Abstract:
:Animals rely heavily on their sense of olfaction to perform various vital interactions with an ever-in-flux environment. The turbulent and combinatorial nature of air-borne odorant cues demands the employment of various coding strategies, which allow the animal to attune to its internal needs and past or present experiences. Furthermore, these internal needs can be dependent on internal states such as hunger, reproductive state and sickness. Neuromodulation is a key component providing flexibility under such conditions. Understanding the contributions of neuromodulation, such as sensory neuron sensitization and choice bias requires manipulation of neuronal activity on a local and global scale. With Drosophila's genetic toolset, these manipulations are feasible and even allow a detailed look on the functional role of classical neuromodulators such as dopamine, octopamine and neuropeptides. The past years unraveled various mechanisms adapting chemosensory processing and perception to internal states such as hunger and reproductive state. However, future research should also investigate the mechanisms underlying other internal states including the modulatory influence of endogenous microbiota on Drosophila behavior. Furthermore, sickness induced by pathogenic infection could lead to novel insights as to the neuromodulators of circuits that integrate such a negative postingestive signal within the circuits governing olfactory behavior and learning. The enriched emporium of tools Drosophila provides will help to build a concrete picture of the influence of neuromodulation on olfaction and metabolism, adaptive behavior and our overall understanding of how a brain works.
journal_name
Front Cell Neuroscijournal_title
Frontiers in cellular neuroscienceauthors
Sayin S,Boehm AC,Kobler JM,De Backer JF,Grunwald Kadow ICdoi
10.3389/fncel.2018.00011subject
Has Abstractpub_date
2018-01-30 00:00:00pages
11issn
1662-5102journal_volume
12pub_type
杂志文章,评审abstract::Local circuit and long-range GABAergic projections provide powerful inhibitory control over the operation of hippocampal inhibitory circuits, yet little is known about the input- and target-specific organization of interacting inhibitory networks in relation to their specific functions. Using a combination of two-phot...
journal_title:Frontiers in cellular neuroscience
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journal_title:Frontiers in cellular neuroscience
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journal_title:Frontiers in cellular neuroscience
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journal_title:Frontiers in cellular neuroscience
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journal_title:Frontiers in cellular neuroscience
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journal_title:Frontiers in cellular neuroscience
pub_type: 杂志文章
doi:10.3389/fncel.2018.00275
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journal_title:Frontiers in cellular neuroscience
pub_type: 杂志文章
doi:10.3389/fncel.2019.00107
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journal_title:Frontiers in cellular neuroscience
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journal_title:Frontiers in cellular neuroscience
pub_type: 杂志文章
doi:10.3389/fncel.2018.00321
更新日期:2018-09-25 00:00:00
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journal_title:Frontiers in cellular neuroscience
pub_type: 杂志文章
doi:10.3389/fncel.2017.00365
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journal_title:Frontiers in cellular neuroscience
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doi:10.3389/fncel.2011.00023
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journal_title:Frontiers in cellular neuroscience
pub_type: 杂志文章
doi:10.3389/fncel.2013.00054
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abstract::Mutations within the FUS gene (Fused in Sarcoma) are known to cause Amyotrophic Lateral Sclerosis (ALS), a neurodegenerative disease affecting upper and lower motoneurons. The FUS gene codes for a multifunctional RNA/DNA-binding protein that is primarily localized in the nucleus and is involved in cellular processes s...
journal_title:Frontiers in cellular neuroscience
pub_type: 杂志文章
doi:10.3389/fncel.2016.00290
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journal_title:Frontiers in cellular neuroscience
pub_type: 杂志文章,评审
doi:10.3389/fncel.2015.00412
更新日期:2015-10-13 00:00:00
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journal_title:Frontiers in cellular neuroscience
pub_type: 杂志文章,评审
doi:10.3389/fncel.2020.563446
更新日期:2020-09-18 00:00:00
abstract::[This corrects the article on p. 56 in vol. 11, PMID: 28303091.]. ...
journal_title:Frontiers in cellular neuroscience
pub_type: 已发布勘误
doi:10.3389/fncel.2017.00256
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journal_title:Frontiers in cellular neuroscience
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doi:10.3389/fncel.2020.625513
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pub_type: 杂志文章
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doi:10.3389/fncel.2018.00430
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journal_title:Frontiers in cellular neuroscience
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journal_title:Frontiers in cellular neuroscience
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journal_title:Frontiers in cellular neuroscience
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journal_title:Frontiers in cellular neuroscience
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abstract::Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease with a complicated and poorly understood pathogenesis. Recently, alterations in the blood-Central Nervous System barrier (B-CNS-B) have been recognized as a key factor possibly aggravating motor neuron damage. The majority of findings on ALS mic...
journal_title:Frontiers in cellular neuroscience
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