Nanobodies as modulators of inflammation: potential applications for acute brain injury.

abstract：:Propofol is a widely used anesthetic in the clinic while several studies have demonstrated that propofol exposure may cause neurotoxicity in the developing brain. However, the effects of early propofol exposure on cerebellar development are not well understood. Propofol (30 or 60 mg/kg) was administered to mice on pos...

journal_title：Frontiers in cellular neuroscience

authors： Xiao R,Yu D,Li X,Huang J,Jing S,Bao X,Yang T,Fan X

更新日期：2017-11-22 00:00:00

abstract：:The role of the cerebellum in cognitive function has been broadly investigated in the last decades from an anatomical, clinical, and functional point of view and new evidence points toward a significant contribution of the posterior lobes of the cerebellum in cognition in Alzheimer's disease (AD). In the present work ...

journal_title：Frontiers in cellular neuroscience

authors： Toniolo S,Serra L,Olivito G,Marra C,Bozzali M,Cercignani M

更新日期：2018-11-20 00:00:00

abstract：:Chronic pain is accompanied with long-term sensory, affective and cognitive disturbances. What are the mechanisms that mediate the long-term consequences of painful experiences and embed them in the genome? We hypothesize that alterations in DNA methylation, an enzymatic covalent modification of cytosine bases in DNA,...

journal_title：Frontiers in cellular neuroscience

authors： Alvarado S,Tajerian M,Suderman M,Machnes Z,Pierfelice S,Millecamps M,Stone LS,Szyf M

更新日期：2015-03-24 00:00:00

abstract：:Schwann cells (SCs) are one of the most promising cellular candidates for the treatment of spinal cord injury. However, SCs show poor migratory ability within the astrocyte-rich central nervous system (CNS) environment and exhibit only limited integration with host astrocytes. Our strategy for improving the therapeuti...

journal_title：Frontiers in cellular neuroscience

authors： Huang L,Xia B,Liu Z,Cao Q,Huang J,Luo Z

更新日期：2017-03-28 00:00:00

abstract：:Ischemic stroke can induce rapid activation of the microglia. It has been reported that the microglia's survival is dependent on colony-stimulating factor 1 receptor (CSF1R) signaling and that pharmacological inhibition of CSF1R leads to morphological changes in the microglia in the healthy brain. However, the impact ...

journal_title：Frontiers in cellular neuroscience

authors： Hou B,Jiang C,Wang D,Wang G,Wang Z,Zhu M,Kang Y,Su J,Wei P,Ren H,Ju F

更新日期：2020-10-16 00:00:00

abstract：:Intrastriatal transplantation of fetal human ventral mesencephalic dopaminergic neurons is an experimental therapy for patients suffering from Parkinson's disease. The success of this approach depends on several host brain parameters including neurotrophic factors and growth inhibitors that guide survival and integrat...

journal_title：Frontiers in cellular neuroscience

authors： Seiler S,Di Santo S,Andereggen L,Widmer HR

更新日期：2017-05-26 00:00:00

abstract：:The klotho gene family consists of α-, β-, and γ-Klotho, which encode type I single-pass transmembrane proteins with large extracellular domains. α-Klotho exists as a full-length membrane-bound and as a soluble form after cleavage of the extracellular domain. Due to gene splicing, a short extracellular Klotho form can...

journal_title：Frontiers in cellular neuroscience

authors： Li D,Jing D,Liu Z,Chen Y,Huang F,Behnisch T

更新日期：2019-04-02 00:00:00

abstract：:Rodents engage in active touch using their facial whiskers: they explore their environment by making rapid back-and-forth movements. The fast nature of whisker movements, during which whiskers often cross each other, makes it notoriously difficult to track individual whiskers of the intact whisker field. We present he...

journal_title：Frontiers in cellular neuroscience

authors： Betting JLF,Romano V,Al-Ars Z,Bosman LWJ,Strydis C,De Zeeuw CI

更新日期：2020-11-17 00:00:00

abstract：:The mammalian olfactory bulb (OB) displays robust activity-dependent plasticity throughout life. Dopaminergic (DA) neurons in the glomerular layer (GL) of the OB are particularly plastic, with loss of sensory input rapidly reducing tyrosine hydroxylase (TH) expression and dopamine production, followed by a substantial...

journal_title：Frontiers in cellular neuroscience

authors： Grier BD,Belluscio L,Cheetham CE

更新日期：2016-07-15 00:00:00

abstract：:The immune system provides protection in the CNS via resident microglial cells and those that traffic into it in the course of pathological challenges. These populations of cells are key players in modulating immune functions that are involved in disease outcomes. In this review, we briefly summarize and highlight the...

