Combination Low-Dose Tissue-Type Plasminogen Activator Plus Annexin A2 for Improving Thrombolytic Stroke Therapy.

abstract：:Early odor preference learning in rodents occurs within a sensitive period [≤postnatal day (P)10-12], during which pups show a heightened ability to form an odor preference when a novel odor is paired with a tactile stimulation (e.g., stroking). Norepinephrine (NE) release from the locus coeruleus during stroking medi...

journal_title：Frontiers in cellular neuroscience

authors： Ghosh A,Purchase NC,Chen X,Yuan Q

更新日期：2015-11-19 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fncel.2019.00150.]. ...

journal_title：Frontiers in cellular neuroscience

authors： Chen Q,Qiao Y,Xu XJ,You X,Tao Y

更新日期：2019-08-22 00:00:00

abstract：:Long axons and their enwrapping glia (EG; Schwann cells (SCs) and oligodendrocytes (OLGs)) form a unique compound structure that serves as conduit for transport of electric and chemical information in the nervous system. The peculiar cytoarchitecture over an enormous length as well as its substantial energetic require...

journal_title：Frontiers in cellular neuroscience

authors： Beirowski B

更新日期：2013-12-19 00:00:00

abstract：:Neurons must establish and stabilize connections made with diverse targets, each with distinct demands and functional characteristics. At Drosophila neuromuscular junctions (NMJs), synaptic strength remains stable in a manipulation that simultaneously induces hypo-innervation on one target and hyper-innervation on the...

journal_title：Frontiers in cellular neuroscience

authors： Goel P,Nishimura S,Chetlapalli K,Li X,Chen C,Dickman D

更新日期：2020-06-26 00:00:00

abstract：:Circadian behavioral rhythms offer an excellent model to study intricate interactions between the molecular and neuronal mechanisms of behavior. In mammals, pacemaker neurons in the suprachiasmatic nucleus (SCN) generate rhythms cell-autonomously, which are synchronized by the network interactions within the circadian...

journal_title：Frontiers in cellular neuroscience

authors： Sabado V,Vienne L,Nagoshi E

更新日期：2017-10-12 00:00:00

abstract：:Chronic inflammation and oxidative stress (OS) are present in Alzheimer's disease (AD) brains in addition to neuronal loss, Amyloid-β (Aβ) plaques and hyperphosphorylated tau-protein neurofibrillary tangles (NFTs). Previously we showed that levels of the pro-inflammatory cytokine, interleukin-18 (IL-18), are elevated ...

journal_title：Frontiers in cellular neuroscience

authors： Sutinen EM,Korolainen MA,Häyrinen J,Alafuzoff I,Petratos S,Salminen A,Soininen H,Pirttilä T,Ojala JO

更新日期：2014-08-07 00:00:00

abstract：:Binge-drinking is the most prevalent form of alcohol abuse and while an early life history of binge-drinking is a significant risk factor for subsequent alcoholism and co-morbid affective disorders, relatively little is known regarding the biobehavioral impact of binge-drinking during the sensitive neurodevelopmental ...

journal_title：Frontiers in cellular neuroscience

authors： Lee KM,Coelho MA,McGregor HA,Solton NR,Cohen M,Szumlinski KK

更新日期：2016-11-18 00:00:00

abstract：:After damage, axons in the peripheral nervous system (PNS) regenerate and regrow following a process termed Wallerian degeneration, but the regenerative process is often incomplete and usually the system does not reach full recovery. Key steps to the creation of a permissive environment for axonal regrowth are the tra...

journal_title：Frontiers in cellular neuroscience

authors： Pellegatta M,Taveggia C

更新日期：2019-03-20 00:00:00

abstract：:Thermal Fluctuations Spectroscopy (TFS) in combination with novel optical-based instrumentation was used to study mechanical properties of cell-cultured neurites with a spatial resolution limited only by the light diffraction. The analysis of thermal fluctuations together with a physical model of cellular elasticity a...

journal_title：Frontiers in cellular neuroscience

authors： Gárate F,Pertusa M,Arana Y,Bernal R

更新日期：2018-07-06 00:00:00

abstract：:Epilepsy is a common neurological disorder characterized by recurrent uncontrolled seizures and has an idiopathic "genetic" etiology or a symptomatic "acquired" component. Genetic studies have revealed that many epilepsy susceptibility genes encode ion channels, including voltage-gated sodium, potassium and calcium ch...

journal_title：Frontiers in cellular neuroscience

authors： van Loo KMJ,Becker AJ

更新日期：2020-01-14 00:00:00

abstract：:Schwann cells (SCs) are one of the most promising cellular candidates for the treatment of spinal cord injury. However, SCs show poor migratory ability within the astrocyte-rich central nervous system (CNS) environment and exhibit only limited integration with host astrocytes. Our strategy for improving the therapeuti...

