Activated PPARγ Abrogates Misprocessing of Amyloid Precursor Protein, Tau Missorting and Synaptotoxicity.

abstract：:Recent research into axon-glial interactions in the nervous system has made a compelling case that glial cells have a relevant role in the metabolic support of axons, and that, in the case of myelinating cells, this role is independent of myelination itself. In this mini-review article, we summarize some of those obse...

journal_title：Frontiers in cellular neuroscience

authors： Bouçanova F,Chrast R

更新日期：2020-05-29 00:00:00

abstract：:In the primary motor cortex (M1), layer 5 projection neurons signal directly to distant motor structures to drive movement. Despite their pivotal position and acknowledged diversity these neurons are traditionally separated into broad commissural and corticofugal types, and until now no attempt has been made at resolv...

journal_title：Frontiers in cellular neuroscience

authors： Oswald MJ,Tantirigama ML,Sonntag I,Hughes SM,Empson RM

更新日期：2013-10-16 00:00:00

abstract：:Mammalian teeth have evolved as dentin units that enclose a complex system of sensory innervation to protect and preserve their structure and function. In human dental pulp (DP), mechanosensory and nociceptive fibers form a dense meshwork of nerve endings at the coronal dentin-pulp interface, which arise from myelinat...

journal_title：Frontiers in cellular neuroscience

authors： Couve E,Schmachtenberg O

更新日期：2018-09-05 00:00:00

abstract：:Manipulation of metabolic pathways (e.g., ketogenic diet (KD), glycolytic inhibition) alters neural excitability and represents a novel strategy for treatment of drug-refractory seizures. We have previously shown that inhibition of glycolysis suppresses epileptiform activity in hippocampal slices. In the present study...

journal_title：Frontiers in cellular neuroscience

authors： Shao LR,Wang G,Stafstrom CE

更新日期：2018-06-15 00:00:00

abstract：:In vitro approaches have suggested that neuropsin (or kallikrein 8/KLK8), which controls gamma-aminobutyric acid (GABA) neurotransmission through neuregulin-1 (NRG-1) and its receptor (ErbB4), is involved in neural plasticity (Tamura et al., 2012, 2013). In the present study, we examined whether parvalbumin (PV)-posit...

journal_title：Frontiers in cellular neuroscience

authors： Suzuki H,Kanagawa D,Nakazawa H,Tawara-Hirata Y,Kogure Y,Shimizu-Okabe C,Takayama C,Ishikawa Y,Shiosaka S

更新日期：2014-12-10 00:00:00

abstract：:Calcium transients in thin astrocytic processes can be important in synaptic plasticity, but their mechanism is not completely understood. Clearance of synaptic glutamate leads to increase in astrocytic sodium. This can electrochemically favor the reverse mode of the Na/Ca-exchanger (NCX) and allow calcium into the ce...

journal_title：Frontiers in cellular neuroscience

authors： Brazhe AR,Verisokin AY,Verveyko DV,Postnov DE

更新日期：2018-08-14 00:00:00

abstract：:Loss of auditory sensory hair cells (HCs) is the most common cause of hearing loss. This review addresses the signaling pathways that are involved in the programmed and necrotic cell death of auditory HCs that occur in response to ototoxic and traumatic stressor events. The roles of inflammatory processes, oxidative s...

journal_title：Frontiers in cellular neuroscience

authors： Dinh CT,Goncalves S,Bas E,Van De Water TR,Zine A

更新日期：2015-03-31 00:00:00

abstract：:Slc4a10 is a Na(+)-coupled Cl(-)-HCO3 (-) exchanger, which is expressed in principal and inhibitory neurons as well as in choroid plexus epithelial cells of the brain. Slc4a10 knockout (KO) mice have collapsed brain ventricles and display an increased seizure threshold, while heterozygous deletions in man have been as...

journal_title：Frontiers in cellular neuroscience

authors： Sinning A,Liebmann L,Hübner CA

更新日期：2015-06-16 00:00:00

abstract：:When retrieval occurs concomitantly with novelty detection, mismatch perception or reactivation of conflicting information, consolidated memories can enter into a labile state, and to persist, must be restabilized through a protein synthesis-dependent reconsolidation process during which their strength and content can...

journal_title：Frontiers in cellular neuroscience

authors： Gonzalez MC,Radiske A,Cammarota M

更新日期：2019-08-22 00:00:00

abstract：:Fatty acids (FAs) are typically associated with structural and metabolic roles, as they can be stored as triglycerides, degraded by β-oxidation or used in phospholipids' synthesis, the main components of biological membranes. It has been shown that these lipids exhibit also regulatory functions in different cell types...

journal_title：Frontiers in cellular neuroscience

authors： Falomir-Lockhart LJ,Cavazzutti GF,Giménez E,Toscani AM

更新日期：2019-04-24 00:00:00

abstract：:In the last decade, there is an increasing application of induced pluripotent stem cells (iPSCs) for disease modeling. The iPSC technology enables the study of patient-specific neuronal cell lines in vitro to evaluate dysfunction at the cellular level and identify the responsible genetic factors. This approach might b...

