Impairments in Oxidative Glucose Metabolism in Epilepsy and Metabolic Treatments Thereof.

abstract：:Since monumental studies from scientists like His, Ramón y Cajal, Lorente de Nó and many others have put down roots for modern neuroscience, the scientific community has spent a considerable amount of time, and money, investigating any possible aspect of the evolution, development and function of neurons. Today, the c...

journal_title：Frontiers in cellular neuroscience

authors： Tomassy GS,Fossati V

更新日期：2014-07-28 00:00:00

abstract：:Increasing evidence suggest that astrocytes significantly modulate neuronal function at the level of the tripartite synapse both in physiological and pathophysiological conditions. The global control of the astrocytic syncytium over neuronal networks, however, is still less recognized. Here we examined astrocytic sign...

journal_title：Frontiers in cellular neuroscience

authors： Kékesi O,Ioja E,Szabó Z,Kardos J,Héja L

更新日期：2015-06-18 00:00:00

abstract：:Calcium transients in thin astrocytic processes can be important in synaptic plasticity, but their mechanism is not completely understood. Clearance of synaptic glutamate leads to increase in astrocytic sodium. This can electrochemically favor the reverse mode of the Na/Ca-exchanger (NCX) and allow calcium into the ce...

journal_title：Frontiers in cellular neuroscience

authors： Brazhe AR,Verisokin AY,Verveyko DV,Postnov DE

更新日期：2018-08-14 00:00:00

abstract：:Neuronal synchronization at gamma band frequency (20-80 Hz, γ oscillations) is closely associated with higher brain function, such as learning, memory and attention. Nicotinic acetylcholine receptors (nAChRs) are highly expressed in the hippocampus, and modulate hippocampal γ oscillations, but the intracellular mechan...

journal_title：Frontiers in cellular neuroscience

authors： Wang J,He X,Guo F,Cheng X,Wang Y,Wang X,Feng Z,Vreugdenhil M,Lu C

更新日期：2017-03-06 00:00:00

abstract：:Meningioma expressed antigen 6 (MEA6), also called cutaneous T cell lymphoma-associated antigen 5 (cTAGE5), was initially found in tumor tissues. MEA6 is located in endoplasmic reticulum (ER) exit sites and regulates the transport of collagen, very low density lipoprotein, and insulin. It is also reported that MEA6 mi...

journal_title：Frontiers in cellular neuroscience

authors： Wang XT,Cai XY,Xu FX,Zhou L,Zheng R,Ma KY,Xu ZH,Shen Y

更新日期：2019-06-11 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease manifested by progressive muscle atrophy and paralysis due to the loss of upper and lower motoneurons (MN). Spasticity appears in ALS patients leading to further disabling consequences. Loss of the inhibitory tone induced by downregulation of the potas...

journal_title：Frontiers in cellular neuroscience

authors： Mòdol L,Mancuso R,Alé A,Francos-Quijorna I,Navarro X

更新日期：2014-01-24 00:00:00

abstract：:When retrieval occurs concomitantly with novelty detection, mismatch perception or reactivation of conflicting information, consolidated memories can enter into a labile state, and to persist, must be restabilized through a protein synthesis-dependent reconsolidation process during which their strength and content can...

journal_title：Frontiers in cellular neuroscience

authors： Gonzalez MC,Radiske A,Cammarota M

更新日期：2019-08-22 00:00:00

abstract：:An experience-driven increase in oligodendrocytes and myelin in the somatosensory cortex (S1) has emerged as a new marker of adult cortical plasticity. That finding contrasts with the view that myelin is a structural brake on plasticity, and that contributes to ending the critical period (CP) in the visual cortex (V1)...

journal_title：Frontiers in cellular neuroscience

authors： Murphy KM,Mancini SJ,Clayworth KV,Arbabi K,Beshara S

更新日期：2020-03-17 00:00:00

abstract：:The main olfactory epithelium (MOE) functions to detect odor molecules, provide an epithelial surface barrier, and remove xenobiotics from inhaled air. Mechanisms coordinating the activities of different cell types within the MOE to maintain these functions are poorly understood. Previously, we showed that superficial...

journal_title：Frontiers in cellular neuroscience

authors： Fu Z,Ogura T,Luo W,Lin W

更新日期：2018-03-20 00:00:00

abstract：:Spontaneous calcium transients are present during early postnatal development in the mouse retina and cochlea, and play an important role in maturation of the sensory organs and neural circuits in the central nervous system (CNS). It is not known whether similar calcium transients occur during postnatal development in...

