Automated Morphological Analysis of Microglia After Stroke.

abstract：:Antiphospholipid syndrome (APS) is characterized by arterial and venous thrombosis, pregnancy morbidity and fetal loss caused by pathogenic autoantibodies directed against phospholipids (PL) and PL-cofactors. Isolated neurological APS may represent a significant diagnostic challenge, as epidemiological, clinical and n...

journal_title：Frontiers in cellular neuroscience

authors： D'Angelo C,Franch O,Fernández-Paredes L,Oreja-Guevara C,Núñez-Beltrán M,Comins-Boo A,Reale M,Sánchez-Ramón S

更新日期：2019-03-19 00:00:00

abstract：:The brain is the most functionally organized structure of all organs. It manages behavior, perception and higher cognitive functions. The WWOX gene is non-classical tumor suppressor gene, which has been shown to have an impact on proliferation, apoptosis and migration processes. Moreover, genetic aberrations in WWOX i...

journal_title：Frontiers in cellular neuroscience

authors： Kośla K,Płuciennik E,Styczeń-Binkowska E,Nowakowska M,Orzechowska M,Bednarek AK

更新日期：2019-08-30 00:00:00

abstract：:Until recently, the visualization of cerebral microvessels was hampered by the fact that only short segments of vessels could be evaluated in brain sections by histochemistry. These limitations have been overcome by light sheet microscopy, which allows the 3D analysis of microvasculature in cleared brains. A major lim...

journal_title：Frontiers in cellular neuroscience

authors： Mohamud Yusuf A,Hagemann N,Schulten S,Rausch O,Wagner K,Hussner T,Qi Y,Totzeck M,Kleinschnitz C,Squire A,Gunzer M,Hermann DM

更新日期：2021-01-05 00:00:00

abstract：:The inferior olive (IO) is a nucleus located in the brainstem and it is part of the olivo-cerebellar loop. This circuit plays a fundamental role in generation and acquisition of coherent motor patterns and it relies on synchronous activation of groups of Purkinje cells (PC) in the cerebellar cortex. IO neurons integra...

journal_title：Frontiers in cellular neuroscience

authors： Bazzigaluppi P,Isenia SC,Haasdijk ED,Elgersma Y,De Zeeuw CI,van der Giessen RS,de Jeu MTG

更新日期：2017-12-14 00:00:00

abstract：:Synapses undergo rapid activity-dependent plasticity to store information, which when left uncompensated can lead to destabilization of neural function. It has been well documented that homeostatic changes, which operate at a slower time scale, are required to maintain stability of neural networks. While there are man...

journal_title：Frontiers in cellular neuroscience

authors： Lee HK,Kirkwood A

更新日期：2019-12-03 00:00:00

abstract：:Prenatal immune challenge has been associated with alteration in brain development and plasticity that last into adulthood. We have previously shown that prenatal activation of toll-like receptor 4 by lipopolysaccharide (LPS) induces IL-6-dependent STAT-3 signaling pathway in the fetal brain. Whether this IL-6-depende...

journal_title：Frontiers in cellular neuroscience

authors： Mouihate A

更新日期：2016-06-30 00:00:00

abstract：:AGAP1 is an Arf1 GTPase activating protein that interacts with the vesicle-associated protein complexes adaptor protein 3 (AP-3) and Biogenesis of Lysosome Related Organelles Complex-1 (BLOC-1). Overexpression of AGAP1 in non-neuronal cells results in an accumulation of endosomal cargoes, which suggests a role in endo...

journal_title：Frontiers in cellular neuroscience

authors： Arnold M,Cross R,Singleton KS,Zlatic S,Chapleau C,Mullin AP,Rolle I,Moore CC,Theibert A,Pozzo-Miller L,Faundez V,Larimore J

更新日期：2016-09-22 00:00:00

abstract：:Up to 15 years ago, bibliographic searches based on keywords such as "photoreceptor degeneration, inner retina" or "photoreceptor degeneration, second order neurons" returned only a handful of papers, as the field was dominated by the general assumption that retinal degeneration had direct effects on the sole populati...

journal_title：Frontiers in cellular neuroscience

authors： Strettoi E

更新日期：2015-12-23 00:00:00

abstract：:The substantia nigra pars reticulata (SNr) is one of the output nuclei of the basal ganglia (BG) and plays a vital role in movement execution. Death of dopaminergic neurons in the neighboring nucleus, the substantia nigra pars compacta (SNc), leads to Parkinson's disease. The ensuing dopamine depletion affects all BG ...

