Effect of Neuroinflammation on Synaptic Organization and Function in the Developing Brain: Implications for Neurodevelopmental and Neurodegenerative Disorders.

abstract：:Since monumental studies from scientists like His, Ramón y Cajal, Lorente de Nó and many others have put down roots for modern neuroscience, the scientific community has spent a considerable amount of time, and money, investigating any possible aspect of the evolution, development and function of neurons. Today, the c...

journal_title：Frontiers in cellular neuroscience

authors： Tomassy GS,Fossati V

更新日期：2014-07-28 00:00:00

abstract：:Schizophrenia affects more than 1% of the world's population and shows very high heterogeneity in the positive, negative, and cognitive symptoms experienced by patients. The pathogenic mechanisms underlying this neurodevelopmental disorder are largely unknown, although it is proposed to emerge from multiple genetic an...

journal_title：Frontiers in cellular neuroscience

authors： Carrier M,Guilbert J,Lévesque JP,Tremblay MÈ,Desjardins M

更新日期：2021-01-15 00:00:00

abstract：:The inferior olive (IO) is a nucleus located in the brainstem and it is part of the olivo-cerebellar loop. This circuit plays a fundamental role in generation and acquisition of coherent motor patterns and it relies on synchronous activation of groups of Purkinje cells (PC) in the cerebellar cortex. IO neurons integra...

journal_title：Frontiers in cellular neuroscience

authors： Bazzigaluppi P,Isenia SC,Haasdijk ED,Elgersma Y,De Zeeuw CI,van der Giessen RS,de Jeu MTG

更新日期：2017-12-14 00:00:00

abstract：:Regulatory T cells (Tregs) play an anti-inflammatory effect to protect against ischemic stroke. Plasmacytoid dendritic cells (pDCs) can induce regulatory T cells tolerance in sterile-inflammation conditions. However, whether and how pDCs-mediated Tregs response play a part in the pathology of ischemic stroke remains u...

journal_title：Frontiers in cellular neuroscience

authors： Chen C,Chencheng Z,Cuiying L,Xiaokun G

更新日期：2020-01-31 00:00:00

abstract：:Evidence that synaptic vesicles (SVs) can be gated by a single voltage sensitive calcium channel (CaV2.2) predict a molecular linking mechanism or "tether" (Stanley, 1993). Recent studies have proposed that the SV binds to the distal C-terminal on the CaV2.2 calcium channel (Kaeser et al., 2011; Wong et al., 2013) whi...

journal_title：Frontiers in cellular neuroscience

authors： Wong FK,Nath AR,Chen RH,Gardezi SR,Li Q,Stanley EF

更新日期：2014-03-07 00:00:00

abstract：:Heterotrimeric G-proteins mediate a variety of cellular functions, including signal transduction in sensory neurons of the olfactory system. Whereas the Gα subunits in these neurons are well characterized, the gene transcript expression profile of Gβγ subunits is largely missing. Here we report our comprehensive expre...

journal_title：Frontiers in cellular neuroscience

authors： Sathyanesan A,Feijoo AA,Mehta ST,Nimarko AF,Lin W

更新日期：2013-06-04 00:00:00

abstract：:Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder with a high prevalence rate. The core symptoms of ASD patients are impaired social communication and repetitive behavior. Genetic and environmental factors contribute to pathophysiology of ASD. Regarding environmental risk factors, it is kno...

journal_title：Frontiers in cellular neuroscience

authors： Kuo HY,Liu FC

更新日期：2018-11-20 00:00:00

abstract：:Increasing evidence suggest that astrocytes significantly modulate neuronal function at the level of the tripartite synapse both in physiological and pathophysiological conditions. The global control of the astrocytic syncytium over neuronal networks, however, is still less recognized. Here we examined astrocytic sign...

journal_title：Frontiers in cellular neuroscience

authors： Kékesi O,Ioja E,Szabó Z,Kardos J,Héja L

更新日期：2015-06-18 00:00:00

abstract：:Spontaneous or medically induced reperfusion occurs in up to 70% of patients within 24 h after cerebral ischemia. Reperfusion of ischemic brain tissue can augment the inflammatory response that causes additional injury. Recently, T cells have been shown to be an essential part of the post-ischemic tissue damage, and e...

journal_title：Frontiers in cellular neuroscience

authors： Gelderblom M,Arunachalam P,Magnus T

更新日期：2014-11-05 00:00:00

abstract：:Corticotropin-releasing hormone (CRH) plays an important role in a substantial number of patients with stress-related mental disorders, such as anxiety disorders and depression. CRH has been shown to increase neuronal excitability in the hippocampus, but the underlying mechanisms are poorly understood. The effects of ...

journal_title：Frontiers in cellular neuroscience

authors： Kratzer S,Mattusch C,Metzger MW,Dedic N,Noll-Hussong M,Kafitz KW,Eder M,Deussing JM,Holsboer F,Kochs E,Rammes G

