Neural precursor cells in the ischemic brain - integration, cellular crosstalk, and consequences for stroke recovery.

Abstract:

:After an ischemic stroke, neural precursor cells (NPCs) proliferate within major germinal niches of the brain. Endogenous NPCs subsequently migrate toward the ischemic lesion where they promote tissue remodeling and neural repair. Unfortunately, this restorative process is generally insufficient and thus unable to support a full recovery of lost neurological functions. Supported by solid experimental and preclinical data, the transplantation of exogenous NPCs has emerged as a potential tool for stroke treatment. Transplanted NPCs are thought to act mainly via trophic and immune modulatory effects, thereby complementing the restorative responses initially executed by the endogenous NPC population. Recent studies have attempted to elucidate how the therapeutic properties of transplanted NPCs vary depending on the route of transplantation. Systemic NPC delivery leads to potent immune modulatory actions, which prevent secondary neuronal degeneration, reduces glial scar formation, diminishes oxidative stress and stabilizes blood-brain barrier integrity. On the contrary, local stem cell delivery allows for the accumulation of large numbers of transplanted NPCs in the brain, thus achieving high levels of locally available tissue trophic factors, which may better induce a strong endogenous NPC proliferative response. Herein we describe the diverse capabilities of exogenous (systemically vs. locally transplanted) NPCs in enhancing the endogenous neurogenic response after stroke, and how the route of transplantation may affect migration, survival, bystander effects and integration of the cellular graft. It is the authors' claim that understanding these aspects will be of pivotal importance in discerning how transplanted NPCs exert their therapeutic effects in stroke.

journal_name

Front Cell Neurosci

authors

Hermann DM,Peruzzotti-Jametti L,Schlechter J,Bernstock JD,Doeppner TR,Pluchino S

doi

10.3389/fncel.2014.00291

subject

Has Abstract

pub_date

2014-09-16 00:00:00

pages

291

issn

1662-5102

journal_volume

8

pub_type

杂志文章,评审
  • Distribution of nitric oxide-producing cells along spinal cord in urodeles.

    abstract::Nitric oxide is a unique neurotransmitter, which participates in many physiological and pathological processes in the organism. There are little data about the neuronal nitric oxide synthase immunoreactivity in the spinal cord of amphibians. In this respect, the present study aims to investigate the distribution of ni...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2014.00299

    authors: Mahmoud MA,Fahmy GH,Moftah MZ,Sabry I

    更新日期:2014-09-25 00:00:00

  • Norepinephrine Modulates Pyramidal Cell Synaptic Properties in the Anterior Piriform Cortex of Mice: Age-Dependent Effects of β-adrenoceptors.

    abstract::Early odor preference learning in rodents occurs within a sensitive period [≤postnatal day (P)10-12], during which pups show a heightened ability to form an odor preference when a novel odor is paired with a tactile stimulation (e.g., stroking). Norepinephrine (NE) release from the locus coeruleus during stroking medi...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2015.00450

    authors: Ghosh A,Purchase NC,Chen X,Yuan Q

    更新日期:2015-11-19 00:00:00

  • Fatty Acid Signaling Mechanisms in Neural Cells: Fatty Acid Receptors.

    abstract::Fatty acids (FAs) are typically associated with structural and metabolic roles, as they can be stored as triglycerides, degraded by β-oxidation or used in phospholipids' synthesis, the main components of biological membranes. It has been shown that these lipids exhibit also regulatory functions in different cell types...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fncel.2019.00162

    authors: Falomir-Lockhart LJ,Cavazzutti GF,Giménez E,Toscani AM

    更新日期:2019-04-24 00:00:00

  • Modeling neural differentiation on micropatterned substrates coated with neural matrix components.

    abstract::Topographical and biochemical characteristics of the substrate are critical for neuronal differentiation including axonal outgrowth and regeneration of neural circuits in vivo. Contact stimuli and signaling molecules allow neurons to develop and stabilize synaptic contacts. Here we present the development, characteriz...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2012.00010

    authors: García-Parra P,Cavaliere F,Maroto M,Bilbao L,Obieta I,López de Munain A,Alava JI,Izeta A

