Spontaneous and Acetylcholine Evoked Calcium Transients in the Developing Mouse Utricle.

abstract：:Major depressive disorder (MDD) is a mood disorder of multifactorial origin affecting millions of people worldwide. The alarming estimated rates of prevalence and relapse make it a global public health concern. Moreover, the current setback of available antidepressants in the clinical setting is discouraging. Therefor...

journal_title：Frontiers in cellular neuroscience

authors： Jo WK,Zhang Y,Emrich HM,Dietrich DE

更新日期：2015-07-10 00:00:00

abstract：:Mammalian teeth have evolved as dentin units that enclose a complex system of sensory innervation to protect and preserve their structure and function. In human dental pulp (DP), mechanosensory and nociceptive fibers form a dense meshwork of nerve endings at the coronal dentin-pulp interface, which arise from myelinat...

journal_title：Frontiers in cellular neuroscience

authors： Couve E,Schmachtenberg O

更新日期：2018-09-05 00:00:00

abstract：:A recurrent and devastating feature of addiction to a drug of abuse is its persistence, which is mediated by maladaptive long-term memories of the highly pleasurable experience initially associated with the consumption of the drug. We have recently found that members of the CPEB family of proteins (Cytoplasmic Polyade...

journal_title：Frontiers in cellular neuroscience

authors： Drisaldi B,Colnaghi L,Levine A,Huang Y,Snyder AM,Metzger DJ,Theis M,Kandel DB,Kandel ER,Fioriti L

更新日期：2020-07-09 00:00:00

abstract：:GABAergic plasticity is recognized as a key mechanism of shaping the activity of the neuronal networks. However, its description is challenging because of numerous neuron-specific mechanisms. In particular, while essential role of glial cells in the excitatory plasticity is well established, their involvement in GABAe...

journal_title：Frontiers in cellular neuroscience

authors： Kaczor PT,Mozrzymas JW

更新日期：2017-05-16 00:00:00

abstract：:Prenatal hypoxic injury (HI) is a leading cause of neurological disability. The immediate and long-term effects of hypoxia on progenitor homeostasis and developmental progression during early human brain development remain unclear. This gap is due to difficulty to access human fetal brain tissues and inadequate animal...

journal_title：Frontiers in cellular neuroscience

authors： Daviaud N,Chevalier C,Friedel RH,Zou H

更新日期：2019-07-30 00:00:00

abstract：:Degenerative retinopathies are the leading causes of irreversible visual impairment in the elderly, affecting hundreds of millions of patients. Müller glia cells (MGC), the main type of glia found in the vertebrate retina, can resume proliferation in the rodent adult injured retina but contribute weakly to tissue repa...

journal_title：Frontiers in cellular neuroscience

authors： Guimarães RPM,Landeira BS,Coelho DM,Golbert DCF,Silveira MS,Linden R,de Melo Reis RA,Costa MR

更新日期：2018-11-12 00:00:00

abstract：:To improve the outcome after autologous nerve grafting in the clinic, it is important to understand the limiting variables such as distinct phenotypes of motor and sensory Schwann cells. This study investigated the properties of phenotypically different autografts in a 6 mm femoral nerve defect model in the rat, where...

journal_title：Frontiers in cellular neuroscience

authors： Hercher D,Kerbl M,Schuh CMAP,Heinzel J,Gal L,Stainer M,Schmidhammer R,Hausner T,Redl H,Nógrádi A,Hacobian A

更新日期：2019-05-08 00:00:00

abstract：:Orexin and melanin-concentrating hormone (MCH) neurons have complementary roles in various physiological functions including energy balance and the sleep/wake cycle. in vitro electrophysiological studies investigating these cells typically use post-weaning rodents, corresponding to adolescence. However, it is unclear ...

journal_title：Frontiers in cellular neuroscience

authors： Linehan V,Hirasawa M

更新日期：2018-03-13 00:00:00

abstract：:Fragile X Syndrome (FXS) is caused by the lack of expression of the fragile X mental retardation protein (FMRP), which results in intellectual disability and other debilitating symptoms including impairment of visual-spatial functioning. FXS is the only single-gene disorder that is highly co-morbid with autism spectru...

journal_title：Frontiers in cellular neuroscience

authors： Gandhi RM,Kogan CS,Messier C

更新日期：2014-03-06 00:00:00

abstract：:Nitric oxide is a unique neurotransmitter, which participates in many physiological and pathological processes in the organism. There are little data about the neuronal nitric oxide synthase immunoreactivity in the spinal cord of amphibians. In this respect, the present study aims to investigate the distribution of ni...

