Reduced Annexin A1 Secretion by ABCA1 Causes Retinal Inflammation and Ganglion Cell Apoptosis in a Murine Glaucoma Model.

abstract：:Accumulating evidence has highlighted the potential role of long non-coding RNAs (lncRNAs) as biomarkers and therapeutic targets in solid tumors. Here, we elucidated the function and possible molecular mechanisms of lncRNA KCNQ1OT1 in human glioma U87 and U251 cells. Quantitative Real-Time polymerase chain reaction (q...

journal_title：Frontiers in cellular neuroscience

authors： Gong W,Zheng J,Liu X,Liu Y,Guo J,Gao Y,Tao W,Chen J,Li Z,Ma J,Xue Y

更新日期：2017-03-22 00:00:00

abstract：:Tyrosine hydroxylase (Th) expression has previously been reported in Purkinje cells (PCs) of rodents and humans, but its role in the regulation of behavior is not understood. Catecholamines are well known for facilitating cognitive behaviors and are expressed in many regions of the brain. Here, we investigated a possi...

journal_title：Frontiers in cellular neuroscience

authors： Locke TM,Fujita H,Hunker A,Johanson SS,Darvas M,du Lac S,Zweifel LS,Carlson ES

更新日期：2020-07-29 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, characterized by the progressive loss of motor neurons. The cause of this selective neuronal death is unknown, but transcriptional dysregulation is recently emerging as an important factor. The physical substrate for the regulation of the transc...

journal_title：Frontiers in cellular neuroscience

authors： Lazo-Gómez R,Ramírez-Jarquín UN,Tovar-Y-Romo LB,Tapia R

更新日期：2013-12-05 00:00:00

abstract：:Soon after its discovery, microRNA-9 (miR-9) attracted the attention of neurobiologists, since it is one of the most highly expressed microRNAs in the developing and adult vertebrate brain. Functional analyses in different vertebrate species have revealed a prominent role of this microRNA in balancing proliferation in...

journal_title：Frontiers in cellular neuroscience

authors： Coolen M,Katz S,Bally-Cuif L

更新日期：2013-11-20 00:00:00

abstract：:Chronic pain is accompanied with long-term sensory, affective and cognitive disturbances. What are the mechanisms that mediate the long-term consequences of painful experiences and embed them in the genome? We hypothesize that alterations in DNA methylation, an enzymatic covalent modification of cytosine bases in DNA,...

journal_title：Frontiers in cellular neuroscience

authors： Alvarado S,Tajerian M,Suderman M,Machnes Z,Pierfelice S,Millecamps M,Stone LS,Szyf M

更新日期：2015-03-24 00:00:00

abstract：:In humans, auditory hair cells are not replaced when injured. Thus, cochlear hair cell loss causes progressive and permanent hearing loss. Conversely, non-mammalian vertebrates are capable of regenerating lost sensory hair cells. The zebrafish lateral line has numerous qualities that make it well-suited for studying h...

journal_title：Frontiers in cellular neuroscience

authors： He Y,Cai C,Tang D,Sun S,Li H

更新日期：2014-11-13 00:00:00

abstract：:Membrane tethering is an important communication method for membrane-packaged organelles. Mitochondria are organelles with a bilayer membrane, and the membrane contact between mitochondria and other organelles is indispensable for maintaining cellular homeostasis. Increased levels of molecular determinants that mediat...

journal_title：Frontiers in cellular neuroscience

authors： Liao Y,Dong Y,Cheng J

更新日期：2020-08-07 00:00:00

abstract：:Climbing fiber (CF) triggered complex spikes (CS) are massive depolarization bursts in the cerebellar Purkinje cell (PC), showing several high frequency spikelet components (±600 Hz). Since its early observations, the CS is known to vary in shape. In this study we describe CS waveforms, extracellularly recorded in awa...

journal_title：Frontiers in cellular neuroscience

authors： Warnaar P,Couto J,Negrello M,Junker M,Smilgin A,Ignashchenkova A,Giugliano M,Thier P,De Schutter E

更新日期：2015-04-13 00:00:00

abstract：:After an ischemic stroke, neural precursor cells (NPCs) proliferate within major germinal niches of the brain. Endogenous NPCs subsequently migrate toward the ischemic lesion where they promote tissue remodeling and neural repair. Unfortunately, this restorative process is generally insufficient and thus unable to sup...

journal_title：Frontiers in cellular neuroscience

authors： Hermann DM,Peruzzotti-Jametti L,Schlechter J,Bernstock JD,Doeppner TR,Pluchino S

更新日期：2014-09-16 00:00:00

abstract：:The postnatal development of cerebellar climbing fiber (CF) to Purkinje neuron (PN) synapses is characterized by a substantial pruning during the first 3 weeks after birth, switching from multiple- to single-CF innervation. Previous studies suggested that CF maturation is governed by bidirectional changes of synaptic ...

