Olfactory Sensory Activity Modulates Microglial-Neuronal Interactions during Dopaminergic Cell Loss in the Olfactory Bulb.

abstract：:Xenon has been shown to have neuroprotective effects and is clinically used as a favorable safe inhalation anesthetic. We previously confirmed the neuroprotective effects of xenon treatment in epileptic animals. However, the mechanism underlying these protective effects remains unclear. We aimed to assess the effects ...

journal_title：Frontiers in cellular neuroscience

authors： Zhu W,Zhu J,Zhao S,Li J,Hou D,Zhang Y,Sun H

更新日期：2020-10-06 00:00:00

abstract：:Germinal matrix hemorrhage (GMH) is a serious complication in extremely preterm infants associated with neurological deficits and mortality. The purpose of the present study was to develop and characterize a grade III and IV GMH model in postnatal day 5 (P5) rats, the equivalent of preterm human brain maturation. P5 W...

journal_title：Frontiers in cellular neuroscience

authors： Jinnai M,Koning G,Singh-Mallah G,Jonsdotter A,Leverin AL,Svedin P,Nair S,Takeda S,Wang X,Mallard C,Ek CJ,Rocha-Ferreira E,Hagberg H

更新日期：2020-12-03 00:00:00

abstract：:There is evidence for both neurotoxic and neuroprotective roles of nitric oxide (NO) in the brain and changes in the expression of the neuronal isoform of NO synthase (nNOS) gene occur during aging. The current studies have investigated potential support for either a neurotoxic or neuroprotective role of NO derived fr...

journal_title：Frontiers in cellular neuroscience

authors： James BM,Li Q,Luo L,Kendrick KM

更新日期：2015-03-27 00:00:00

abstract：:Maturation of neuronal and synaptic functions during early life is essential for the development of neuronal circuits and behaviors. In newborns synaptic transmission at excitatory synapses is primarily mediated by N-methyl-D-aspartate receptors (NMDARs), and NMDAR-mediated signaling plays an important role in synapti...

journal_title：Frontiers in cellular neuroscience

authors： Hou G,Zhang ZW

更新日期：2017-11-07 00:00:00

abstract：:Nanobodies are single domain antibodies derived from llama heavy-chain only antibodies (HCAbs). They represent a new generation of biologicals with unique properties: nanobodies show excellent tissue distribution, high temperature and pH stability, are easy to produce recombinantly and can readily be converted into di...

journal_title：Frontiers in cellular neuroscience

authors： Rissiek B,Koch-Nolte F,Magnus T

更新日期：2014-10-21 00:00:00

abstract：:Background: Recent studies have found that rifampicin has neuroprotective properties in neurodegenerative diseases. However, the exact mechanisms of action remain unclear. The nuclear factor erythroid 2-related factor 2 (Nrf2) has been considered a potential target for neuroprotection. In this study, we examined wheth...

journal_title：Frontiers in cellular neuroscience

authors： Chen B,Cao H,Chen L,Yang X,Tian X,Li R,Cheng O

更新日期：2016-11-29 00:00:00

abstract：:Many neurodegenerative disorders are linked to irreversible protein aggregation, a process that usually comes along with toxicity and serious cellular damage. However, it is emerging that protein aggregation can also serve for physiological purposes, as impressively shown for prions. While the aggregation of this prot...

journal_title：Frontiers in cellular neuroscience

authors： Falsone A,Falsone SF

更新日期：2015-02-18 00:00:00

abstract：:Anabolic-androgenic steroids (AAS) are lipophilic hormones often taken in excessive quantities by athletes and bodybuilders to enhance performance and increase muscle mass. AAS exert well known toxic effects on specific cell and tissue types and organ systems. The attention that androgen abuse has received lately shou...

journal_title：Frontiers in cellular neuroscience

authors： Basile JR,Binmadi NO,Zhou H,Yang YH,Paoli A,Proia P

更新日期：2013-05-09 00:00:00

abstract：:Thermal Fluctuations Spectroscopy (TFS) in combination with novel optical-based instrumentation was used to study mechanical properties of cell-cultured neurites with a spatial resolution limited only by the light diffraction. The analysis of thermal fluctuations together with a physical model of cellular elasticity a...

journal_title：Frontiers in cellular neuroscience

authors： Gárate F,Pertusa M,Arana Y,Bernal R

更新日期：2018-07-06 00:00:00

abstract：:The hippocampal mossy fibers (MFs), the axons of the granule cells (GCs) of the dentate gyrus, innervate mossy cells and interneurons in the hilus on their way to CA3 where they innervate interneurons and pyramidal cells. Synapses on each target cell have distinct anatomical and functional characteristics. In recent y...

