Effect of human immunodeficiency virus on blood-brain barrier integrity and function: an update.

abstract：:In humans, auditory hair cells are not replaced when injured. Thus, cochlear hair cell loss causes progressive and permanent hearing loss. Conversely, non-mammalian vertebrates are capable of regenerating lost sensory hair cells. The zebrafish lateral line has numerous qualities that make it well-suited for studying h...

journal_title：Frontiers in cellular neuroscience

authors： He Y,Cai C,Tang D,Sun S,Li H

更新日期：2014-11-13 00:00:00

abstract：:Mechanical force plays a fundamental role in neuronal development, physiology, and regeneration. In particular, research has shown that force is involved in growth cone-mediated axonal growth and guidance as well as stretch-induced elongation when an organism increases in size after forming initial synaptic connection...

journal_title：Frontiers in cellular neuroscience

authors： Athamneh AI,Suter DM

更新日期：2015-09-16 00:00:00

abstract：:Microglia are the resident immune cells of the brain and react quickly to changes in their environment with transcriptional regulation and morphological changes. Brain tissue injury such as ischemic stroke induces a local inflammatory response encompassing microglial activation. The change in activation status of a mi...

journal_title：Frontiers in cellular neuroscience

authors： Heindl S,Gesierich B,Benakis C,Llovera G,Duering M,Liesz A

更新日期：2018-04-19 00:00:00

abstract：:Understanding synaptic connectivity and plasticity within brain circuits and their relationship to learning and behavior is a fundamental quest in neuroscience. Visualizing the fine details of synapses using optical microscopy remains however a major technical challenge. Super resolution microscopy opens the possibili...

journal_title：Frontiers in cellular neuroscience

authors： Spühler IA,Conley GM,Scheffold F,Sprecher SG

更新日期：2016-05-26 00:00:00

abstract：:Central neurons express a variety of neuronal types and ion channels that promote firing heterogeneity among their distinct neuronal populations. Action potential (AP) phasic firing, produced by low-threshold voltage-activated potassium currents (VAKCs), is commonly observed in mammalian brainstem neurons involved in ...

journal_title：Frontiers in cellular neuroscience

authors： Dagostin AA,Lovell PV,Hilscher MM,Mello CV,Leão RM

更新日期：2015-12-10 00:00:00

abstract：:It is well established that the endothelium responds to mechanical forces induced by changes in shear stress and strain. However, our understanding of vascular remodeling following traumatic brain injury (TBI) remains incomplete. Recently published studies have revealed that lung and umbilical endothelial cells produc...

journal_title：Frontiers in cellular neuroscience

authors： Andrews AM,Lutton EM,Merkel SF,Razmpour R,Ramirez SH

更新日期：2016-02-29 00:00:00

abstract：:A major consequence of traumatic brain and spinal cord injury is the loss of the myelin sheath, a cholesterol-rich layer of insulation that wraps around axons of the nervous system. In the central nervous system (CNS), myelin is produced and maintained by oligodendrocytes. Damage to the CNS may result in oligodendrocy...

journal_title：Frontiers in cellular neuroscience

authors： Huntemer-Silveira A,Patil N,Brickner MA,Parr AM

更新日期：2021-01-11 00:00:00

abstract：:Selective negative allosteric modulators (NAMs), targeting α5 subunit-containing GABAA receptors (GABAARs) as potential therapeutic targets for disorders associated with cognitive deficits, including Alzheimer's disease (AD), continually fail clinical trials. We investigated whether this was due to the change in the e...

journal_title：Frontiers in cellular neuroscience

authors： Petrache AL,Khan AA,Nicholson MW,Monaco A,Kuta-Siejkowska M,Haider S,Hilton S,Jovanovic JN,Ali AB

更新日期：2020-11-11 00:00:00

abstract：:Loud sound exposure exacerbates aminoglycoside ototoxicity, increasing the risk of permanent hearing loss and degrading the quality of life in affected individuals. We previously reported that loud sound exposure induces temporary threshold shifts (TTS) and enhances uptake of aminoglycosides, like gentamicin, by cochl...

journal_title：Frontiers in cellular neuroscience

authors： Li H,Kachelmeier A,Furness DN,Steyger PS

更新日期：2015-04-14 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease with a complicated and poorly understood pathogenesis. Recently, alterations in the blood-Central Nervous System barrier (B-CNS-B) have been recognized as a key factor possibly aggravating motor neuron damage. The majority of findings on ALS mic...

journal_title：Frontiers in cellular neuroscience

authors： Garbuzova-Davis S,Sanberg PR

更新日期：2014-02-03 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a progressive, fatal, and incurable neurodegenerative disease. Recent studies suggest that dysregulation of gene expression by microRNAs (miRNAs) may play an important role in ALS pathogenesis. The reversible nature of this dysregulation makes miRNAs attractive pharmacological ta...