更新日期：2013-07-19 00:00:00

abstract：:Ischemic stroke can induce rapid activation of the microglia. It has been reported that the microglia's survival is dependent on colony-stimulating factor 1 receptor (CSF1R) signaling and that pharmacological inhibition of CSF1R leads to morphological changes in the microglia in the healthy brain. However, the impact ...

journal_title：Frontiers in cellular neuroscience

authors： Hou B,Jiang C,Wang D,Wang G,Wang Z,Zhu M,Kang Y,Su J,Wei P,Ren H,Ju F

更新日期：2020-10-16 00:00:00

abstract：:Intensity and frequency are the two main properties of sound. The non-monotonic neurons in the auditory system are thought to represent sound intensity. The central nucleus of the inferior colliculus (ICC), as an important information integration nucleus of the auditory system, is also involved in the processing of in...

journal_title：Frontiers in cellular neuroscience

authors： Liu Y,Zhang G,Yu H,Li H,Wei J,Xiao Z

更新日期：2019-04-04 00:00:00

abstract：:Recent research into axon-glial interactions in the nervous system has made a compelling case that glial cells have a relevant role in the metabolic support of axons, and that, in the case of myelinating cells, this role is independent of myelination itself. In this mini-review article, we summarize some of those obse...

journal_title：Frontiers in cellular neuroscience

authors： Bouçanova F,Chrast R

更新日期：2020-05-29 00:00:00

abstract：:MicroRNA (miR)-210 is the most consistently and predominantly up-regulated miR in response to hypoxia in multiple cancer cells. The roles of miR-210 in rat adrenal gland pheochromocytoma (PC-12) cells remain unknown. We aimed to explore the possible effect of miR-210 in neonatal brain injury. We explored the potential...

journal_title：Frontiers in cellular neuroscience

authors： Luan Y,Zhang X,Zhang Y,Dong Y

更新日期：2017-09-22 00:00:00

abstract：:AGAP1 is an Arf1 GTPase activating protein that interacts with the vesicle-associated protein complexes adaptor protein 3 (AP-3) and Biogenesis of Lysosome Related Organelles Complex-1 (BLOC-1). Overexpression of AGAP1 in non-neuronal cells results in an accumulation of endosomal cargoes, which suggests a role in endo...

journal_title：Frontiers in cellular neuroscience

authors： Arnold M,Cross R,Singleton KS,Zlatic S,Chapleau C,Mullin AP,Rolle I,Moore CC,Theibert A,Pozzo-Miller L,Faundez V,Larimore J

更新日期：2016-09-22 00:00:00

abstract：:The design of therapeutic strategies that focus on the repositioning of anti-inflammatory and antioxidant drugs are a great bet to slow down the progression of neurodegenerative disorders. Despite the fact that Parkinson's disease (PD) is an age-related pathology, almost all experimental studies are carried out in you...

journal_title：Frontiers in cellular neuroscience

authors： Gil-Martínez AL,Cuenca L,Estrada C,Sánchez-Rodrigo C,Fernández-Villalba E,Herrero MT

更新日期：2018-11-30 00:00:00

abstract：:Alteration of glutamatergic synaptic plasticity in the Nucleus Accumbens (NAc) has been implicated in cocaine-seeking behaviors. Astroglial mechanisms for maintaining extracellular glutamate homeostasis through cysteine/glutamate exchanger (xCT) and glutamate transporter GLT1 are dysregulated following cocaine exposur...

journal_title：Frontiers in cellular neuroscience

authors： Jarvis R,Tamashiro-Orrego A,Promes V,Tu L,Shi J,Yang Y

更新日期：2020-01-10 00:00:00

abstract：:Brain edema formation and the ensuing brain damages are the major cause of high mortality and long term disability following the occurrence of ischemic stroke. In this process, oxygen and glucose deprivation and the resulting reperfusion injury play primary roles. In response to the ischemic insult, the neurovascular ...

journal_title：Frontiers in cellular neuroscience

authors： Wang YF,Parpura V

更新日期：2016-05-13 00:00:00

abstract：:Circadian behavioral rhythms offer an excellent model to study intricate interactions between the molecular and neuronal mechanisms of behavior. In mammals, pacemaker neurons in the suprachiasmatic nucleus (SCN) generate rhythms cell-autonomously, which are synchronized by the network interactions within the circadian...

journal_title：Frontiers in cellular neuroscience

authors： Sabado V,Vienne L,Nagoshi E

更新日期：2017-10-12 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is characterized by massive loss of motor neurons. Data from ALS patients and experimental models indicate that mitochondria are severely damaged within dying or spared motor neurons. Nonetheless, recent data indicate that mitochondrial preservation, although preventing motor neuron...

