Plasticity of GABA transporters: an unconventional route to shape inhibitory synaptic transmission.

abstract：:In this review, I present and discuss the current understanding of aberrant electrical activity found in the ganglion cell layer (GCL) of rod-degenerated (rd) mouse retinas. The reported electrophysiological properties revealed by electrical imaging using high-density microelectrode arrays can be subdivided between sp...

journal_title：Frontiers in cellular neuroscience

authors： Zeck G

更新日期：2016-02-08 00:00:00

abstract：:During the last decades it became increasingly evident that electrical synapses are capable of activity-dependent plasticity. However, measuring the actual strength of electrical transmission remains difficult. Usually changes in coupling strength can only be inferred indirectly from measures such as the coupling coef...

journal_title：Frontiers in cellular neuroscience

authors： Welzel G,Schuster S

更新日期：2019-02-12 00:00:00

abstract：:The inferior olive (IO) is a nucleus located in the brainstem and it is part of the olivo-cerebellar loop. This circuit plays a fundamental role in generation and acquisition of coherent motor patterns and it relies on synchronous activation of groups of Purkinje cells (PC) in the cerebellar cortex. IO neurons integra...

journal_title：Frontiers in cellular neuroscience

authors： Bazzigaluppi P,Isenia SC,Haasdijk ED,Elgersma Y,De Zeeuw CI,van der Giessen RS,de Jeu MTG

更新日期：2017-12-14 00:00:00

abstract：:Alteration of glutamatergic synaptic plasticity in the Nucleus Accumbens (NAc) has been implicated in cocaine-seeking behaviors. Astroglial mechanisms for maintaining extracellular glutamate homeostasis through cysteine/glutamate exchanger (xCT) and glutamate transporter GLT1 are dysregulated following cocaine exposur...

journal_title：Frontiers in cellular neuroscience

authors： Jarvis R,Tamashiro-Orrego A,Promes V,Tu L,Shi J,Yang Y

更新日期：2020-01-10 00:00:00

abstract：:Neuronal synchronization at gamma band frequency (20-80 Hz, γ oscillations) is closely associated with higher brain function, such as learning, memory and attention. Nicotinic acetylcholine receptors (nAChRs) are highly expressed in the hippocampus, and modulate hippocampal γ oscillations, but the intracellular mechan...

journal_title：Frontiers in cellular neuroscience

authors： Wang J,He X,Guo F,Cheng X,Wang Y,Wang X,Feng Z,Vreugdenhil M,Lu C

更新日期：2017-03-06 00:00:00

abstract：BACKGROUND:Amyotrophic lateral sclerosis (ALS) is an incurable fatal motoneuron disease with a lifetime risk of approximately 1:400. It is characterized by progressive weakness, muscle wasting, and death ensuing 3-5 years after diagnosis. Granulocyte-colony stimulating factor (G-CSF) is a drug candidate for ALS, with e...

journal_title：Frontiers in cellular neuroscience

authors： Henriques A,Kastner S,Chatzikonstantinou E,Pitzer C,Plaas C,Kirsch F,Wafzig O,Krüger C,Spoelgen R,Gonzalez De Aguilar JL,Gretz N,Schneider A

更新日期：2015-01-20 00:00:00

abstract：:Intermittent fasting (IF) was suggested to be a powerful nutritional strategy to prevent the onset of age-related neurodegenerative diseases associated with compromised brain bioenergetics. Whether the application of IF in combination with a mitochondrial insult could buffer the neurodegenerative process has never bee...

journal_title：Frontiers in cellular neuroscience

authors： Tatulli G,Mitro N,Cannata SM,Audano M,Caruso D,D'Arcangelo G,Lettieri-Barbato D,Aquilano K

更新日期：2018-01-17 00:00:00

abstract：:Glia, a non-excitable cell type once considered merely as the connective tissue between neurons, is nowadays acknowledged for its essential contribution to multiple physiological processes including learning, memory formation, excitability, synaptic plasticity, ion homeostasis, and energy metabolism. Moreover, as glia...

journal_title：Frontiers in cellular neuroscience

authors： Stevenson R,Samokhina E,Rossetti I,Morley JW,Buskila Y

更新日期：2020-08-21 00:00:00

abstract：:Soon after its discovery, microRNA-9 (miR-9) attracted the attention of neurobiologists, since it is one of the most highly expressed microRNAs in the developing and adult vertebrate brain. Functional analyses in different vertebrate species have revealed a prominent role of this microRNA in balancing proliferation in...

journal_title：Frontiers in cellular neuroscience

authors： Coolen M,Katz S,Bally-Cuif L

更新日期：2013-11-20 00:00:00

abstract：:Methamphetamine (METH), an extremely and widely abused illicit drug, can cause serious nervous system damage and social problems. Previous research has shown that METH use causes dopaminergic neuron apoptosis and astrocyte-related neuroinflammation. However, the relationship of astrocytes and neurons in METH-induced n...