journal_title：Frontiers in cellular neuroscience

authors： Re S,Dogan AA,Ben-Shachar D,Berger G,Werling AM,Walitza S,Grünblatt E

更新日期：2018-09-25 00:00:00

abstract：:The microtubule-associated axonal specification collapsin response mediator protein 2 (CRMP2) is a novel target for neuroprotection. A CRMP2 peptide (TAT-CBD3) conjugated to the HIV transactivator of transcription (TAT) protein's cationic cell penetrating peptide (CPP) motif protected neurons in the face of toxic leve...

journal_title：Frontiers in cellular neuroscience

authors： Moutal A,François-Moutal L,Brittain JM,Khanna M,Khanna R

更新日期：2015-01-26 00:00:00

abstract：Background:The functional aspects of mast cell-microglia interactions are important in neuroinflammation. Our previous studies have demonstrated that mast cell degranulation can directly induce microglia activation. However, the role of mast cells in Lipopolysaccharide (LPS)-induced microglia activation, neuroinflammat...

journal_title：Frontiers in cellular neuroscience

authors： Dong H,Wang Y,Zhang X,Zhang X,Qian Y,Ding H,Zhang S

更新日期：2019-05-03 00:00:00

abstract：:Neurons receive thousands of synaptic inputs that are distributed in space and time. The systematic study of how neurons process these inputs requires a technique to stimulate multiple yet highly targeted points of interest along the neuron's dendritic tree. Three-dimensional multi-focal patterns produced via holograp...

journal_title：Frontiers in cellular neuroscience

authors： Go MA,To MS,Stricker C,Redman S,Bachor HA,Stuart GJ,Daria VR

更新日期：2013-12-02 00:00:00

abstract：:It has been estimated that 20% of pregnant women suffer from depression and it is well-documented that maternal depression can have long-lasting effects on the child. Currently, common treatment for maternal depression has been the selective serotonin reuptake inhibitor medications (SSRIs) which are used by 2-3% of pr...

journal_title：Frontiers in cellular neuroscience

authors： Olivier JD,Akerud H,Kaihola H,Pawluski JL,Skalkidou A,Högberg U,Sundström-Poromaa I

更新日期：2013-05-21 00:00:00

abstract：:The blood-brain barrier (BBB) is a diffusion barrier that has an important role in maintaining a precisely regulated microenvironment protecting the neural tissue from infectious agents and toxins in the circulating system. Compromised BBB integrity plays a major role in the pathogenesis of retroviral associated neuro...

journal_title：Frontiers in cellular neuroscience

authors： Atluri VS,Hidalgo M,Samikkannu T,Kurapati KR,Jayant RD,Sagar V,Nair MP

更新日期：2015-06-10 00:00:00

abstract：:Epilepsy is a common neurological disorder characterized by recurrent uncontrolled seizures and has an idiopathic "genetic" etiology or a symptomatic "acquired" component. Genetic studies have revealed that many epilepsy susceptibility genes encode ion channels, including voltage-gated sodium, potassium and calcium ch...

journal_title：Frontiers in cellular neuroscience

authors： van Loo KMJ,Becker AJ

更新日期：2020-01-14 00:00:00

abstract：:Variants near the ATP-binding cassette transporter A1 (ABCA1) gene are associated with elevated intraocular pressure and newly discovered risk factors for glaucoma. Previous studies have shown an association between ABCA1 deficiency and retinal inflammation. Using a mouse model of ischemia-reperfusion (IR) induced by ...

journal_title：Frontiers in cellular neuroscience

authors： Li L,Xu L,Chen W,Li X,Xia Q,Zheng L,Duan Q,Zhang H,Zhao Y

更新日期：2018-10-11 00:00:00

abstract：:The phase of firing of hippocampal neurons during theta oscillations encodes spatial information. Moreover, the spike phase response to synaptic inputs in individual cells depends on the expression of the hyperpolarization-activated mixed cation current (I h ), which differs between CA3 and CA1 pyramidal neurons. Here...

journal_title：Frontiers in cellular neuroscience

authors： Borel M,Guadagna S,Jang HJ,Kwag J,Paulsen O

更新日期：2013-12-25 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is characterized by massive loss of motor neurons. Data from ALS patients and experimental models indicate that mitochondria are severely damaged within dying or spared motor neurons. Nonetheless, recent data indicate that mitochondrial preservation, although preventing motor neuron...

journal_title：Frontiers in cellular neuroscience

authors： Natale G,Lenzi P,Lazzeri G,Falleni A,Biagioni F,Ryskalin L,Fornai F

更新日期：2015-11-06 00:00:00

abstract：:Anabolic-androgenic steroids (AAS) are lipophilic hormones often taken in excessive quantities by athletes and bodybuilders to enhance performance and increase muscle mass. AAS exert well known toxic effects on specific cell and tissue types and organ systems. The attention that androgen abuse has received lately shou...

