Striatal Gαolf/cAMP Signal-Dependent Mechanism to Generate Levodopa-Induced Dyskinesia in Parkinson's Disease.

abstract：:To improve the outcome after autologous nerve grafting in the clinic, it is important to understand the limiting variables such as distinct phenotypes of motor and sensory Schwann cells. This study investigated the properties of phenotypically different autografts in a 6 mm femoral nerve defect model in the rat, where...

journal_title：Frontiers in cellular neuroscience

authors： Hercher D,Kerbl M,Schuh CMAP,Heinzel J,Gal L,Stainer M,Schmidhammer R,Hausner T,Redl H,Nógrádi A,Hacobian A

更新日期：2019-05-08 00:00:00

abstract：:The medial prefrontal cortex (mPFC) receives dense noradrenergic projections from the locus coeruleus. Adrenergic innervation of mPFC pyramidal neurons plays an essential role in both physiology (control of memory formation, attention, working memory, and cognitive behavior) and pathophysiology (attention deficit hype...

journal_title：Frontiers in cellular neuroscience

authors： Grzelka K,Kurowski P,Gawlak M,Szulczyk P

更新日期：2017-11-02 00:00:00

abstract：:Amyloid peptide is able to promote the activation of microglia and astrocytes in Alzheimer's disease (AD), and this stimulates the production of pro-inflammatory cytokines. Inflammation contributes to the process of neurodegeneration and therefore is a key factor in the development of AD. Some of the most important pr...

journal_title：Frontiers in cellular neuroscience

authors： Toral-Rios D,Franco-Bocanegra D,Rosas-Carrasco O,Mena-Barranco F,Carvajal-García R,Meraz-Ríos MA,Campos-Peña V

更新日期：2015-05-18 00:00:00

abstract：:Nitric oxide (NO) is a pleiotropic janus-faced molecule synthesized by nitric oxide synthases (NOS) which plays a critical role in a number of physiological and pathological processes in humans. The physiological roles of NO depend on its local concentrations, as well as its availability and the nature of downstream t...

journal_title：Frontiers in cellular neuroscience

authors： Yuste JE,Tarragon E,Campuzano CM,Ros-Bernal F

更新日期：2015-08-17 00:00:00

abstract：:Proper communication between neurons depends upon appropriate patterning of dendrites and correct distribution and structure of spines. Schizophrenia is a neuropsychiatric disorder characterized by alterations in dendrite branching and spine density. Nitric oxide synthase 1 adaptor protein (NOS1AP), a risk gene for sc...

journal_title：Frontiers in cellular neuroscience

authors： Hernandez K,Swiatkowski P,Patel MV,Liang C,Dudzinski NR,Brzustowicz LM,Firestein BL

更新日期：2016-02-02 00:00:00

abstract：:The opioid peptide receptors consist of three major subclasses, namely, μ, δ, and κ (MOR, DOR, and KOR, respectively). They are involved in the regulation of striatal dopamine functions, and increased opioid transmissions are thought to play a compensatory role in altered functions of the basal ganglia in Parkinson's ...

journal_title：Frontiers in cellular neuroscience

authors： Koizumi H,Morigaki R,Okita S,Nagahiro S,Kaji R,Nakagawa M,Goto S

更新日期：2013-05-17 00:00:00

abstract：:Amyloid beta (Aβ) is a peptide cleaved from amyloid precursor protein that contributes to the formation of senile plaques in Alzheimer's disease (AD). The relationship between Aβ and astrocyte proliferation in AD remains controversial. Despite pathological findings of increased astrocytic mitosis in AD brains, in vitr...

journal_title：Frontiers in cellular neuroscience

authors： Ohki EC,Langan TJ,Rodgers KR,Chou RC

更新日期：2017-09-26 00:00:00

abstract：:Functionally related neurons assemble into connected networks that process and transmit electrochemical information. To do this in a coordinated manner, the number and strength of synaptic connections is tightly regulated. Synapse function relies on the microtubule (MT) cytoskeleton, the dynamics of which are in turn ...

journal_title：Frontiers in cellular neuroscience

authors： Verstraelen P,Detrez JR,Verschuuren M,Kuijlaars J,Nuydens R,Timmermans JP,De Vos WH

更新日期：2017-06-22 00:00:00

abstract：:Nitric oxide is a unique neurotransmitter, which participates in many physiological and pathological processes in the organism. There are little data about the neuronal nitric oxide synthase immunoreactivity in the spinal cord of amphibians. In this respect, the present study aims to investigate the distribution of ni...

journal_title：Frontiers in cellular neuroscience

authors： Mahmoud MA,Fahmy GH,Moftah MZ,Sabry I

更新日期：2014-09-25 00:00:00

abstract：:After damage, axons in the peripheral nervous system (PNS) regenerate and regrow following a process termed Wallerian degeneration, but the regenerative process is often incomplete and usually the system does not reach full recovery. Key steps to the creation of a permissive environment for axonal regrowth are the tra...

