Glia in the cytokine-mediated onset of depression: fine tuning the immune response.

abstract：:The N-methyl-D-aspartate receptors (NMDARs) are part of a large multiprotein complex at the glutamatergic synapse. The assembly of NMDARs with synaptic proteins offers a means to regulate NMDAR channel properties and receptor trafficking, and couples NMDAR activation to distinct intracellular signaling pathways, thus ...

journal_title：Frontiers in cellular neuroscience

authors： Fan X,Jin WY,Wang YT

更新日期：2014-06-10 00:00:00

abstract：:It has been shown that matrix metalloproteinase 9 (MMP-9) is required for synaptic plasticity, learning and memory. In particular, MMP-9 involvement in long-term potentiation (LTP, the model of synaptic plasticity) in the hippocampus and prefrontal cortex has previously been demonstrated. Recent data suggest the role ...

journal_title：Frontiers in cellular neuroscience

authors： Gorkiewicz T,Balcerzyk M,Kaczmarek L,Knapska E

更新日期：2015-03-11 00:00:00

abstract：:The complex and elaborate architecture of a neuron poses a great challenge to the cellular machinery which localizes proteins and organelles, such as mitochondria, to necessary locations. Proper mitochondrial localization in neurons is particularly important as this organelle provides energy and metabolites essential ...

journal_title：Frontiers in cellular neuroscience

authors： Mandal A,Drerup CM

更新日期：2019-08-09 00:00:00

abstract：:Glia, a non-excitable cell type once considered merely as the connective tissue between neurons, is nowadays acknowledged for its essential contribution to multiple physiological processes including learning, memory formation, excitability, synaptic plasticity, ion homeostasis, and energy metabolism. Moreover, as glia...

journal_title：Frontiers in cellular neuroscience

authors： Stevenson R,Samokhina E,Rossetti I,Morley JW,Buskila Y

更新日期：2020-08-21 00:00:00

abstract：:Schwann cells (SCs) are one of the most promising cellular candidates for the treatment of spinal cord injury. However, SCs show poor migratory ability within the astrocyte-rich central nervous system (CNS) environment and exhibit only limited integration with host astrocytes. Our strategy for improving the therapeuti...

journal_title：Frontiers in cellular neuroscience

authors： Huang L,Xia B,Liu Z,Cao Q,Huang J,Luo Z

更新日期：2017-03-28 00:00:00

abstract：:Gastrointestinal (GI) pain is a common clinical problem, for which effective therapy is quite limited. Sensations from the GI tract, including pain, are mediated largely by neurons in the dorsal root ganglia (DRG), and to a smaller extent by vagal afferents emerging from neurons in the nodose/jugular ganglia. Neurons ...

journal_title：Frontiers in cellular neuroscience

authors： Hanani M

更新日期：2015-10-13 00:00:00

abstract：:Recent advances in single-cell technologies are paving the way to a comprehensive understanding of the cellular complexity in the brain. Protocols for single-cell transcriptomics combine a variety of sophisticated methods for the purpose of isolating the heavily interconnected and heterogeneous neuronal cell types in ...

journal_title：Frontiers in cellular neuroscience

authors： Ho H,Both M,Siniard A,Sharma S,Notwell JH,Wallace M,Leone DP,Nguyen A,Zhao E,Lee H,Zwilling D,Thompson KR,Braithwaite SP,Huentelman M,Portmann T

更新日期：2018-06-15 00:00:00

abstract：:The neuronal potassium-chloride co-transporter 2 [indicated thereafter as KCC2 (for protein) and Kcc2 (for gene)] is thought to play an important role in the post natal excitatory to inhibitory switch of GABA actions in the rodent hippocampus. Here, by studying hippocampi of wild-type (Kcc2(+/+)) and Kcc2 deficient (K...

journal_title：Frontiers in cellular neuroscience

authors： Khalilov I,Chazal G,Chudotvorova I,Pellegrino C,Corby S,Ferrand N,Gubkina O,Nardou R,Tyzio R,Yamamoto S,Jentsch TJ,Hübner CA,Gaiarsa JL,Ben-Ari Y,Medina I

更新日期：2011-11-01 00:00:00

abstract：:Understanding non-stationary neuronal activity as seen in vivo requires estimation of both excitatory and inhibitory synaptic conductances from a single trial of recording. For this purpose, we propose a new intracellular recording method, called "firing clamp." Synaptic conductances are estimated from the characteris...

journal_title：Frontiers in cellular neuroscience

authors： Chizhov AV,Malinina E,Druzin M,Graham LJ,Johansson S

更新日期：2014-03-27 00:00:00

abstract：:Intrastriatal transplantation of fetal human ventral mesencephalic dopaminergic neurons is an experimental therapy for patients suffering from Parkinson's disease. The success of this approach depends on several host brain parameters including neurotrophic factors and growth inhibitors that guide survival and integrat...