journal_title：Frontiers in cellular neuroscience

authors： Pätz C,Brachtendorf S,Eilers J

更新日期：2019-05-01 00:00:00

abstract：:Most stroke studies dealing with functional deficits and assessing stem cell therapy produce extensive hemispheric damage and can be seen as a model for severe clinical strokes. However, mild strokes have a better prospect for functional recovery. Recently, anatomic and behavioral changes have been reported for distal...

journal_title：Frontiers in cellular neuroscience

authors： Minassian A,Green C,Diedenhofen M,Vogel S,Hess S,Stoeber M,Radmilovic MD,Wiedermann D,Kloppenburg P,Hoehn M

更新日期：2020-04-07 00:00:00

abstract：:IN ADULT MAMMALS, UNDER PHYSIOLOGICAL CONDITIONS, NEUROGENESIS, THE PROCESS OF GENERATING NEW FUNCTIONAL NEURONS FROM PRECURSOR CELLS, OCCURS MAINLY IN TWO BRAIN AREAS: the subgranular zone in the dentate gyrus of the hippocampus, and the subventricular zone (SVZ) lining the walls of the brain lateral ventricles. Taki...

journal_title：Frontiers in cellular neuroscience

authors： Falcão AM,Marques F,Novais A,Sousa N,Palha JA,Sousa JC

更新日期：2012-08-09 00:00:00

abstract：:Recent advances in fast volumetric imaging have enabled rapid generation of large amounts of multi-dimensional functional data. While many computer frameworks exist for data storage and analysis of the multi-gigabyte Ca2+ imaging experiments in neurons, they are less useful for analyzing Ca2+ dynamics in astrocytes, w...

journal_title：Frontiers in cellular neuroscience

authors： Savtchouk I,Carriero G,Volterra A

更新日期：2018-04-13 00:00:00

abstract：:The complex and elaborate architecture of a neuron poses a great challenge to the cellular machinery which localizes proteins and organelles, such as mitochondria, to necessary locations. Proper mitochondrial localization in neurons is particularly important as this organelle provides energy and metabolites essential ...

journal_title：Frontiers in cellular neuroscience

authors： Mandal A,Drerup CM

更新日期：2019-08-09 00:00:00

abstract：:Electroacupuncture (EA) pretreatment is a clinically useful therapy for several brain disorders. However, whether and via which exact molecular mechanisms it ameliorates post-traumatic stress disorder (PTSD) remains unclear. In the present study, rats received EA stimulation for seven consecutive days before exposure ...

journal_title：Frontiers in cellular neuroscience

authors： Zhou CH,Xue F,Xue SS,Sang HF,Liu L,Wang Y,Cai M,Zhang ZJ,Tan QR,Wang HN,Peng ZW

更新日期：2019-06-21 00:00:00

abstract：:Activity-dependent changes in the input-output (I-O) relationship of a neural circuit are central in the learning and memory function of the brain. To understand circuit-wide adjustments, optical imaging techniques to probe the membrane potential at every component of neurons, such as dendrites, axons and somas, in th...

journal_title：Frontiers in cellular neuroscience

authors： Tominaga Y,Taketoshi M,Tominaga T

更新日期：2018-10-24 00:00:00

abstract：:Human brain organoids (mini-brains) consist of self-organized three-dimensional (3D) neural tissue which can be derived from reprogrammed adult cells and maintained for months in culture. These 3D structures manifest substantial potential for the modeling of neurodegenerative diseases and pave the way for personalized...

journal_title：Frontiers in cellular neuroscience

authors： Nassor F,Jarray R,Biard DSF,Maïza A,Papy-Garcia D,Pavoni S,Deslys JP,Yates F

更新日期：2020-02-11 00:00:00

abstract：:The brain relies on GABAergic neurons to control the ongoing activity of neuronal networks. GABAergic neurons control the firing pattern of excitatory cells, the temporal structure of membrane potential oscillations and the time window for integration of synaptic inputs. These actions require a fine control of the tim...

journal_title：Frontiers in cellular neuroscience

authors： Scimemi A

更新日期：2014-05-13 00:00:00

abstract：:Epilepsy is a disorder of abnormal brain activity typified by spontaneous and recurrent seizures. MicroRNAs (miRNAs) are short non-coding RNAs, critical for the post-transcriptional regulation of gene expression. MiRNA dysregulation has previously been implicated in the induction of epilepsy. In this study, we examine...

journal_title：Frontiers in cellular neuroscience

authors： Gao X,Guo M,Meng D,Sun F,Guan L,Cui Y,Zhao Y,Wang X,Gu X,Sun J,Qi S

更新日期：2019-04-12 00:00:00

abstract：:Background: Accumulation of amyloid β (Aβ) is one of the main hallmarks of Alzheimer's disease (AD). The enhancement of Aβ clearance may provide therapeutic means to restrict AD pathology. The cellular responses to different forms of Aβ in monocytic cells are poorly known. We aimed to study whether different forms of ...

journal_title：Frontiers in cellular neuroscience

authors： Savchenko E,Malm T,Konttinen H,Hämäläinen RH,Guerrero-Toro C,Wojciechowski S,Giniatullin R,Koistinaho J,Magga J

