. Despite pathological findings of increased astrocytic mitosis in AD brains, in vitr...

journal_title：Frontiers in cellular neuroscience

authors： Ohki EC,Langan TJ,Rodgers KR,Chou RC

更新日期：2017-09-26 00:00:00

abstract：:The subventricular zone (SVZ) is the largest source of newly generated cells in the adult mammalian brain. SVZ-derived neuroblasts migrate via the rostral migratory stream (RMS) to the olfactory bulb (OB), where they differentiate into mature neurons. Additionally, a small proportion of SVZ-derived cells contribute to...

journal_title：Frontiers in cellular neuroscience

authors： Capilla-Gonzalez V,Cebrian-Silla A,Guerrero-Cazares H,Garcia-Verdugo JM,Quiñones-Hinojosa A

更新日期：2013-09-11 00:00:00

abstract：:GABAergic plasticity is recognized as a key mechanism of shaping the activity of the neuronal networks. However, its description is challenging because of numerous neuron-specific mechanisms. In particular, while essential role of glial cells in the excitatory plasticity is well established, their involvement in GABAe...

journal_title：Frontiers in cellular neuroscience

authors： Kaczor PT,Mozrzymas JW

更新日期：2017-05-16 00:00:00

abstract：BACKGROUND:Numerous studies have reported a beneficial impact of neural progenitor cell transplantation on functional outcome after traumatic brain injury (TBI) during short and medium follow-up periods. However, our knowledge regarding long-term functional effects is fragmentary while a direct comparison between local...

journal_title：Frontiers in cellular neuroscience

authors： Skardelly M,Gaber K,Burdack S,Scheidt F,Schuhmann MU,Hilbig H,Meixensberger J,Boltze J

更新日期：2014-10-14 00:00:00

abstract：:Central neurons express a variety of neuronal types and ion channels that promote firing heterogeneity among their distinct neuronal populations. Action potential (AP) phasic firing, produced by low-threshold voltage-activated potassium currents (VAKCs), is commonly observed in mammalian brainstem neurons involved in ...

journal_title：Frontiers in cellular neuroscience

authors： Dagostin AA,Lovell PV,Hilscher MM,Mello CV,Leão RM

更新日期：2015-12-10 00:00:00

abstract：:The schizophrenia brain is differentiated from the normal brain by subtle changes, with significant overlap in measures between normal and disease states. For the past 25 years, schizophrenia has increasingly been considered a neurodevelopmental disorder. This frame of reference challenges biological researchers to co...

journal_title：Frontiers in cellular neuroscience

authors： Catts VS,Fung SJ,Long LE,Joshi D,Vercammen A,Allen KM,Fillman SG,Rothmond DA,Sinclair D,Tiwari Y,Tsai SY,Weickert TW,Shannon Weickert C

更新日期：2013-05-15 00:00:00

abstract：:An experience-driven increase in oligodendrocytes and myelin in the somatosensory cortex (S1) has emerged as a new marker of adult cortical plasticity. That finding contrasts with the view that myelin is a structural brake on plasticity, and that contributes to ending the critical period (CP) in the visual cortex (V1)...

journal_title：Frontiers in cellular neuroscience

authors： Murphy KM,Mancini SJ,Clayworth KV,Arbabi K,Beshara S

更新日期：2020-03-17 00:00:00

abstract：:Neural transplantation is a promising therapeutic strategy for neurodegenerative diseases and other disorders of the central nervous system (CNS) such as Parkinson and Huntington diseases, multiple sclerosis or stroke. Although cell replacement therapy already went through clinical trials for some of these diseases us...

journal_title：Frontiers in cellular neuroscience

authors： Bonnamain V,Neveu I,Naveilhan P

更新日期：2012-04-11 00:00:00

abstract：:In the last decade, there is an increasing application of induced pluripotent stem cells (iPSCs) for disease modeling. The iPSC technology enables the study of patient-specific neuronal cell lines in vitro to evaluate dysfunction at the cellular level and identify the responsible genetic factors. This approach might b...

