Molecular Characterization of an SV Capture Site in the Mid-Region of the Presynaptic CaV2.1 Calcium Channel C-Terminal.

abstract：:We live in a world continuously immersed in noise, an environmental, recreational, and occupational factor present in almost every daily human activity. Exposure to high-level noise could affect the auditory function of individuals at any age, resulting in a condition called noise-induced hearing loss (NIHL). Given th...

journal_title：Frontiers in cellular neuroscience

authors： Alvarado JC,Fuentes-Santamaría V,Juiz JM

更新日期：2020-07-22 00:00:00

abstract：:Neurons receive thousands of synaptic inputs that are distributed in space and time. The systematic study of how neurons process these inputs requires a technique to stimulate multiple yet highly targeted points of interest along the neuron's dendritic tree. Three-dimensional multi-focal patterns produced via holograp...

journal_title：Frontiers in cellular neuroscience

authors： Go MA,To MS,Stricker C,Redman S,Bachor HA,Stuart GJ,Daria VR

更新日期：2013-12-02 00:00:00

abstract：:The N-methyl-D-aspartate receptors (NMDARs) are part of a large multiprotein complex at the glutamatergic synapse. The assembly of NMDARs with synaptic proteins offers a means to regulate NMDAR channel properties and receptor trafficking, and couples NMDAR activation to distinct intracellular signaling pathways, thus ...

journal_title：Frontiers in cellular neuroscience

authors： Fan X,Jin WY,Wang YT

更新日期：2014-06-10 00:00:00

abstract：:Biologically relevant large-scale computational models currently represent one of the main methods in neuroscience for studying information processing primitives of brain areas. However, biologically realistic neuron models tend to be computationally heavy and thus prevent these models from being part of brain-area mo...

journal_title：Frontiers in cellular neuroscience

authors： Marín M,Sáez-Lara MJ,Ros E,Garrido JA

更新日期：2020-07-14 00:00:00

abstract：:Fatty acids (FAs) are typically associated with structural and metabolic roles, as they can be stored as triglycerides, degraded by β-oxidation or used in phospholipids' synthesis, the main components of biological membranes. It has been shown that these lipids exhibit also regulatory functions in different cell types...

journal_title：Frontiers in cellular neuroscience

authors： Falomir-Lockhart LJ,Cavazzutti GF,Giménez E,Toscani AM

更新日期：2019-04-24 00:00:00

abstract：:Active memory forgetting is a well-regulated biological process thought to be adaptive and to allow proper cognitive functions. Recent efforts have elucidated several molecular players involved in the regulation of olfactory forgetting in Drosophila, including the small G protein Rac1, the dopamine receptor DAMB, and ...

journal_title：Frontiers in cellular neuroscience

authors： Cervantes-Sandoval I,Davis RL,Berry JA

更新日期：2020-08-25 00:00:00

abstract：:Type 2 diabetes increases the risk for dementia, including Alzheimer's disease (AD). Pioglitazone (Pio), a pharmacological agonist of the peroxisome proliferator-activated receptor γ (PPARγ), improves insulin sensitivity and has been suggested to have potential in the management of AD symptoms, albeit through mostly u...

journal_title：Frontiers in cellular neuroscience

authors： Moosecker S,Gomes P,Dioli C,Yu S,Sotiropoulos I,Almeida OFX

更新日期：2019-06-12 00:00:00

abstract：:The postnatal development of cerebellar climbing fiber (CF) to Purkinje neuron (PN) synapses is characterized by a substantial pruning during the first 3 weeks after birth, switching from multiple- to single-CF innervation. Previous studies suggested that CF maturation is governed by bidirectional changes of synaptic ...

journal_title：Frontiers in cellular neuroscience

authors： Pätz C,Brachtendorf S,Eilers J

更新日期：2019-05-01 00:00:00

abstract：:Previous studies have shown that the pial microcirculation remodeling improves neurological outcome after middle cerebral artery occlusion (MCAO), accompanied by higher expression of vascular endothelial growth factor (VEGF) and endothelial nitric oxide synthase (eNOS), modulating in vivo angiogenesis. This study was ...

journal_title：Frontiers in cellular neuroscience

authors： Lapi D,Vagnani S,Sapio D,Mastantuono T,Boscia F,Pignataro G,Penna C,Pagliaro P,Colantuoni A

更新日期：2015-08-25 00:00:00

abstract：:Methamphetamine (METH), an extremely and widely abused illicit drug, can cause serious nervous system damage and social problems. Previous research has shown that METH use causes dopaminergic neuron apoptosis and astrocyte-related neuroinflammation. However, the relationship of astrocytes and neurons in METH-induced n...