    更新日期:2012-03-14 00:00:00

  • Quantitating the subtleties of microglial morphology with fractal analysis.

    abstract::It is well established that microglial form and function are inextricably linked. In recent years, the traditional view that microglial form ranges between "ramified resting" and "activated amoeboid" has been emphasized through advancing imaging techniques that point to microglial form being highly dynamic even within...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2013.00003

    authors: Karperien A,Ahammer H,Jelinek HF

    更新日期:2013-01-30 00:00:00

  • Overall Assay of Neuronal Signal Propagation Pattern With Long-Term Potentiation (LTP) in Hippocampal Slices From the CA1 Area With Fast Voltage-Sensitive Dye Imaging.

    abstract::Activity-dependent changes in the input-output (I-O) relationship of a neural circuit are central in the learning and memory function of the brain. To understand circuit-wide adjustments, optical imaging techniques to probe the membrane potential at every component of neurons, such as dendrites, axons and somas, in th...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2018.00389

    authors: Tominaga Y,Taketoshi M,Tominaga T

    更新日期:2018-10-24 00:00:00

  • Rac1 at the crossroad of actin dynamics and neuroinflammation in Amyotrophic Lateral Sclerosis.

    abstract::Rac1 is a major player of the Rho family of small GTPases that controls multiple cell signaling pathways, such as the organization of cytoskeleton (including adhesion and motility), cell proliferation, apoptosis and activation of immune cells. In the nervous system, in particular, Rac1 GTPase plays a key regulatory fu...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fncel.2014.00279

    authors: D'Ambrosi N,Rossi S,Gerbino V,Cozzolino M

    更新日期:2014-09-08 00:00:00

  • NKCC1-Deficiency Results in Abnormal Proliferation of Neural Progenitor Cells of the Lateral Ganglionic Eminence.

    abstract::The proliferative pool of neural progenitor cells is maintained by exquisitely controlled mechanisms for cell cycle regulation. The Na-K-Cl cotransporter (NKCC1) is important for regulating cell volume and the proliferation of different cell types in vitro. NKCC1 is expressed in ventral telencephalon of embryonic brai...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2016.00200

    authors: Magalhães AC,Rivera C

    更新日期:2016-08-17 00:00:00

  • The Glycolytic Metabolite, Fructose-1,6-bisphosphate, Blocks Epileptiform Bursts by Attenuating Voltage-Activated Calcium Currents in Hippocampal Slices.

    abstract::Manipulation of metabolic pathways (e.g., ketogenic diet (KD), glycolytic inhibition) alters neural excitability and represents a novel strategy for treatment of drug-refractory seizures. We have previously shown that inhibition of glycolysis suppresses epileptiform activity in hippocampal slices. In the present study...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2018.00168

    authors: Shao LR,Wang G,Stafstrom CE

    更新日期:2018-06-15 00:00:00

  • Distinct Residential and Infiltrated Macrophage Populations and Their Phagocytic Function in Mild and Severe Neonatal Hypoxic-Ischemic Brain Damage.

    abstract::Neonatal brain injury, especially severe injury induced by hypoxia-ischemia (HI), causes mortality and long-term neurological impairments. Our previous study demonstrated activation of CD11b+ myeloid cells, including residential microglial cells (MGs) and infiltrating monocyte-derived macrophages (MDMs) in a murine mo...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2020.00244

    authors: Min Y,Yan L,Wang Q,Wang F,Hua H,Yuan Y,Jin H,Zhang M,Zhao Y,Yang J,Jiang X,Yang Y,Li F

    更新日期:2020-08-10 00:00:00

  • Flexor and Extensor Ankle Afferents Broadly Innervate Locomotor Spinal Shox2 Neurons and Induce Similar Effects in Neonatal Mice.