journal_title：Frontiers in cellular neuroscience

authors： Mahmoud MA,Fahmy GH,Moftah MZ,Sabry I

更新日期：2014-09-25 00:00:00

abstract：:Cellular senescence has classically been associated with aging. Intriguingly, recent studies have also unraveled key roles for senescence in embryonic development, regeneration, and reprogramming. Developmental senescence has been reported during embryonic development in different organisms and structures, such as the...

journal_title：Frontiers in cellular neuroscience

authors： Magariños M,Barajas-Azpeleta R,Varela-Nieto I,R Aburto M

更新日期：2020-08-17 00:00:00

abstract：:Membrane tethering is an important communication method for membrane-packaged organelles. Mitochondria are organelles with a bilayer membrane, and the membrane contact between mitochondria and other organelles is indispensable for maintaining cellular homeostasis. Increased levels of molecular determinants that mediat...

journal_title：Frontiers in cellular neuroscience

authors： Liao Y,Dong Y,Cheng J

更新日期：2020-08-07 00:00:00

abstract：:Autoreactive T cells that infiltrate into the central nervous system (CNS) are believed to have a significant role in mediating the pathology of neuroinflammatory diseases like multiple sclerosis. Their interaction with microglia and astrocytes in the CNS is crucial for the regulation of neuroinflammatory processes. O...

journal_title：Frontiers in cellular neuroscience

authors： Prajeeth CK,Dittrich-Breiholz O,Talbot SR,Robert PA,Huehn J,Stangel M

更新日期：2018-10-10 00:00:00

abstract：:Synaptic transmission and its activity-dependent modulation, known as synaptic plasticity, are fundamental processes in nervous system function. Neurons may receive thousands of synaptic contacts, but synaptic regulation may occur only at individual or discrete subsets of synapses, which may have important consequence...

journal_title：Frontiers in cellular neuroscience

authors： Lines J,Covelo A,Gómez R,Liu L,Araque A

更新日期：2017-11-23 00:00:00

abstract：:Brain injuries of different etiologies lead to irreversible neuronal loss and persisting neuronal deficits. New therapeutic strategies are emerging to compensate neuronal damage upon brain injury. Some of these strategies focus on enhancing endogenous generation of neurons from neural stem cells (NSCs) to substitute t...

journal_title：Frontiers in cellular neuroscience

authors： García-Bernal F,Geribaldi-Doldán N,Domínguez-García S,Carrasco M,Murillo-Carretero M,Delgado-Ariza A,Díez-Salguero M,Verástegui C,Castro C

更新日期：2018-11-27 00:00:00

abstract：:Cortical fast-spiking (FS) neurons generate high-frequency action potentials (APs) without apparent frequency accommodation, thus providing fast and precise inhibition. However, the maximal firing frequency that they can reach, particularly in primate neocortex, remains unclear. Here, by recording in human, monkey, an...

journal_title：Frontiers in cellular neuroscience

authors： Wang B,Ke W,Guang J,Chen G,Yin L,Deng S,He Q,Liu Y,He T,Zheng R,Jiang Y,Zhang X,Li T,Luan G,Lu HD,Zhang M,Zhang X,Shu Y

更新日期：2016-10-18 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most malignant brain tumor and is associated with poor prognosis due to its thorny localization, lack of efficacious therapies and complex biology. Among the numerous pathways driving GBM biology studied so far, PTEN/phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/AKT/mechani...

journal_title：Frontiers in cellular neuroscience

authors： Mecca C,Giambanco I,Bruscoli S,Bereshchenko O,Fioretti B,Riccardi C,Donato R,Arcuri C

更新日期：2018-04-10 00:00:00

abstract：:It has been shown that matrix metalloproteinase 9 (MMP-9) is required for synaptic plasticity, learning and memory. In particular, MMP-9 involvement in long-term potentiation (LTP, the model of synaptic plasticity) in the hippocampus and prefrontal cortex has previously been demonstrated. Recent data suggest the role ...

journal_title：Frontiers in cellular neuroscience

authors： Gorkiewicz T,Balcerzyk M,Kaczmarek L,Knapska E

更新日期：2015-03-11 00:00:00

abstract：:Recently, with the development of the space program there are growing concerns about the influence of spaceflight on tissue engineering. The purpose of this study was thus to determine the variations of neural stem cells (NSCs) during spaceflight. RNA-Sequencing (RNA-Seq) based transcriptomic profiling of NSCs identif...

journal_title：Frontiers in cellular neuroscience

authors： Cui Y,Han J,Xiao Z,Qi Y,Zhao Y,Chen B,Fang Y,Liu S,Wu X,Dai J

更新日期：2018-01-11 00:00:00

abstract：:Accumulation of proteins in aberrant conformation occurs in many neurodegenerative diseases. Furthermore, dysfunctions in protein handling in endoplasmic reticulum (ER) and the following ER stress have been implicated in a vast number of diseases, such as amyotrophic lateral sclerosis (ALS). During excessive ER stress...