journal_title：Frontiers in cellular neuroscience

authors： Pellegatta M,Taveggia C

更新日期：2019-03-20 00:00:00

abstract：:The differentiated state of spinal cord ependymal cells in regeneration-competent amphibians varies between a constitutively active state in what is essentially a developing organism, the tadpole of the frog Xenopus laevis, and a quiescent, activatable state in a slowly growing adult salamander Ambystoma mexicanum, th...

journal_title：Frontiers in cellular neuroscience

authors： Chernoff EAG,Sato K,Salfity HVN,Sarria DA,Belecky-Adams T

更新日期：2018-02-27 00:00:00

abstract：:Aberrant ion channel function has been heralded as a main underlying mechanism driving epilepsy and its symptoms. However, it has become increasingly clear that treatment strategies targeting voltage-gated sodium or calcium channels merely mask the symptoms of epilepsy without providing disease-modifying benefits. Ion...

journal_title：Frontiers in cellular neuroscience

authors： Wilson SM,Ki Yeon S,Yang XF,Park KD,Khanna R

更新日期：2014-05-28 00:00:00

abstract：:Cortical malformations are often associated with pharmaco-resistant epilepsy. Alterations in hyperpolarization-activated, cyclic nucleotide-gated, non-specific cation (HCN) channels have been shown to contribute to malformation associated hyperexcitability. We have recently demonstrated that expression of HCN channels...

journal_title：Frontiers in cellular neuroscience

authors： Albertson AJ,Bohannon AS,Hablitz JJ

更新日期：2017-04-19 00:00:00

abstract：:The blood brain barrier (BBB) and the blood cerebrospinal fluid barrier (BCSFB) form the barriers of the brain. These barriers are essential not only for the protection of the brain, but also in regulating the exchange of cells and molecules in and out of the brain. The choroid plexus (CP) epithelial cells and the ara...

journal_title：Frontiers in cellular neuroscience

authors： Marques F,Sousa JC

更新日期：2015-04-13 00:00:00

abstract：:Binge-drinking is the most prevalent form of alcohol abuse and while an early life history of binge-drinking is a significant risk factor for subsequent alcoholism and co-morbid affective disorders, relatively little is known regarding the biobehavioral impact of binge-drinking during the sensitive neurodevelopmental ...

journal_title：Frontiers in cellular neuroscience

authors： Lee KM,Coelho MA,McGregor HA,Solton NR,Cohen M,Szumlinski KK

更新日期：2016-11-18 00:00:00

abstract：:The proliferative pool of neural progenitor cells is maintained by exquisitely controlled mechanisms for cell cycle regulation. The Na-K-Cl cotransporter (NKCC1) is important for regulating cell volume and the proliferation of different cell types in vitro. NKCC1 is expressed in ventral telencephalon of embryonic brai...

journal_title：Frontiers in cellular neuroscience

authors： Magalhães AC,Rivera C

更新日期：2016-08-17 00:00:00

abstract：:Thyrotropin-releasing hormone (TRH) and its analogs are able to stimulate the release of the endogenic dopamine (DA) in the central nervous system. However, this effect has not been tested in the Parkinson's disease (PD), which is characterized by the DA deficiency due to the dopaminergic neurons loss in the substanti...

journal_title：Frontiers in cellular neuroscience

authors： Zheng C,Chen G,Tan Y,Zeng W,Peng Q,Wang J,Cheng C,Yang X,Nie S,Xu Y,Zhang Z,Papa SM,Ye K,Cao X

更新日期：2018-11-13 00:00:00

abstract：:Sensory perception is fundamental to everyday life, yet understanding of human sensory physiology at the molecular level is hindered due to constraints on tissue availability. Emerging strategies to study and characterize peripheral neuropathies in vitro involve the use of human pluripotent stem cells (hPSCs) differen...

journal_title：Frontiers in cellular neuroscience

authors： Hulme AJ,McArthur JR,Maksour S,Miellet S,Ooi L,Adams DJ,Finol-Urdaneta RK,Dottori M

更新日期：2020-12-04 00:00:00

abstract：:There is mounting evidence that oxidative glucose metabolism is impaired in epilepsy and recent work has further characterized the metabolic mechanisms involved. In healthy people eating a traditional diet, including carbohydrates, fats and protein, the major energy substrate in brain is glucose. Cytosolic glucose met...

journal_title：Frontiers in cellular neuroscience

authors： McDonald T,Puchowicz M,Borges K

更新日期：2018-08-31 00:00:00

abstract：:The substantia nigra pars reticulata (SNr) is one of the output nuclei of the basal ganglia (BG) and plays a vital role in movement execution. Death of dopaminergic neurons in the neighboring nucleus, the substantia nigra pars compacta (SNc), leads to Parkinson's disease. The ensuing dopamine depletion affects all BG ...

