LRRK2: an éminence grise of Wnt-mediated neurogenesis?

abstract：:Brain edema formation and the ensuing brain damages are the major cause of high mortality and long term disability following the occurrence of ischemic stroke. In this process, oxygen and glucose deprivation and the resulting reperfusion injury play primary roles. In response to the ischemic insult, the neurovascular ...

journal_title：Frontiers in cellular neuroscience

authors： Wang YF,Parpura V

更新日期：2016-05-13 00:00:00

abstract：:Despite a century of intensive investigation the effective treatment of protein aggregation diseases remains elusive. Ordinarily, molecular chaperones ensure that proteins maintain their functional conformation. The appearance of misfolded proteins that aggregate implies the collapse of the cellular chaperone quality ...

journal_title：Frontiers in cellular neuroscience

authors： Koutras C,Braun JE

更新日期：2014-07-08 00:00:00

abstract：:The cerebellum is well-established as a primary center for controlling sensorimotor functions. However, recent experiments have demonstrated additional roles for the cerebellum in higher-order cognitive functions such as language, emotion, reward, social behavior, and working memory. Based on the diversity of behavior...

journal_title：Frontiers in cellular neuroscience

authors： Gill JS,Sillitoe RV

更新日期：2019-10-04 00:00:00

abstract：:Heterotrimeric G-proteins mediate a variety of cellular functions, including signal transduction in sensory neurons of the olfactory system. Whereas the Gα subunits in these neurons are well characterized, the gene transcript expression profile of Gβγ subunits is largely missing. Here we report our comprehensive expre...

journal_title：Frontiers in cellular neuroscience

authors： Sathyanesan A,Feijoo AA,Mehta ST,Nimarko AF,Lin W

更新日期：2013-06-04 00:00:00

abstract：:Objective: DL-3n-butylphthalide (NBP) has beneficial effects in different stages of ischemic stroke. Our previous studies have demonstrated that NBP promoted angiogenesis in the perifocal region of the ischemic brain. However, the molecular mechanism of NBP for blood-brain barrier protection in acute ischemic stroke w...

journal_title：Frontiers in cellular neuroscience

authors： Mamtilahun M,Wei Z,Qin C,Wang Y,Tang Y,Shen FX,Tian HL,Zhang Z,Yang GY

更新日期：2021-01-12 00:00:00

abstract：:Bone marrow-derived mononuclear cells (BM-MNCs) were shown to improve the outcome in animal stroke models and clinical pilot studies on BM-MNCs for stroke patients were already conducted. However, relevant aspects of pre-clinical evaluation, such as the use of animals with comorbidities and dose-response studies, were...

journal_title：Frontiers in cellular neuroscience

authors： Minnerup J,Wagner DC,Strecker JK,Pösel C,Sevimli-Abdis S,Schmidt A,Schilling M,Boltze J,Diederich K,Schäbitz WR

更新日期：2014-01-08 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is characterized by the progressive degeneration of the motor neurons that innervate muscle, resulting in gradual paralysis and culminating in the inability to breathe or swallow. This neuronal degeneration occurs in a spatiotemporal manner from a point of onset in the central nervo...

journal_title：Frontiers in cellular neuroscience

authors： McAlary L,Chew YL,Lum JS,Geraghty NJ,Yerbury JJ,Cashman NR

更新日期：2020-11-04 00:00:00

abstract：:A major challenge in the development of pharmacotherapies for autism is the failure to identify pathophysiological mechanisms that could be targetable. The majority of developing strategies mainly aim at restoring the brain excitatory/inhibitory imbalance described in autism, by targeting glutamate or GABA receptors. ...

journal_title：Frontiers in cellular neuroscience

authors： DelaCuesta-Barrutia J,Peñagarikano O,Erdozain AM

更新日期：2020-10-30 00:00:00

abstract：:Disturbances in mitochondrial biogenesis and bioenergetics, combined with neuroinflammation, play cardinal roles in the cognitive impairment during aging that is further exacerbated by transient cerebral ischemia. Both near-infrared (NIR) photobiomodulation (PBM) and Coenzyme Q10 (CoQ10) administration are known to st...

journal_title：Frontiers in cellular neuroscience

authors： Salehpour F,Farajdokht F,Mahmoudi J,Erfani M,Farhoudi M,Karimi P,Rasta SH,Sadigh-Eteghad S,Hamblin MR,Gjedde A

更新日期：2019-03-19 00:00:00

abstract：:Slc4a10 is a Na(+)-coupled Cl(-)-HCO3 (-) exchanger, which is expressed in principal and inhibitory neurons as well as in choroid plexus epithelial cells of the brain. Slc4a10 knockout (KO) mice have collapsed brain ventricles and display an increased seizure threshold, while heterozygous deletions in man have been as...