journal_title：Frontiers in cellular neuroscience

authors： Seiler S,Di Santo S,Andereggen L,Widmer HR

更新日期：2017-05-26 00:00:00

abstract：:Anabolic-androgenic steroids (AAS) are lipophilic hormones often taken in excessive quantities by athletes and bodybuilders to enhance performance and increase muscle mass. AAS exert well known toxic effects on specific cell and tissue types and organ systems. The attention that androgen abuse has received lately shou...

journal_title：Frontiers in cellular neuroscience

authors： Basile JR,Binmadi NO,Zhou H,Yang YH,Paoli A,Proia P

更新日期：2013-05-09 00:00:00

abstract：:Background: Non-alcoholic fatty liver disease (NAFLD) is a common liver condition characterized by a significant accumulation of lipids in the liver without excessive alcohol consumption. Accumulating evidence suggests a significantly increased risk of intracerebral hemorrhage (ICH) in NAFLD patients. However, it rema...

journal_title：Frontiers in cellular neuroscience

authors： Li X,Cheng X,Wang X,Liu Q,Ma H,Li M

更新日期：2020-06-08 00:00:00

abstract：:Functional maturation of visual cortex is linked with dynamic changes in synaptic expression of GABAergic mechanisms. These include setting the excitation-inhibition balance required for experience-dependent plasticity, as well as, intracortical inhibition underlying development and aging of receptive field properties...

journal_title：Frontiers in cellular neuroscience

authors： Pinto JG,Hornby KR,Jones DG,Murphy KM

更新日期：2010-06-10 00:00:00

abstract：:Autoreactive T cells that infiltrate into the central nervous system (CNS) are believed to have a significant role in mediating the pathology of neuroinflammatory diseases like multiple sclerosis. Their interaction with microglia and astrocytes in the CNS is crucial for the regulation of neuroinflammatory processes. O...

journal_title：Frontiers in cellular neuroscience

authors： Prajeeth CK,Dittrich-Breiholz O,Talbot SR,Robert PA,Huehn J,Stangel M

更新日期：2018-10-10 00:00:00

abstract：:The motor symptoms of Parkinson's disease (PD) result from striatal dopamine (DA) deficiency due to a progressive degeneration of nigral dopaminergic cells. Although DA replacement therapy is the mainstay to treat parkinsonian symptoms, a long-term daily administration of levodopa often develops levodopa-induced dyski...

journal_title：Frontiers in cellular neuroscience

authors： Goto S

更新日期：2017-11-21 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease manifested by progressive muscle atrophy and paralysis due to the loss of upper and lower motoneurons (MN). Spasticity appears in ALS patients leading to further disabling consequences. Loss of the inhibitory tone induced by downregulation of the potas...

journal_title：Frontiers in cellular neuroscience

authors： Mòdol L,Mancuso R,Alé A,Francos-Quijorna I,Navarro X

更新日期：2014-01-24 00:00:00

abstract：:Hybridization of sympatric closely related species may sometimes lead to introgression and speciation. The sister species Helicoverpa armigera and Helicoverpa assulta both use (Z)-11-hexadecenal and (Z)-9-hexadecenal as sex pheromone components but in reversed ratios. Female H. armigera and male H. assulta could hybri...

journal_title：Frontiers in cellular neuroscience

authors： Xu M,Dong JF,Wu H,Zhao XC,Huang LQ,Wang CZ

更新日期：2017-01-10 00:00:00

abstract：:The Hessian fly, Mayetiola destructor Say (Diptera, Cecidomyiidae), is a pest of wheat and belongs to a group of gall-inducing herbivores. This species has a unique life history and several ecological features that differentiate it from other Diptera such as Drosophila melanogaster and blood-feeding mosquitoes. These ...

journal_title：Frontiers in cellular neuroscience

authors： Andersson MN,Corcoran JA,Zhang DD,Hillbur Y,Newcomb RD,Löfstedt C

更新日期：2016-09-07 00:00:00

abstract：:Epilepsy is a common neurological disorder characterized by recurrent uncontrolled seizures and has an idiopathic "genetic" etiology or a symptomatic "acquired" component. Genetic studies have revealed that many epilepsy susceptibility genes encode ion channels, including voltage-gated sodium, potassium and calcium ch...

journal_title：Frontiers in cellular neuroscience

authors： van Loo KMJ,Becker AJ

更新日期：2020-01-14 00:00:00

abstract：:Genetic anomalies on the JNK pathway confer susceptibility to autism spectrum disorders, schizophrenia, and intellectual disability. The mechanism whereby a gain or loss of function in JNK signaling predisposes to these prevalent dendrite disorders, with associated motor dysfunction, remains unclear. Here we find that...