journal_title：Frontiers in cellular neuroscience

authors： Holman HA,Poppi LA,Frerck M,Rabbitt RD

更新日期：2019-05-07 00:00:00

abstract：:Interleukin-33 (IL-33) is a member of the interleukin-1 (IL-1) cytokine family and an extracellular ligand for the orphan IL-1 receptor ST2. Accumulated evidence shows that the IL-33/ST2 axis plays a crucial role in the pathogenesis of central nervous system (CNS) diseases and injury, including traumatic brain injury ...

journal_title：Frontiers in cellular neuroscience

authors： Gao Y,Zhang MY,Wang T,Fan YY,Yu LS,Ye GH,Wang ZF,Gao C,Wang HC,Luo CL,Tao LY

更新日期：2018-04-25 00:00:00

abstract：:The transcription factor Pax6 controls multiple aspects of forebrain development. Conditional deletion of Pax6 in embryonic mouse cortex causes increased proliferation of cortical progenitor cells and a concomitant decrease in neural differentiation. Notch signaling regulates the balance between proliferation and diff...

journal_title：Frontiers in cellular neuroscience

authors： Dorà E,Price DJ,Mason JO

更新日期：2019-03-06 00:00:00

abstract：:Brain neurons, to support their neurotransmitter functions, require a several times higher supply of glucose than non-excitable cells. Pyruvate, the end product of glycolysis, through pyruvate dehydrogenase complex reaction, is a principal source of acetyl-CoA, which is a direct energy substrate in all brain cells. Se...

journal_title：Frontiers in cellular neuroscience

authors： Ronowska A,Szutowicz A,Bielarczyk H,Gul-Hinc S,Klimaszewska-Łata J,Dyś A,Zyśk M,Jankowska-Kulawy A

更新日期：2018-07-10 00:00:00

abstract：:Despite a century of intensive investigation the effective treatment of protein aggregation diseases remains elusive. Ordinarily, molecular chaperones ensure that proteins maintain their functional conformation. The appearance of misfolded proteins that aggregate implies the collapse of the cellular chaperone quality ...

journal_title：Frontiers in cellular neuroscience

authors： Koutras C,Braun JE

更新日期：2014-07-08 00:00:00

abstract：:The cerebellar cortex is remarkable for its organizational regularity, out of which task-related neural networks should emerge. In Purkinje cells, both complex and simple spike network patterns are evident in sensorimotor behavior. However, task-related patterns of activity in the granule cell layer (GCL) have been le...

journal_title：Frontiers in cellular neuroscience

authors： Courtemanche R,Chabaud P,Lamarre Y

更新日期：2009-07-20 00:00:00

abstract：:Background: Recent studies have found that rifampicin has neuroprotective properties in neurodegenerative diseases. However, the exact mechanisms of action remain unclear. The nuclear factor erythroid 2-related factor 2 (Nrf2) has been considered a potential target for neuroprotection. In this study, we examined wheth...

journal_title：Frontiers in cellular neuroscience

authors： Chen B,Cao H,Chen L,Yang X,Tian X,Li R,Cheng O

更新日期：2016-11-29 00:00:00

abstract：:Nanobodies are single domain antibodies derived from llama heavy-chain only antibodies (HCAbs). They represent a new generation of biologicals with unique properties: nanobodies show excellent tissue distribution, high temperature and pH stability, are easy to produce recombinantly and can readily be converted into di...

journal_title：Frontiers in cellular neuroscience

authors： Rissiek B,Koch-Nolte F,Magnus T

更新日期：2014-10-21 00:00:00

abstract：:Electroacupuncture (EA) pretreatment is a clinically useful therapy for several brain disorders. However, whether and via which exact molecular mechanisms it ameliorates post-traumatic stress disorder (PTSD) remains unclear. In the present study, rats received EA stimulation for seven consecutive days before exposure ...

journal_title：Frontiers in cellular neuroscience

authors： Zhou CH,Xue F,Xue SS,Sang HF,Liu L,Wang Y,Cai M,Zhang ZJ,Tan QR,Wang HN,Peng ZW

更新日期：2019-06-21 00:00:00

abstract：:The extracellular matrix (ECM) is known to play important roles in regulating neuronal recovery from injury. The ECM can also impact physiological synaptic plasticity, although this process is less well understood. To understand the impact of the ECM on synaptic function and remodeling in vivo, we examined ECM composi...

journal_title：Frontiers in cellular neuroscience

authors： Kelly EA,Russo AS,Jackson CD,Lamantia CE,Majewska AK

更新日期：2015-09-22 00:00:00

abstract：:Glucagon-like peptide-1 (GLP-1), a metabolic signal molecule, regulates reproduction, although, the involved molecular mechanisms have not been elucidated, yet. Therefore, responsiveness of gonadotropin-releasing hormone (GnRH) neurons to the GLP-1 analog Exendin-4 and elucidation of molecular pathways acting downstre...

journal_title：Frontiers in cellular neuroscience

authors： Farkas I,Vastagh C,Farkas E,Bálint F,Skrapits K,Hrabovszky E,Fekete C,Liposits Z

