Adeno-Associated Viral Vector Serotype DJ-Mediated Overexpression of N171-82Q-Mutant Huntingtin in the Striatum of Juvenile Mice Is a New Model for Huntington's Disease.

abstract：:Schwann cells (SCs) are one of the most promising cellular candidates for the treatment of spinal cord injury. However, SCs show poor migratory ability within the astrocyte-rich central nervous system (CNS) environment and exhibit only limited integration with host astrocytes. Our strategy for improving the therapeuti...

journal_title：Frontiers in cellular neuroscience

authors： Huang L,Xia B,Liu Z,Cao Q,Huang J,Luo Z

更新日期：2017-03-28 00:00:00

abstract：:Membrane tethering is an important communication method for membrane-packaged organelles. Mitochondria are organelles with a bilayer membrane, and the membrane contact between mitochondria and other organelles is indispensable for maintaining cellular homeostasis. Increased levels of molecular determinants that mediat...

journal_title：Frontiers in cellular neuroscience

authors： Liao Y,Dong Y,Cheng J

更新日期：2020-08-07 00:00:00

abstract：:Despite a century of intensive investigation the effective treatment of protein aggregation diseases remains elusive. Ordinarily, molecular chaperones ensure that proteins maintain their functional conformation. The appearance of misfolded proteins that aggregate implies the collapse of the cellular chaperone quality ...

journal_title：Frontiers in cellular neuroscience

authors： Koutras C,Braun JE

更新日期：2014-07-08 00:00:00

abstract：:Soon after its discovery, microRNA-9 (miR-9) attracted the attention of neurobiologists, since it is one of the most highly expressed microRNAs in the developing and adult vertebrate brain. Functional analyses in different vertebrate species have revealed a prominent role of this microRNA in balancing proliferation in...

journal_title：Frontiers in cellular neuroscience

authors： Coolen M,Katz S,Bally-Cuif L

更新日期：2013-11-20 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is characterized by massive loss of motor neurons. Data from ALS patients and experimental models indicate that mitochondria are severely damaged within dying or spared motor neurons. Nonetheless, recent data indicate that mitochondrial preservation, although preventing motor neuron...

journal_title：Frontiers in cellular neuroscience

authors： Natale G,Lenzi P,Lazzeri G,Falleni A,Biagioni F,Ryskalin L,Fornai F

更新日期：2015-11-06 00:00:00

abstract：:Limited axon regeneration in the injured adult mammalian central nervous system (CNS) usually results in irreversible functional deficits. Both the presence of extrinsic inhibitory molecules at the injury site and the intrinsically low capacity of adult neurons to grow axons are responsible for the diminished capacity...

journal_title：Frontiers in cellular neuroscience

authors： Ribas VT,Costa MR

更新日期：2017-08-07 00:00:00

abstract：:Neuron-glia interactions contribute to tissue homeostasis and functional plasticity in the mammalian brain, but it remains unclear how this is achieved. The potential of central auditory brain tissue for stimulation-dependent cellular remodeling was studied in hearing-experienced and neonatally deafened rats. At adult...

journal_title：Frontiers in cellular neuroscience

authors： Rosskothen-Kuhl N,Hildebrandt H,Birkenhäger R,Illing RB

更新日期：2018-02-22 00:00:00

abstract：:Shank3 is an excitatory postsynaptic scaffolding protein implicated in multiple brain disorders, including autism spectrum disorders (ASD) and Phelan-McDermid syndrome (PMS). Although previous neurobiological studies on Shank3 and Shank3-mutant mice have revealed diverse roles of Shank3 in the regulation of synaptic, ...

journal_title：Frontiers in cellular neuroscience

authors： Yoo T,Cho H,Lee J,Park H,Yoo YE,Yang E,Kim JY,Kim H,Kim E

更新日期：2018-10-09 00:00:00

abstract：:Variants near the ATP-binding cassette transporter A1 (ABCA1) gene are associated with elevated intraocular pressure and newly discovered risk factors for glaucoma. Previous studies have shown an association between ABCA1 deficiency and retinal inflammation. Using a mouse model of ischemia-reperfusion (IR) induced by ...

journal_title：Frontiers in cellular neuroscience

authors： Li L,Xu L,Chen W,Li X,Xia Q,Zheng L,Duan Q,Zhang H,Zhao Y

更新日期：2018-10-11 00:00:00

abstract：:Hippocampal inhibitory interneurons exhibit a large diversity of dendritic Ca2+ mechanisms that are involved in the induction of Hebbian and anti-Hebbian synaptic plasticity. High resolution imaging techniques allowed examining somatic Ca2+ signals and, accordingly, the recruitment of hippocampal interneurons in awake...