    abstract::Central pattern generators (CPGs) in the thoracolumbar spinal cord generate the basic hindlimb locomotor pattern. The locomotor CPG integrates descending commands and sensory information from the periphery to activate, modulate and halt the rhythmic program. General CPG function and response to sensory perturbations a...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2019.00452

    authors: Li EZ,Garcia-Ramirez DL,Dougherty KJ

    更新日期:2019-10-09 00:00:00

  • Lack of serotonin reuptake during brain development alters rostral raphe-prefrontal network formation.

    abstract::Besides its "classical" neurotransmitter function, serotonin (5-HT) has been found to also act as a neurodevelopmental signal. During development, the 5-HT projection system, besides an external placental source, represents one of the earliest neurotransmitter systems to innervate the brain. One of the targets of the ...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2013.00143

    authors: Witteveen JS,Middelman A,van Hulten JA,Martens GJ,Homberg JR,Kolk SM

    更新日期:2013-10-04 00:00:00

  • Differential vulnerability of interneurons in the epileptic hippocampus.

    abstract::The loss of hippocampal interneurons has been considered as one reason for the onset of temporal lobe epilepsy (TLE) by shifting the excitation-inhibition balance. Yet, there are many different interneuron types which show differential vulnerability in the context of an epileptogenic insult. We used the intrahippocamp...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2013.00167

    authors: Marx M,Haas CA,Häussler U

    更新日期:2013-10-01 00:00:00

  • Why looking at the whole hippocampus is not enough-a critical role for anteroposterior axis, subfield and activation analyses to enhance predictive value of hippocampal changes for Alzheimer's disease diagnosis.

    abstract::The hippocampus is one of the earliest affected brain regions in Alzheimer's disease (AD) and its dysfunction is believed to underlie the core feature of the disease-memory impairment. Given that hippocampal volume is one of the best AD biomarkers, our review focuses on distinct subfields within the hippocampus, pinpo...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fncel.2014.00095

    authors: Maruszak A,Thuret S

    更新日期:2014-03-31 00:00:00

  • TRACE: An Unbiased Method to Permanently Tag Transiently Activated Inputs.

    abstract::A fundamental interest in circuit analysis is to parse out the synaptic inputs underlying a behavioral experience. Toward this aim, we have devised an unbiased strategy that specifically labels the afferent inputs that are activated by a defined stimulus in an activity-dependent manner. We validated this strategy in f...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2020.00114

    authors: Krauth N,Khalil V,Jariwala M,Mermet-Joret N,Vestergaard AK,Capogna M,Nabavi S

    更新日期:2020-05-12 00:00:00

  • Restraint stress increases hemichannel activity in hippocampal glial cells and neurons.

    abstract::Stress affects brain areas involved in learning and emotional responses, which may contribute in the development of cognitive deficits associated with major depression. These effects have been linked to glial cell activation, glutamate release and changes in neuronal plasticity and survival including atrophy of hippoc...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2015.00102

    authors: Orellana JA,Moraga-Amaro R,Díaz-Galarce R,Rojas S,Maturana CJ,Stehberg J,Sáez JC

    更新日期:2015-04-02 00:00:00

  • GnRH-1 Neural Migration From the Nose to the Brain Is Independent From Slit2, Robo3 and NELL2 Signaling.

    abstract::Gonadotropin releasing hormone-1 (GnRH-1) neurons play a pivotal role in controlling pubertal onset and fertility once they reach their hypothalamic location. During embryonic development, GnRH-1 neurons migrate from the nasal area to the hypothalamus where they modulate gonadotropin release from the pituitary gland. ...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2019.00070

    authors: Taroc EZM,Lin JM,Tulloch AJ,Jaworski A,Forni PE

    更新日期:2019-03-01 00:00:00

  • A Model of Germinal Matrix Hemorrhage in Preterm Rat Pups.

    abstract::Germinal matrix hemorrhage (GMH) is a serious complication in extremely preterm infants associated with neurological deficits and mortality. The purpose of the present study was to develop and characterize a grade III and IV GMH model in postnatal day 5 (P5) rats, the equivalent of preterm human brain maturation. P5 W...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2020.535320

    authors: Jinnai M,Koning G,Singh-Mallah G,Jonsdotter A,Leverin AL,Svedin P,Nair S,Takeda S,Wang X,Mallard C,Ek CJ,Rocha-Ferreira E,Hagberg H

