Adenosine Actions on Oligodendroglia and Myelination in Autism Spectrum Disorder.

abstract：:Hippocampal neurons produce in their early stages of growth propagative, actin-rich dynamical structures called actin waves. The directional motion of actin waves from the soma to the tip of neuronal extensions has been associated with net forward growth, and ultimately with the specification of neurites into axon and...

journal_title：Frontiers in cellular neuroscience

authors： Tomba C,Braïni C,Bugnicourt G,Cohen F,Friedrich BM,Gov NS,Villard C

更新日期：2017-03-29 00:00:00

abstract：:Behavioral and electrophysiological studies of Alzheimer's disease (AD) and other tauopathies have revealed that the onset of cognitive decline correlates better with synaptic dysfunctions than with hallmark pathologies such as extracellular amyloid-β plaques, intracellular hyperphosphorylated tau or neuronal loss. Re...

journal_title：Frontiers in cellular neuroscience

authors： Erez H,Shemesh OA,Spira ME

更新日期：2014-02-10 00:00:00

abstract：:Studying the distribution of astrocytic antigens is particularly hard when they are localized in their fine, peripheral astrocyte processes (PAPs), since these processes often have a diameter comparable to vesicles and small organelles. The most appropriate technique is immunoelectron microscopy, which is, however, a ...

journal_title：Frontiers in cellular neuroscience

authors： Haseleu J,Anlauf E,Blaess S,Endl E,Derouiche A

更新日期：2013-05-03 00:00:00

abstract：:Circadian behavioral rhythms offer an excellent model to study intricate interactions between the molecular and neuronal mechanisms of behavior. In mammals, pacemaker neurons in the suprachiasmatic nucleus (SCN) generate rhythms cell-autonomously, which are synchronized by the network interactions within the circadian...

journal_title：Frontiers in cellular neuroscience

authors： Sabado V,Vienne L,Nagoshi E

更新日期：2017-10-12 00:00:00

abstract：:Type III adenylyl cyclase (AC3, ADCY3) is predominantly enriched in neuronal primary cilia throughout the central nervous system (CNS). Genome-wide association studies in humans have associated ADCY3 with major depressive disorder and autistic spectrum disorder, both of which exhibit sexual dimorphism. To date, it is ...

journal_title：Frontiers in cellular neuroscience

authors： Zhou Y,Qiu L,Sterpka A,Wang H,Chu F,Chen X

更新日期：2019-02-13 00:00:00

abstract：:In the neonatal rodent hippocampus, the first and predominant pattern of correlated neuronal network activity is early sharp waves (eSPWs). Whether and how eSPWs are organized bilaterally remains unknown. Here, using simultaneous silicone probe recordings from the left and right hippocampus in neonatal rats in vivo we...

journal_title：Frontiers in cellular neuroscience

authors： Valeeva G,Nasretdinov A,Rychkova V,Khazipov R

更新日期：2019-02-07 00:00:00

abstract：:Cells under stress activate cell survival and cell death signaling pathways. Cell death signaling frequently converges on mitochondria, a process that is controlled by the activities of pro- and anti-apoptotic B-cell lymphoma 2 (BCL-2) proteins. In this review, we summarize current knowledge on the control of neuronal...

journal_title：Frontiers in cellular neuroscience

authors： Anilkumar U,Prehn JH

更新日期：2014-09-30 00:00:00

abstract：:Membrane tethering is an important communication method for membrane-packaged organelles. Mitochondria are organelles with a bilayer membrane, and the membrane contact between mitochondria and other organelles is indispensable for maintaining cellular homeostasis. Increased levels of molecular determinants that mediat...

journal_title：Frontiers in cellular neuroscience

authors： Liao Y,Dong Y,Cheng J

更新日期：2020-08-07 00:00:00

abstract：:One century after its first description, pathology of Alzheimer's disease (AD) is still poorly understood. Amyloid-related dendritic atrophy and membrane alterations of susceptible brain neurons in AD, and in animal models of AD are widely recognized. However, little effort has been made to study the potential effects...

journal_title：Frontiers in cellular neuroscience

authors： Somogyi A,Katonai Z,Alpár A,Wolf E

更新日期：2016-06-16 00:00:00

abstract：:The schizophrenia brain is differentiated from the normal brain by subtle changes, with significant overlap in measures between normal and disease states. For the past 25 years, schizophrenia has increasingly been considered a neurodevelopmental disorder. This frame of reference challenges biological researchers to co...

journal_title：Frontiers in cellular neuroscience

authors： Catts VS,Fung SJ,Long LE,Joshi D,Vercammen A,Allen KM,Fillman SG,Rothmond DA,Sinclair D,Tiwari Y,Tsai SY,Weickert TW,Shannon Weickert C