journal_title：Frontiers in cellular neuroscience

authors： Huang L,Xia B,Liu Z,Cao Q,Huang J,Luo Z

更新日期：2017-03-28 00:00:00

abstract：:Vasoinhibins are prolactin fragments present in the retina, where they have been shown to prevent the hypervasopermeability associated with diabetes. Enhanced bradykinin (BK) production contributes to the increased transport through the blood-retina barrier (BRB) in diabetes. Here, we studied if vasoinhibins regulate ...

journal_title：Frontiers in cellular neuroscience

authors： Arredondo Zamarripa D,Díaz-Lezama N,Meléndez García R,Chávez Balderas J,Adán N,Ledesma-Colunga MG,Arnold E,Clapp C,Thebault S

更新日期：2014-10-20 00:00:00

abstract：:Abnormal accumulation of protein inclusions in motor neurons has been known as a major pathological change in amyotrophic lateral sclerosis (ALS). Increasing numbers of proteins including mutant Cu, Zn-superoxide dismutase (SOD1) have been identified as constituents of pathological inclusions in a form of insoluble fi...

journal_title：Frontiers in cellular neuroscience

authors： Ogawa M,Furukawa Y

更新日期：2014-03-18 00:00:00

abstract：:Mammalian teeth have evolved as dentin units that enclose a complex system of sensory innervation to protect and preserve their structure and function. In human dental pulp (DP), mechanosensory and nociceptive fibers form a dense meshwork of nerve endings at the coronal dentin-pulp interface, which arise from myelinat...

journal_title：Frontiers in cellular neuroscience

authors： Couve E,Schmachtenberg O

更新日期：2018-09-05 00:00:00

abstract：:To improve the outcome after autologous nerve grafting in the clinic, it is important to understand the limiting variables such as distinct phenotypes of motor and sensory Schwann cells. This study investigated the properties of phenotypically different autografts in a 6 mm femoral nerve defect model in the rat, where...

journal_title：Frontiers in cellular neuroscience

authors： Hercher D,Kerbl M,Schuh CMAP,Heinzel J,Gal L,Stainer M,Schmidhammer R,Hausner T,Redl H,Nógrádi A,Hacobian A

更新日期：2019-05-08 00:00:00

abstract：:Traumatic spinal cord injury (SCI) leads to disruption of sensory, motor and autonomic function, and triggers structural, physiological and biochemical changes that cause reorganization of existing circuits that affect functional recovery. Propriospinal neurons (PN) appear to be very plastic within the inhibitory micr...

journal_title：Frontiers in cellular neuroscience

authors： Michael FM,Patel SP,Rabchevsky AG

更新日期：2019-11-08 00:00:00

abstract：:Ion channel receptors are a vital component of nervous system signaling, allowing rapid and direct conversion of a chemical neurotransmitter message to an electrical current. In recent decades, it has become apparent that ionotropic receptors are regulated by protein-protein interactions with other ion channels, G-pro...

journal_title：Frontiers in cellular neuroscience

authors： Li S,Wong AH,Liu F

更新日期：2014-05-09 00:00:00

abstract：:During the last decades it became increasingly evident that electrical synapses are capable of activity-dependent plasticity. However, measuring the actual strength of electrical transmission remains difficult. Usually changes in coupling strength can only be inferred indirectly from measures such as the coupling coef...

journal_title：Frontiers in cellular neuroscience

authors： Welzel G,Schuster S

更新日期：2019-02-12 00:00:00

abstract：Background:The functional aspects of mast cell-microglia interactions are important in neuroinflammation. Our previous studies have demonstrated that mast cell degranulation can directly induce microglia activation. However, the role of mast cells in Lipopolysaccharide (LPS)-induced microglia activation, neuroinflammat...

journal_title：Frontiers in cellular neuroscience

authors： Dong H,Wang Y,Zhang X,Zhang X,Qian Y,Ding H,Zhang S

更新日期：2019-05-03 00:00:00

abstract：:Recent advances in fast volumetric imaging have enabled rapid generation of large amounts of multi-dimensional functional data. While many computer frameworks exist for data storage and analysis of the multi-gigabyte Ca2+ imaging experiments in neurons, they are less useful for analyzing Ca2+ dynamics in astrocytes, w...

journal_title：Frontiers in cellular neuroscience

authors： Savtchouk I,Carriero G,Volterra A

更新日期：2018-04-13 00:00:00

abstract：:During pregnancy, a decreased availability of zinc to the fetus can disrupt the development of the central nervous system leading to defects ranging from severe malformations to subtle neurological and cognitive effects. We previously found that marginal zinc deficiency down-regulates the extracellular signal-regulate...