    更新日期:2020-12-03 00:00:00

  • Simultaneous Complement Response via Lectin Pathway in Retina and Optic Nerve in an Experimental Autoimmune Glaucoma Model.

    abstract::Glaucoma is a multifactorial disease and especially mechanisms occurring independently from an elevated intraocular pressure (IOP) are still unknown. Likely, the immune system contributes to the glaucoma pathogenesis. Previously, IgG antibody depositions and retinal ganglion cell (RGC) loss were found in an IOP-indepe...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2016.00140

    authors: Reinehr S,Reinhard J,Gandej M,Kuehn S,Noristani R,Faissner A,Dick HB,Joachim SC

    更新日期:2016-06-01 00:00:00

  • Early Impairment of Synaptic and Intrinsic Excitability in Mice Expressing ALS/Dementia-Linked Mutant UBQLN2.

    abstract::Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are believed to represent the different outcomes of a common pathogenic mechanism. However, while researchers have intensely studied the involvement of motor neurons in the ALS/FTD syndrome, very little is known about the function of hippocampal neu...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2016.00216

    authors: Radzicki D,Liu E,Deng HX,Siddique T,Martina M

    更新日期:2016-09-20 00:00:00

  • Thyroid hormone treated astrocytes induce maturation of cerebral cortical neurons through modulation of proteoglycan levels.

    abstract::Proper brain neuronal circuitry formation and synapse development is dependent on specific cues, either genetic or epigenetic, provided by the surrounding neural environment. Within these signals, thyroid hormones (T3 and T4) play crucial role in several steps of brain morphogenesis including proliferation of progenit...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2013.00125

    authors: Dezonne RS,Stipursky J,Araujo AP,Nones J,Pavão MS,Porcionatto M,Gomes FC

    更新日期:2013-08-12 00:00:00

  • Combination Low-Dose Tissue-Type Plasminogen Activator Plus Annexin A2 for Improving Thrombolytic Stroke Therapy.

    abstract::Risk of hemorrhagic transformation, incomplete reperfusion, neurotoxicity, and a short treatment time window comprises major challenges for tissue plasminogen activator (tPA) thrombolytic stroke therapy. Improving tPA therapy has become one of the highest priorities in the stroke field. This mini review article focuse...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fncel.2015.00397

    authors: Jiang Y,Fan X,Yu Z,Liao Z,Wang XS,van Leyen K,Sun X,Lo EH,Wang X

    更新日期:2015-10-14 00:00:00

  • Fetal microglial phenotype in vitro carries memory of prior in vivo exposure to inflammation.

    abstract:OBJECTIVE:Neuroinflammation in utero may result in life-long neurological disabilities. The molecular mechanisms whereby microglia contribute to this response remain incompletely understood. METHODS:Lipopolysaccharide (LPS) or saline were administered intravenously to non-anesthetized chronically instrumented near-ter...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2015.00294

    authors: Cao M,Cortes M,Moore CS,Leong SY,Durosier LD,Burns P,Fecteau G,Desrochers A,Auer RN,Barreiro LB,Antel JP,Frasch MG

    更新日期:2015-08-04 00:00:00

  • The Endosome Localized Arf-GAP AGAP1 Modulates Dendritic Spine Morphology Downstream of the Neurodevelopmental Disorder Factor Dysbindin.

    abstract::AGAP1 is an Arf1 GTPase activating protein that interacts with the vesicle-associated protein complexes adaptor protein 3 (AP-3) and Biogenesis of Lysosome Related Organelles Complex-1 (BLOC-1). Overexpression of AGAP1 in non-neuronal cells results in an accumulation of endosomal cargoes, which suggests a role in endo...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2016.00218

    authors: Arnold M,Cross R,Singleton KS,Zlatic S,Chapleau C,Mullin AP,Rolle I,Moore CC,Theibert A,Pozzo-Miller L,Faundez V,Larimore J