journal_title：Frontiers in cellular neuroscience

authors： Du SH,Zhang W,Yue X,Luo XQ,Tan XH,Liu C,Qiao DF,Wang H

更新日期：2018-08-03 00:00:00

abstract：:Expansion of CAG repeats, which code for the disease-causing polyglutamine protein, is a common feature in polyglutamine diseases. RNA-mediated mechanisms that contribute to neuropathology in polyglutamine diseases are important. RNA-toxicity describes a phenomenon by which the mutant CAG repeat RNA recruits RNA-bindi...

journal_title：Frontiers in cellular neuroscience

authors： Griesche N,Schilling J,Weber S,Rohm M,Pesch V,Matthes F,Auburger G,Krauss S

更新日期：2016-10-07 00:00:00

abstract：:The pannexin family of channels consists of three members-pannexin-1 (Panx1), pannexin-2 (Panx2), and pannexin-3 (Panx3) that enable the exchange of metabolites and signaling molecules between intracellular and extracellular compartments. Pannexin-mediated release of intracellular ATP into the extracellular space has ...

journal_title：Frontiers in cellular neuroscience

authors： Horton SM,Luna Lopez C,Blevins E,Howarth H,Weisberg J,Shestopalov VI,Makarenkova HP,Shah SB

更新日期：2017-11-22 00:00:00

abstract：:The blood-brain barrier (BBB) is a physical and biochemical barrier that maintains cerebral homeostasis. BBB dysfunction in an ischemic stroke, results in brain injury and subsequent neurological impairment. The aim of this study was to determine the possible protective effects of 1, 25-dihydroxyvitamin D3 [1, 25(OH)2...

journal_title：Frontiers in cellular neuroscience

authors： Guo T,Wang Y,Guo Y,Wu S,Chen W,Liu N,Wang Y,Geng D

更新日期：2018-12-17 00:00:00

abstract：:Microglia, the immune competent cells of the central nervous system (CNS), normally exist in a resting state characterized by a ramified morphology with many processes, and become activated to amoeboid morphology in response to brain injury, infection, and a variety of neuroinflammatory stimuli. Many studies focused o...

journal_title：Frontiers in cellular neuroscience

authors： Fan Y,Chen Z,Pathak JL,Carneiro AMD,Chung CY

更新日期：2018-09-11 00:00:00

abstract：:Schwann cells (SCs) are one of the most promising cellular candidates for the treatment of spinal cord injury. However, SCs show poor migratory ability within the astrocyte-rich central nervous system (CNS) environment and exhibit only limited integration with host astrocytes. Our strategy for improving the therapeuti...

journal_title：Frontiers in cellular neuroscience

authors： Huang L,Xia B,Liu Z,Cao Q,Huang J,Luo Z

更新日期：2017-03-28 00:00:00

abstract：:Neural stem cells in the subventricular zone (SVZ) of the lateral ventricle of adult rodent brain generate oligodendrocyte progenitor cells (OPCs) that disperse throughout the corpus callosum and striatum where some of OPCs differentiate into mature oligodendrocytes. Studies in animal models of stroke demonstrate that...

journal_title：Frontiers in cellular neuroscience

authors： Zhang R,Chopp M,Zhang ZG

更新日期：2013-10-29 00:00:00

abstract：:Brain edema formation and the ensuing brain damages are the major cause of high mortality and long term disability following the occurrence of ischemic stroke. In this process, oxygen and glucose deprivation and the resulting reperfusion injury play primary roles. In response to the ischemic insult, the neurovascular ...

journal_title：Frontiers in cellular neuroscience

authors： Wang YF,Parpura V

更新日期：2016-05-13 00:00:00

abstract：:Genetically encoded Ca(2+) indicators (GECIs) are promising tools for cell type-specific and chronic recording of neuronal activity. In the mammalian central nervous system, however, GECIs have been tested almost exclusively in cortical and hippocampal pyramidal cells, and the usefulness of recently developed GECIs ha...

journal_title：Frontiers in cellular neuroscience

authors： Yamada Y,Michikawa T,Hashimoto M,Horikawa K,Nagai T,Miyawaki A,Häusser M,Mikoshiba K

更新日期：2011-09-29 00:00:00

abstract：:Understanding non-stationary neuronal activity as seen in vivo requires estimation of both excitatory and inhibitory synaptic conductances from a single trial of recording. For this purpose, we propose a new intracellular recording method, called "firing clamp." Synaptic conductances are estimated from the characteris...

journal_title：Frontiers in cellular neuroscience

authors： Chizhov AV,Malinina E,Druzin M,Graham LJ,Johansson S

更新日期：2014-03-27 00:00:00

abstract：:The brain relies on GABAergic neurons to control the ongoing activity of neuronal networks. GABAergic neurons control the firing pattern of excitatory cells, the temporal structure of membrane potential oscillations and the time window for integration of synaptic inputs. These actions require a fine control of the tim...