journal_title：Frontiers in cellular neuroscience

authors： Re S,Dogan AA,Ben-Shachar D,Berger G,Werling AM,Walitza S,Grünblatt E

更新日期：2018-09-25 00:00:00

abstract：:The N-methyl-D-aspartate receptors (NMDARs) are part of a large multiprotein complex at the glutamatergic synapse. The assembly of NMDARs with synaptic proteins offers a means to regulate NMDAR channel properties and receptor trafficking, and couples NMDAR activation to distinct intracellular signaling pathways, thus ...

journal_title：Frontiers in cellular neuroscience

authors： Fan X,Jin WY,Wang YT

更新日期：2014-06-10 00:00:00

abstract：:Autism is a neurodevelopmental disorder marked by social skills and communication deficits and interfering repetitive behavior. Intellectual disability often accompanies autism. In addition to behavioral deficits, autism is characterized by neuropathology and brain overgrowth. Increased intracranial volume often accom...

journal_title：Frontiers in cellular neuroscience

authors： Lahiri DK,Sokol DK,Erickson C,Ray B,Ho CY,Maloney B

更新日期：2013-06-21 00:00:00

abstract：:[This corrects the article on p. 56 in vol. 11, PMID: 28303091.]. ...

journal_title：Frontiers in cellular neuroscience

authors： Owens R,Grabert K,Davies CL,Alfieri A,Antel JP,Healy LM,McColl BW

更新日期：2017-08-24 00:00:00

abstract：OBJECTIVE:Neuroinflammation in utero may result in life-long neurological disabilities. The molecular mechanisms whereby microglia contribute to this response remain incompletely understood. METHODS:Lipopolysaccharide (LPS) or saline were administered intravenously to non-anesthetized chronically instrumented near-ter...

journal_title：Frontiers in cellular neuroscience

authors： Cao M,Cortes M,Moore CS,Leong SY,Durosier LD,Burns P,Fecteau G,Desrochers A,Auer RN,Barreiro LB,Antel JP,Frasch MG

更新日期：2015-08-04 00:00:00

abstract：:Traumatic spinal cord injury (SCI) impedes signal transmission by disrupting both the local neurons and their surrounding synaptic connections. Although the majority of SCI patients retain spared neural tissue at the injury site, they predominantly suffer from complete autonomic and sensorimotor dysfunction. While the...

journal_title：Frontiers in cellular neuroscience

authors： Zavvarian MM,Hong J,Fehlings MG

更新日期：2020-05-18 00:00:00

abstract：:Huntington disease (HD) is an inherited neurodegenerative disease characterized by a clinical triad of motor, psychiatric and cognitive symptoms. HD is caused by a CAG repeat expansion in the gene encoding the huntingtin protein. Homozygosity for the HD-causing mutation is extremely rare; thus, the majority of HD pati...

journal_title：Frontiers in cellular neuroscience

authors： Quirion JG,Parsons MP

更新日期：2019-07-17 00:00:00

abstract：:Ischemic stroke is a debilitating disease for which there are currently no effective treatments besides the clot-buster, tissue plasminogen activator (t-PA), which is administered to less than 10% of patients due to a limited (4.5 h) time window of efficacy. Thus, there is an urgent need for novel therapies that can p...

journal_title：Frontiers in cellular neuroscience

authors： Broughton BR,Lim R,Arumugam TV,Drummond GR,Wallace EM,Sobey CG

更新日期：2013-01-17 00:00:00

abstract：:Thyrotropin-releasing hormone (TRH) and its analogs are able to stimulate the release of the endogenic dopamine (DA) in the central nervous system. However, this effect has not been tested in the Parkinson's disease (PD), which is characterized by the DA deficiency due to the dopaminergic neurons loss in the substanti...

journal_title：Frontiers in cellular neuroscience

authors： Zheng C,Chen G,Tan Y,Zeng W,Peng Q,Wang J,Cheng C,Yang X,Nie S,Xu Y,Zhang Z,Papa SM,Ye K,Cao X

更新日期：2018-11-13 00:00:00