journal_title：Frontiers in cellular neuroscience

authors： Faynveitz A,Lavian H,Jacob A,Korngreen A

更新日期：2019-09-13 00:00:00

abstract：:In recent years, P2X receptors have attracted increasing attention as regulators of exocytosis and cellular secretion. In various cell types, P2X receptors have been found to stimulate vesicle exocytosis directly via Ca(2+) influx and elevation of the intracellular Ca(2+) concentration. Recently, a new role for P2X4 r...

journal_title：Frontiers in cellular neuroscience

authors： Miklavc P,Thompson KE,Frick M

更新日期：2013-10-08 00:00:00

abstract：:Objective: DL-3n-butylphthalide (NBP) has beneficial effects in different stages of ischemic stroke. Our previous studies have demonstrated that NBP promoted angiogenesis in the perifocal region of the ischemic brain. However, the molecular mechanism of NBP for blood-brain barrier protection in acute ischemic stroke w...

journal_title：Frontiers in cellular neuroscience

authors： Mamtilahun M,Wei Z,Qin C,Wang Y,Tang Y,Shen FX,Tian HL,Zhang Z,Yang GY

更新日期：2021-01-12 00:00:00

abstract：:Inflammatory cells may contribute to secondary brain injury following cerebral ischemia. The C57Bl/6 mouse strain is known to exhibit a T helper 1-prone, pro-inflammatory type response to injury, whereas the FVB strain is relatively T helper 2-prone, or anti-inflammatory, in its immune response. We tested whether stro...

journal_title：Frontiers in cellular neuroscience

authors： Kim HA,Whittle SC,Lee S,Chu HX,Zhang SR,Wei Z,Arumugam TV,Vinh A,Drummond GR,Sobey CG

更新日期：2014-11-19 00:00:00

abstract：:Understanding non-stationary neuronal activity as seen in vivo requires estimation of both excitatory and inhibitory synaptic conductances from a single trial of recording. For this purpose, we propose a new intracellular recording method, called "firing clamp." Synaptic conductances are estimated from the characteris...

journal_title：Frontiers in cellular neuroscience

authors： Chizhov AV,Malinina E,Druzin M,Graham LJ,Johansson S

更新日期：2014-03-27 00:00:00

abstract：:The neural extracellular matrix (ECM) is enriched with hyaluronic acid, chondroitin sulfate proteoglycans (CSPGs) and the glycoprotein tenascin-R, which play important roles in synaptic plasticity, as shown by studies of the CA1 region of the hippocampus. However, ECM molecules are strongly expressed in the CA2 region...

journal_title：Frontiers in cellular neuroscience

authors： Hayani H,Song I,Dityatev A

更新日期：2018-05-30 00:00:00

abstract：:Schwann cells (SCs) are one of the most promising cellular candidates for the treatment of spinal cord injury. However, SCs show poor migratory ability within the astrocyte-rich central nervous system (CNS) environment and exhibit only limited integration with host astrocytes. Our strategy for improving the therapeuti...

journal_title：Frontiers in cellular neuroscience

authors： Huang L,Xia B,Liu Z,Cao Q,Huang J,Luo Z

更新日期：2017-03-28 00:00:00

abstract：:Analysis of presynaptic protein expression in glutamatergic and GABAergic central synapses performed in several laboratories and with different techniques is unveiling a complex scenario, largely because each presynaptic protein exists in several isoforms. The interpretation of these findings is generally based on the...

journal_title：Frontiers in cellular neuroscience

authors： Bragina L,Fattorini G,Giovedì S,Bosco F,Benfenati F,Conti F

更新日期：2013-02-04 00:00:00

abstract：:Traumatic spinal cord injury (SCI) impedes signal transmission by disrupting both the local neurons and their surrounding synaptic connections. Although the majority of SCI patients retain spared neural tissue at the injury site, they predominantly suffer from complete autonomic and sensorimotor dysfunction. While the...

journal_title：Frontiers in cellular neuroscience

authors： Zavvarian MM,Hong J,Fehlings MG

更新日期：2020-05-18 00:00:00

abstract：:Microglia are the resident immune cells of the brain and react quickly to changes in their environment with transcriptional regulation and morphological changes. Brain tissue injury such as ischemic stroke induces a local inflammatory response encompassing microglial activation. The change in activation status of a mi...

journal_title：Frontiers in cellular neuroscience

authors： Heindl S,Gesierich B,Benakis C,Llovera G,Duering M,Liesz A

更新日期：2018-04-19 00:00:00

abstract：:The axon provides a sole output of the neuron which propagates action potentials reliably to the axon terminal and transmits neuronal information to the postsynaptic neuron across the synapse. A classical view of neuronal signaling is based on these two processes, namely binary (all or none) signaling along the axon a...

journal_title：Frontiers in cellular neuroscience

authors： Kamiya H

更新日期：2019-09-06 00:00:00