Modeling neural differentiation on micropatterned substrates coated with neural matrix components.

abstract：:Neurodegenerative disorders such as Parkinson's (PD) and Huntington's disease (HD) are characterized by a selective detrimental impact on neurons in a specific brain area. Currently, these diseases have no cures, although some promising trials of therapies that may be able to slow the loss of brain cells are underway....

journal_title：Frontiers in cellular neuroscience

authors： Salado-Manzano C,Perpiña U,Straccia M,Molina-Ruiz FJ,Cozzi E,Rosser AE,Canals JM

更新日期：2020-08-11 00:00:00

abstract：:The paraventricular nucleus (PVN) is involved in the control of sympathetic tone and the secretion of hormones, both functions known to be influenced by ghrelin, suggesting direct effect of ghrelin in this nucleus. However, the effects of ghrelin on the excitability of different PVN neuronal populations have not been ...

journal_title：Frontiers in cellular neuroscience

authors： Dos-Santos RC,Grover HM,Reis LC,Ferguson AV,Mecawi AS

更新日期：2018-08-24 00:00:00

abstract：:Heterotrimeric G-proteins mediate a variety of cellular functions, including signal transduction in sensory neurons of the olfactory system. Whereas the Gα subunits in these neurons are well characterized, the gene transcript expression profile of Gβγ subunits is largely missing. Here we report our comprehensive expre...

journal_title：Frontiers in cellular neuroscience

authors： Sathyanesan A,Feijoo AA,Mehta ST,Nimarko AF,Lin W

更新日期：2013-06-04 00:00:00

abstract：:Climbing fiber (CF) triggered complex spikes (CS) are massive depolarization bursts in the cerebellar Purkinje cell (PC), showing several high frequency spikelet components (±600 Hz). Since its early observations, the CS is known to vary in shape. In this study we describe CS waveforms, extracellularly recorded in awa...

journal_title：Frontiers in cellular neuroscience

authors： Warnaar P,Couto J,Negrello M,Junker M,Smilgin A,Ignashchenkova A,Giugliano M,Thier P,De Schutter E

更新日期：2015-04-13 00:00:00

abstract：:Up to 15 years ago, bibliographic searches based on keywords such as "photoreceptor degeneration, inner retina" or "photoreceptor degeneration, second order neurons" returned only a handful of papers, as the field was dominated by the general assumption that retinal degeneration had direct effects on the sole populati...

journal_title：Frontiers in cellular neuroscience

authors： Strettoi E

更新日期：2015-12-23 00:00:00

abstract：:Transcallosal projection neurons are a population of pyramidal excitatory neurons located in layers II/III and to a lesser extent layer V of the cortex. Their axons form the corpus callosum thereby providing an inter-hemispheric connection in the brain. While transcallosal projection neurons have been described in som...

journal_title：Frontiers in cellular neuroscience

authors： Chovsepian A,Empl L,Correa D,Bareyre FM

更新日期：2017-02-21 00:00:00

abstract：:The dopamine precursor, l-3,4-dihydroxyphenylalanine (l-DOPA), exerts powerful therapeutic effects but eventually generates l-DOPA-induced dyskinesia (LID) in patients with Parkinson's disease (PD). LID has a close link with deregulation of striatal dopamine/cAMP signaling, which is integrated by medium spiny neurons ...

journal_title：Frontiers in cellular neuroscience

authors： Morigaki R,Okita S,Goto S

更新日期：2017-02-10 00:00:00

abstract：:Cortical malformations are often associated with pharmaco-resistant epilepsy. Alterations in hyperpolarization-activated, cyclic nucleotide-gated, non-specific cation (HCN) channels have been shown to contribute to malformation associated hyperexcitability. We have recently demonstrated that expression of HCN channels...

journal_title：Frontiers in cellular neuroscience

authors： Albertson AJ,Bohannon AS,Hablitz JJ

更新日期：2017-04-19 00:00:00

abstract：:Cortical fast-spiking (FS) neurons generate high-frequency action potentials (APs) without apparent frequency accommodation, thus providing fast and precise inhibition. However, the maximal firing frequency that they can reach, particularly in primate neocortex, remains unclear. Here, by recording in human, monkey, an...

journal_title：Frontiers in cellular neuroscience

authors： Wang B,Ke W,Guang J,Chen G,Yin L,Deng S,He Q,Liu Y,He T,Zheng R,Jiang Y,Zhang X,Li T,Luan G,Lu HD,Zhang M,Zhang X,Shu Y

更新日期：2016-10-18 00:00:00

abstract：:Functionally related neurons assemble into connected networks that process and transmit electrochemical information. To do this in a coordinated manner, the number and strength of synaptic connections is tightly regulated. Synapse function relies on the microtubule (MT) cytoskeleton, the dynamics of which are in turn ...

journal_title：Frontiers in cellular neuroscience

authors： Verstraelen P,Detrez JR,Verschuuren M,Kuijlaars J,Nuydens R,Timmermans JP,De Vos WH