journal_title：Frontiers in cellular neuroscience

authors： Fani Maleki A,Rivest S

更新日期：2019-07-31 00:00:00

abstract：:Oligodendrocytes are the myelinating cells of the central nervous system (CNS). While the phrase is oft repeated and holds true, the last few years have borne witness to radical change in our understanding of this unique cell type. Once considered static glue, oligodendrocytes are now seen as plastic and adaptive, cap...

journal_title：Frontiers in cellular neuroscience

authors： Michalski JP,Kothary R

更新日期：2015-09-01 00:00:00

abstract：:Topographical and biochemical characteristics of the substrate are critical for neuronal differentiation including axonal outgrowth and regeneration of neural circuits in vivo. Contact stimuli and signaling molecules allow neurons to develop and stabilize synaptic contacts. Here we present the development, characteriz...

journal_title：Frontiers in cellular neuroscience

authors： García-Parra P,Cavaliere F,Maroto M,Bilbao L,Obieta I,López de Munain A,Alava JI,Izeta A

更新日期：2012-03-14 00:00:00

abstract：:The blood-brain barrier (BBB) is a physical and biochemical barrier that maintains cerebral homeostasis. BBB dysfunction in an ischemic stroke, results in brain injury and subsequent neurological impairment. The aim of this study was to determine the possible protective effects of 1, 25-dihydroxyvitamin D3 [1, 25(OH)2...

journal_title：Frontiers in cellular neuroscience

authors： Guo T,Wang Y,Guo Y,Wu S,Chen W,Liu N,Wang Y,Geng D

更新日期：2018-12-17 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder characterized by amyloid-β (Aβ) plaques and the formation of neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau. In response to Aβ and tau aggregates, microglia, the primary innate immune cells of the central nervous system (CNS), facilitate Aβ a...

journal_title：Frontiers in cellular neuroscience

authors： Shippy DC,Ulland TK

更新日期：2020-09-18 00:00:00

abstract：:The remarkable ability of the nervous system to modify its structure and function is mostly experience and activity modulated. The molecular basis of neuronal plasticity has been studied in higher behavioral processes, such as learning and memory formation. However, neuronal plasticity is not restricted to higher brai...

journal_title：Frontiers in cellular neuroscience

authors： Farca-Luna AJ,Sprecher SG

更新日期：2013-07-04 00:00:00

abstract：:Background: Non-alcoholic fatty liver disease (NAFLD) is a common liver condition characterized by a significant accumulation of lipids in the liver without excessive alcohol consumption. Accumulating evidence suggests a significantly increased risk of intracerebral hemorrhage (ICH) in NAFLD patients. However, it rema...

journal_title：Frontiers in cellular neuroscience

authors： Li X,Cheng X,Wang X,Liu Q,Ma H,Li M

更新日期：2020-06-08 00:00:00

abstract：:Exposing developing cerebellar Purkinje neurons (PNs) to mutant Ataxin1 (ATXN1) in 82Q spinocerebellar ataxia type 1 (SCA1) mice disrupts motor behavior and cerebellar climbing fiber (CF) architecture from as early as 4 weeks of age. In contrast, if mutant ATXN1 expression is silenced until after cerebellar developmen...

journal_title：Frontiers in cellular neuroscience

authors： Ibrahim MF,Power EM,Potapov K,Empson RM

更新日期：2017-09-20 00:00:00

abstract：:The use of human pluripotent stem cells (PSCs) for cell therapy faces a number of challenges that are progressively answered by results from clinical trials and experimental research. Among these is the control of differentiation before transplantation and the prediction of cell fate after administration into the huma...

journal_title：Frontiers in cellular neuroscience

authors： Benchoua A,Onteniente B

更新日期：2012-01-27 00:00:00

abstract：:The brain is a plastic organ where both the intrinsic CNS milieu and extrinsic cues play important roles in shaping and wiring neural connections. The perinatal period constitutes a critical time in central nervous system development with extensive refinement of neural connections, which are highly sensitive to fetal ...

journal_title：Frontiers in cellular neuroscience

authors： Mottahedin A,Ardalan M,Chumak T,Riebe I,Ek J,Mallard C

更新日期：2017-07-11 00:00:00

abstract：:Neurons receive thousands of synaptic inputs that are distributed in space and time. The systematic study of how neurons process these inputs requires a technique to stimulate multiple yet highly targeted points of interest along the neuron's dendritic tree. Three-dimensional multi-focal patterns produced via holograp...

journal_title：Frontiers in cellular neuroscience

authors： Go MA,To MS,Stricker C,Redman S,Bachor HA,Stuart GJ,Daria VR

更新日期：2013-12-02 00:00:00

abstract：:Soon after its discovery, microRNA-9 (miR-9) attracted the attention of neurobiologists, since it is one of the most highly expressed microRNAs in the developing and adult vertebrate brain. Functional analyses in different vertebrate species have revealed a prominent role of this microRNA in balancing proliferation in...