journal_title：Frontiers in cellular neuroscience

authors： Francavilla R,Villette V,Martel O,Topolnik L

更新日期：2019-03-15 00:00:00

abstract：:The opioid peptide receptors consist of three major subclasses, namely, μ, δ, and κ (MOR, DOR, and KOR, respectively). They are involved in the regulation of striatal dopamine functions, and increased opioid transmissions are thought to play a compensatory role in altered functions of the basal ganglia in Parkinson's ...

journal_title：Frontiers in cellular neuroscience

authors： Koizumi H,Morigaki R,Okita S,Nagahiro S,Kaji R,Nakagawa M,Goto S

更新日期：2013-05-17 00:00:00

abstract：:Electroacupuncture (EA) pretreatment is a clinically useful therapy for several brain disorders. However, whether and via which exact molecular mechanisms it ameliorates post-traumatic stress disorder (PTSD) remains unclear. In the present study, rats received EA stimulation for seven consecutive days before exposure ...

journal_title：Frontiers in cellular neuroscience

authors： Zhou CH,Xue F,Xue SS,Sang HF,Liu L,Wang Y,Cai M,Zhang ZJ,Tan QR,Wang HN,Peng ZW

更新日期：2019-06-21 00:00:00

abstract：:Topographical and biochemical characteristics of the substrate are critical for neuronal differentiation including axonal outgrowth and regeneration of neural circuits in vivo. Contact stimuli and signaling molecules allow neurons to develop and stabilize synaptic contacts. Here we present the development, characteriz...

journal_title：Frontiers in cellular neuroscience

authors： García-Parra P,Cavaliere F,Maroto M,Bilbao L,Obieta I,López de Munain A,Alava JI,Izeta A

更新日期：2012-03-14 00:00:00

abstract：:The malignancy of glioblastoma multiform (GBM), the most common and aggressive form of human brain tumors, strongly correlates with the presence of hypoxic areas, but the mechanisms controlling the hypoxia-induced aggressiveness are still unclear. GBM cells express a number of ion channels whose activity supports cell...

journal_title：Frontiers in cellular neuroscience

authors： Sforna L,Cenciarini M,Belia S,D'Adamo MC,Pessia M,Franciolini F,Catacuzzeno L

更新日期：2015-01-15 00:00:00

abstract：:Sensory perception is fundamental to everyday life, yet understanding of human sensory physiology at the molecular level is hindered due to constraints on tissue availability. Emerging strategies to study and characterize peripheral neuropathies in vitro involve the use of human pluripotent stem cells (hPSCs) differen...

journal_title：Frontiers in cellular neuroscience

authors： Hulme AJ,McArthur JR,Maksour S,Miellet S,Ooi L,Adams DJ,Finol-Urdaneta RK,Dottori M

更新日期：2020-12-04 00:00:00

abstract：:GABA transporters belong to a large family of neurotransmitter:sodium symporters. They are widely expressed throughout the brain, with different levels of expression in different brain regions. GABA transporters are present in neurons and in astrocytes and their activity is crucial to regulate the extracellular concen...

journal_title：Frontiers in cellular neuroscience

authors： Scimemi A

更新日期：2014-06-17 00:00:00

abstract：:Understanding non-stationary neuronal activity as seen in vivo requires estimation of both excitatory and inhibitory synaptic conductances from a single trial of recording. For this purpose, we propose a new intracellular recording method, called "firing clamp." Synaptic conductances are estimated from the characteris...

journal_title：Frontiers in cellular neuroscience

authors： Chizhov AV,Malinina E,Druzin M,Graham LJ,Johansson S

更新日期：2014-03-27 00:00:00

abstract：:Glioblastoma is the most common malignant tumor in central nervous system (CNS), and it is still insurmountable and has a poor prognosis. The proliferation and survival mechanism of glioma cells needs to be explored further for the development of glioma treatment. Hematopoietic-substrate-1 associated protein X-1 (HAX-...

journal_title：Frontiers in cellular neuroscience

authors： Deng X,Song L,Zhao W,Wei Y,Guo XB

更新日期：2017-12-21 00:00:00

abstract：:Action potential-dependent release of synaptic vesicles and short-term synaptic plasticity are dynamically regulated by the endogenous Ca(2+) buffers that shape [Ca(2+)] profiles within a presynaptic bouton. Calmodulin is one of the most abundant presynaptic proteins and it binds Ca(2+) faster than any other character...

journal_title：Frontiers in cellular neuroscience

authors： Timofeeva Y,Volynski KE

更新日期：2015-07-01 00:00:00

abstract：:Neural stem cells in the subventricular zone (SVZ) of the lateral ventricle of adult rodent brain generate oligodendrocyte progenitor cells (OPCs) that disperse throughout the corpus callosum and striatum where some of OPCs differentiate into mature oligodendrocytes. Studies in animal models of stroke demonstrate that...

