GABA Neuronal Deletion of Shank3 Exons 14-16 in Mice Suppresses Striatal Excitatory Synaptic Input and Induces Social and Locomotor Abnormalities.

abstract：:Propofol is a widely used anesthetic in the clinic while several studies have demonstrated that propofol exposure may cause neurotoxicity in the developing brain. However, the effects of early propofol exposure on cerebellar development are not well understood. Propofol (30 or 60 mg/kg) was administered to mice on pos...

journal_title：Frontiers in cellular neuroscience

authors： Xiao R,Yu D,Li X,Huang J,Jing S,Bao X,Yang T,Fan X

更新日期：2017-11-22 00:00:00

abstract：:Cellular senescence has classically been associated with aging. Intriguingly, recent studies have also unraveled key roles for senescence in embryonic development, regeneration, and reprogramming. Developmental senescence has been reported during embryonic development in different organisms and structures, such as the...

journal_title：Frontiers in cellular neuroscience

authors： Magariños M,Barajas-Azpeleta R,Varela-Nieto I,R Aburto M

更新日期：2020-08-17 00:00:00

abstract：:Amyloid beta (Aβ) is a peptide cleaved from amyloid precursor protein that contributes to the formation of senile plaques in Alzheimer's disease (AD). The relationship between Aβ and astrocyte proliferation in AD remains controversial. Despite pathological findings of increased astrocytic mitosis in AD brains, in vitr...

journal_title：Frontiers in cellular neuroscience

authors： Ohki EC,Langan TJ,Rodgers KR,Chou RC

更新日期：2017-09-26 00:00:00

abstract：:The Hessian fly, Mayetiola destructor Say (Diptera, Cecidomyiidae), is a pest of wheat and belongs to a group of gall-inducing herbivores. This species has a unique life history and several ecological features that differentiate it from other Diptera such as Drosophila melanogaster and blood-feeding mosquitoes. These ...

journal_title：Frontiers in cellular neuroscience

authors： Andersson MN,Corcoran JA,Zhang DD,Hillbur Y,Newcomb RD,Löfstedt C

更新日期：2016-09-07 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two progressive, fatal neurodegenerative syndromes with considerable clinical, genetic and pathological overlap. Clinical symptoms of FTD can be seen in ALS patients and vice versa. Recent genetic discoveries conclusively link the two diseases, ...

journal_title：Frontiers in cellular neuroscience

authors： Radford RA,Morsch M,Rayner SL,Cole NJ,Pountney DL,Chung RS

更新日期：2015-10-27 00:00:00

abstract：:Vasoinhibins are prolactin fragments present in the retina, where they have been shown to prevent the hypervasopermeability associated with diabetes. Enhanced bradykinin (BK) production contributes to the increased transport through the blood-retina barrier (BRB) in diabetes. Here, we studied if vasoinhibins regulate ...

journal_title：Frontiers in cellular neuroscience

authors： Arredondo Zamarripa D,Díaz-Lezama N,Meléndez García R,Chávez Balderas J,Adán N,Ledesma-Colunga MG,Arnold E,Clapp C,Thebault S

更新日期：2014-10-20 00:00:00

abstract：:Mammalian teeth have evolved as dentin units that enclose a complex system of sensory innervation to protect and preserve their structure and function. In human dental pulp (DP), mechanosensory and nociceptive fibers form a dense meshwork of nerve endings at the coronal dentin-pulp interface, which arise from myelinat...

journal_title：Frontiers in cellular neuroscience

authors： Couve E,Schmachtenberg O

更新日期：2018-09-05 00:00:00

abstract：:Functional maturation of visual cortex is linked with dynamic changes in synaptic expression of GABAergic mechanisms. These include setting the excitation-inhibition balance required for experience-dependent plasticity, as well as, intracortical inhibition underlying development and aging of receptive field properties...

journal_title：Frontiers in cellular neuroscience

authors： Pinto JG,Hornby KR,Jones DG,Murphy KM

更新日期：2010-06-10 00:00:00

abstract：:The klotho gene family consists of α-, β-, and γ-Klotho, which encode type I single-pass transmembrane proteins with large extracellular domains. α-Klotho exists as a full-length membrane-bound and as a soluble form after cleavage of the extracellular domain. Due to gene splicing, a short extracellular Klotho form can...

journal_title：Frontiers in cellular neuroscience

authors： Li D,Jing D,Liu Z,Chen Y,Huang F,Behnisch T

更新日期：2019-04-02 00:00:00

abstract：:Recent research has revealed that uncontrolled chronic neuroinflammation is closely associated with diverse neurodegenerative diseases, by impairing blood-brain barrier (BBB) function and astrocytic reaction. Endoplasmic reticulum (ER) stress is conventionally linked to the loss of neuronal structure and function and ...