journal_title：Frontiers in cellular neuroscience

authors： Paez-Colasante X,Figueroa-Romero C,Rumora AE,Hur J,Mendelson FE,Hayes JM,Backus C,Taubman GF,Heinicke L,Walter NG,Barmada SJ,Sakowski SA,Feldman EL

更新日期：2020-05-12 00:00:00

abstract：:Manipulation of metabolic pathways (e.g., ketogenic diet (KD), glycolytic inhibition) alters neural excitability and represents a novel strategy for treatment of drug-refractory seizures. We have previously shown that inhibition of glycolysis suppresses epileptiform activity in hippocampal slices. In the present study...

journal_title：Frontiers in cellular neuroscience

authors： Shao LR,Wang G,Stafstrom CE

更新日期：2018-06-15 00:00:00

abstract：:Spatially localized proteolysis represents an elegant means by which neuronal activity dependent changes in synaptic structure, and thus experience dependent learning and memory, can be achieved. In vitro and in vivo studies suggest that matrix metalloproteinase and adamalysin activity is concentrated at the cell surf...

journal_title：Frontiers in cellular neuroscience

authors： Conant K,Allen M,Lim ST

更新日期：2015-08-11 00:00:00

abstract：:Endoplasmic reticulum (ER) stress and protein misfolding are associated with various neurodegenerative diseases. ER stress activates unfolded protein response (UPR), an adaptative response. However, severe ER stress can induce cell death. Here we show that the E3 ubiquitin ligase and co-chaperone Carboxyl Terminus HSP...

journal_title：Frontiers in cellular neuroscience

authors： Cabral Miranda F,Adão-Novaes J,Hauswirth WW,Linden R,Petrs-Silva H,Chiarini LB

更新日期：2015-01-09 00:00:00

abstract：:Chronic stress is a risk factor for the development of psychiatric disorders, some of which involve dysfunction of the prefrontal cortex (PFC). There is a higher prevalence of these chronic stress-related psychiatric disorders during adolescence, when the PFC has not yet fully matured. In the present work we studied t...

journal_title：Frontiers in cellular neuroscience

authors： Negrón-Oyarzo I,Dagnino-Subiabre A,Muñoz Carvajal P

更新日期：2015-11-12 00:00:00

abstract：:Mutation of the GJB2 gene, which encodes the connexin 26 (Cx26) gap junction (GJ) protein, is the most common cause of hereditary, sensorineural hearing loss. Cx26 is not expressed in hair cells, but is widely expressed throughout the non-sensory epithelial cells of the cochlea. Most GJB2 mutations produce non-syndrom...

journal_title：Frontiers in cellular neuroscience

authors： Sanchez HA,Verselis VK

更新日期：2014-10-27 00:00:00

abstract：:The actin cytoskeleton is crucial for function and morphology of neuronal synapses. Moreover, altered regulation of the neuronal actin cytoskeleton has been implicated in neuropsychiatric diseases such as autism spectrum disorder (ASD). Myosin XVI is a neuronally expressed unconventional myosin known to bind the WAVE ...

journal_title：Frontiers in cellular neuroscience

authors： Roesler MK,Lombino FL,Freitag S,Schweizer M,Hermans-Borgmeyer I,Schwarz JR,Kneussel M,Wagner W

更新日期：2019-08-13 00:00:00

abstract：:Members of the Shank family of multidomain proteins (Shank1, Shank2, and Shank3) are core components of the postsynaptic density (PSD) of excitatory synapses. At synaptic sites Shanks serve as scaffolding molecules that cluster neurotransmitter receptors as well as cell adhesion molecules attaching them to the actin c...

journal_title：Frontiers in cellular neuroscience

authors： Heise C,Schroeder JC,Schoen M,Halbedl S,Reim D,Woelfle S,Kreutz MR,Schmeisser MJ,Boeckers TM

更新日期：2016-04-26 00:00:00

abstract：:Intensity and frequency are the two main properties of sound. The non-monotonic neurons in the auditory system are thought to represent sound intensity. The central nucleus of the inferior colliculus (ICC), as an important information integration nucleus of the auditory system, is also involved in the processing of in...

journal_title：Frontiers in cellular neuroscience

authors： Liu Y,Zhang G,Yu H,Li H,Wei J,Xiao Z

更新日期：2019-04-04 00:00:00

abstract：:Friedreich's Ataxia (FRDA) is an autosomal recessive neurodegenerative disorder, affecting dorsal root ganglia (DRG), cerebellar dentate nuclei and heart. It is caused by a GAA repeat expansion mutation within the frataxin gene (FXN). This impedes FXN transcription resulting in a progressive decrease of the mitochondr...