journal_title：Frontiers in cellular neuroscience

authors： Faynveitz A,Lavian H,Jacob A,Korngreen A

更新日期：2019-09-13 00:00:00

abstract：:Neurodegenerative disorders such as Parkinson's (PD) and Huntington's disease (HD) are characterized by a selective detrimental impact on neurons in a specific brain area. Currently, these diseases have no cures, although some promising trials of therapies that may be able to slow the loss of brain cells are underway....

journal_title：Frontiers in cellular neuroscience

authors： Salado-Manzano C,Perpiña U,Straccia M,Molina-Ruiz FJ,Cozzi E,Rosser AE,Canals JM

更新日期：2020-08-11 00:00:00

abstract：Background:The functional aspects of mast cell-microglia interactions are important in neuroinflammation. Our previous studies have demonstrated that mast cell degranulation can directly induce microglia activation. However, the role of mast cells in Lipopolysaccharide (LPS)-induced microglia activation, neuroinflammat...

journal_title：Frontiers in cellular neuroscience

authors： Dong H,Wang Y,Zhang X,Zhang X,Qian Y,Ding H,Zhang S

更新日期：2019-05-03 00:00:00

abstract：:Mutation of the GJB2 gene, which encodes the connexin 26 (Cx26) gap junction (GJ) protein, is the most common cause of hereditary, sensorineural hearing loss. Cx26 is not expressed in hair cells, but is widely expressed throughout the non-sensory epithelial cells of the cochlea. Most GJB2 mutations produce non-syndrom...

journal_title：Frontiers in cellular neuroscience

authors： Sanchez HA,Verselis VK

更新日期：2014-10-27 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is characterized by the progressive degeneration of the motor neurons that innervate muscle, resulting in gradual paralysis and culminating in the inability to breathe or swallow. This neuronal degeneration occurs in a spatiotemporal manner from a point of onset in the central nervo...

journal_title：Frontiers in cellular neuroscience

authors： McAlary L,Chew YL,Lum JS,Geraghty NJ,Yerbury JJ,Cashman NR

更新日期：2020-11-04 00:00:00

abstract：:Nitric oxide (NO) is a pleiotropic janus-faced molecule synthesized by nitric oxide synthases (NOS) which plays a critical role in a number of physiological and pathological processes in humans. The physiological roles of NO depend on its local concentrations, as well as its availability and the nature of downstream t...

journal_title：Frontiers in cellular neuroscience

authors： Yuste JE,Tarragon E,Campuzano CM,Ros-Bernal F

更新日期：2015-08-17 00:00:00

abstract：:Tyrosine hydroxylase (Th) expression has previously been reported in Purkinje cells (PCs) of rodents and humans, but its role in the regulation of behavior is not understood. Catecholamines are well known for facilitating cognitive behaviors and are expressed in many regions of the brain. Here, we investigated a possi...

journal_title：Frontiers in cellular neuroscience

authors： Locke TM,Fujita H,Hunker A,Johanson SS,Darvas M,du Lac S,Zweifel LS,Carlson ES

更新日期：2020-07-29 00:00:00

abstract：:The inner ear houses the sensory epithelium responsible for vestibular and auditory function. The sensory epithelia are driven by pressure and vibration of the fluid filled structures in which they are embedded so that understanding the homeostatic mechanisms regulating fluid dynamics within these structures is critic...

journal_title：Frontiers in cellular neuroscience

authors： Talaei S,Schnee ME,Aaron KA,Ricci AJ

更新日期：2019-10-30 00:00:00

abstract：:The motor symptoms of Parkinson's disease (PD) result from striatal dopamine (DA) deficiency due to a progressive degeneration of nigral dopaminergic cells. Although DA replacement therapy is the mainstay to treat parkinsonian symptoms, a long-term daily administration of levodopa often develops levodopa-induced dyski...

journal_title：Frontiers in cellular neuroscience

authors： Goto S

更新日期：2017-11-21 00:00:00

abstract：:Intensity and frequency are the two main properties of sound. The non-monotonic neurons in the auditory system are thought to represent sound intensity. The central nucleus of the inferior colliculus (ICC), as an important information integration nucleus of the auditory system, is also involved in the processing of in...

journal_title：Frontiers in cellular neuroscience

authors： Liu Y,Zhang G,Yu H,Li H,Wei J,Xiao Z

更新日期：2019-04-04 00:00:00

abstract：:Evidence that synaptic vesicles (SVs) can be gated by a single voltage sensitive calcium channel (CaV2.2) predict a molecular linking mechanism or "tether" (Stanley, 1993). Recent studies have proposed that the SV binds to the distal C-terminal on the CaV2.2 calcium channel (Kaeser et al., 2011; Wong et al., 2013) whi...