journal_title：Frontiers in cellular neuroscience

authors： Münster-Wandowski A,Gómez-Lira G,Gutiérrez R

更新日期：2013-11-22 00:00:00

abstract：:Nitric oxide (NO) is a pleiotropic janus-faced molecule synthesized by nitric oxide synthases (NOS) which plays a critical role in a number of physiological and pathological processes in humans. The physiological roles of NO depend on its local concentrations, as well as its availability and the nature of downstream t...

journal_title：Frontiers in cellular neuroscience

authors： Yuste JE,Tarragon E,Campuzano CM,Ros-Bernal F

更新日期：2015-08-17 00:00:00

abstract：:Human brain organoids (mini-brains) consist of self-organized three-dimensional (3D) neural tissue which can be derived from reprogrammed adult cells and maintained for months in culture. These 3D structures manifest substantial potential for the modeling of neurodegenerative diseases and pave the way for personalized...

journal_title：Frontiers in cellular neuroscience

authors： Nassor F,Jarray R,Biard DSF,Maïza A,Papy-Garcia D,Pavoni S,Deslys JP,Yates F

更新日期：2020-02-11 00:00:00

abstract：:Accumulating evidence suggests that epigenetic alterations lie behind the induction and maintenance of neuropathic pain. Neuropathic pain is usually a chronic condition caused by a lesion, or pathological change, within the nervous system. Neuropathic pain appears frequently after nerve and spinal cord injuries or dis...

journal_title：Frontiers in cellular neuroscience

authors： Penas C,Navarro X

更新日期：2018-06-07 00:00:00

abstract：:Transcallosal projection neurons are a population of pyramidal excitatory neurons located in layers II/III and to a lesser extent layer V of the cortex. Their axons form the corpus callosum thereby providing an inter-hemispheric connection in the brain. While transcallosal projection neurons have been described in som...

journal_title：Frontiers in cellular neuroscience

authors： Chovsepian A,Empl L,Correa D,Bareyre FM

更新日期：2017-02-21 00:00:00

abstract：:In the primary motor cortex (M1), layer 5 projection neurons signal directly to distant motor structures to drive movement. Despite their pivotal position and acknowledged diversity these neurons are traditionally separated into broad commissural and corticofugal types, and until now no attempt has been made at resolv...

journal_title：Frontiers in cellular neuroscience

authors： Oswald MJ,Tantirigama ML,Sonntag I,Hughes SM,Empson RM

更新日期：2013-10-16 00:00:00

abstract：:Type III adenylyl cyclase (AC3, ADCY3) is predominantly enriched in neuronal primary cilia throughout the central nervous system (CNS). Genome-wide association studies in humans have associated ADCY3 with major depressive disorder and autistic spectrum disorder, both of which exhibit sexual dimorphism. To date, it is ...

journal_title：Frontiers in cellular neuroscience

authors： Zhou Y,Qiu L,Sterpka A,Wang H,Chu F,Chen X

更新日期：2019-02-13 00:00:00

abstract：:Vasoinhibins are prolactin fragments present in the retina, where they have been shown to prevent the hypervasopermeability associated with diabetes. Enhanced bradykinin (BK) production contributes to the increased transport through the blood-retina barrier (BRB) in diabetes. Here, we studied if vasoinhibins regulate ...

journal_title：Frontiers in cellular neuroscience

authors： Arredondo Zamarripa D,Díaz-Lezama N,Meléndez García R,Chávez Balderas J,Adán N,Ledesma-Colunga MG,Arnold E,Clapp C,Thebault S

更新日期：2014-10-20 00:00:00

abstract：:The brain relies on GABAergic neurons to control the ongoing activity of neuronal networks. GABAergic neurons control the firing pattern of excitatory cells, the temporal structure of membrane potential oscillations and the time window for integration of synaptic inputs. These actions require a fine control of the tim...

journal_title：Frontiers in cellular neuroscience

authors： Scimemi A

更新日期：2014-05-13 00:00:00

abstract：:Heterotrimeric G-proteins mediate a variety of cellular functions, including signal transduction in sensory neurons of the olfactory system. Whereas the Gα subunits in these neurons are well characterized, the gene transcript expression profile of Gβγ subunits is largely missing. Here we report our comprehensive expre...

journal_title：Frontiers in cellular neuroscience

authors： Sathyanesan A,Feijoo AA,Mehta ST,Nimarko AF,Lin W

更新日期：2013-06-04 00:00:00

abstract：:Adult neurogenesis has been convincingly demonstrated in two regions of the mammalian brain: the sub-granular zone (SGZ) of the dentate gyrus (DG) in the hippocampus, and the sub-ventricular zone (SVZ) of the lateral ventricles (LV). SGZ newborn neurons are destined to the granular cell layer (GCL) of the DG, while ne...

journal_title：Frontiers in cellular neuroscience

authors： Bátiz LF,Castro MA,Burgos PV,Velásquez ZD,Muñoz RI,Lafourcade CA,Troncoso-Escudero P,Wyneken U