更新日期：2016-12-05 00:00:00

abstract：:Loss of auditory sensory hair cells (HCs) is the most common cause of hearing loss. This review addresses the signaling pathways that are involved in the programmed and necrotic cell death of auditory HCs that occur in response to ototoxic and traumatic stressor events. The roles of inflammatory processes, oxidative s...

journal_title：Frontiers in cellular neuroscience

authors： Dinh CT,Goncalves S,Bas E,Van De Water TR,Zine A

更新日期：2015-03-31 00:00:00

abstract：:The present study was designed to observe the effect of COX2/PGD2-related autophagy on brain injury in type 2 diabetes rats. The histopathology was detected by haematoxylin-eosin staining. The learning and memory functions were evaluated by Morris water maze. The levels of insulin and PGD2 were measured by enzyme-link...

journal_title：Frontiers in cellular neuroscience

authors： Yang Y,Chen Q,Zhao Q,Luo Y,Xu Y,Du W,Wang H,Li H,Yang L,Hu C,Zhang J,Li Y,Xia H,Chen Z,Ma J,Tian X,Yang J

更新日期：2019-02-27 00:00:00

abstract：:Glaucoma is a multifactorial disease and especially mechanisms occurring independently from an elevated intraocular pressure (IOP) are still unknown. Likely, the immune system contributes to the glaucoma pathogenesis. Previously, IgG antibody depositions and retinal ganglion cell (RGC) loss were found in an IOP-indepe...

journal_title：Frontiers in cellular neuroscience

authors： Reinehr S,Reinhard J,Gandej M,Kuehn S,Noristani R,Faissner A,Dick HB,Joachim SC

更新日期：2016-06-01 00:00:00

abstract：:Exposing developing cerebellar Purkinje neurons (PNs) to mutant Ataxin1 (ATXN1) in 82Q spinocerebellar ataxia type 1 (SCA1) mice disrupts motor behavior and cerebellar climbing fiber (CF) architecture from as early as 4 weeks of age. In contrast, if mutant ATXN1 expression is silenced until after cerebellar developmen...

journal_title：Frontiers in cellular neuroscience

authors： Ibrahim MF,Power EM,Potapov K,Empson RM

更新日期：2017-09-20 00:00:00

abstract：:Differentiation and maturation of oligodendroglial cells are postnatal processes that involve specific morphological changes correlated with the expression of stage-specific surface antigens and functional voltage-gated ion channels. A small fraction of oligodendrocyte progenitor cells (OPCs) generated during developm...

journal_title：Frontiers in cellular neuroscience

authors： Coppi E,Cellai L,Maraula G,Dettori I,Melani A,Pugliese AM,Pedata F

更新日期：2015-04-24 00:00:00

abstract：:It is well established that the endothelium responds to mechanical forces induced by changes in shear stress and strain. However, our understanding of vascular remodeling following traumatic brain injury (TBI) remains incomplete. Recently published studies have revealed that lung and umbilical endothelial cells produc...

journal_title：Frontiers in cellular neuroscience

authors： Andrews AM,Lutton EM,Merkel SF,Razmpour R,Ramirez SH

更新日期：2016-02-29 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most malignant brain tumor and is associated with poor prognosis due to its thorny localization, lack of efficacious therapies and complex biology. Among the numerous pathways driving GBM biology studied so far, PTEN/phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/AKT/mechani...

journal_title：Frontiers in cellular neuroscience

authors： Mecca C,Giambanco I,Bruscoli S,Bereshchenko O,Fioretti B,Riccardi C,Donato R,Arcuri C

更新日期：2018-04-10 00:00:00

abstract：:What is the function of dendritic spikes? One might argue that they provide conditions for neuronal plasticity or that they are essential for neural computation. However, despite a long history of dendritic research, the physiological relevance of dendritic spikes in brain function remains unknown. This could stem fro...

journal_title：Frontiers in cellular neuroscience

authors： Manita S,Miyakawa H,Kitamura K,Murayama M

更新日期：2017-02-15 00:00:00

abstract：:Long axons and their enwrapping glia (EG; Schwann cells (SCs) and oligodendrocytes (OLGs)) form a unique compound structure that serves as conduit for transport of electric and chemical information in the nervous system. The peculiar cytoarchitecture over an enormous length as well as its substantial energetic require...

journal_title：Frontiers in cellular neuroscience

authors： Beirowski B

更新日期：2013-12-19 00:00:00

abstract：:Amyotrophic Lateral Sclerosis (ALS) is a progressive and fatal neurodegenerative disease affecting both upper and lower motor neurons. The molecular mechanisms underlying disease pathogenesis remain largely unknown. Multiple genetic loci including genes involved in proteostasis and ribostasis have been linked to ALS p...

journal_title：Frontiers in cellular neuroscience

authors： Coyne AN,Zaepfel BL,Zarnescu DC

更新日期：2017-08-17 00:00:00