MEA6 Deficiency Impairs Cerebellar Development and Motor Performance by Tethering Protein Trafficking.

abstract：:Neuron-glia interactions contribute to tissue homeostasis and functional plasticity in the mammalian brain, but it remains unclear how this is achieved. The potential of central auditory brain tissue for stimulation-dependent cellular remodeling was studied in hearing-experienced and neonatally deafened rats. At adult...

journal_title：Frontiers in cellular neuroscience

authors： Rosskothen-Kuhl N,Hildebrandt H,Birkenhäger R,Illing RB

更新日期：2018-02-22 00:00:00

abstract：:Cortical fast-spiking (FS) neurons generate high-frequency action potentials (APs) without apparent frequency accommodation, thus providing fast and precise inhibition. However, the maximal firing frequency that they can reach, particularly in primate neocortex, remains unclear. Here, by recording in human, monkey, an...

journal_title：Frontiers in cellular neuroscience

authors： Wang B,Ke W,Guang J,Chen G,Yin L,Deng S,He Q,Liu Y,He T,Zheng R,Jiang Y,Zhang X,Li T,Luan G,Lu HD,Zhang M,Zhang X,Shu Y

更新日期：2016-10-18 00:00:00

abstract：:Optogenetic and pharmacogenetic techniques have been effective to analyze the role of neuronal activity in controlling oligodendroglia lineage cells in behaving juvenile and adult mice. This kind of studies is also of high interest during early postnatal (PN) development since important changes in oligodendroglia dyna...

journal_title：Frontiers in cellular neuroscience

authors： Ortolani D,Manot-Saillet B,Orduz D,Ortiz FC,Angulo MC

更新日期：2018-12-06 00:00:00

abstract：:The neural extracellular matrix (ECM) is enriched with hyaluronic acid, chondroitin sulfate proteoglycans (CSPGs) and the glycoprotein tenascin-R, which play important roles in synaptic plasticity, as shown by studies of the CA1 region of the hippocampus. However, ECM molecules are strongly expressed in the CA2 region...

journal_title：Frontiers in cellular neuroscience

authors： Hayani H,Song I,Dityatev A

更新日期：2018-05-30 00:00:00

abstract：:Schizophrenia affects more than 1% of the world's population and shows very high heterogeneity in the positive, negative, and cognitive symptoms experienced by patients. The pathogenic mechanisms underlying this neurodevelopmental disorder are largely unknown, although it is proposed to emerge from multiple genetic an...

journal_title：Frontiers in cellular neuroscience

authors： Carrier M,Guilbert J,Lévesque JP,Tremblay MÈ,Desjardins M

更新日期：2021-01-15 00:00:00

abstract：:In recent years, P2X receptors have attracted increasing attention as regulators of exocytosis and cellular secretion. In various cell types, P2X receptors have been found to stimulate vesicle exocytosis directly via Ca(2+) influx and elevation of the intracellular Ca(2+) concentration. Recently, a new role for P2X4 r...

journal_title：Frontiers in cellular neuroscience

authors： Miklavc P,Thompson KE,Frick M

更新日期：2013-10-08 00:00:00

abstract：:Topographical and biochemical characteristics of the substrate are critical for neuronal differentiation including axonal outgrowth and regeneration of neural circuits in vivo. Contact stimuli and signaling molecules allow neurons to develop and stabilize synaptic contacts. Here we present the development, characteriz...

journal_title：Frontiers in cellular neuroscience

authors： García-Parra P,Cavaliere F,Maroto M,Bilbao L,Obieta I,López de Munain A,Alava JI,Izeta A

更新日期：2012-03-14 00:00:00

abstract：:Accumulating evidence suggests that epigenetic alterations lie behind the induction and maintenance of neuropathic pain. Neuropathic pain is usually a chronic condition caused by a lesion, or pathological change, within the nervous system. Neuropathic pain appears frequently after nerve and spinal cord injuries or dis...

journal_title：Frontiers in cellular neuroscience

authors： Penas C,Navarro X

更新日期：2018-06-07 00:00:00

abstract：:MicroRNA (miR)-210 is the most consistently and predominantly up-regulated miR in response to hypoxia in multiple cancer cells. The roles of miR-210 in rat adrenal gland pheochromocytoma (PC-12) cells remain unknown. We aimed to explore the possible effect of miR-210 in neonatal brain injury. We explored the potential...

journal_title：Frontiers in cellular neuroscience

authors： Luan Y,Zhang X,Zhang Y,Dong Y

更新日期：2017-09-22 00:00:00

abstract：:A number of studies have shown pharmacologic evidence indicating that stimulation of type I dopamine receptor (DR), favors T-helper-17 (Th17)-mediated immunity involved in experimental autoimmune encephalomyelitis (EAE) and in some other inflammatory disorders. Nevertheless, the lack of drugs that might discriminate b...