journal_title：Frontiers in cellular neuroscience

authors： Komulainen E,Zdrojewska J,Freemantle E,Mohammad H,Kulesskaya N,Deshpande P,Marchisella F,Mysore R,Hollos P,Michelsen KA,Mågard M,Rauvala H,James P,Coffey ET

更新日期：2014-09-12 00:00:00

abstract：:To find satisfactory treatment strategies for neuropathic pain syndromes, the cellular mechanisms should be illuminated. Central sensitization is a generator of pain hypersensitivity, and is mainly reflected in neuronal hyperexcitability in pain pathway. Neuronal excitability depends on two components, the synaptic in...

journal_title：Frontiers in cellular neuroscience

authors： Yang Z,Tan Q,Cheng D,Zhang L,Zhang J,Gu EW,Fang W,Lu X,Liu X

更新日期：2018-11-21 00:00:00

abstract：:Neurodegenerative disorders such as Parkinson's (PD) and Huntington's disease (HD) are characterized by a selective detrimental impact on neurons in a specific brain area. Currently, these diseases have no cures, although some promising trials of therapies that may be able to slow the loss of brain cells are underway....

journal_title：Frontiers in cellular neuroscience

authors： Salado-Manzano C,Perpiña U,Straccia M,Molina-Ruiz FJ,Cozzi E,Rosser AE,Canals JM

更新日期：2020-08-11 00:00:00

abstract：:Biologically relevant large-scale computational models currently represent one of the main methods in neuroscience for studying information processing primitives of brain areas. However, biologically realistic neuron models tend to be computationally heavy and thus prevent these models from being part of brain-area mo...

journal_title：Frontiers in cellular neuroscience

authors： Marín M,Sáez-Lara MJ,Ros E,Garrido JA

更新日期：2020-07-14 00:00:00

abstract：:Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder with a high prevalence rate. The core symptoms of ASD patients are impaired social communication and repetitive behavior. Genetic and environmental factors contribute to pathophysiology of ASD. Regarding environmental risk factors, it is kno...

journal_title：Frontiers in cellular neuroscience

authors： Kuo HY,Liu FC

更新日期：2018-11-20 00:00:00

abstract：:Neural stem cells in the subventricular zone (SVZ) of the lateral ventricle of adult rodent brain generate oligodendrocyte progenitor cells (OPCs) that disperse throughout the corpus callosum and striatum where some of OPCs differentiate into mature oligodendrocytes. Studies in animal models of stroke demonstrate that...

journal_title：Frontiers in cellular neuroscience

authors： Zhang R,Chopp M,Zhang ZG

更新日期：2013-10-29 00:00:00

abstract：:MicroRNA (miR)-210 is the most consistently and predominantly up-regulated miR in response to hypoxia in multiple cancer cells. The roles of miR-210 in rat adrenal gland pheochromocytoma (PC-12) cells remain unknown. We aimed to explore the possible effect of miR-210 in neonatal brain injury. We explored the potential...

journal_title：Frontiers in cellular neuroscience

authors： Luan Y,Zhang X,Zhang Y,Dong Y

更新日期：2017-09-22 00:00:00

abstract：:The dopamine transporter (DAT) is a plasma membrane protein responsible for the uptake of released dopamine back to the presynaptic terminal and ending dopamine neurotransmission. The DAT is the molecular target for cocaine and amphetamine as well as a number of pathological conditions including autism spectrum disord...

journal_title：Frontiers in cellular neuroscience

authors： Cartier E,Garcia-Olivares J,Janezic E,Viana J,Moore M,Lin ML,Caplan JL,Torres G,Kim YH

更新日期：2019-02-08 00:00:00

abstract：:Synapses undergo rapid activity-dependent plasticity to store information, which when left uncompensated can lead to destabilization of neural function. It has been well documented that homeostatic changes, which operate at a slower time scale, are required to maintain stability of neural networks. While there are man...

journal_title：Frontiers in cellular neuroscience

authors： Lee HK,Kirkwood A

更新日期：2019-12-03 00:00:00

abstract：:Chronic stress is a risk factor for the development of psychiatric disorders, some of which involve dysfunction of the prefrontal cortex (PFC). There is a higher prevalence of these chronic stress-related psychiatric disorders during adolescence, when the PFC has not yet fully matured. In the present work we studied t...

journal_title：Frontiers in cellular neuroscience

authors： Negrón-Oyarzo I,Dagnino-Subiabre A,Muñoz Carvajal P

更新日期：2015-11-12 00:00:00

abstract：:Stem cell research depends on extensive in vitro research. Poly-D-lysine (PDL) and polyornithine (PornT) are chemically synthesized amino acid chains promoting cell adhesion to solid substrates. Although, PDL and PornT are extensively used, there is no common agreement regarding the most optimal substance and its conc...

journal_title：Frontiers in cellular neuroscience

authors： Sanchez-Mendoza EH,Schlechter J,Hermann DM,Doeppner TR

更新日期：2016-03-07 00:00:00