Brain immune cell composition and functional outcome after cerebral ischemia: comparison of two mouse strains.

abstract：:The inferior olive (IO) is a nucleus located in the brainstem and it is part of the olivo-cerebellar loop. This circuit plays a fundamental role in generation and acquisition of coherent motor patterns and it relies on synchronous activation of groups of Purkinje cells (PC) in the cerebellar cortex. IO neurons integra...

journal_title：Frontiers in cellular neuroscience

authors： Bazzigaluppi P,Isenia SC,Haasdijk ED,Elgersma Y,De Zeeuw CI,van der Giessen RS,de Jeu MTG

更新日期：2017-12-14 00:00:00

abstract：:Gastrointestinal (GI) pain is a common clinical problem, for which effective therapy is quite limited. Sensations from the GI tract, including pain, are mediated largely by neurons in the dorsal root ganglia (DRG), and to a smaller extent by vagal afferents emerging from neurons in the nodose/jugular ganglia. Neurons ...

journal_title：Frontiers in cellular neuroscience

authors： Hanani M

更新日期：2015-10-13 00:00:00

abstract：:Endogenous Netrin-1 (NT-1) protein was significantly increased after cerebral ischemia, which may participate in the repair after transient cerebral ischemic injury. In this work, we explored whether NT-1 can be steadily overexpressed by adeno-associated virus (AAV) and the exogenous NT-1 can promote neural stem cells...

journal_title：Frontiers in cellular neuroscience

authors： Lu H,Song X,Wang F,Wang G,Wu Y,Wang Q,Wang Y,Yang GY,Zhang Z

更新日期：2016-09-30 00:00:00

abstract：:Neural transplantation is a promising therapeutic strategy for neurodegenerative diseases and other disorders of the central nervous system (CNS) such as Parkinson and Huntington diseases, multiple sclerosis or stroke. Although cell replacement therapy already went through clinical trials for some of these diseases us...

journal_title：Frontiers in cellular neuroscience

authors： Bonnamain V,Neveu I,Naveilhan P

更新日期：2012-04-11 00:00:00

abstract：:Accumulating evidence suggests that epigenetic alterations lie behind the induction and maintenance of neuropathic pain. Neuropathic pain is usually a chronic condition caused by a lesion, or pathological change, within the nervous system. Neuropathic pain appears frequently after nerve and spinal cord injuries or dis...

journal_title：Frontiers in cellular neuroscience

authors： Penas C,Navarro X

更新日期：2018-06-07 00:00:00

abstract：:Heterotrimeric G-proteins mediate a variety of cellular functions, including signal transduction in sensory neurons of the olfactory system. Whereas the Gα subunits in these neurons are well characterized, the gene transcript expression profile of Gβγ subunits is largely missing. Here we report our comprehensive expre...

journal_title：Frontiers in cellular neuroscience

authors： Sathyanesan A,Feijoo AA,Mehta ST,Nimarko AF,Lin W

更新日期：2013-06-04 00:00:00

abstract：:Several cytokines and chemokines are now known to play normal physiological roles in the brain where they act as key regulators of communication between neurons, glia, and microglia. In particular, cytokines and chemokines can affect cardinal cellular and molecular processes of hippocampal-dependent long-term memory c...

journal_title：Frontiers in cellular neuroscience

authors： Sheridan GK,Wdowicz A,Pickering M,Watters O,Halley P,O'Sullivan NC,Mooney C,O'Connell DJ,O'Connor JJ,Murphy KJ

更新日期：2014-08-12 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease manifested by progressive muscle atrophy and paralysis due to the loss of upper and lower motoneurons (MN). Spasticity appears in ALS patients leading to further disabling consequences. Loss of the inhibitory tone induced by downregulation of the potas...

journal_title：Frontiers in cellular neuroscience

authors： Mòdol L,Mancuso R,Alé A,Francos-Quijorna I,Navarro X

更新日期：2014-01-24 00:00:00

abstract：:Type III adenylyl cyclase (AC3, ADCY3) is predominantly enriched in neuronal primary cilia throughout the central nervous system (CNS). Genome-wide association studies in humans have associated ADCY3 with major depressive disorder and autistic spectrum disorder, both of which exhibit sexual dimorphism. To date, it is ...

journal_title：Frontiers in cellular neuroscience

authors： Zhou Y,Qiu L,Sterpka A,Wang H,Chu F,Chen X

更新日期：2019-02-13 00:00:00

abstract：:NMDARs, the Ca2+ permeable channels, play central roles in synaptic plasticity, brain development, learning, and memory. NMDAR binding partners and associated signaling has been extensively studied in synapse-to-nucleus communications. However, whether NMDARs could directly regulate synapse-to-nucleus communications i...