    更新日期:2016-09-22 00:00:00

  • Action potential processing in a detailed Purkinje cell model reveals a critical role for axonal compartmentalization.

    abstract::The Purkinje cell (PC) is among the most complex neurons in the brain and plays a critical role for cerebellar functioning. PCs operate as fast pacemakers modulated by synaptic inputs but can switch from simple spikes to complex bursts and, in some conditions, show bistability. In contrast to original works emphasizin...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2015.00047

    authors: Masoli S,Solinas S,D'Angelo E

    更新日期:2015-02-24 00:00:00

  • Astrocyte Hypertrophy and Microglia Activation in the Rat Auditory Midbrain Is Induced by Electrical Intracochlear Stimulation.

    abstract::Neuron-glia interactions contribute to tissue homeostasis and functional plasticity in the mammalian brain, but it remains unclear how this is achieved. The potential of central auditory brain tissue for stimulation-dependent cellular remodeling was studied in hearing-experienced and neonatally deafened rats. At adult...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2018.00043

    authors: Rosskothen-Kuhl N,Hildebrandt H,Birkenhäger R,Illing RB

    更新日期:2018-02-22 00:00:00

  • TRH Analog, Taltirelin Improves Motor Function of Hemi-PD Rats Without Inducing Dyskinesia via Sustained Dopamine Stimulating Effect.

    abstract::Thyrotropin-releasing hormone (TRH) and its analogs are able to stimulate the release of the endogenic dopamine (DA) in the central nervous system. However, this effect has not been tested in the Parkinson's disease (PD), which is characterized by the DA deficiency due to the dopaminergic neurons loss in the substanti...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2018.00417

    authors: Zheng C,Chen G,Tan Y,Zeng W,Peng Q,Wang J,Cheng C,Yang X,Nie S,Xu Y,Zhang Z,Papa SM,Ye K,Cao X

    更新日期:2018-11-13 00:00:00

  • Increased Inflammation and Unchanged Density of Synaptic Vesicle Glycoprotein 2A (SV2A) in the Postmortem Frontal Cortex of Alzheimer's Disease Patients.

    abstract::Sections from the middle frontal gyrus (Brodmann area 46) of autopsy-confirmed Alzheimer's disease (AD) patients and non-demented subjects were examined for the prevalence of hallmark AD pathology, including amyloid-β (Aβ) plaques, phosphorylated tau (pTau) tangles, neuroinflammation and synaptic loss (n = 7 subjects/...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2019.00538

    authors: Metaxas A,Thygesen C,Briting SRR,Landau AM,Darvesh S,Finsen B

    更新日期:2019-12-05 00:00:00

  • Reduced Annexin A1 Secretion by ABCA1 Causes Retinal Inflammation and Ganglion Cell Apoptosis in a Murine Glaucoma Model.

    abstract::Variants near the ATP-binding cassette transporter A1 (ABCA1) gene are associated with elevated intraocular pressure and newly discovered risk factors for glaucoma. Previous studies have shown an association between ABCA1 deficiency and retinal inflammation. Using a mouse model of ischemia-reperfusion (IR) induced by ...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章

    doi:10.3389/fncel.2018.00347

    authors: Li L,Xu L,Chen W,Li X,Xia Q,Zheng L,Duan Q,Zhang H,Zhao Y

    更新日期:2018-10-11 00:00:00

  • The Role of Serotonin beyond the Central Nervous System during Embryogenesis.

    abstract::Serotonin, or 5-hydroxytryptamine (5-HT), is a well-known neurotransmitter that plays vital roles in neural activities and social behaviors. Clinically, deficiency of serotonin is linked with many psychiatric disorders. Interestingly, a large proportion of serotonin is also produced outside the central nervous system ...

    journal_title:Frontiers in cellular neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fncel.2017.00074

    authors: Lv J,Liu F

    更新日期:2017-03-13 00:00:00