更新日期：2016-09-12 00:00:00

abstract：BACKGROUND:Numerous studies have reported a beneficial impact of neural progenitor cell transplantation on functional outcome after traumatic brain injury (TBI) during short and medium follow-up periods. However, our knowledge regarding long-term functional effects is fragmentary while a direct comparison between local...

journal_title：Frontiers in cellular neuroscience

authors： Skardelly M,Gaber K,Burdack S,Scheidt F,Schuhmann MU,Hilbig H,Meixensberger J,Boltze J

更新日期：2014-10-14 00:00:00

abstract：:Stressors, during early life or adulthood, can alter steroid-sensitive behaviors, such as exploration, anxiety, and/or cognitive processes. We investigated if exposure to acute stressors in adulthood may alter behavioral and neuroendocrine responses of male rats that were exposed to gestational stress or not. We hypot...

journal_title：Frontiers in cellular neuroscience

authors： Walf AA,Frye CA

更新日期：2012-12-18 00:00:00

abstract：:In humans, auditory hair cells are not replaced when injured. Thus, cochlear hair cell loss causes progressive and permanent hearing loss. Conversely, non-mammalian vertebrates are capable of regenerating lost sensory hair cells. The zebrafish lateral line has numerous qualities that make it well-suited for studying h...

journal_title：Frontiers in cellular neuroscience

authors： He Y,Cai C,Tang D,Sun S,Li H

更新日期：2014-11-13 00:00:00

abstract：:Selective negative allosteric modulators (NAMs), targeting α5 subunit-containing GABAA receptors (GABAARs) as potential therapeutic targets for disorders associated with cognitive deficits, including Alzheimer's disease (AD), continually fail clinical trials. We investigated whether this was due to the change in the e...

journal_title：Frontiers in cellular neuroscience

authors： Petrache AL,Khan AA,Nicholson MW,Monaco A,Kuta-Siejkowska M,Haider S,Hilton S,Jovanovic JN,Ali AB

更新日期：2020-11-11 00:00:00

abstract：:Methamphetamine (METH), an extremely and widely abused illicit drug, can cause serious nervous system damage and social problems. Previous research has shown that METH use causes dopaminergic neuron apoptosis and astrocyte-related neuroinflammation. However, the relationship of astrocytes and neurons in METH-induced n...

journal_title：Frontiers in cellular neuroscience

authors： Du SH,Zhang W,Yue X,Luo XQ,Tan XH,Liu C,Qiao DF,Wang H

更新日期：2018-08-03 00:00:00

abstract：:Local circuit and long-range GABAergic projections provide powerful inhibitory control over the operation of hippocampal inhibitory circuits, yet little is known about the input- and target-specific organization of interacting inhibitory networks in relation to their specific functions. Using a combination of two-phot...

journal_title：Frontiers in cellular neuroscience

authors： Chamberland S,Salesse C,Topolnik D,Topolnik L

更新日期：2010-10-15 00:00:00

abstract：:Autism spectrum disorder (ASD) is the most commonly diagnosed neurodevelopmental disorder. Independent of neuronal dysfunction, ASD and its associated comorbidities have been linked to hypomyelination and oligodendroglial dysfunction. Additionally, the neuromodulator adenosine has been shown to affect certain ASD como...

journal_title：Frontiers in cellular neuroscience

authors： Shen HY,Huang N,Reemmer J,Xiao L

更新日期：2018-12-07 00:00:00

abstract：:Human brain organoids (mini-brains) consist of self-organized three-dimensional (3D) neural tissue which can be derived from reprogrammed adult cells and maintained for months in culture. These 3D structures manifest substantial potential for the modeling of neurodegenerative diseases and pave the way for personalized...

journal_title：Frontiers in cellular neuroscience

authors： Nassor F,Jarray R,Biard DSF,Maïza A,Papy-Garcia D,Pavoni S,Deslys JP,Yates F

更新日期：2020-02-11 00:00:00

abstract：:The use of human pluripotent stem cells (PSCs) for cell therapy faces a number of challenges that are progressively answered by results from clinical trials and experimental research. Among these is the control of differentiation before transplantation and the prediction of cell fate after administration into the huma...

journal_title：Frontiers in cellular neuroscience

authors： Benchoua A,Onteniente B

更新日期：2012-01-27 00:00:00

abstract：:Dyneins are a small class of molecular motors that bind to microtubules and walk toward their minus ends. They are essential for the transport and distribution of organelles, signaling complexes and cytoskeletal elements. In addition dyneins generate forces on microtubule arrays that power the beating of cilia and fla...

journal_title：Frontiers in cellular neuroscience

authors： Roossien DH,Miller KE,Gallo G

更新日期：2015-07-06 00:00:00