journal_title：Frontiers in cellular neuroscience

authors： Zhou L,Duan J

更新日期：2018-10-02 00:00:00

abstract：:The brain relies on GABAergic neurons to control the ongoing activity of neuronal networks. GABAergic neurons control the firing pattern of excitatory cells, the temporal structure of membrane potential oscillations and the time window for integration of synaptic inputs. These actions require a fine control of the tim...

journal_title：Frontiers in cellular neuroscience

authors： Scimemi A

更新日期：2014-05-13 00:00:00

abstract：:Xenon has been shown to have neuroprotective effects and is clinically used as a favorable safe inhalation anesthetic. We previously confirmed the neuroprotective effects of xenon treatment in epileptic animals. However, the mechanism underlying these protective effects remains unclear. We aimed to assess the effects ...

journal_title：Frontiers in cellular neuroscience

authors： Zhu W,Zhu J,Zhao S,Li J,Hou D,Zhang Y,Sun H

更新日期：2020-10-06 00:00:00

abstract：:Experimental and epidemiological data show that the severity and the duration of brain inflammation are attenuated in females compared to males. This attenuated brain inflammation is ascribed to 17β-estradiol. However, several studies suggest that 17β-estradiol is also endowed with proinflammatory properties. The aim ...

journal_title：Frontiers in cellular neuroscience

authors： Mouihate A

更新日期：2014-05-27 00:00:00

abstract：:Manipulation of metabolic pathways (e.g., ketogenic diet (KD), glycolytic inhibition) alters neural excitability and represents a novel strategy for treatment of drug-refractory seizures. We have previously shown that inhibition of glycolysis suppresses epileptiform activity in hippocampal slices. In the present study...

journal_title：Frontiers in cellular neuroscience

authors： Shao LR,Wang G,Stafstrom CE

更新日期：2018-06-15 00:00:00

abstract：:The substantia nigra pars reticulata (SNr) is one of the output nuclei of the basal ganglia (BG) and plays a vital role in movement execution. Death of dopaminergic neurons in the neighboring nucleus, the substantia nigra pars compacta (SNc), leads to Parkinson's disease. The ensuing dopamine depletion affects all BG ...

journal_title：Frontiers in cellular neuroscience

authors： Faynveitz A,Lavian H,Jacob A,Korngreen A

更新日期：2019-09-13 00:00:00

abstract：:Orexin and melanin-concentrating hormone (MCH) neurons have complementary roles in various physiological functions including energy balance and the sleep/wake cycle. in vitro electrophysiological studies investigating these cells typically use post-weaning rodents, corresponding to adolescence. However, it is unclear ...

journal_title：Frontiers in cellular neuroscience

authors： Linehan V,Hirasawa M

更新日期：2018-03-13 00:00:00

abstract：:Spatially localized proteolysis represents an elegant means by which neuronal activity dependent changes in synaptic structure, and thus experience dependent learning and memory, can be achieved. In vitro and in vivo studies suggest that matrix metalloproteinase and adamalysin activity is concentrated at the cell surf...

journal_title：Frontiers in cellular neuroscience

authors： Conant K,Allen M,Lim ST

更新日期：2015-08-11 00:00:00

abstract：:Nonlinear dendritic integration is thought to increase the computational ability of neurons. Most studies focus on how supralinear summation of excitatory synaptic responses arising from clustered inputs within single dendrites result in the enhancement of neuronal firing, enabling simple computations such as feature ...

journal_title：Frontiers in cellular neuroscience

authors： Tran-Van-Minh A,Cazé RD,Abrahamsson T,Cathala L,Gutkin BS,DiGregorio DA

更新日期：2015-03-24 00:00:00

abstract：:Glioblastoma is the most common malignant tumor in central nervous system (CNS), and it is still insurmountable and has a poor prognosis. The proliferation and survival mechanism of glioma cells needs to be explored further for the development of glioma treatment. Hematopoietic-substrate-1 associated protein X-1 (HAX-...

journal_title：Frontiers in cellular neuroscience

authors： Deng X,Song L,Zhao W,Wei Y,Guo XB

更新日期：2017-12-21 00:00:00

abstract：:The dopamine transporter (DAT) is a plasma membrane protein responsible for the uptake of released dopamine back to the presynaptic terminal and ending dopamine neurotransmission. The DAT is the molecular target for cocaine and amphetamine as well as a number of pathological conditions including autism spectrum disord...

journal_title：Frontiers in cellular neuroscience

authors： Cartier E,Garcia-Olivares J,Janezic E,Viana J,Moore M,Lin ML,Caplan JL,Torres G,Kim YH