journal_title：Frontiers in cellular neuroscience

authors： Sinning A,Liebmann L,Hübner CA

更新日期：2015-06-16 00:00:00

abstract：:Cortical malformations are often associated with pharmaco-resistant epilepsy. Alterations in hyperpolarization-activated, cyclic nucleotide-gated, non-specific cation (HCN) channels have been shown to contribute to malformation associated hyperexcitability. We have recently demonstrated that expression of HCN channels...

journal_title：Frontiers in cellular neuroscience

authors： Albertson AJ,Bohannon AS,Hablitz JJ

更新日期：2017-04-19 00:00:00

abstract：:Autism spectrum disorder (ASD) is the most commonly diagnosed neurodevelopmental disorder. Independent of neuronal dysfunction, ASD and its associated comorbidities have been linked to hypomyelination and oligodendroglial dysfunction. Additionally, the neuromodulator adenosine has been shown to affect certain ASD como...

journal_title：Frontiers in cellular neuroscience

authors： Shen HY,Huang N,Reemmer J,Xiao L

更新日期：2018-12-07 00:00:00

abstract：:Alterations in NGF/TrkA signaling have been suggested to underlie the selective degeneration of the cholinergic basal forebrain neurons occurring in vivo in AD (Counts and Mufson, 2005; Mufson et al., 2008; Niewiadomska et al., 2011) and significant reduction of cognitive decline along with an improvement of cholinerg...

journal_title：Frontiers in cellular neuroscience

authors： Latina V,Caioli S,Zona C,Ciotti MT,Amadoro G,Calissano P

更新日期：2017-03-15 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder characterized by amyloid-β (Aβ) plaques and the formation of neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau. In response to Aβ and tau aggregates, microglia, the primary innate immune cells of the central nervous system (CNS), facilitate Aβ a...

journal_title：Frontiers in cellular neuroscience

authors： Shippy DC,Ulland TK

更新日期：2020-09-18 00:00:00

abstract：:Since monumental studies from scientists like His, Ramón y Cajal, Lorente de Nó and many others have put down roots for modern neuroscience, the scientific community has spent a considerable amount of time, and money, investigating any possible aspect of the evolution, development and function of neurons. Today, the c...

journal_title：Frontiers in cellular neuroscience

authors： Tomassy GS,Fossati V

更新日期：2014-07-28 00:00:00

abstract：:The brain is a plastic organ where both the intrinsic CNS milieu and extrinsic cues play important roles in shaping and wiring neural connections. The perinatal period constitutes a critical time in central nervous system development with extensive refinement of neural connections, which are highly sensitive to fetal ...

journal_title：Frontiers in cellular neuroscience

authors： Mottahedin A,Ardalan M,Chumak T,Riebe I,Ek J,Mallard C

更新日期：2017-07-11 00:00:00

abstract：:Microglial activation is a key pathogenic process at the onset of Alzheimer's disease (AD). Identifying regulators of microglial activation bears great potential in elucidating causes and mechanisms of AD and determining candidates for early intervention. Previous studies demonstrate abnormal elevation of glutaminase ...

journal_title：Frontiers in cellular neuroscience

authors： Gao G,Zhao S,Xia X,Li C,Li C,Ji C,Sheng S,Tang Y,Zhu J,Wang Y,Huang Y,Zheng JC

更新日期：2019-06-28 00:00:00

abstract：:During the last decades it became increasingly evident that electrical synapses are capable of activity-dependent plasticity. However, measuring the actual strength of electrical transmission remains difficult. Usually changes in coupling strength can only be inferred indirectly from measures such as the coupling coef...

journal_title：Frontiers in cellular neuroscience

authors： Welzel G,Schuster S

更新日期：2019-02-12 00:00:00

abstract：:The complex and elaborate architecture of a neuron poses a great challenge to the cellular machinery which localizes proteins and organelles, such as mitochondria, to necessary locations. Proper mitochondrial localization in neurons is particularly important as this organelle provides energy and metabolites essential ...

journal_title：Frontiers in cellular neuroscience

authors： Mandal A,Drerup CM

更新日期：2019-08-09 00:00:00

abstract：:Proper brain neuronal circuitry formation and synapse development is dependent on specific cues, either genetic or epigenetic, provided by the surrounding neural environment. Within these signals, thyroid hormones (T3 and T4) play crucial role in several steps of brain morphogenesis including proliferation of progenit...

journal_title：Frontiers in cellular neuroscience

authors： Dezonne RS,Stipursky J,Araujo AP,Nones J,Pavão MS,Porcionatto M,Gomes FC