journal_title：Frontiers in cellular neuroscience

authors： Du SH,Zhang W,Yue X,Luo XQ,Tan XH,Liu C,Qiao DF,Wang H

更新日期：2018-08-03 00:00:00

abstract：:Aims: We have previously shown that the neurosteroid androstenediol (ADIOL) promotes remyelination following gliotoxin-induced demyelination. However, the impact of this ADIOL on axonal recovery is not yet known. In the present study, we investigated the impact of ADIOL on axonal integrity following a focal demyelinat...

journal_title：Frontiers in cellular neuroscience

authors： Kalakh S,Mouihate A

更新日期：2017-02-23 00:00:00

abstract：:Tyrosine hydroxylase (Th) expression has previously been reported in Purkinje cells (PCs) of rodents and humans, but its role in the regulation of behavior is not understood. Catecholamines are well known for facilitating cognitive behaviors and are expressed in many regions of the brain. Here, we investigated a possi...

journal_title：Frontiers in cellular neuroscience

authors： Locke TM,Fujita H,Hunker A,Johanson SS,Darvas M,du Lac S,Zweifel LS,Carlson ES

更新日期：2020-07-29 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fncel.2017.00013.]. ...

journal_title：Frontiers in cellular neuroscience

authors： So JH,Huang C,Ge M,Cai G,Zhang L,Lu Y,Mu Y

更新日期：2019-07-09 00:00:00

abstract：:Electroacupuncture (EA) pretreatment is a clinically useful therapy for several brain disorders. However, whether and via which exact molecular mechanisms it ameliorates post-traumatic stress disorder (PTSD) remains unclear. In the present study, rats received EA stimulation for seven consecutive days before exposure ...

journal_title：Frontiers in cellular neuroscience

authors： Zhou CH,Xue F,Xue SS,Sang HF,Liu L,Wang Y,Cai M,Zhang ZJ,Tan QR,Wang HN,Peng ZW

更新日期：2019-06-21 00:00:00

abstract：:Long non-coding (lnc) RNAs are defined as non-protein coding RNAs distinct from housekeeping RNAs such as tRNAs, rRNAs, and snRNAs, and independent from small RNAs with specific molecular processing machinery such as micro- or piwi-RNAs. Recent studies of lncRNAs across different species have revealed a diverse popula...

journal_title：Frontiers in cellular neuroscience

authors： Ernst C,Morton CC

更新日期：2013-10-02 00:00:00

abstract：:The brain is the most functionally organized structure of all organs. It manages behavior, perception and higher cognitive functions. The WWOX gene is non-classical tumor suppressor gene, which has been shown to have an impact on proliferation, apoptosis and migration processes. Moreover, genetic aberrations in WWOX i...

journal_title：Frontiers in cellular neuroscience

authors： Kośla K,Płuciennik E,Styczeń-Binkowska E,Nowakowska M,Orzechowska M,Bednarek AK

更新日期：2019-08-30 00:00:00

abstract：:Chronic stress is a risk factor for the development of psychiatric disorders, some of which involve dysfunction of the prefrontal cortex (PFC). There is a higher prevalence of these chronic stress-related psychiatric disorders during adolescence, when the PFC has not yet fully matured. In the present work we studied t...

journal_title：Frontiers in cellular neuroscience

authors： Negrón-Oyarzo I,Dagnino-Subiabre A,Muñoz Carvajal P

更新日期：2015-11-12 00:00:00

abstract：:When retrieval occurs concomitantly with novelty detection, mismatch perception or reactivation of conflicting information, consolidated memories can enter into a labile state, and to persist, must be restabilized through a protein synthesis-dependent reconsolidation process during which their strength and content can...

journal_title：Frontiers in cellular neuroscience

authors： Gonzalez MC,Radiske A,Cammarota M

更新日期：2019-08-22 00:00:00

abstract：:Action potential-dependent release of synaptic vesicles and short-term synaptic plasticity are dynamically regulated by the endogenous Ca(2+) buffers that shape [Ca(2+)] profiles within a presynaptic bouton. Calmodulin is one of the most abundant presynaptic proteins and it binds Ca(2+) faster than any other character...

journal_title：Frontiers in cellular neuroscience

authors： Timofeeva Y,Volynski KE

更新日期：2015-07-01 00:00:00

abstract：:A number of studies have shown pharmacologic evidence indicating that stimulation of type I dopamine receptor (DR), favors T-helper-17 (Th17)-mediated immunity involved in experimental autoimmune encephalomyelitis (EAE) and in some other inflammatory disorders. Nevertheless, the lack of drugs that might discriminate b...