journal_title：Frontiers in cellular neuroscience

authors： Abeti R,Baccaro A,Esteras N,Giunti P

更新日期：2018-07-17 00:00:00

abstract：:Ischemic stroke can induce rapid activation of the microglia. It has been reported that the microglia's survival is dependent on colony-stimulating factor 1 receptor (CSF1R) signaling and that pharmacological inhibition of CSF1R leads to morphological changes in the microglia in the healthy brain. However, the impact ...

journal_title：Frontiers in cellular neuroscience

authors： Hou B,Jiang C,Wang D,Wang G,Wang Z,Zhu M,Kang Y,Su J,Wei P,Ren H,Ju F

更新日期：2020-10-16 00:00:00

abstract：:Huntington disease (HD) is an inherited neurodegenerative disease characterized by a clinical triad of motor, psychiatric and cognitive symptoms. HD is caused by a CAG repeat expansion in the gene encoding the huntingtin protein. Homozygosity for the HD-causing mutation is extremely rare; thus, the majority of HD pati...

journal_title：Frontiers in cellular neuroscience

authors： Quirion JG,Parsons MP

更新日期：2019-07-17 00:00:00

abstract：:Cortical malformations are often associated with pharmaco-resistant epilepsy. Alterations in hyperpolarization-activated, cyclic nucleotide-gated, non-specific cation (HCN) channels have been shown to contribute to malformation associated hyperexcitability. We have recently demonstrated that expression of HCN channels...

journal_title：Frontiers in cellular neuroscience

authors： Albertson AJ,Bohannon AS,Hablitz JJ

更新日期：2017-04-19 00:00:00

abstract：:Since monumental studies from scientists like His, Ramón y Cajal, Lorente de Nó and many others have put down roots for modern neuroscience, the scientific community has spent a considerable amount of time, and money, investigating any possible aspect of the evolution, development and function of neurons. Today, the c...

journal_title：Frontiers in cellular neuroscience

authors： Tomassy GS,Fossati V

更新日期：2014-07-28 00:00:00

abstract：:Spontaneous calcium transients are present during early postnatal development in the mouse retina and cochlea, and play an important role in maturation of the sensory organs and neural circuits in the central nervous system (CNS). It is not known whether similar calcium transients occur during postnatal development in...

journal_title：Frontiers in cellular neuroscience

authors： Holman HA,Poppi LA,Frerck M,Rabbitt RD

更新日期：2019-05-07 00:00:00

abstract：:The early auditory pathway processes information at high rates and with utmost temporal fidelity. Consequently, the synapses in the auditory pathway are highly specialized to meet the extraordinary requirements on signal transmission. The calyceal synapses in the auditory brainstem feature more than a hundred active z...

journal_title：Frontiers in cellular neuroscience

authors： Huang CH,Moser T

更新日期：2018-10-17 00:00:00

abstract：:Neurons typically receive synaptic input in their dendritic arbor, integrate inputs in their soma, and send output action potentials through their axon, following Cajal's law of dynamic polarization. Two notable exceptions are retinal amacrine cells and olfactory granule cells (GCs), which flout Cajal's edict by provi...

journal_title：Frontiers in cellular neuroscience

authors： Egger V,Diamond JS

更新日期：2020-11-05 00:00:00

abstract：:The Purkinje cell (PC) is among the most complex neurons in the brain and plays a critical role for cerebellar functioning. PCs operate as fast pacemakers modulated by synaptic inputs but can switch from simple spikes to complex bursts and, in some conditions, show bistability. In contrast to original works emphasizin...

journal_title：Frontiers in cellular neuroscience

authors： Masoli S,Solinas S,D'Angelo E

更新日期：2015-02-24 00:00:00

abstract：:The paraventricular nucleus (PVN) is involved in the control of sympathetic tone and the secretion of hormones, both functions known to be influenced by ghrelin, suggesting direct effect of ghrelin in this nucleus. However, the effects of ghrelin on the excitability of different PVN neuronal populations have not been ...

journal_title：Frontiers in cellular neuroscience

authors： Dos-Santos RC,Grover HM,Reis LC,Ferguson AV,Mecawi AS

更新日期：2018-08-24 00:00:00

abstract：:Synapses undergo rapid activity-dependent plasticity to store information, which when left uncompensated can lead to destabilization of neural function. It has been well documented that homeostatic changes, which operate at a slower time scale, are required to maintain stability of neural networks. While there are man...

journal_title：Frontiers in cellular neuroscience

authors： Lee HK,Kirkwood A

更新日期：2019-12-03 00:00:00