更新日期：2017-06-22 00:00:00

abstract：:The intact synaptic structure is critical for information processing in neural circuits. During synaptic transmission, rapid vesicle exocytosis increases the size of never terminals and endocytosis counteracts the increase. Accumulating evidence suggests that SV exocytosis and endocytosis are tightly connected in time...

journal_title：Frontiers in cellular neuroscience

authors： Lou X

更新日期：2018-03-14 00:00:00

abstract：:The malignancy of glioblastoma multiform (GBM), the most common and aggressive form of human brain tumors, strongly correlates with the presence of hypoxic areas, but the mechanisms controlling the hypoxia-induced aggressiveness are still unclear. GBM cells express a number of ion channels whose activity supports cell...

journal_title：Frontiers in cellular neuroscience

authors： Sforna L,Cenciarini M,Belia S,D'Adamo MC,Pessia M,Franciolini F,Catacuzzeno L

更新日期：2015-01-15 00:00:00

abstract：:The proliferative pool of neural progenitor cells is maintained by exquisitely controlled mechanisms for cell cycle regulation. The Na-K-Cl cotransporter (NKCC1) is important for regulating cell volume and the proliferation of different cell types in vitro. NKCC1 is expressed in ventral telencephalon of embryonic brai...

journal_title：Frontiers in cellular neuroscience

authors： Magalhães AC,Rivera C

更新日期：2016-08-17 00:00:00

abstract：:The silent mating type information regulation 2 proteins (sirtuins) 1 of class III histone deacetylases (HDACs) have been associated with health span and longevity. SIRT1, the best studied member of the mammalian sirtuins, has a myriad of roles in multiple tissues and organs. However, a significant part of SIRT1's rol...

journal_title：Frontiers in cellular neuroscience

authors： Ng F,Wijaya L,Tang BL

更新日期：2015-03-09 00:00:00

abstract：:Clinical and experimental data suggest that fronto-cortical GABAergic deficits contribute to the pathophysiology of major depressive disorder (MDD). To further test this hypothesis, we used a well characterized rat model for depression and examined the effect of stress on GABAergic neuron numbers and GABA-mediated syn...

journal_title：Frontiers in cellular neuroscience

authors： Czéh B,Vardya I,Varga Z,Febbraro F,Csabai D,Martis LS,Højgaard K,Henningsen K,Bouzinova EV,Miseta A,Jensen K,Wiborg O

更新日期：2018-06-20 00:00:00

abstract：:The schizophrenia brain is differentiated from the normal brain by subtle changes, with significant overlap in measures between normal and disease states. For the past 25 years, schizophrenia has increasingly been considered a neurodevelopmental disorder. This frame of reference challenges biological researchers to co...

journal_title：Frontiers in cellular neuroscience

authors： Catts VS,Fung SJ,Long LE,Joshi D,Vercammen A,Allen KM,Fillman SG,Rothmond DA,Sinclair D,Tiwari Y,Tsai SY,Weickert TW,Shannon Weickert C

更新日期：2013-05-15 00:00:00

abstract：:Stabilization of the blood-brain barrier during and after stroke can lead to less adverse outcome. For elucidation of underlying mechanisms and development of novel therapeutic strategies validated in vitro disease models of the blood-brain barrier could be very helpful. To mimic in vitro stroke conditions we have est...

journal_title：Frontiers in cellular neuroscience

authors： Neuhaus W,Gaiser F,Mahringer A,Franz J,Riethmüller C,Förster C

更新日期：2014-10-28 00:00:00

abstract：:Tyrosine hydroxylase (Th) expression has previously been reported in Purkinje cells (PCs) of rodents and humans, but its role in the regulation of behavior is not understood. Catecholamines are well known for facilitating cognitive behaviors and are expressed in many regions of the brain. Here, we investigated a possi...

journal_title：Frontiers in cellular neuroscience

authors： Locke TM,Fujita H,Hunker A,Johanson SS,Darvas M,du Lac S,Zweifel LS,Carlson ES

更新日期：2020-07-29 00:00:00

abstract：:Thermal Fluctuations Spectroscopy (TFS) in combination with novel optical-based instrumentation was used to study mechanical properties of cell-cultured neurites with a spatial resolution limited only by the light diffraction. The analysis of thermal fluctuations together with a physical model of cellular elasticity a...

journal_title：Frontiers in cellular neuroscience

authors： Gárate F,Pertusa M,Arana Y,Bernal R

更新日期：2018-07-06 00:00:00

abstract：:Previous studies have demonstrated the presence of cannabinoid 2 receptor (CB2R) in the rat cochlea which was induced by cisplatin. In an organ of Corti-derived cell culture model, it was also shown that an agonist of the CB2R protected these cells against cisplatin-induced apoptosis. In the current study, we determin...

journal_title：Frontiers in cellular neuroscience

authors： Ghosh S,Sheth S,Sheehan K,Mukherjea D,Dhukhwa A,Borse V,Rybak LP,Ramkumar V