journal_title：Frontiers in cellular neuroscience

authors： Osorio-Barrios F,Prado C,Contreras F,Pacheco R

更新日期：2018-07-10 00:00:00

abstract：:In the last decade, there is an increasing application of induced pluripotent stem cells (iPSCs) for disease modeling. The iPSC technology enables the study of patient-specific neuronal cell lines in vitro to evaluate dysfunction at the cellular level and identify the responsible genetic factors. This approach might b...

journal_title：Frontiers in cellular neuroscience

authors： Re S,Dogan AA,Ben-Shachar D,Berger G,Werling AM,Walitza S,Grünblatt E

更新日期：2018-09-25 00:00:00

abstract：:Axon growth inhibitors generated by reactive glial scars play an important role in failure of axon regeneration after CNS injury in mature mammals. Among the inhibitory factors, chondroitin sulfate proteoglycans (CSPGs) are potent suppressors of axon regeneration and are important molecular targets for designing effec...

journal_title：Frontiers in cellular neuroscience

authors： Sami A,Selzer ME,Li S

更新日期：2020-07-02 00:00:00

abstract：:It has been shown that matrix metalloproteinase 9 (MMP-9) is required for synaptic plasticity, learning and memory. In particular, MMP-9 involvement in long-term potentiation (LTP, the model of synaptic plasticity) in the hippocampus and prefrontal cortex has previously been demonstrated. Recent data suggest the role ...

journal_title：Frontiers in cellular neuroscience

authors： Gorkiewicz T,Balcerzyk M,Kaczmarek L,Knapska E

更新日期：2015-03-11 00:00:00

abstract：:Mammalian teeth have evolved as dentin units that enclose a complex system of sensory innervation to protect and preserve their structure and function. In human dental pulp (DP), mechanosensory and nociceptive fibers form a dense meshwork of nerve endings at the coronal dentin-pulp interface, which arise from myelinat...

journal_title：Frontiers in cellular neuroscience

authors： Couve E,Schmachtenberg O

更新日期：2018-09-05 00:00:00

abstract：:The axon provides a sole output of the neuron which propagates action potentials reliably to the axon terminal and transmits neuronal information to the postsynaptic neuron across the synapse. A classical view of neuronal signaling is based on these two processes, namely binary (all or none) signaling along the axon a...

journal_title：Frontiers in cellular neuroscience

authors： Kamiya H

更新日期：2019-09-06 00:00:00

abstract：:Previous studies have demonstrated the presence of cannabinoid 2 receptor (CB2R) in the rat cochlea which was induced by cisplatin. In an organ of Corti-derived cell culture model, it was also shown that an agonist of the CB2R protected these cells against cisplatin-induced apoptosis. In the current study, we determin...

journal_title：Frontiers in cellular neuroscience

authors： Ghosh S,Sheth S,Sheehan K,Mukherjea D,Dhukhwa A,Borse V,Rybak LP,Ramkumar V

更新日期：2018-08-21 00:00:00

abstract：:Anoxic depolarization (AD) is a hallmark of ischemic brain damage. AD is associated with a spreading wave of neuronal depolarization and an increase in light transmittance. However, initiation and spread of AD across the layers of the somatosensory cortex, which is one of the most frequently affected brain regions in ...

journal_title：Frontiers in cellular neuroscience

authors： Juzekaeva E,Nasretdinov A,Gainutdinov A,Sintsov M,Mukhtarov M,Khazipov R

更新日期：2017-12-15 00:00:00

abstract：:GABAergic plasticity is recognized as a key mechanism of shaping the activity of the neuronal networks. However, its description is challenging because of numerous neuron-specific mechanisms. In particular, while essential role of glial cells in the excitatory plasticity is well established, their involvement in GABAe...

journal_title：Frontiers in cellular neuroscience

authors： Kaczor PT,Mozrzymas JW

更新日期：2017-05-16 00:00:00

abstract：:Sections from the middle frontal gyrus (Brodmann area 46) of autopsy-confirmed Alzheimer's disease (AD) patients and non-demented subjects were examined for the prevalence of hallmark AD pathology, including amyloid-β (Aβ) plaques, phosphorylated tau (pTau) tangles, neuroinflammation and synaptic loss (n = 7 subjects/...

journal_title：Frontiers in cellular neuroscience

authors： Metaxas A,Thygesen C,Briting SRR,Landau AM,Darvesh S,Finsen B

更新日期：2019-12-05 00:00:00

abstract：:Animals rely heavily on their sense of olfaction to perform various vital interactions with an ever-in-flux environment. The turbulent and combinatorial nature of air-borne odorant cues demands the employment of various coding strategies, which allow the animal to attune to its internal needs and past or present exper...

journal_title：Frontiers in cellular neuroscience

authors： Sayin S,Boehm AC,Kobler JM,De Backer JF,Grunwald Kadow IC

更新日期：2018-01-30 00:00:00