ER stress and unfolded protein response in amyotrophic lateral sclerosis-a controversial role of protein disulphide isomerase.

abstract：:[This corrects the article on p. 396 in vol. 8, PMID: 25505873.]. ...

journal_title：Frontiers in cellular neuroscience

authors： Frontiers Production Office.

更新日期：2015-04-23 00:00:00

abstract：:Proper communication between neurons depends upon appropriate patterning of dendrites and correct distribution and structure of spines. Schizophrenia is a neuropsychiatric disorder characterized by alterations in dendrite branching and spine density. Nitric oxide synthase 1 adaptor protein (NOS1AP), a risk gene for sc...

journal_title：Frontiers in cellular neuroscience

authors： Hernandez K,Swiatkowski P,Patel MV,Liang C,Dudzinski NR,Brzustowicz LM,Firestein BL

更新日期：2016-02-02 00:00:00

abstract：:During pregnancy, a decreased availability of zinc to the fetus can disrupt the development of the central nervous system leading to defects ranging from severe malformations to subtle neurological and cognitive effects. We previously found that marginal zinc deficiency down-regulates the extracellular signal-regulate...

journal_title：Frontiers in cellular neuroscience

authors： Adamo AM,Liu X,Mathieu P,Nuttall JR,Supasai S,Oteiza PI

更新日期：2019-03-01 00:00:00

abstract：:Adeno-associated virus (AAV) is the preferred vector for gene therapy of hereditary deafness, and different viral serotypes, promoters and transduction pathways can influence the targeting of AAV to different types of cells and the expression levels of numerous exogenous genes. To determine the transduction and expres...

journal_title：Frontiers in cellular neuroscience

authors： Gu X,Chai R,Guo L,Dong B,Li W,Shu Y,Huang X,Li H

更新日期：2019-01-24 00:00:00

abstract：:Proper brain neuronal circuitry formation and synapse development is dependent on specific cues, either genetic or epigenetic, provided by the surrounding neural environment. Within these signals, thyroid hormones (T3 and T4) play crucial role in several steps of brain morphogenesis including proliferation of progenit...

journal_title：Frontiers in cellular neuroscience

authors： Dezonne RS,Stipursky J,Araujo AP,Nones J,Pavão MS,Porcionatto M,Gomes FC

更新日期：2013-08-12 00:00:00

abstract：:Degenerative retinopathies are the leading causes of irreversible visual impairment in the elderly, affecting hundreds of millions of patients. Müller glia cells (MGC), the main type of glia found in the vertebrate retina, can resume proliferation in the rodent adult injured retina but contribute weakly to tissue repa...

journal_title：Frontiers in cellular neuroscience

authors： Guimarães RPM,Landeira BS,Coelho DM,Golbert DCF,Silveira MS,Linden R,de Melo Reis RA,Costa MR

更新日期：2018-11-12 00:00:00

abstract：:Heterotrimeric G-proteins mediate a variety of cellular functions, including signal transduction in sensory neurons of the olfactory system. Whereas the Gα subunits in these neurons are well characterized, the gene transcript expression profile of Gβγ subunits is largely missing. Here we report our comprehensive expre...

journal_title：Frontiers in cellular neuroscience

authors： Sathyanesan A,Feijoo AA,Mehta ST,Nimarko AF,Lin W

更新日期：2013-06-04 00:00:00

abstract：:The Golgi cells have been recently shown to beat regularly in vitro (Forti et al., 2006. J. Physiol. 574, 711-729). Four main currents were shown to be involved, namely a persistent sodium current (I(Na-p)), an h current (I(h)), an SK-type calcium-dependent potassium current (I(K-AHP)), and a slow M-like potassium cur...

journal_title：Frontiers in cellular neuroscience

authors： Solinas S,Forti L,Cesana E,Mapelli J,De Schutter E,D'Angelo E

更新日期：2007-12-30 00:00:00

abstract：:The possible cognitive effects of low frequency external electric fields (EFs), such as those generated by power lines, are poorly understood. Their functional consequences for mechanisms at the single neuron level are very difficult to study and identify experimentally, especially in vivo. The major open problem is t...

journal_title：Frontiers in cellular neuroscience

authors： Cavarretta F,Carnevale NT,Tegolo D,Migliore M

更新日期：2014-10-09 00:00:00

abstract：:The postnatal development of cerebellar climbing fiber (CF) to Purkinje neuron (PN) synapses is characterized by a substantial pruning during the first 3 weeks after birth, switching from multiple- to single-CF innervation. Previous studies suggested that CF maturation is governed by bidirectional changes of synaptic ...