更新日期：2016-01-19 00:00:00

abstract：:The microdomain that orchestrates action potential initiation in neurons is the axon initial segment (AIS). It has long been considered to be a rather homogeneous domain at the very proximal axon hillock with relatively stable length, particularly in cortical pyramidal cells. However, studies in other brain regions pa...

journal_title：Frontiers in cellular neuroscience

authors： Höfflin F,Jack A,Riedel C,Mack-Bucher J,Roos J,Corcelli C,Schultz C,Wahle P,Engelhardt M

更新日期：2017-11-06 00:00:00

abstract：:Abnormal accumulation of protein inclusions in motor neurons has been known as a major pathological change in amyotrophic lateral sclerosis (ALS). Increasing numbers of proteins including mutant Cu, Zn-superoxide dismutase (SOD1) have been identified as constituents of pathological inclusions in a form of insoluble fi...

journal_title：Frontiers in cellular neuroscience

authors： Ogawa M,Furukawa Y

更新日期：2014-03-18 00:00:00

abstract：:The piriform cortex (PC) is richly innervated by corticotropin-releasing factor (CRF) and serotonin (5-HT) containing axons arising from central amygdala and Raphe nucleus. CRFR1 and 5-HT2A/2CRs have been shown to interact in manner where CRFR activation subsequently potentiates the activity of 5-HT2A/2CRs. The purpos...

journal_title：Frontiers in cellular neuroscience

authors： Narla C,Dunn HA,Ferguson SS,Poulter MO

更新日期：2015-05-28 00:00:00

abstract：:Studying the distribution of astrocytic antigens is particularly hard when they are localized in their fine, peripheral astrocyte processes (PAPs), since these processes often have a diameter comparable to vesicles and small organelles. The most appropriate technique is immunoelectron microscopy, which is, however, a ...

journal_title：Frontiers in cellular neuroscience

authors： Haseleu J,Anlauf E,Blaess S,Endl E,Derouiche A

更新日期：2013-05-03 00:00:00

abstract：:Axon growth inhibitors generated by reactive glial scars play an important role in failure of axon regeneration after CNS injury in mature mammals. Among the inhibitory factors, chondroitin sulfate proteoglycans (CSPGs) are potent suppressors of axon regeneration and are important molecular targets for designing effec...

journal_title：Frontiers in cellular neuroscience

authors： Sami A,Selzer ME,Li S

更新日期：2020-07-02 00:00:00

abstract：:Regulatory T cells (Tregs) play an anti-inflammatory effect to protect against ischemic stroke. Plasmacytoid dendritic cells (pDCs) can induce regulatory T cells tolerance in sterile-inflammation conditions. However, whether and how pDCs-mediated Tregs response play a part in the pathology of ischemic stroke remains u...

journal_title：Frontiers in cellular neuroscience

authors： Chen C,Chencheng Z,Cuiying L,Xiaokun G

更新日期：2020-01-31 00:00:00

abstract：:The paraventricular nucleus (PVN) is involved in the control of sympathetic tone and the secretion of hormones, both functions known to be influenced by ghrelin, suggesting direct effect of ghrelin in this nucleus. However, the effects of ghrelin on the excitability of different PVN neuronal populations have not been ...

journal_title：Frontiers in cellular neuroscience

authors： Dos-Santos RC,Grover HM,Reis LC,Ferguson AV,Mecawi AS

更新日期：2018-08-24 00:00:00

abstract：:Current research indicates that the causes of autism spectrum disorders (ASDs) are multifactorial and include both genetic and environmental factors. To date, several works have associated ASDs with mutations in genes that encode proteins involved in neuronal synapses; however other factors and the way they can intera...

journal_title：Frontiers in cellular neuroscience

authors： Gámez-Del-Estal MM,Contreras I,Prieto-Pérez R,Ruiz-Rubio M

更新日期：2014-03-04 00:00:00

abstract：:Rodents engage in active touch using their facial whiskers: they explore their environment by making rapid back-and-forth movements. The fast nature of whisker movements, during which whiskers often cross each other, makes it notoriously difficult to track individual whiskers of the intact whisker field. We present he...

journal_title：Frontiers in cellular neuroscience

authors： Betting JLF,Romano V,Al-Ars Z,Bosman LWJ,Strydis C,De Zeeuw CI

更新日期：2020-11-17 00:00:00

abstract：:Mammalian teeth have evolved as dentin units that enclose a complex system of sensory innervation to protect and preserve their structure and function. In human dental pulp (DP), mechanosensory and nociceptive fibers form a dense meshwork of nerve endings at the coronal dentin-pulp interface, which arise from myelinat...

journal_title：Frontiers in cellular neuroscience

authors： Couve E,Schmachtenberg O

更新日期：2018-09-05 00:00:00