更新日期：2019-02-08 00:00:00

abstract：:Ischemic stroke is a debilitating disease for which there are currently no effective treatments besides the clot-buster, tissue plasminogen activator (t-PA), which is administered to less than 10% of patients due to a limited (4.5 h) time window of efficacy. Thus, there is an urgent need for novel therapies that can p...

journal_title：Frontiers in cellular neuroscience

authors： Broughton BR,Lim R,Arumugam TV,Drummond GR,Wallace EM,Sobey CG

更新日期：2013-01-17 00:00:00

abstract：:Prenatal hypoxic injury (HI) is a leading cause of neurological disability. The immediate and long-term effects of hypoxia on progenitor homeostasis and developmental progression during early human brain development remain unclear. This gap is due to difficulty to access human fetal brain tissues and inadequate animal...

journal_title：Frontiers in cellular neuroscience

authors： Daviaud N,Chevalier C,Friedel RH,Zou H

更新日期：2019-07-30 00:00:00

abstract：:Many neurodegenerative disorders are linked to irreversible protein aggregation, a process that usually comes along with toxicity and serious cellular damage. However, it is emerging that protein aggregation can also serve for physiological purposes, as impressively shown for prions. While the aggregation of this prot...

journal_title：Frontiers in cellular neuroscience

authors： Falsone A,Falsone SF

更新日期：2015-02-18 00:00:00

abstract：:To improve the outcome after autologous nerve grafting in the clinic, it is important to understand the limiting variables such as distinct phenotypes of motor and sensory Schwann cells. This study investigated the properties of phenotypically different autografts in a 6 mm femoral nerve defect model in the rat, where...

journal_title：Frontiers in cellular neuroscience

authors： Hercher D,Kerbl M,Schuh CMAP,Heinzel J,Gal L,Stainer M,Schmidhammer R,Hausner T,Redl H,Nógrádi A,Hacobian A

更新日期：2019-05-08 00:00:00

abstract：:Nanobodies are single domain antibodies derived from llama heavy-chain only antibodies (HCAbs). They represent a new generation of biologicals with unique properties: nanobodies show excellent tissue distribution, high temperature and pH stability, are easy to produce recombinantly and can readily be converted into di...

journal_title：Frontiers in cellular neuroscience

authors： Rissiek B,Koch-Nolte F,Magnus T

更新日期：2014-10-21 00:00:00

abstract：:Chronic pain is accompanied with long-term sensory, affective and cognitive disturbances. What are the mechanisms that mediate the long-term consequences of painful experiences and embed them in the genome? We hypothesize that alterations in DNA methylation, an enzymatic covalent modification of cytosine bases in DNA,...

journal_title：Frontiers in cellular neuroscience

authors： Alvarado S,Tajerian M,Suderman M,Machnes Z,Pierfelice S,Millecamps M,Stone LS,Szyf M

更新日期：2015-03-24 00:00:00

abstract：:Fatty acids (FAs) are typically associated with structural and metabolic roles, as they can be stored as triglycerides, degraded by β-oxidation or used in phospholipids' synthesis, the main components of biological membranes. It has been shown that these lipids exhibit also regulatory functions in different cell types...

journal_title：Frontiers in cellular neuroscience

authors： Falomir-Lockhart LJ,Cavazzutti GF,Giménez E,Toscani AM

更新日期：2019-04-24 00:00:00

abstract：:In the last decade, there is an increasing application of induced pluripotent stem cells (iPSCs) for disease modeling. The iPSC technology enables the study of patient-specific neuronal cell lines in vitro to evaluate dysfunction at the cellular level and identify the responsible genetic factors. This approach might b...

journal_title：Frontiers in cellular neuroscience

authors： Re S,Dogan AA,Ben-Shachar D,Berger G,Werling AM,Walitza S,Grünblatt E

更新日期：2018-09-25 00:00:00

abstract：:Stabilization of the blood-brain barrier during and after stroke can lead to less adverse outcome. For elucidation of underlying mechanisms and development of novel therapeutic strategies validated in vitro disease models of the blood-brain barrier could be very helpful. To mimic in vitro stroke conditions we have est...

journal_title：Frontiers in cellular neuroscience

authors： Neuhaus W,Gaiser F,Mahringer A,Franz J,Riethmüller C,Förster C

更新日期：2014-10-28 00:00:00

abstract：:Hippocampal inhibitory interneurons exhibit a large diversity of dendritic Ca2+ mechanisms that are involved in the induction of Hebbian and anti-Hebbian synaptic plasticity. High resolution imaging techniques allowed examining somatic Ca2+ signals and, accordingly, the recruitment of hippocampal interneurons in awake...

journal_title：Frontiers in cellular neuroscience

authors： Francavilla R,Villette V,Martel O,Topolnik L

更新日期：2019-03-15 00:00:00