journal_title：Frontiers in cellular neuroscience

authors： Jaronen M,Goldsteins G,Koistinaho J

更新日期：2014-12-02 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease with a complicated and poorly understood pathogenesis. Recently, alterations in the blood-Central Nervous System barrier (B-CNS-B) have been recognized as a key factor possibly aggravating motor neuron damage. The majority of findings on ALS mic...

journal_title：Frontiers in cellular neuroscience

authors： Garbuzova-Davis S,Sanberg PR

更新日期：2014-02-03 00:00:00

abstract：:The loss of hippocampal interneurons has been considered as one reason for the onset of temporal lobe epilepsy (TLE) by shifting the excitation-inhibition balance. Yet, there are many different interneuron types which show differential vulnerability in the context of an epileptogenic insult. We used the intrahippocamp...

journal_title：Frontiers in cellular neuroscience

authors： Marx M,Haas CA,Häussler U

更新日期：2013-10-01 00:00:00

abstract：:The particular location of myenteric neurons, sandwiched between the 2 muscle layers of the gut, implies that their somata and neurites undergo mechanical stress during gastrointestinal motility. Existence of mechanosensitive enteric neurons (MEN) is undoubted but many of their basic features remain to be studied. In ...

journal_title：Frontiers in cellular neuroscience

authors： Kugler EM,Michel K,Zeller F,Demir IE,Ceyhan GO,Schemann M,Mazzuoli-Weber G

更新日期：2015-09-15 00:00:00

abstract：:Understanding non-stationary neuronal activity as seen in vivo requires estimation of both excitatory and inhibitory synaptic conductances from a single trial of recording. For this purpose, we propose a new intracellular recording method, called "firing clamp." Synaptic conductances are estimated from the characteris...

journal_title：Frontiers in cellular neuroscience

authors： Chizhov AV,Malinina E,Druzin M,Graham LJ,Johansson S

更新日期：2014-03-27 00:00:00

abstract：:The klotho gene family consists of α-, β-, and γ-Klotho, which encode type I single-pass transmembrane proteins with large extracellular domains. α-Klotho exists as a full-length membrane-bound and as a soluble form after cleavage of the extracellular domain. Due to gene splicing, a short extracellular Klotho form can...

journal_title：Frontiers in cellular neuroscience

authors： Li D,Jing D,Liu Z,Chen Y,Huang F,Behnisch T

更新日期：2019-04-02 00:00:00

abstract：:Hair cells in the inner ear convert mechanical stimuli provided by sound waves and head movements into electrical signal. Several mechanically evoked ionic currents with different properties have been recorded in hair cells. The search for the proteins that form the underlying ion channels is still in progress. The me...

journal_title：Frontiers in cellular neuroscience

authors： Qiu X,Müller U

更新日期：2018-04-11 00:00:00

abstract：:The brain relies on GABAergic neurons to control the ongoing activity of neuronal networks. GABAergic neurons control the firing pattern of excitatory cells, the temporal structure of membrane potential oscillations and the time window for integration of synaptic inputs. These actions require a fine control of the tim...

journal_title：Frontiers in cellular neuroscience

authors： Scimemi A

更新日期：2014-05-13 00:00:00

abstract：:Adeno-associated virus (AAV) is the preferred vector for gene therapy of hereditary deafness, and different viral serotypes, promoters and transduction pathways can influence the targeting of AAV to different types of cells and the expression levels of numerous exogenous genes. To determine the transduction and expres...

journal_title：Frontiers in cellular neuroscience

authors： Gu X,Chai R,Guo L,Dong B,Li W,Shu Y,Huang X,Li H

更新日期：2019-01-24 00:00:00

abstract：:Gene knockout by homologous recombination is a popular method to study gene functions in the mouse in vivo. However, its lack of temporal control has limited the interpretation of knockout studies because the complete elimination of a gene product often alters developmental processes, and can induce severe malformatio...

journal_title：Frontiers in cellular neuroscience

authors： Heitz F,Johansson T,Baumgärtel K,Gecaj R,Pelczar P,Mansuy IM

更新日期：2014-03-19 00:00:00

abstract：:The inner ear houses the sensory epithelium responsible for vestibular and auditory function. The sensory epithelia are driven by pressure and vibration of the fluid filled structures in which they are embedded so that understanding the homeostatic mechanisms regulating fluid dynamics within these structures is critic...

journal_title：Frontiers in cellular neuroscience

authors： Talaei S,Schnee ME,Aaron KA,Ricci AJ

更新日期：2019-10-30 00:00:00