journal_title：Frontiers in cellular neuroscience

authors： Zhang R,Chopp M,Zhang ZG

更新日期：2013-10-29 00:00:00

abstract：:The transcription factor Pax6 controls multiple aspects of forebrain development. Conditional deletion of Pax6 in embryonic mouse cortex causes increased proliferation of cortical progenitor cells and a concomitant decrease in neural differentiation. Notch signaling regulates the balance between proliferation and diff...

journal_title：Frontiers in cellular neuroscience

authors： Dorà E,Price DJ,Mason JO

更新日期：2019-03-06 00:00:00

abstract：:Propofol is a widely used anesthetic in the clinic while several studies have demonstrated that propofol exposure may cause neurotoxicity in the developing brain. However, the effects of early propofol exposure on cerebellar development are not well understood. Propofol (30 or 60 mg/kg) was administered to mice on pos...

journal_title：Frontiers in cellular neuroscience

authors： Xiao R,Yu D,Li X,Huang J,Jing S,Bao X,Yang T,Fan X

更新日期：2017-11-22 00:00:00

abstract：:Alzheimer's disease (AD) is the most common form of dementia, affecting two-thirds of people with dementia in the world. To date, no disease-modifying treatments are available to stop or delay the progression of AD. This chronic neurodegenerative disease is dominated by a strong innate immune response, whereby microgl...

journal_title：Frontiers in cellular neuroscience

authors： Martin-Estebane M,Gomez-Nicola D

更新日期：2020-06-05 00:00:00

abstract：:Ischemic stroke is a debilitating disease for which there are currently no effective treatments besides the clot-buster, tissue plasminogen activator (t-PA), which is administered to less than 10% of patients due to a limited (4.5 h) time window of efficacy. Thus, there is an urgent need for novel therapies that can p...

journal_title：Frontiers in cellular neuroscience

authors： Broughton BR,Lim R,Arumugam TV,Drummond GR,Wallace EM,Sobey CG

更新日期：2013-01-17 00:00:00

abstract：:One century after its first description, pathology of Alzheimer's disease (AD) is still poorly understood. Amyloid-related dendritic atrophy and membrane alterations of susceptible brain neurons in AD, and in animal models of AD are widely recognized. However, little effort has been made to study the potential effects...

journal_title：Frontiers in cellular neuroscience

authors： Somogyi A,Katonai Z,Alpár A,Wolf E

更新日期：2016-06-16 00:00:00

abstract：:Meningioma expressed antigen 6 (MEA6), also called cutaneous T cell lymphoma-associated antigen 5 (cTAGE5), was initially found in tumor tissues. MEA6 is located in endoplasmic reticulum (ER) exit sites and regulates the transport of collagen, very low density lipoprotein, and insulin. It is also reported that MEA6 mi...

journal_title：Frontiers in cellular neuroscience

authors： Wang XT,Cai XY,Xu FX,Zhou L,Zheng R,Ma KY,Xu ZH,Shen Y

更新日期：2019-06-11 00:00:00

abstract：:Intensity and frequency are the two main properties of sound. The non-monotonic neurons in the auditory system are thought to represent sound intensity. The central nucleus of the inferior colliculus (ICC), as an important information integration nucleus of the auditory system, is also involved in the processing of in...

journal_title：Frontiers in cellular neuroscience

authors： Liu Y,Zhang G,Yu H,Li H,Wei J,Xiao Z

更新日期：2019-04-04 00:00:00

abstract：:When retrieval occurs concomitantly with novelty detection, mismatch perception or reactivation of conflicting information, consolidated memories can enter into a labile state, and to persist, must be restabilized through a protein synthesis-dependent reconsolidation process during which their strength and content can...

journal_title：Frontiers in cellular neuroscience

authors： Gonzalez MC,Radiske A,Cammarota M

更新日期：2019-08-22 00:00:00

abstract：:Brain neurons, to support their neurotransmitter functions, require a several times higher supply of glucose than non-excitable cells. Pyruvate, the end product of glycolysis, through pyruvate dehydrogenase complex reaction, is a principal source of acetyl-CoA, which is a direct energy substrate in all brain cells. Se...

journal_title：Frontiers in cellular neuroscience

authors： Ronowska A,Szutowicz A,Bielarczyk H,Gul-Hinc S,Klimaszewska-Łata J,Dyś A,Zyśk M,Jankowska-Kulawy A

更新日期：2018-07-10 00:00:00

abstract：:Neurons receive thousands of synaptic inputs that are distributed in space and time. The systematic study of how neurons process these inputs requires a technique to stimulate multiple yet highly targeted points of interest along the neuron's dendritic tree. Three-dimensional multi-focal patterns produced via holograp...

journal_title：Frontiers in cellular neuroscience

authors： Go MA,To MS,Stricker C,Redman S,Bachor HA,Stuart GJ,Daria VR

更新日期：2013-12-02 00:00:00