journal_title：Frontiers in cellular neuroscience

authors： Scimemi A

更新日期：2014-05-13 00:00:00

abstract：:The blood brain barrier (BBB) and the blood cerebrospinal fluid barrier (BCSFB) form the barriers of the brain. These barriers are essential not only for the protection of the brain, but also in regulating the exchange of cells and molecules in and out of the brain. The choroid plexus (CP) epithelial cells and the ara...

journal_title：Frontiers in cellular neuroscience

authors： Marques F,Sousa JC

更新日期：2015-04-13 00:00:00

abstract：:Manipulation of metabolic pathways (e.g., ketogenic diet (KD), glycolytic inhibition) alters neural excitability and represents a novel strategy for treatment of drug-refractory seizures. We have previously shown that inhibition of glycolysis suppresses epileptiform activity in hippocampal slices. In the present study...

journal_title：Frontiers in cellular neuroscience

authors： Shao LR,Wang G,Stafstrom CE

更新日期：2018-06-15 00:00:00

abstract：:Background: Non-alcoholic fatty liver disease (NAFLD) is a common liver condition characterized by a significant accumulation of lipids in the liver without excessive alcohol consumption. Accumulating evidence suggests a significantly increased risk of intracerebral hemorrhage (ICH) in NAFLD patients. However, it rema...

journal_title：Frontiers in cellular neuroscience

authors： Li X,Cheng X,Wang X,Liu Q,Ma H,Li M

更新日期：2020-06-08 00:00:00

abstract：:Alzheimer's disease (AD) is the most common form of dementia, affecting two-thirds of people with dementia in the world. To date, no disease-modifying treatments are available to stop or delay the progression of AD. This chronic neurodegenerative disease is dominated by a strong innate immune response, whereby microgl...

journal_title：Frontiers in cellular neuroscience

authors： Martin-Estebane M,Gomez-Nicola D

更新日期：2020-06-05 00:00:00

abstract：:Regulatory T cells (Tregs) play an anti-inflammatory effect to protect against ischemic stroke. Plasmacytoid dendritic cells (pDCs) can induce regulatory T cells tolerance in sterile-inflammation conditions. However, whether and how pDCs-mediated Tregs response play a part in the pathology of ischemic stroke remains u...

journal_title：Frontiers in cellular neuroscience

authors： Chen C,Chencheng Z,Cuiying L,Xiaokun G

更新日期：2020-01-31 00:00:00

abstract：:Up to 15 years ago, bibliographic searches based on keywords such as "photoreceptor degeneration, inner retina" or "photoreceptor degeneration, second order neurons" returned only a handful of papers, as the field was dominated by the general assumption that retinal degeneration had direct effects on the sole populati...

journal_title：Frontiers in cellular neuroscience

authors： Strettoi E

更新日期：2015-12-23 00:00:00

abstract：:To find satisfactory treatment strategies for neuropathic pain syndromes, the cellular mechanisms should be illuminated. Central sensitization is a generator of pain hypersensitivity, and is mainly reflected in neuronal hyperexcitability in pain pathway. Neuronal excitability depends on two components, the synaptic in...

journal_title：Frontiers in cellular neuroscience

authors： Yang Z,Tan Q,Cheng D,Zhang L,Zhang J,Gu EW,Fang W,Lu X,Liu X

更新日期：2018-11-21 00:00:00

abstract：:Amyloid peptide is able to promote the activation of microglia and astrocytes in Alzheimer's disease (AD), and this stimulates the production of pro-inflammatory cytokines. Inflammation contributes to the process of neurodegeneration and therefore is a key factor in the development of AD. Some of the most important pr...

journal_title：Frontiers in cellular neuroscience

authors： Toral-Rios D,Franco-Bocanegra D,Rosas-Carrasco O,Mena-Barranco F,Carvajal-García R,Meraz-Ríos MA,Campos-Peña V

更新日期：2015-05-18 00:00:00

abstract：:Recent research into axon-glial interactions in the nervous system has made a compelling case that glial cells have a relevant role in the metabolic support of axons, and that, in the case of myelinating cells, this role is independent of myelination itself. In this mini-review article, we summarize some of those obse...

journal_title：Frontiers in cellular neuroscience

authors： Bouçanova F,Chrast R

更新日期：2020-05-29 00:00:00

abstract：:The particular location of myenteric neurons, sandwiched between the 2 muscle layers of the gut, implies that their somata and neurites undergo mechanical stress during gastrointestinal motility. Existence of mechanosensitive enteric neurons (MEN) is undoubted but many of their basic features remain to be studied. In ...

journal_title：Frontiers in cellular neuroscience

authors： Kugler EM,Michel K,Zeller F,Demir IE,Ceyhan GO,Schemann M,Mazzuoli-Weber G

更新日期：2015-09-15 00:00:00