journal_title：Frontiers in cellular neuroscience

authors： Adamo AM,Liu X,Mathieu P,Nuttall JR,Supasai S,Oteiza PI

更新日期：2019-03-01 00:00:00

abstract：:The malignancy of glioblastoma multiform (GBM), the most common and aggressive form of human brain tumors, strongly correlates with the presence of hypoxic areas, but the mechanisms controlling the hypoxia-induced aggressiveness are still unclear. GBM cells express a number of ion channels whose activity supports cell...

journal_title：Frontiers in cellular neuroscience

authors： Sforna L,Cenciarini M,Belia S,D'Adamo MC,Pessia M,Franciolini F,Catacuzzeno L

更新日期：2015-01-15 00:00:00

abstract：:The process of store-operated calcium entry (SOCE) leads to refilling the endoplasmic reticulum (ER) with calcium ions (Ca2+) after their release into the cytoplasm. Interactions between (ER)-located Ca2+ sensors (stromal interaction molecule 1 [STIM1] and STIM2) and plasma membrane-located Ca2+ channel-forming protei...

journal_title：Frontiers in cellular neuroscience

authors： Gruszczynska-Biegala J,Sladowska M,Kuznicki J

更新日期：2016-10-25 00:00:00

abstract：:The immune system provides protection in the CNS via resident microglial cells and those that traffic into it in the course of pathological challenges. These populations of cells are key players in modulating immune functions that are involved in disease outcomes. In this review, we briefly summarize and highlight the...

journal_title：Frontiers in cellular neuroscience

authors： Fani Maleki A,Rivest S

更新日期：2019-07-31 00:00:00

abstract：:Long non-coding (lnc) RNAs are defined as non-protein coding RNAs distinct from housekeeping RNAs such as tRNAs, rRNAs, and snRNAs, and independent from small RNAs with specific molecular processing machinery such as micro- or piwi-RNAs. Recent studies of lncRNAs across different species have revealed a diverse popula...

journal_title：Frontiers in cellular neuroscience

authors： Ernst C,Morton CC

更新日期：2013-10-02 00:00:00

abstract：:The role of the cerebellum in cognitive function has been broadly investigated in the last decades from an anatomical, clinical, and functional point of view and new evidence points toward a significant contribution of the posterior lobes of the cerebellum in cognition in Alzheimer's disease (AD). In the present work ...

journal_title：Frontiers in cellular neuroscience

authors： Toniolo S,Serra L,Olivito G,Marra C,Bozzali M,Cercignani M

更新日期：2018-11-20 00:00:00

abstract：:Recently, with the development of the space program there are growing concerns about the influence of spaceflight on tissue engineering. The purpose of this study was thus to determine the variations of neural stem cells (NSCs) during spaceflight. RNA-Sequencing (RNA-Seq) based transcriptomic profiling of NSCs identif...

journal_title：Frontiers in cellular neuroscience

authors： Cui Y,Han J,Xiao Z,Qi Y,Zhao Y,Chen B,Fang Y,Liu S,Wu X,Dai J

更新日期：2018-01-11 00:00:00

abstract：:Spinal cord injury (SCI) and spinal infarction lead to neurological complications and eventually to paraplegia or quadriplegia. These extremely debilitating conditions are major contributors to morbidity. Our understanding of SCI has certainly increased during the last decade, but remains far from clear. SCI consists ...

journal_title：Frontiers in cellular neuroscience

authors： Anwar MA,Al Shehabi TS,Eid AH

更新日期：2016-04-13 00:00:00

abstract：:Tyrosine hydroxylase (Th) expression has previously been reported in Purkinje cells (PCs) of rodents and humans, but its role in the regulation of behavior is not understood. Catecholamines are well known for facilitating cognitive behaviors and are expressed in many regions of the brain. Here, we investigated a possi...

journal_title：Frontiers in cellular neuroscience

authors： Locke TM,Fujita H,Hunker A,Johanson SS,Darvas M,du Lac S,Zweifel LS,Carlson ES

更新日期：2020-07-29 00:00:00

abstract：:Neurodegenerative diseases in general and specifically late-onset Alzheimer's disease (LOAD) involve a genetically complex and largely obscure ensemble of causative and risk factors accompanied by complex feedback responses. The advent of "high-throughput" transcriptome investigation technologies such as microarray an...

journal_title：Frontiers in cellular neuroscience

authors： Guffanti A,Simchovitz A,Soreq H

更新日期：2014-03-27 00:00:00