更新日期：2018-08-21 00:00:00

abstract：:Increasing evidence suggest that astrocytes significantly modulate neuronal function at the level of the tripartite synapse both in physiological and pathophysiological conditions. The global control of the astrocytic syncytium over neuronal networks, however, is still less recognized. Here we examined astrocytic sign...

journal_title：Frontiers in cellular neuroscience

authors： Kékesi O,Ioja E,Szabó Z,Kardos J,Héja L

更新日期：2015-06-18 00:00:00

abstract：:Brain neurons, to support their neurotransmitter functions, require a several times higher supply of glucose than non-excitable cells. Pyruvate, the end product of glycolysis, through pyruvate dehydrogenase complex reaction, is a principal source of acetyl-CoA, which is a direct energy substrate in all brain cells. Se...

journal_title：Frontiers in cellular neuroscience

authors： Ronowska A,Szutowicz A,Bielarczyk H,Gul-Hinc S,Klimaszewska-Łata J,Dyś A,Zyśk M,Jankowska-Kulawy A

更新日期：2018-07-10 00:00:00

abstract：:Neural transplantation is a promising therapeutic strategy for neurodegenerative diseases and other disorders of the central nervous system (CNS) such as Parkinson and Huntington diseases, multiple sclerosis or stroke. Although cell replacement therapy already went through clinical trials for some of these diseases us...

journal_title：Frontiers in cellular neuroscience

authors： Bonnamain V,Neveu I,Naveilhan P

更新日期：2012-04-11 00:00:00

abstract：:Accumulation of proteins in aberrant conformation occurs in many neurodegenerative diseases. Furthermore, dysfunctions in protein handling in endoplasmic reticulum (ER) and the following ER stress have been implicated in a vast number of diseases, such as amyotrophic lateral sclerosis (ALS). During excessive ER stress...

journal_title：Frontiers in cellular neuroscience

authors： Jaronen M,Goldsteins G,Koistinaho J

更新日期：2014-12-02 00:00:00

abstract：:Hippocampal neurons produce in their early stages of growth propagative, actin-rich dynamical structures called actin waves. The directional motion of actin waves from the soma to the tip of neuronal extensions has been associated with net forward growth, and ultimately with the specification of neurites into axon and...

journal_title：Frontiers in cellular neuroscience

authors： Tomba C,Braïni C,Bugnicourt G,Cohen F,Friedrich BM,Gov NS,Villard C

更新日期：2017-03-29 00:00:00

abstract：:The dysfunction of the hypothalamus-pituitary-adrenal (HPA) axis is often seen in Alzheimer's disease (AD) patients with cognitive deficits. Selective inhibition of phosphodiesterase (PDE) 4 and 5 has already proven to be effective in reducing beta-amyloid 1-42 (Aβ1-42)-mediated pathology by regulating corticotropin-r...

journal_title：Frontiers in cellular neuroscience

authors： Ruan L,Du K,Tao M,Shan C,Ye R,Tang Y,Pan H,Lv J,Zhang M,Pan J

更新日期：2019-10-02 00:00:00

abstract：:The process of store-operated calcium entry (SOCE) leads to refilling the endoplasmic reticulum (ER) with calcium ions (Ca2+) after their release into the cytoplasm. Interactions between (ER)-located Ca2+ sensors (stromal interaction molecule 1 [STIM1] and STIM2) and plasma membrane-located Ca2+ channel-forming protei...

journal_title：Frontiers in cellular neuroscience

authors： Gruszczynska-Biegala J,Sladowska M,Kuznicki J

更新日期：2016-10-25 00:00:00

abstract：:Genetically encoded Ca(2+) indicators (GECIs) are promising tools for cell type-specific and chronic recording of neuronal activity. In the mammalian central nervous system, however, GECIs have been tested almost exclusively in cortical and hippocampal pyramidal cells, and the usefulness of recently developed GECIs ha...

journal_title：Frontiers in cellular neuroscience

authors： Yamada Y,Michikawa T,Hashimoto M,Horikawa K,Nagai T,Miyawaki A,Häusser M,Mikoshiba K

更新日期：2011-09-29 00:00:00

abstract：:Glioblastoma is the most common malignant tumor in central nervous system (CNS), and it is still insurmountable and has a poor prognosis. The proliferation and survival mechanism of glioma cells needs to be explored further for the development of glioma treatment. Hematopoietic-substrate-1 associated protein X-1 (HAX-...

journal_title：Frontiers in cellular neuroscience

authors： Deng X,Song L,Zhao W,Wei Y,Guo XB

更新日期：2017-12-21 00:00:00

abstract：:Circadian behavioral rhythms offer an excellent model to study intricate interactions between the molecular and neuronal mechanisms of behavior. In mammals, pacemaker neurons in the suprachiasmatic nucleus (SCN) generate rhythms cell-autonomously, which are synchronized by the network interactions within the circadian...

journal_title：Frontiers in cellular neuroscience

authors： Sabado V,Vienne L,Nagoshi E

更新日期：2017-10-12 00:00:00