journal_title：Frontiers in cellular neuroscience

authors： Wang Y,Chen Y,Zhou Q,Xu J,Qian Q,Ni P,Qian Y

更新日期：2018-07-27 00:00:00

abstract：:Autism is a neurodevelopmental disorder marked by social skills and communication deficits and interfering repetitive behavior. Intellectual disability often accompanies autism. In addition to behavioral deficits, autism is characterized by neuropathology and brain overgrowth. Increased intracranial volume often accom...

journal_title：Frontiers in cellular neuroscience

authors： Lahiri DK,Sokol DK,Erickson C,Ray B,Ho CY,Maloney B

更新日期：2013-06-21 00:00:00

abstract：:The loss of hippocampal interneurons has been considered as one reason for the onset of temporal lobe epilepsy (TLE) by shifting the excitation-inhibition balance. Yet, there are many different interneuron types which show differential vulnerability in the context of an epileptogenic insult. We used the intrahippocamp...

journal_title：Frontiers in cellular neuroscience

authors： Marx M,Haas CA,Häussler U

更新日期：2013-10-01 00:00:00

abstract：:To improve the outcome after autologous nerve grafting in the clinic, it is important to understand the limiting variables such as distinct phenotypes of motor and sensory Schwann cells. This study investigated the properties of phenotypically different autografts in a 6 mm femoral nerve defect model in the rat, where...

journal_title：Frontiers in cellular neuroscience

authors： Hercher D,Kerbl M,Schuh CMAP,Heinzel J,Gal L,Stainer M,Schmidhammer R,Hausner T,Redl H,Nógrádi A,Hacobian A

更新日期：2019-05-08 00:00:00

abstract：:Neurodegenerative disorders such as Parkinson's (PD) and Huntington's disease (HD) are characterized by a selective detrimental impact on neurons in a specific brain area. Currently, these diseases have no cures, although some promising trials of therapies that may be able to slow the loss of brain cells are underway....

journal_title：Frontiers in cellular neuroscience

authors： Salado-Manzano C,Perpiña U,Straccia M,Molina-Ruiz FJ,Cozzi E,Rosser AE,Canals JM

更新日期：2020-08-11 00:00:00

abstract：:The dopamine transporter (DAT) is a plasma membrane protein responsible for the uptake of released dopamine back to the presynaptic terminal and ending dopamine neurotransmission. The DAT is the molecular target for cocaine and amphetamine as well as a number of pathological conditions including autism spectrum disord...

journal_title：Frontiers in cellular neuroscience

authors： Cartier E,Garcia-Olivares J,Janezic E,Viana J,Moore M,Lin ML,Caplan JL,Torres G,Kim YH

更新日期：2019-02-08 00:00:00

abstract：:Several cytokines and chemokines are now known to play normal physiological roles in the brain where they act as key regulators of communication between neurons, glia, and microglia. In particular, cytokines and chemokines can affect cardinal cellular and molecular processes of hippocampal-dependent long-term memory c...

journal_title：Frontiers in cellular neuroscience

authors： Sheridan GK,Wdowicz A,Pickering M,Watters O,Halley P,O'Sullivan NC,Mooney C,O'Connell DJ,O'Connor JJ,Murphy KJ

更新日期：2014-08-12 00:00:00

abstract：:The development of new techniques to study glial cells has revealed that they are active participants in the development of functional neuronal circuits. Calcium imaging studies demonstrate that glial cells actively sense and respond to neuronal activity. Glial cells can produce and release neurotransmitter-like molec...

journal_title：Frontiers in cellular neuroscience

authors： Van Horn MR,Sild M,Ruthazer ES

更新日期：2013-04-23 00:00:00

abstract：:Neurons must establish and stabilize connections made with diverse targets, each with distinct demands and functional characteristics. At Drosophila neuromuscular junctions (NMJs), synaptic strength remains stable in a manipulation that simultaneously induces hypo-innervation on one target and hyper-innervation on the...

journal_title：Frontiers in cellular neuroscience

authors： Goel P,Nishimura S,Chetlapalli K,Li X,Chen C,Dickman D

更新日期：2020-06-26 00:00:00

abstract：:Understanding non-stationary neuronal activity as seen in vivo requires estimation of both excitatory and inhibitory synaptic conductances from a single trial of recording. For this purpose, we propose a new intracellular recording method, called "firing clamp." Synaptic conductances are estimated from the characteris...

journal_title：Frontiers in cellular neuroscience

authors： Chizhov AV,Malinina E,Druzin M,Graham LJ,Johansson S

更新日期：2014-03-27 00:00:00

abstract：:Previous studies have shown that the pial microcirculation remodeling improves neurological outcome after middle cerebral artery occlusion (MCAO), accompanied by higher expression of vascular endothelial growth factor (VEGF) and endothelial nitric oxide synthase (eNOS), modulating in vivo angiogenesis. This study was ...