journal_title：Frontiers in cellular neuroscience

authors： Osorio-Barrios F,Prado C,Contreras F,Pacheco R

更新日期：2018-07-10 00:00:00

abstract：:Inflammatory cells may contribute to secondary brain injury following cerebral ischemia. The C57Bl/6 mouse strain is known to exhibit a T helper 1-prone, pro-inflammatory type response to injury, whereas the FVB strain is relatively T helper 2-prone, or anti-inflammatory, in its immune response. We tested whether stro...

journal_title：Frontiers in cellular neuroscience

authors： Kim HA,Whittle SC,Lee S,Chu HX,Zhang SR,Wei Z,Arumugam TV,Vinh A,Drummond GR,Sobey CG

更新日期：2014-11-19 00:00:00

abstract：:The complex and elaborate architecture of a neuron poses a great challenge to the cellular machinery which localizes proteins and organelles, such as mitochondria, to necessary locations. Proper mitochondrial localization in neurons is particularly important as this organelle provides energy and metabolites essential ...

journal_title：Frontiers in cellular neuroscience

authors： Mandal A,Drerup CM

更新日期：2019-08-09 00:00:00

abstract：:The paraventricular nucleus (PVN) is involved in the control of sympathetic tone and the secretion of hormones, both functions known to be influenced by ghrelin, suggesting direct effect of ghrelin in this nucleus. However, the effects of ghrelin on the excitability of different PVN neuronal populations have not been ...

journal_title：Frontiers in cellular neuroscience

authors： Dos-Santos RC,Grover HM,Reis LC,Ferguson AV,Mecawi AS

更新日期：2018-08-24 00:00:00

abstract：:Alternative polyadenylation (APA) is a widespread mechanism involving about half of the expressed genes, resulting in varying lengths of the 3' untranslated region (3'UTR). Variations in length and sequence of the 3'UTR may underlie changes of post-transcriptional processing, localization, miRNA targeting and stabilit...

journal_title：Frontiers in cellular neuroscience

authors： Grassi E,Santoro R,Umbach A,Grosso A,Oliviero S,Neri F,Conti L,Ala U,Provero P,DiCunto F,Merlo GR

更新日期：2019-01-10 00:00:00

abstract：:An experience-driven increase in oligodendrocytes and myelin in the somatosensory cortex (S1) has emerged as a new marker of adult cortical plasticity. That finding contrasts with the view that myelin is a structural brake on plasticity, and that contributes to ending the critical period (CP) in the visual cortex (V1)...

journal_title：Frontiers in cellular neuroscience

authors： Murphy KM,Mancini SJ,Clayworth KV,Arbabi K,Beshara S

更新日期：2020-03-17 00:00:00

abstract：:Nonlinear dendritic integration is thought to increase the computational ability of neurons. Most studies focus on how supralinear summation of excitatory synaptic responses arising from clustered inputs within single dendrites result in the enhancement of neuronal firing, enabling simple computations such as feature ...

journal_title：Frontiers in cellular neuroscience

authors： Tran-Van-Minh A,Cazé RD,Abrahamsson T,Cathala L,Gutkin BS,DiGregorio DA

更新日期：2015-03-24 00:00:00

abstract：:Members of the Shank family of multidomain proteins (Shank1, Shank2, and Shank3) are core components of the postsynaptic density (PSD) of excitatory synapses. At synaptic sites Shanks serve as scaffolding molecules that cluster neurotransmitter receptors as well as cell adhesion molecules attaching them to the actin c...

journal_title：Frontiers in cellular neuroscience

authors： Heise C,Schroeder JC,Schoen M,Halbedl S,Reim D,Woelfle S,Kreutz MR,Schmeisser MJ,Boeckers TM

更新日期：2016-04-26 00:00:00

abstract：:It is well established that microglial form and function are inextricably linked. In recent years, the traditional view that microglial form ranges between "ramified resting" and "activated amoeboid" has been emphasized through advancing imaging techniques that point to microglial form being highly dynamic even within...

journal_title：Frontiers in cellular neuroscience

authors： Karperien A,Ahammer H,Jelinek HF

更新日期：2013-01-30 00:00:00

abstract：:The opioid peptide receptors consist of three major subclasses, namely, μ, δ, and κ (MOR, DOR, and KOR, respectively). They are involved in the regulation of striatal dopamine functions, and increased opioid transmissions are thought to play a compensatory role in altered functions of the basal ganglia in Parkinson's ...

journal_title：Frontiers in cellular neuroscience

authors： Koizumi H,Morigaki R,Okita S,Nagahiro S,Kaji R,Nakagawa M,Goto S

更新日期：2013-05-17 00:00:00

abstract：:Distal astrocytic processes have a complex morphology, reminiscent of branchlets and leaflets. Astrocytic branchlets are rod-like processes containing mitochondria and endoplasmic reticulum, capable of generating inositol-3-phosphate (IP3)-dependent Ca2+ signals. Leaflets are small and flat processes that protrude fro...