journal_title：Frontiers in cellular neuroscience

authors： Pätz C,Brachtendorf S,Eilers J

更新日期：2019-05-01 00:00:00

abstract：:Antiphospholipid syndrome (APS) is characterized by arterial and venous thrombosis, pregnancy morbidity and fetal loss caused by pathogenic autoantibodies directed against phospholipids (PL) and PL-cofactors. Isolated neurological APS may represent a significant diagnostic challenge, as epidemiological, clinical and n...

journal_title：Frontiers in cellular neuroscience

authors： D'Angelo C,Franch O,Fernández-Paredes L,Oreja-Guevara C,Núñez-Beltrán M,Comins-Boo A,Reale M,Sánchez-Ramón S

更新日期：2019-03-19 00:00:00

abstract：:Membrane tethering is an important communication method for membrane-packaged organelles. Mitochondria are organelles with a bilayer membrane, and the membrane contact between mitochondria and other organelles is indispensable for maintaining cellular homeostasis. Increased levels of molecular determinants that mediat...

journal_title：Frontiers in cellular neuroscience

authors： Liao Y,Dong Y,Cheng J

更新日期：2020-08-07 00:00:00

abstract：:One century after its first description, pathology of Alzheimer's disease (AD) is still poorly understood. Amyloid-related dendritic atrophy and membrane alterations of susceptible brain neurons in AD, and in animal models of AD are widely recognized. However, little effort has been made to study the potential effects...

journal_title：Frontiers in cellular neuroscience

authors： Somogyi A,Katonai Z,Alpár A,Wolf E

更新日期：2016-06-16 00:00:00

abstract：:Binge-drinking is the most prevalent form of alcohol abuse and while an early life history of binge-drinking is a significant risk factor for subsequent alcoholism and co-morbid affective disorders, relatively little is known regarding the biobehavioral impact of binge-drinking during the sensitive neurodevelopmental ...

journal_title：Frontiers in cellular neuroscience

authors： Lee KM,Coelho MA,McGregor HA,Solton NR,Cohen M,Szumlinski KK

更新日期：2016-11-18 00:00:00

abstract：:The striatum is a key structure for movement control, but the mechanisms that dictate the output of distinct subpopulations of medium spiny projection neurons (MSNs), striatonigral projecting and dopamine D1 receptor- (D1+) or striatopallidal projecting and dopamine D2 receptor- (D2+) expressing neurons, remains poorl...

journal_title：Frontiers in cellular neuroscience

authors： Janssen MJ,Yasuda RP,Vicini S

更新日期：2011-07-28 00:00:00

abstract：:The klotho gene family consists of α-, β-, and γ-Klotho, which encode type I single-pass transmembrane proteins with large extracellular domains. α-Klotho exists as a full-length membrane-bound and as a soluble form after cleavage of the extracellular domain. Due to gene splicing, a short extracellular Klotho form can...

journal_title：Frontiers in cellular neuroscience

authors： Li D,Jing D,Liu Z,Chen Y,Huang F,Behnisch T

更新日期：2019-04-02 00:00:00

abstract：:Traumatic spinal cord injury (SCI) leads to disruption of sensory, motor and autonomic function, and triggers structural, physiological and biochemical changes that cause reorganization of existing circuits that affect functional recovery. Propriospinal neurons (PN) appear to be very plastic within the inhibitory micr...

journal_title：Frontiers in cellular neuroscience

authors： Michael FM,Patel SP,Rabchevsky AG

更新日期：2019-11-08 00:00:00

abstract：:The medial prefrontal cortex (mPFC) receives dense noradrenergic projections from the locus coeruleus. Adrenergic innervation of mPFC pyramidal neurons plays an essential role in both physiology (control of memory formation, attention, working memory, and cognitive behavior) and pathophysiology (attention deficit hype...

journal_title：Frontiers in cellular neuroscience

authors： Grzelka K,Kurowski P,Gawlak M,Szulczyk P

更新日期：2017-11-02 00:00:00

abstract：:Cellular senescence has classically been associated with aging. Intriguingly, recent studies have also unraveled key roles for senescence in embryonic development, regeneration, and reprogramming. Developmental senescence has been reported during embryonic development in different organisms and structures, such as the...

journal_title：Frontiers in cellular neuroscience

authors： Magariños M,Barajas-Azpeleta R,Varela-Nieto I,R Aburto M

更新日期：2020-08-17 00:00:00

abstract：:The hippocampus is one of the earliest affected brain regions in Alzheimer's disease (AD) and its dysfunction is believed to underlie the core feature of the disease-memory impairment. Given that hippocampal volume is one of the best AD biomarkers, our review focuses on distinct subfields within the hippocampus, pinpo...