journal_title：Frontiers in cellular neuroscience

authors： Basile JR,Binmadi NO,Zhou H,Yang YH,Paoli A,Proia P

更新日期：2013-05-09 00:00:00

abstract：:The main olfactory epithelium (MOE) functions to detect odor molecules, provide an epithelial surface barrier, and remove xenobiotics from inhaled air. Mechanisms coordinating the activities of different cell types within the MOE to maintain these functions are poorly understood. Previously, we showed that superficial...

journal_title：Frontiers in cellular neuroscience

authors： Fu Z,Ogura T,Luo W,Lin W

更新日期：2018-03-20 00:00:00

abstract：:Adeno-associated virus (AAV) is the preferred vector for gene therapy of hereditary deafness, and different viral serotypes, promoters and transduction pathways can influence the targeting of AAV to different types of cells and the expression levels of numerous exogenous genes. To determine the transduction and expres...

journal_title：Frontiers in cellular neuroscience

authors： Gu X,Chai R,Guo L,Dong B,Li W,Shu Y,Huang X,Li H

更新日期：2019-01-24 00:00:00

abstract：:The piriform cortex (PC) is richly innervated by corticotropin-releasing factor (CRF) and serotonin (5-HT) containing axons arising from central amygdala and Raphe nucleus. CRFR1 and 5-HT2A/2CRs have been shown to interact in manner where CRFR activation subsequently potentiates the activity of 5-HT2A/2CRs. The purpos...

journal_title：Frontiers in cellular neuroscience

authors： Narla C,Dunn HA,Ferguson SS,Poulter MO

更新日期：2015-05-28 00:00:00

abstract：:Glioblastoma is the most common malignant tumor in central nervous system (CNS), and it is still insurmountable and has a poor prognosis. The proliferation and survival mechanism of glioma cells needs to be explored further for the development of glioma treatment. Hematopoietic-substrate-1 associated protein X-1 (HAX-...

journal_title：Frontiers in cellular neuroscience

authors： Deng X,Song L,Zhao W,Wei Y,Guo XB

更新日期：2017-12-21 00:00:00

abstract：:Activity-dependent changes in the input-output (I-O) relationship of a neural circuit are central in the learning and memory function of the brain. To understand circuit-wide adjustments, optical imaging techniques to probe the membrane potential at every component of neurons, such as dendrites, axons and somas, in th...

journal_title：Frontiers in cellular neuroscience

authors： Tominaga Y,Taketoshi M,Tominaga T

更新日期：2018-10-24 00:00:00

abstract：:Until recently, the visualization of cerebral microvessels was hampered by the fact that only short segments of vessels could be evaluated in brain sections by histochemistry. These limitations have been overcome by light sheet microscopy, which allows the 3D analysis of microvasculature in cleared brains. A major lim...

journal_title：Frontiers in cellular neuroscience

authors： Mohamud Yusuf A,Hagemann N,Schulten S,Rausch O,Wagner K,Hussner T,Qi Y,Totzeck M,Kleinschnitz C,Squire A,Gunzer M,Hermann DM

更新日期：2021-01-05 00:00:00

abstract：:Analysis of presynaptic protein expression in glutamatergic and GABAergic central synapses performed in several laboratories and with different techniques is unveiling a complex scenario, largely because each presynaptic protein exists in several isoforms. The interpretation of these findings is generally based on the...

journal_title：Frontiers in cellular neuroscience

authors： Bragina L,Fattorini G,Giovedì S,Bosco F,Benfenati F,Conti F

更新日期：2013-02-04 00:00:00

abstract：:Vasoinhibins are prolactin fragments present in the retina, where they have been shown to prevent the hypervasopermeability associated with diabetes. Enhanced bradykinin (BK) production contributes to the increased transport through the blood-retina barrier (BRB) in diabetes. Here, we studied if vasoinhibins regulate ...

journal_title：Frontiers in cellular neuroscience

authors： Arredondo Zamarripa D,Díaz-Lezama N,Meléndez García R,Chávez Balderas J,Adán N,Ledesma-Colunga MG,Arnold E,Clapp C,Thebault S

更新日期：2014-10-20 00:00:00

abstract：:Neuronal synchronization at gamma band frequency (20-80 Hz, γ oscillations) is closely associated with higher brain function, such as learning, memory and attention. Nicotinic acetylcholine receptors (nAChRs) are highly expressed in the hippocampus, and modulate hippocampal γ oscillations, but the intracellular mechan...

journal_title：Frontiers in cellular neuroscience

authors： Wang J,He X,Guo F,Cheng X,Wang Y,Wang X,Feng Z,Vreugdenhil M,Lu C

更新日期：2017-03-06 00:00:00