Abstract:
:The possible cognitive effects of low frequency external electric fields (EFs), such as those generated by power lines, are poorly understood. Their functional consequences for mechanisms at the single neuron level are very difficult to study and identify experimentally, especially in vivo. The major open problem is that experimental investigations on humans have given inconsistent or contradictory results, making it difficult to estimate the possible effects of external low frequency electric fields on cognitive functions. Here we investigate this issue with realistic models of hippocampal CA1 pyramidal neurons. Our findings suggest how and why EFs, with environmentally observed frequencies and intensities far lower than what is required for direct neural activation, can perturb dendritic signal processing and somatic firing of neurons that are crucially involved in cognitive tasks such as learning and memory. These results show that individual neuronal morphology, ion channel dendritic distribution, and alignment with the electric field are major determinants of overall effects, and provide a physiologically plausible explanation of why experimental findings can appear to be small and difficult to reproduce, yet deserve serious consideration.
journal_name
Front Cell Neuroscijournal_title
Frontiers in cellular neuroscienceauthors
Cavarretta F,Carnevale NT,Tegolo D,Migliore Mdoi
10.3389/fncel.2014.00310subject
Has Abstractpub_date
2014-10-09 00:00:00pages
310issn
1662-5102journal_volume
8pub_type
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journal_title:Frontiers in cellular neuroscience
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journal_title:Frontiers in cellular neuroscience
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Frontiers in cellular neuroscience
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pub_type: 杂志文章
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doi:10.3389/fncel.2014.00125
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journal_title:Frontiers in cellular neuroscience
pub_type: 杂志文章
doi:10.3389/fncel.2013.00039
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pub_type: 杂志文章
doi:10.3389/fncel.2020.00194
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abstract::Sections from the middle frontal gyrus (Brodmann area 46) of autopsy-confirmed Alzheimer's disease (AD) patients and non-demented subjects were examined for the prevalence of hallmark AD pathology, including amyloid-β (Aβ) plaques, phosphorylated tau (pTau) tangles, neuroinflammation and synaptic loss (n = 7 subjects/...
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journal_title:Frontiers in cellular neuroscience
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doi:10.3389/fncel.2018.00230
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
doi:10.3389/fncel.2014.00201
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