更新日期：2013-05-15 00:00:00

abstract：:It has been shown that matrix metalloproteinase 9 (MMP-9) is required for synaptic plasticity, learning and memory. In particular, MMP-9 involvement in long-term potentiation (LTP, the model of synaptic plasticity) in the hippocampus and prefrontal cortex has previously been demonstrated. Recent data suggest the role ...

journal_title：Frontiers in cellular neuroscience

authors： Gorkiewicz T,Balcerzyk M,Kaczmarek L,Knapska E

更新日期：2015-03-11 00:00:00

abstract：:Thrombin is a serine protease playing an essential role in the blood coagulation cascade. Recent work, however, has identified a novel role for thrombin-mediated signaling pathways in the central nervous system. Binding of thrombin to protease-activated receptors (PARs) in the brain appears to have multiple actions af...

journal_title：Frontiers in cellular neuroscience

authors： Maggio N,Blatt I,Vlachos A,Tanne D,Chapman J,Segal M

更新日期：2013-03-05 00:00:00

abstract：:Background: Recent studies have found that rifampicin has neuroprotective properties in neurodegenerative diseases. However, the exact mechanisms of action remain unclear. The nuclear factor erythroid 2-related factor 2 (Nrf2) has been considered a potential target for neuroprotection. In this study, we examined wheth...

journal_title：Frontiers in cellular neuroscience

authors： Chen B,Cao H,Chen L,Yang X,Tian X,Li R,Cheng O

更新日期：2016-11-29 00:00:00

abstract：:Animals rely heavily on their sense of olfaction to perform various vital interactions with an ever-in-flux environment. The turbulent and combinatorial nature of air-borne odorant cues demands the employment of various coding strategies, which allow the animal to attune to its internal needs and past or present exper...

journal_title：Frontiers in cellular neuroscience

authors： Sayin S,Boehm AC,Kobler JM,De Backer JF,Grunwald Kadow IC

更新日期：2018-01-30 00:00:00

abstract：:Outer Hair Cells (OHCs) in the mammalian cochlea display a unique type of voltage-induced mechanical movement termed electromotility, which amplifies auditory signals and contributes to the sensitivity and frequency selectivity of mammalian hearing. Electromotility occurs in the OHC lateral wall, but it is not fully u...

journal_title：Frontiers in cellular neuroscience

authors： Triffo WJ,Palsdottir H,Song J,Morgan DG,McDonald KL,Auer M,Raphael RM

更新日期：2019-12-20 00:00:00

abstract：:The brain relies on GABAergic neurons to control the ongoing activity of neuronal networks. GABAergic neurons control the firing pattern of excitatory cells, the temporal structure of membrane potential oscillations and the time window for integration of synaptic inputs. These actions require a fine control of the tim...

journal_title：Frontiers in cellular neuroscience

authors： Scimemi A

更新日期：2014-05-13 00:00:00

abstract：:Recently, with the development of the space program there are growing concerns about the influence of spaceflight on tissue engineering. The purpose of this study was thus to determine the variations of neural stem cells (NSCs) during spaceflight. RNA-Sequencing (RNA-Seq) based transcriptomic profiling of NSCs identif...

journal_title：Frontiers in cellular neuroscience

authors： Cui Y,Han J,Xiao Z,Qi Y,Zhao Y,Chen B,Fang Y,Liu S,Wu X,Dai J

更新日期：2018-01-11 00:00:00

abstract：:Degenerative retinopathies are the leading causes of irreversible visual impairment in the elderly, affecting hundreds of millions of patients. Müller glia cells (MGC), the main type of glia found in the vertebrate retina, can resume proliferation in the rodent adult injured retina but contribute weakly to tissue repa...

journal_title：Frontiers in cellular neuroscience

authors： Guimarães RPM,Landeira BS,Coelho DM,Golbert DCF,Silveira MS,Linden R,de Melo Reis RA,Costa MR

更新日期：2018-11-12 00:00:00

abstract：:The cerebral cortical tissue of murine embryo and pluripotent stem cell (PSC)-derived neurons can survive in the brain and extend axons to the spinal cord. For efficient cell integration to the corticospinal tract (CST) after transplantation, the induction or selection of cortical motor neurons is important. However, ...

journal_title：Frontiers in cellular neuroscience

authors： Sano N,Shimogawa T,Sakaguchi H,Ioroi Y,Miyawaki Y,Morizane A,Miyamoto S,Takahashi J

更新日期：2017-05-01 00:00:00

abstract：:Prenatal immune challenge has been associated with alteration in brain development and plasticity that last into adulthood. We have previously shown that prenatal activation of toll-like receptor 4 by lipopolysaccharide (LPS) induces IL-6-dependent STAT-3 signaling pathway in the fetal brain. Whether this IL-6-depende...