journal_title：Frontiers in cellular neuroscience

authors： Maruszak A,Thuret S

更新日期：2014-03-31 00:00:00

abstract：:The transcription factor Pax6 controls multiple aspects of forebrain development. Conditional deletion of Pax6 in embryonic mouse cortex causes increased proliferation of cortical progenitor cells and a concomitant decrease in neural differentiation. Notch signaling regulates the balance between proliferation and diff...

journal_title：Frontiers in cellular neuroscience

authors： Dorà E,Price DJ,Mason JO

更新日期：2019-03-06 00:00:00

abstract：:Intrastriatal transplantation of fetal human ventral mesencephalic dopaminergic neurons is an experimental therapy for patients suffering from Parkinson's disease. The success of this approach depends on several host brain parameters including neurotrophic factors and growth inhibitors that guide survival and integrat...

journal_title：Frontiers in cellular neuroscience

authors： Seiler S,Di Santo S,Andereggen L,Widmer HR

更新日期：2017-05-26 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a progressive, fatal, and incurable neurodegenerative disease. Recent studies suggest that dysregulation of gene expression by microRNAs (miRNAs) may play an important role in ALS pathogenesis. The reversible nature of this dysregulation makes miRNAs attractive pharmacological ta...

journal_title：Frontiers in cellular neuroscience

authors： Paez-Colasante X,Figueroa-Romero C,Rumora AE,Hur J,Mendelson FE,Hayes JM,Backus C,Taubman GF,Heinicke L,Walter NG,Barmada SJ,Sakowski SA,Feldman EL

更新日期：2020-05-12 00:00:00

abstract：:Spontaneous or medically induced reperfusion occurs in up to 70% of patients within 24 h after cerebral ischemia. Reperfusion of ischemic brain tissue can augment the inflammatory response that causes additional injury. Recently, T cells have been shown to be an essential part of the post-ischemic tissue damage, and e...

journal_title：Frontiers in cellular neuroscience

authors： Gelderblom M,Arunachalam P,Magnus T

更新日期：2014-11-05 00:00:00

abstract：:The adult hypothalamus regulates many physiological functions and homeostatic loops, including growth, feeding and reproduction. In mammals, the hypothalamus derives from the ventral diencephalon where two distinct ventricular proliferative zones have been described. Although a set of transcription factors regulating ...

journal_title：Frontiers in cellular neuroscience

authors： Maggi R,Zasso J,Conti L

更新日期：2015-01-06 00:00:00

abstract：:Most stroke studies dealing with functional deficits and assessing stem cell therapy produce extensive hemispheric damage and can be seen as a model for severe clinical strokes. However, mild strokes have a better prospect for functional recovery. Recently, anatomic and behavioral changes have been reported for distal...

journal_title：Frontiers in cellular neuroscience

authors： Minassian A,Green C,Diedenhofen M,Vogel S,Hess S,Stoeber M,Radmilovic MD,Wiedermann D,Kloppenburg P,Hoehn M

更新日期：2020-04-07 00:00:00

abstract：:Increased expression of S100B and its specific receptor for advanced glycation end products (RAGE) has been described in patients with multiple sclerosis (MS), being associated with an active demyelinating process. We previously showed that a direct neutralization of S100B reduces lysophosphatidylcholine (LPC)-induced...

journal_title：Frontiers in cellular neuroscience

authors： Santos G,Barateiro A,Brites D,Fernandes A

更新日期：2020-09-04 00:00:00

abstract：:The cerebellar cortex is remarkable for its organizational regularity, out of which task-related neural networks should emerge. In Purkinje cells, both complex and simple spike network patterns are evident in sensorimotor behavior. However, task-related patterns of activity in the granule cell layer (GCL) have been le...

journal_title：Frontiers in cellular neuroscience

authors： Courtemanche R,Chabaud P,Lamarre Y

更新日期：2009-07-20 00:00:00

abstract：:To find satisfactory treatment strategies for neuropathic pain syndromes, the cellular mechanisms should be illuminated. Central sensitization is a generator of pain hypersensitivity, and is mainly reflected in neuronal hyperexcitability in pain pathway. Neuronal excitability depends on two components, the synaptic in...

journal_title：Frontiers in cellular neuroscience

authors： Yang Z,Tan Q,Cheng D,Zhang L,Zhang J,Gu EW,Fang W,Lu X,Liu X

更新日期：2018-11-21 00:00:00

abstract：:The extracellular matrix (ECM) is known to play important roles in regulating neuronal recovery from injury. The ECM can also impact physiological synaptic plasticity, although this process is less well understood. To understand the impact of the ECM on synaptic function and remodeling in vivo, we examined ECM composi...

journal_title：Frontiers in cellular neuroscience

authors： Kelly EA,Russo AS,Jackson CD,Lamantia CE,Majewska AK

更新日期：2015-09-22 00:00:00