journal_title：Frontiers in cellular neuroscience

authors： Wong FK,Nath AR,Chen RH,Gardezi SR,Li Q,Stanley EF

更新日期：2014-03-07 00:00:00

abstract：:Orexin and melanin-concentrating hormone (MCH) neurons have complementary roles in various physiological functions including energy balance and the sleep/wake cycle. in vitro electrophysiological studies investigating these cells typically use post-weaning rodents, corresponding to adolescence. However, it is unclear ...

journal_title：Frontiers in cellular neuroscience

authors： Linehan V,Hirasawa M

更新日期：2018-03-13 00:00:00

abstract：:Membrane tethering is an important communication method for membrane-packaged organelles. Mitochondria are organelles with a bilayer membrane, and the membrane contact between mitochondria and other organelles is indispensable for maintaining cellular homeostasis. Increased levels of molecular determinants that mediat...

journal_title：Frontiers in cellular neuroscience

authors： Liao Y,Dong Y,Cheng J

更新日期：2020-08-07 00:00:00

abstract：:Xenon has been shown to have neuroprotective effects and is clinically used as a favorable safe inhalation anesthetic. We previously confirmed the neuroprotective effects of xenon treatment in epileptic animals. However, the mechanism underlying these protective effects remains unclear. We aimed to assess the effects ...

journal_title：Frontiers in cellular neuroscience

authors： Zhu W,Zhu J,Zhao S,Li J,Hou D,Zhang Y,Sun H

更新日期：2020-10-06 00:00:00

abstract：:A major challenge in the development of pharmacotherapies for autism is the failure to identify pathophysiological mechanisms that could be targetable. The majority of developing strategies mainly aim at restoring the brain excitatory/inhibitory imbalance described in autism, by targeting glutamate or GABA receptors. ...

journal_title：Frontiers in cellular neuroscience

authors： DelaCuesta-Barrutia J,Peñagarikano O,Erdozain AM

更新日期：2020-10-30 00:00:00

abstract：:Heterogeneous populations of cerebellar Purkinje cells (PCs) are arranged into separate longitudinal stripes, which have different topographic afferent and efferent axonal connections presumably involved in different functions, and also show different electrophysiological properties in firing pattern and synaptic plas...

journal_title：Frontiers in cellular neuroscience

authors： Nguyen-Minh VT,Tran-Anh K,Luo Y,Sugihara I

更新日期：2019-01-08 00:00:00

abstract：:The microtubule-associated axonal specification collapsin response mediator protein 2 (CRMP2) is a novel target for neuroprotection. A CRMP2 peptide (TAT-CBD3) conjugated to the HIV transactivator of transcription (TAT) protein's cationic cell penetrating peptide (CPP) motif protected neurons in the face of toxic leve...

journal_title：Frontiers in cellular neuroscience

authors： Moutal A,François-Moutal L,Brittain JM,Khanna M,Khanna R

更新日期：2015-01-26 00:00:00

abstract：:Central pattern generators (CPGs) in the thoracolumbar spinal cord generate the basic hindlimb locomotor pattern. The locomotor CPG integrates descending commands and sensory information from the periphery to activate, modulate and halt the rhythmic program. General CPG function and response to sensory perturbations a...

journal_title：Frontiers in cellular neuroscience

authors： Li EZ,Garcia-Ramirez DL,Dougherty KJ

更新日期：2019-10-09 00:00:00

abstract：:Slc4a10 is a Na(+)-coupled Cl(-)-HCO3 (-) exchanger, which is expressed in principal and inhibitory neurons as well as in choroid plexus epithelial cells of the brain. Slc4a10 knockout (KO) mice have collapsed brain ventricles and display an increased seizure threshold, while heterozygous deletions in man have been as...

journal_title：Frontiers in cellular neuroscience

authors： Sinning A,Liebmann L,Hübner CA

更新日期：2015-06-16 00:00:00

abstract：:Background: Non-alcoholic fatty liver disease (NAFLD) is a common liver condition characterized by a significant accumulation of lipids in the liver without excessive alcohol consumption. Accumulating evidence suggests a significantly increased risk of intracerebral hemorrhage (ICH) in NAFLD patients. However, it rema...

journal_title：Frontiers in cellular neuroscience

authors： Li X,Cheng X,Wang X,Liu Q,Ma H,Li M

更新日期：2020-06-08 00:00:00

abstract：:GABA transporters belong to a large family of neurotransmitter:sodium symporters. They are widely expressed throughout the brain, with different levels of expression in different brain regions. GABA transporters are present in neurons and in astrocytes and their activity is crucial to regulate the extracellular concen...

journal_title：Frontiers in cellular neuroscience

authors： Scimemi A

更新日期：2014-06-17 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fncel.2017.00013.]. ...

journal_title：Frontiers in cellular neuroscience

authors： So JH,Huang C,Ge M,Cai G,Zhang L,Lu Y,Mu Y

更新日期：2019-07-09 00:00:00