更新日期：2013-08-12 00:00:00

abstract：:Huntington's disease (HD) is an autosomal-dominant inherited neurodegenerative disorder characterized by motor, psychiatric and cognitive symptoms. HD is caused by an expansion of CAG repeats in the huntingtin (HTT) gene in various areas of the brain including striatum. There are few suitable animal models to study th...

journal_title：Frontiers in cellular neuroscience

authors： Jang M,Lee SE,Cho IH

更新日期：2018-06-12 00:00:00

abstract：:Natural products have attracted interest in the search for new and effective analgesics and coadjuvant approaches to several types of pain. It is in fact well known that many of their active ingredients, such as anthocyanins (ACNs) and polyphenols, can exert potent anti-inflammatory actions. Nevertheless, their potent...

journal_title：Frontiers in cellular neuroscience

authors： Magni G,Marinelli A,Riccio D,Lecca D,Tonelli C,Abbracchio MP,Petroni K,Ceruti S

更新日期：2018-11-05 00:00:00

abstract：:Synapses undergo rapid activity-dependent plasticity to store information, which when left uncompensated can lead to destabilization of neural function. It has been well documented that homeostatic changes, which operate at a slower time scale, are required to maintain stability of neural networks. While there are man...

journal_title：Frontiers in cellular neuroscience

authors： Lee HK,Kirkwood A

更新日期：2019-12-03 00:00:00

abstract：:The second messengers cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) transduce many neuromodulatory signals from hormones and neurotransmitters into specific functional outputs. Their production, degradation and signaling are spatiotemporally regulated to achieve high specificity in si...

journal_title：Frontiers in cellular neuroscience

authors： Gorshkov K,Zhang J

更新日期：2014-12-04 00:00:00

abstract：:Human brain organoids (mini-brains) consist of self-organized three-dimensional (3D) neural tissue which can be derived from reprogrammed adult cells and maintained for months in culture. These 3D structures manifest substantial potential for the modeling of neurodegenerative diseases and pave the way for personalized...

journal_title：Frontiers in cellular neuroscience

authors： Nassor F,Jarray R,Biard DSF,Maïza A,Papy-Garcia D,Pavoni S,Deslys JP,Yates F

更新日期：2020-02-11 00:00:00

abstract：:Background: Recent studies have found that rifampicin has neuroprotective properties in neurodegenerative diseases. However, the exact mechanisms of action remain unclear. The nuclear factor erythroid 2-related factor 2 (Nrf2) has been considered a potential target for neuroprotection. In this study, we examined wheth...

journal_title：Frontiers in cellular neuroscience

authors： Chen B,Cao H,Chen L,Yang X,Tian X,Li R,Cheng O

更新日期：2016-11-29 00:00:00

abstract：:Nonlinear dendritic integration is thought to increase the computational ability of neurons. Most studies focus on how supralinear summation of excitatory synaptic responses arising from clustered inputs within single dendrites result in the enhancement of neuronal firing, enabling simple computations such as feature ...

journal_title：Frontiers in cellular neuroscience

authors： Tran-Van-Minh A,Cazé RD,Abrahamsson T,Cathala L,Gutkin BS,DiGregorio DA

更新日期：2015-03-24 00:00:00

abstract：:Autism spectrum disorder (ASD) is a neurodevelopmental disorder that lacks clear biological biomarkers. Existing diagnostic methods focus on behavioral and performance characteristics, which complicates the diagnosis of patients younger than 3 years-old. The purpose of this study is to characterize metabolic features ...

journal_title：Frontiers in cellular neuroscience

authors： Chen Q,Qiao Y,Xu XJ,You X,Tao Y

更新日期：2019-04-30 00:00:00

abstract：:In relapsing-remitting multiple sclerosis (RRMS) subtype, the patient's brain itself is capable of repairing the damage, remyelinating the axon and recovering the neurological function. Cerebrospinal fluid (CSF) is in close proximity with brain parenchyma and contains a host of proteins and other molecules, which infl...

journal_title：Frontiers in cellular neuroscience

authors： Mathur D,Riffo-Campos AL,Castillo J,Haines JD,Vidaurre OG,Zhang F,Coret-Ferrer F,Casaccia P,Casanova B,Lopez-Rodas G

更新日期：2017-07-18 00:00:00

abstract：:Afadin 6 (AF-6) is an F-actin binding multidomain-containing scaffolding protein that is known for its function in cell-cell adhesion. Interestingly, besides this well documented role, we recently found that AF-6 is a Parkin-interacting protein that augments Parkin/PINK1-mediated mitophagy. Notably, mutations in Parki...

journal_title：Frontiers in cellular neuroscience

authors： Basil AH,Sim JPL,Lim GGY,Lin S,Chan HY,Engelender S,Lim KL

更新日期：2017-08-10 00:00:00