journal_title：Frontiers in cellular neuroscience

authors： Coolen M,Katz S,Bally-Cuif L

更新日期：2013-11-20 00:00:00

abstract：:Recent research has revealed that uncontrolled chronic neuroinflammation is closely associated with diverse neurodegenerative diseases, by impairing blood-brain barrier (BBB) function and astrocytic reaction. Endoplasmic reticulum (ER) stress is conventionally linked to the loss of neuronal structure and function and ...

journal_title：Frontiers in cellular neuroscience

authors： Wang Y,Chen Y,Zhou Q,Xu J,Qian Q,Ni P,Qian Y

更新日期：2018-07-27 00:00:00

abstract：:Hybridization of sympatric closely related species may sometimes lead to introgression and speciation. The sister species Helicoverpa armigera and Helicoverpa assulta both use (Z)-11-hexadecenal and (Z)-9-hexadecenal as sex pheromone components but in reversed ratios. Female H. armigera and male H. assulta could hybri...

journal_title：Frontiers in cellular neuroscience

authors： Xu M,Dong JF,Wu H,Zhao XC,Huang LQ,Wang CZ

更新日期：2017-01-10 00:00:00

abstract：:Cortical fast-spiking (FS) neurons generate high-frequency action potentials (APs) without apparent frequency accommodation, thus providing fast and precise inhibition. However, the maximal firing frequency that they can reach, particularly in primate neocortex, remains unclear. Here, by recording in human, monkey, an...

journal_title：Frontiers in cellular neuroscience

authors： Wang B,Ke W,Guang J,Chen G,Yin L,Deng S,He Q,Liu Y,He T,Zheng R,Jiang Y,Zhang X,Li T,Luan G,Lu HD,Zhang M,Zhang X,Shu Y

更新日期：2016-10-18 00:00:00

abstract：:The complex and elaborate architecture of a neuron poses a great challenge to the cellular machinery which localizes proteins and organelles, such as mitochondria, to necessary locations. Proper mitochondrial localization in neurons is particularly important as this organelle provides energy and metabolites essential ...

journal_title：Frontiers in cellular neuroscience

authors： Mandal A,Drerup CM

更新日期：2019-08-09 00:00:00

abstract：:There is evidence for both neurotoxic and neuroprotective roles of nitric oxide (NO) in the brain and changes in the expression of the neuronal isoform of NO synthase (nNOS) gene occur during aging. The current studies have investigated potential support for either a neurotoxic or neuroprotective role of NO derived fr...

journal_title：Frontiers in cellular neuroscience

authors： James BM,Li Q,Luo L,Kendrick KM

更新日期：2015-03-27 00:00:00

abstract：:Variants near the ATP-binding cassette transporter A1 (ABCA1) gene are associated with elevated intraocular pressure and newly discovered risk factors for glaucoma. Previous studies have shown an association between ABCA1 deficiency and retinal inflammation. Using a mouse model of ischemia-reperfusion (IR) induced by ...

journal_title：Frontiers in cellular neuroscience

authors： Li L,Xu L,Chen W,Li X,Xia Q,Zheng L,Duan Q,Zhang H,Zhao Y

更新日期：2018-10-11 00:00:00

abstract：:Dyneins are a small class of molecular motors that bind to microtubules and walk toward their minus ends. They are essential for the transport and distribution of organelles, signaling complexes and cytoskeletal elements. In addition dyneins generate forces on microtubule arrays that power the beating of cilia and fla...

journal_title：Frontiers in cellular neuroscience

authors： Roossien DH,Miller KE,Gallo G

更新日期：2015-07-06 00:00:00

abstract：:The development of new techniques to study glial cells has revealed that they are active participants in the development of functional neuronal circuits. Calcium imaging studies demonstrate that glial cells actively sense and respond to neuronal activity. Glial cells can produce and release neurotransmitter-like molec...

journal_title：Frontiers in cellular neuroscience

authors： Van Horn MR,Sild M,Ruthazer ES

更新日期：2013-04-23 00:00:00

abstract：:Glucagon-like peptide-1 (GLP-1), a metabolic signal molecule, regulates reproduction, although, the involved molecular mechanisms have not been elucidated, yet. Therefore, responsiveness of gonadotropin-releasing hormone (GnRH) neurons to the GLP-1 analog Exendin-4 and elucidation of molecular pathways acting downstre...

journal_title：Frontiers in cellular neuroscience

authors： Farkas I,Vastagh C,Farkas E,Bálint F,Skrapits K,Hrabovszky E,Fekete C,Liposits Z

更新日期：2016-09-12 00:00:00