Abstract:
:Loss of auditory sensory hair cells (HCs) is the most common cause of hearing loss. This review addresses the signaling pathways that are involved in the programmed and necrotic cell death of auditory HCs that occur in response to ototoxic and traumatic stressor events. The roles of inflammatory processes, oxidative stress, mitochondrial damage, cell death receptors, members of the mitogen-activated protein kinase (MAPK) signal pathway and pro- and anti-cell death members of the Bcl-2 family are explored. The molecular interaction of these signal pathways that initiates the loss of auditory HCs following acoustic trauma is covered and possible therapeutic interventions that may protect these sensory HCs from loss via apoptotic or non-apoptotic cell death are explored.
journal_name
Front Cell Neuroscijournal_title
Frontiers in cellular neuroscienceauthors
Dinh CT,Goncalves S,Bas E,Van De Water TR,Zine Adoi
10.3389/fncel.2015.00096subject
Has Abstractpub_date
2015-03-31 00:00:00pages
96issn
1662-5102journal_volume
9pub_type
杂志文章,评审abstract::Traumatic spinal cord injury (SCI) leads to disruption of sensory, motor and autonomic function, and triggers structural, physiological and biochemical changes that cause reorganization of existing circuits that affect functional recovery. Propriospinal neurons (PN) appear to be very plastic within the inhibitory micr...
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