journal_title：Frontiers in cellular neuroscience

authors： Gavrilov N,Golyagina I,Brazhe A,Scimemi A,Turlapov V,Semyanov A

更新日期：2018-08-17 00:00:00

abstract：:Analysis of presynaptic protein expression in glutamatergic and GABAergic central synapses performed in several laboratories and with different techniques is unveiling a complex scenario, largely because each presynaptic protein exists in several isoforms. The interpretation of these findings is generally based on the...

journal_title：Frontiers in cellular neuroscience

authors： Bragina L,Fattorini G,Giovedì S,Bosco F,Benfenati F,Conti F

更新日期：2013-02-04 00:00:00

abstract：:The inner ear houses the sensory epithelium responsible for vestibular and auditory function. The sensory epithelia are driven by pressure and vibration of the fluid filled structures in which they are embedded so that understanding the homeostatic mechanisms regulating fluid dynamics within these structures is critic...

journal_title：Frontiers in cellular neuroscience

authors： Talaei S,Schnee ME,Aaron KA,Ricci AJ

更新日期：2019-10-30 00:00:00

abstract：:The design of therapeutic strategies that focus on the repositioning of anti-inflammatory and antioxidant drugs are a great bet to slow down the progression of neurodegenerative disorders. Despite the fact that Parkinson's disease (PD) is an age-related pathology, almost all experimental studies are carried out in you...

journal_title：Frontiers in cellular neuroscience

authors： Gil-Martínez AL,Cuenca L,Estrada C,Sánchez-Rodrigo C,Fernández-Villalba E,Herrero MT

更新日期：2018-11-30 00:00:00

abstract：:Gastrointestinal (GI) pain is a common clinical problem, for which effective therapy is quite limited. Sensations from the GI tract, including pain, are mediated largely by neurons in the dorsal root ganglia (DRG), and to a smaller extent by vagal afferents emerging from neurons in the nodose/jugular ganglia. Neurons ...

journal_title：Frontiers in cellular neuroscience

authors： Hanani M

更新日期：2015-10-13 00:00:00

abstract：:Traumatic spinal cord injury (SCI) impedes signal transmission by disrupting both the local neurons and their surrounding synaptic connections. Although the majority of SCI patients retain spared neural tissue at the injury site, they predominantly suffer from complete autonomic and sensorimotor dysfunction. While the...

journal_title：Frontiers in cellular neuroscience

authors： Zavvarian MM,Hong J,Fehlings MG

更新日期：2020-05-18 00:00:00

abstract：:Clinical and experimental data suggest that fronto-cortical GABAergic deficits contribute to the pathophysiology of major depressive disorder (MDD). To further test this hypothesis, we used a well characterized rat model for depression and examined the effect of stress on GABAergic neuron numbers and GABA-mediated syn...

journal_title：Frontiers in cellular neuroscience

authors： Czéh B,Vardya I,Varga Z,Febbraro F,Csabai D,Martis LS,Højgaard K,Henningsen K,Bouzinova EV,Miseta A,Jensen K,Wiborg O

更新日期：2018-06-20 00:00:00

abstract：:Thrombin is a serine protease playing an essential role in the blood coagulation cascade. Recent work, however, has identified a novel role for thrombin-mediated signaling pathways in the central nervous system. Binding of thrombin to protease-activated receptors (PARs) in the brain appears to have multiple actions af...

journal_title：Frontiers in cellular neuroscience

authors： Maggio N,Blatt I,Vlachos A,Tanne D,Chapman J,Segal M

更新日期：2013-03-05 00:00:00

abstract：:Neurons must establish and stabilize connections made with diverse targets, each with distinct demands and functional characteristics. At Drosophila neuromuscular junctions (NMJs), synaptic strength remains stable in a manipulation that simultaneously induces hypo-innervation on one target and hyper-innervation on the...

journal_title：Frontiers in cellular neuroscience

authors： Goel P,Nishimura S,Chetlapalli K,Li X,Chen C,Dickman D

更新日期：2020-06-26 00:00:00

abstract：:Objective: DL-3n-butylphthalide (NBP) has beneficial effects in different stages of ischemic stroke. Our previous studies have demonstrated that NBP promoted angiogenesis in the perifocal region of the ischemic brain. However, the molecular mechanism of NBP for blood-brain barrier protection in acute ischemic stroke w...

journal_title：Frontiers in cellular neuroscience

authors： Mamtilahun M,Wei Z,Qin C,Wang Y,Tang Y,Shen FX,Tian HL,Zhang Z,Yang GY

更新日期：2021-01-12 00:00:00

abstract：:The blood-brain barrier (BBB) is a diffusion barrier that has an important role in maintaining a precisely regulated microenvironment protecting the neural tissue from infectious agents and toxins in the circulating system. Compromised BBB integrity plays a major role in the pathogenesis of retroviral associated neuro...

journal_title：Frontiers in cellular neuroscience

authors： Atluri VS,Hidalgo M,Samikkannu T,Kurapati KR,Jayant RD,Sagar V,Nair MP

更新日期：2015-06-10 00:00:00