journal_title：Frontiers in cellular neuroscience

authors： Lapi D,Vagnani S,Sapio D,Mastantuono T,Boscia F,Pignataro G,Penna C,Pagliaro P,Colantuoni A

更新日期：2015-08-25 00:00:00

abstract：:The possible cognitive effects of low frequency external electric fields (EFs), such as those generated by power lines, are poorly understood. Their functional consequences for mechanisms at the single neuron level are very difficult to study and identify experimentally, especially in vivo. The major open problem is t...

journal_title：Frontiers in cellular neuroscience

authors： Cavarretta F,Carnevale NT,Tegolo D,Migliore M

更新日期：2014-10-09 00:00:00

abstract：:The Golgi cells have been recently shown to beat regularly in vitro (Forti et al., 2006. J. Physiol. 574, 711-729). Four main currents were shown to be involved, namely a persistent sodium current (I(Na-p)), an h current (I(h)), an SK-type calcium-dependent potassium current (I(K-AHP)), and a slow M-like potassium cur...

journal_title：Frontiers in cellular neuroscience

authors： Solinas S,Forti L,Cesana E,Mapelli J,De Schutter E,D'Angelo E

更新日期：2007-12-30 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, characterized by the progressive loss of motor neurons. The cause of this selective neuronal death is unknown, but transcriptional dysregulation is recently emerging as an important factor. The physical substrate for the regulation of the transc...

journal_title：Frontiers in cellular neuroscience

authors： Lazo-Gómez R,Ramírez-Jarquín UN,Tovar-Y-Romo LB,Tapia R

更新日期：2013-12-05 00:00:00

abstract：BACKGROUND:Amyotrophic lateral sclerosis (ALS) is an incurable fatal motoneuron disease with a lifetime risk of approximately 1:400. It is characterized by progressive weakness, muscle wasting, and death ensuing 3-5 years after diagnosis. Granulocyte-colony stimulating factor (G-CSF) is a drug candidate for ALS, with e...

journal_title：Frontiers in cellular neuroscience

authors： Henriques A,Kastner S,Chatzikonstantinou E,Pitzer C,Plaas C,Kirsch F,Wafzig O,Krüger C,Spoelgen R,Gonzalez De Aguilar JL,Gretz N,Schneider A

更新日期：2015-01-20 00:00:00

abstract：:Clinical and experimental data suggest that fronto-cortical GABAergic deficits contribute to the pathophysiology of major depressive disorder (MDD). To further test this hypothesis, we used a well characterized rat model for depression and examined the effect of stress on GABAergic neuron numbers and GABA-mediated syn...

journal_title：Frontiers in cellular neuroscience

authors： Czéh B,Vardya I,Varga Z,Febbraro F,Csabai D,Martis LS,Højgaard K,Henningsen K,Bouzinova EV,Miseta A,Jensen K,Wiborg O

更新日期：2018-06-20 00:00:00

abstract：:[This corrects the article on p. 396 in vol. 8, PMID: 25505873.]. ...

journal_title：Frontiers in cellular neuroscience

authors： Frontiers Production Office.

更新日期：2015-04-23 00:00:00

abstract：:Membrane tethering is an important communication method for membrane-packaged organelles. Mitochondria are organelles with a bilayer membrane, and the membrane contact between mitochondria and other organelles is indispensable for maintaining cellular homeostasis. Increased levels of molecular determinants that mediat...

journal_title：Frontiers in cellular neuroscience

authors： Liao Y,Dong Y,Cheng J

更新日期：2020-08-07 00:00:00

abstract：:Orexin and melanin-concentrating hormone (MCH) neurons have complementary roles in various physiological functions including energy balance and the sleep/wake cycle. in vitro electrophysiological studies investigating these cells typically use post-weaning rodents, corresponding to adolescence. However, it is unclear ...

journal_title：Frontiers in cellular neuroscience

authors： Linehan V,Hirasawa M

更新日期：2018-03-13 00:00:00

abstract：:The dopamine precursor, l-3,4-dihydroxyphenylalanine (l-DOPA), exerts powerful therapeutic effects but eventually generates l-DOPA-induced dyskinesia (LID) in patients with Parkinson's disease (PD). LID has a close link with deregulation of striatal dopamine/cAMP signaling, which is integrated by medium spiny neurons ...

journal_title：Frontiers in cellular neuroscience

authors： Morigaki R,Okita S,Goto S

更新日期：2017-02-10 00:00:00

abstract：:Background: Non-alcoholic fatty liver disease (NAFLD) is a common liver condition characterized by a significant accumulation of lipids in the liver without excessive alcohol consumption. Accumulating evidence suggests a significantly increased risk of intracerebral hemorrhage (ICH) in NAFLD patients. However, it rema...

journal_title：Frontiers in cellular neuroscience

authors： Li X,Cheng X,Wang X,Liu Q,Ma H,Li M

更新日期：2020-06-08 00:00:00