journal_title：Frontiers in cellular neuroscience

authors： Natale G,Lenzi P,Lazzeri G,Falleni A,Biagioni F,Ryskalin L,Fornai F

更新日期：2015-11-06 00:00:00

abstract：:Tonic spiking of serotonergic neurons establishes serotonin levels in the brain. Since the first observations, slow regular spiking has been considered as a defining feature of serotonergic neurons. Recent studies, however, have revealed the heterogeneity of serotonergic neurons at multiple levels, comprising their el...

journal_title：Frontiers in cellular neuroscience

authors： Mlinar B,Montalbano A,Piszczek L,Gross C,Corradetti R

更新日期：2016-08-03 00:00:00

abstract：:Magnocellular neurons in the supraoptic nucleus (SON), which synthesize and release arginine vasopressin (AVP) and oxytocin (OT), express several subtypes of ATP-stimulated purinergic P2X receptors (P2XR) that modulate neuronal activity as well as neurotransmitter and hormone release. However, the physiological impact...

journal_title：Frontiers in cellular neuroscience

authors： Ivetic M,Bhattacharyya A,Zemkova H

更新日期：2019-06-26 00:00:00

abstract：:Neuroinflammation, characterized by chronic activation of the myeloid-derived microglia, is a hallmark of Alzheimer's disease (AD). Systemic inflammation, typically resulting from infection, has been linked to the progression of AD due to exacerbation of the chronic microglial reaction. However, the mechanism and the ...

journal_title：Frontiers in cellular neuroscience

authors： Thygesen C,Ilkjær L,Kempf SJ,Hemdrup AL,von Linstow CU,Babcock AA,Darvesh S,Larsen MR,Finsen B

更新日期：2018-11-06 00:00:00

abstract：:Epilepsy is a disorder of abnormal brain activity typified by spontaneous and recurrent seizures. MicroRNAs (miRNAs) are short non-coding RNAs, critical for the post-transcriptional regulation of gene expression. MiRNA dysregulation has previously been implicated in the induction of epilepsy. In this study, we examine...

journal_title：Frontiers in cellular neuroscience

authors： Gao X,Guo M,Meng D,Sun F,Guan L,Cui Y,Zhao Y,Wang X,Gu X,Sun J,Qi S

更新日期：2019-04-12 00:00:00

abstract：:Thermal Fluctuations Spectroscopy (TFS) in combination with novel optical-based instrumentation was used to study mechanical properties of cell-cultured neurites with a spatial resolution limited only by the light diffraction. The analysis of thermal fluctuations together with a physical model of cellular elasticity a...

journal_title：Frontiers in cellular neuroscience

authors： Gárate F,Pertusa M,Arana Y,Bernal R

更新日期：2018-07-06 00:00:00

abstract：:Spinal cord injury (SCI) and spinal infarction lead to neurological complications and eventually to paraplegia or quadriplegia. These extremely debilitating conditions are major contributors to morbidity. Our understanding of SCI has certainly increased during the last decade, but remains far from clear. SCI consists ...

journal_title：Frontiers in cellular neuroscience

authors： Anwar MA,Al Shehabi TS,Eid AH

更新日期：2016-04-13 00:00:00

abstract：:Hair cells in the inner ear convert mechanical stimuli provided by sound waves and head movements into electrical signal. Several mechanically evoked ionic currents with different properties have been recorded in hair cells. The search for the proteins that form the underlying ion channels is still in progress. The me...

journal_title：Frontiers in cellular neuroscience

authors： Qiu X,Müller U

更新日期：2018-04-11 00:00:00

abstract：:Calcium transients in thin astrocytic processes can be important in synaptic plasticity, but their mechanism is not completely understood. Clearance of synaptic glutamate leads to increase in astrocytic sodium. This can electrochemically favor the reverse mode of the Na/Ca-exchanger (NCX) and allow calcium into the ce...

journal_title：Frontiers in cellular neuroscience

authors： Brazhe AR,Verisokin AY,Verveyko DV,Postnov DE

更新日期：2018-08-14 00:00:00

abstract：:Gamma aminobutric acid (GABA) is the major inhibitory neurotransmitter in the adult brain and mechanisms of GABAergic inhibition have been intensely investigated in the past decades. Recent studies provided evidence for an important role of astrocytes in shaping GABAergic currents. One of the most obvious, but yet poo...

journal_title：Frontiers in cellular neuroscience

authors： Kaczor P,Rakus D,Mozrzymas JW

更新日期：2015-04-09 00:00:00

abstract：:Nanobodies are single domain antibodies derived from llama heavy-chain only antibodies (HCAbs). They represent a new generation of biologicals with unique properties: nanobodies show excellent tissue distribution, high temperature and pH stability, are easy to produce recombinantly and can readily be converted into di...

journal_title：Frontiers in cellular neuroscience

authors： Rissiek B,Koch-Nolte F,Magnus T

更新日期：2014-10-21 00:00:00