journal_title：Frontiers in cellular neuroscience

authors： Mouihate A

更新日期：2016-06-30 00:00:00

abstract：:Afadin 6 (AF-6) is an F-actin binding multidomain-containing scaffolding protein that is known for its function in cell-cell adhesion. Interestingly, besides this well documented role, we recently found that AF-6 is a Parkin-interacting protein that augments Parkin/PINK1-mediated mitophagy. Notably, mutations in Parki...

journal_title：Frontiers in cellular neuroscience

authors： Basil AH,Sim JPL,Lim GGY,Lin S,Chan HY,Engelender S,Lim KL

更新日期：2017-08-10 00:00:00

abstract：:Up to 15 years ago, bibliographic searches based on keywords such as "photoreceptor degeneration, inner retina" or "photoreceptor degeneration, second order neurons" returned only a handful of papers, as the field was dominated by the general assumption that retinal degeneration had direct effects on the sole populati...

journal_title：Frontiers in cellular neuroscience

authors： Strettoi E

更新日期：2015-12-23 00:00:00

abstract：:Gastrointestinal (GI) pain is a common clinical problem, for which effective therapy is quite limited. Sensations from the GI tract, including pain, are mediated largely by neurons in the dorsal root ganglia (DRG), and to a smaller extent by vagal afferents emerging from neurons in the nodose/jugular ganglia. Neurons ...

journal_title：Frontiers in cellular neuroscience

authors： Hanani M

更新日期：2015-10-13 00:00:00

abstract：:The inferior olive (IO) is a nucleus located in the brainstem and it is part of the olivo-cerebellar loop. This circuit plays a fundamental role in generation and acquisition of coherent motor patterns and it relies on synchronous activation of groups of Purkinje cells (PC) in the cerebellar cortex. IO neurons integra...

journal_title：Frontiers in cellular neuroscience

authors： Bazzigaluppi P,Isenia SC,Haasdijk ED,Elgersma Y,De Zeeuw CI,van der Giessen RS,de Jeu MTG

更新日期：2017-12-14 00:00:00

abstract：:The complex and elaborate architecture of a neuron poses a great challenge to the cellular machinery which localizes proteins and organelles, such as mitochondria, to necessary locations. Proper mitochondrial localization in neurons is particularly important as this organelle provides energy and metabolites essential ...

journal_title：Frontiers in cellular neuroscience

authors： Mandal A,Drerup CM

更新日期：2019-08-09 00:00:00

abstract：:Magnocellular neurons in the supraoptic nucleus (SON), which synthesize and release arginine vasopressin (AVP) and oxytocin (OT), express several subtypes of ATP-stimulated purinergic P2X receptors (P2XR) that modulate neuronal activity as well as neurotransmitter and hormone release. However, the physiological impact...

journal_title：Frontiers in cellular neuroscience

authors： Ivetic M,Bhattacharyya A,Zemkova H

更新日期：2019-06-26 00:00:00

abstract：:The piriform cortex (PC) is richly innervated by corticotropin-releasing factor (CRF) and serotonin (5-HT) containing axons arising from central amygdala and Raphe nucleus. CRFR1 and 5-HT2A/2CRs have been shown to interact in manner where CRFR activation subsequently potentiates the activity of 5-HT2A/2CRs. The purpos...

journal_title：Frontiers in cellular neuroscience

authors： Narla C,Dunn HA,Ferguson SS,Poulter MO

更新日期：2015-05-28 00:00:00

abstract：:The process of store-operated calcium entry (SOCE) leads to refilling the endoplasmic reticulum (ER) with calcium ions (Ca2+) after their release into the cytoplasm. Interactions between (ER)-located Ca2+ sensors (stromal interaction molecule 1 [STIM1] and STIM2) and plasma membrane-located Ca2+ channel-forming protei...

journal_title：Frontiers in cellular neuroscience

authors： Gruszczynska-Biegala J,Sladowska M,Kuznicki J

更新日期：2016-10-25 00:00:00

abstract：:Neurotransmitter is released from presynaptic nerve terminals at fast-transmitting synapses by the action potential-gating of voltage dependent calcium channels (CaV), primarily of the CaV2.1 and CaV2.2 types. Entering Ca2+ diffuses to a nearby calcium sensor associated with a docked synaptic vesicle (SV) and initiate...

journal_title：Frontiers in cellular neuroscience

authors： Snidal CA,Li Q,Elliott BB,Mah HK,Chen RHC,Gardezi SR,Stanley EF

更新日期：2018-05-11 00:00:00

abstract：:Prenatal exposure to the antiepileptic drug valproic acid (VPA) induces autism spectrum disorder (ASD) in humans and autistic-like behaviors in rodents, which makes it a good model to study the neural underpinnings of ASD. Rats prenatally exposed to VPA show profound deficits in the social domain. The altered social b...

journal_title：Frontiers in cellular neuroscience

authors： Schiavi S,Iezzi D,Manduca A,Leone S,Melancia F,Carbone C,Petrella M,Mannaioni G,Masi A,Trezza V

更新日期：2019-10-25 00:00:00