Abstract:
:It has been shown that matrix metalloproteinase 9 (MMP-9) is required for synaptic plasticity, learning and memory. In particular, MMP-9 involvement in long-term potentiation (LTP, the model of synaptic plasticity) in the hippocampus and prefrontal cortex has previously been demonstrated. Recent data suggest the role of MMP-9 in amygdala-dependent learning and memory. Nothing is known, however, about its physiological correlates in the specific pathways in the amygdala. In the present study we show that LTP in the basal and central but not lateral amygdala (LA) is affected by MMP-9 knock-out. The MMP-9 dependency of LTP was confirmed in brain slices treated with a specific MMP-9 inhibitor. The results suggest that MMP-9 plays different roles in synaptic plasticity in different nuclei of the amygdala.
journal_name
Front Cell Neuroscijournal_title
Frontiers in cellular neuroscienceauthors
Gorkiewicz T,Balcerzyk M,Kaczmarek L,Knapska Edoi
10.3389/fncel.2015.00073subject
Has Abstractpub_date
2015-03-11 00:00:00pages
73issn
1662-5102journal_volume
9pub_type
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