Abstract:
BACKGROUND:Recently, human leukocyte antigen (HLA) class-II gene polymorphisms have been reported to be related to Hepatitis C virus (HCV) infection and chronicity. The objective of this study was to explore the relationship of HLA-DP rs9277535 and HLA-DQ rs7453920 with the outcomes of HCV infection. METHODS:The rs9277535 and rs7453920 were genotyped in 370 subjects with chronic HCV infection, 194 subjects with spontaneous HCV clearance, and 973 subjects with non-HCV infection from the Chinese population using the ABI TaqMan allelic discrimination assay. RESULTS:Logistic regression analyses showed that the minor allele A of rs7453920 significantly increased the susceptibility of HCV infection in dominant model (adjusted OR = 1.33, 95% CI: 1.04-1.71, P = 0.026) and additive models (adjusted OR = 1.30, 95% CI: 1.06-1.60, P = 0.012). Rs9277535 A allele significantly increased the risk of chronic HCV infection in dominant model (adjusted OR = 1.52, 95% CI: 1.01-2.28, P = 0.046). Haplotype AA showed a higher risk of HCV infection than the most frequent haplotype GG (adjusted OR = 1.37, 95% CI: 1.05-1.78, P = 0.018). CONCLUSION:The HLA-DQ rs7453920 and -DP rs9277535 mutations were significantly associated with HCV infection susceptibility and chronicity, respectively.
journal_name
Virol Jjournal_title
Virology journalauthors
Huang P,Fan H,Tian T,Liao P,Li J,Yu R,Xia X,Feng Y,Wang J,Liu Y,Zhang Y,Yue Mdoi
10.1186/s12985-017-0901-7subject
Has Abstractpub_date
2017-12-06 00:00:00pages
235issue
1issn
1743-422Xpii
10.1186/s12985-017-0901-7journal_volume
14pub_type
杂志文章相关文献
Virology Journal文献大全abstract:BACKGROUND:Most of the non-B HIV-1 subtypes are predominant in Sub-Saharan Africa and India although they have been found worldwide. In the last decade, immigration from these areas has increased considerably in Spain. The objective of this study was to evaluate the prevalence of non-B subtypes circulating in a cohort ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-416
更新日期:2011-08-26 00:00:00
abstract:BACKGROUND:Farmington virus (FARV) is a rhabdovirus that was isolated from a wild bird during an outbreak of epizootic eastern equine encephalitis on a pheasant farm in Connecticut, USA. FINDINGS:Analysis of the nearly complete genome sequence of the prototype CT AN 114 strain indicates that it encodes the five canoni...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-219
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:The gut microbiome is closely associated with the health of the host; although the interaction between the bacterial microbiome and the whole virome has rarely been studied, it is likely of medical importance. Examination of the interactions between the gut bacterial microbiome and virome of rhesus monkey wo...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-019-1211-z
更新日期:2019-08-19 00:00:00
abstract:BACKGROUND:Chronic HCV is one of the major causes of morbidity and mortality in the present day world. The assessment of disease progression not only provides useful information for diagnosis and therapeutic supervision judgment but also for monitoring disease. Different invasive and non invasive methods are applied to...
journal_title:Virology journal
pub_type: 杂志文章,评审
doi:10.1186/1743-422X-8-53
更新日期:2011-02-08 00:00:00
abstract::Papillomaviruses (PVs) are associated with the development of neoplasias and have been found in several different species, most of them in humans and other mammals. We identified, cloned and sequenced PV DNA from pigmented papilloma-like lesions of a diamond python (Morelia spilota spilota). This represents the first ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-436
更新日期:2011-09-12 00:00:00
abstract:BACKGROUND:Since avian-origin H3N2 canine influenza virus (CIV) was first identified in South Korea in 2008, the novel influenza virus has been reported in several countries in Asia. Reverse zoonotic transmission of pandemic H1N1 (2009) influenza virus (pH1N1) has been observed in a broad range of animal species. Viral...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-015-0343-z
更新日期:2015-09-04 00:00:00
abstract:BACKGROUND:The deciphering of cellular networks to determine susceptibility to infection by HIV or the related simian immunodeficiency virus (SIV) is a major challenge in infection biology. RESULTS:Here, we have compared gene expression profiles of a human CD4+ T cell line at 24 h after infection with a cell line of t...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-11-152
更新日期:2014-08-27 00:00:00
abstract:BACKGROUND:Human papillomavirus (HPV) bivalent and quadrivalent vaccines have been widely implemented in worldwide organized immunization programs. A nonavalent HPV vaccine is now available in several countries. The objective was to describe the fraction of squamous non-invasive high-grade cervical intraepithelial lesi...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-017-0879-1
更新日期:2017-11-06 00:00:00
abstract:BACKGROUND:Saffold Virus (SAFV) is a human cardiovirus that is suspected of causing infection of the central nervous system (CNS) in children. While recent animal studies have started to elucidate the pathogenesis of SAFV, very little is known about the mechanisms behind it. METHOD:In this study, we attempted to eluci...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-016-0654-8
更新日期:2016-11-25 00:00:00
abstract::From April 2007 to March 2008, cloacal swabs were obtained from 246 casualty raptors recovered by various wildlife rehabilitation centers in the United States. The swabs were placed in a virus transport medium and transported to the laboratory on ice packs. At the laboratory, the samples were pooled with each pool con...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-174
更新日期:2010-07-28 00:00:00
abstract:AIM:To evaluate the efficacy and safety of Entecavir (ETV) plus adefovir (ADV) for chronic hepatitis B (CHB) patients after multiple nucleos(t)ide analogue (NAs) failure treatment. METHODS:Hepatitis B e antigen (HBeAg)-positive patients who had a suboptimal response or developed resistance to two or more previous NAs ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-162
更新日期:2013-05-25 00:00:00
abstract:BACKGROUND:The threat of recurring influenza pandemics caused by new viral strains and the occurrence of escape mutants necessitate the search for potent therapeutic targets. The dependence of viruses on cellular factors provides a weak-spot in the viral multiplication strategy and a means to interfere with viral multi...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-108
更新日期:2010-05-26 00:00:00
abstract:BACKGROUND:A novel reassortant H7N9 influenza A virus has crossed the species barrier from poultry to cause human infections in China in 2013 and 2014. Rapid detection of the novel H7N9 virus is important to detect this virus in poultry and reduce the risk of an epidemic in birds or humans. FINDINGS:In this study, a m...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-015-0300-x
更新日期:2015-04-30 00:00:00
abstract:BACKGROUND:Zika virus (ZIKV) is a major human pathogen and member of the Flavivirus genus. Previous studies have identified neutralizing antibodies from Zika patients that bind to quaternary epitopes across neighboring envelope (E) proteins, called E dimer epitopes (EDE). An asparagine-linked glycan on the "glycan loop...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-020-01313-1
更新日期:2020-03-31 00:00:00
abstract:BACKGROUND:Viruses that are incorporating host cell proteins might trigger autoimmune diseases. It is therefore of interest to identify possible host proteins associated with viruses, especially for enveloped viruses that have been suggested to play a role in autoimmune diseases, like human herpesvirus 6A (HHV-6A) in m...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-4-101
更新日期:2007-10-19 00:00:00
abstract:: Previously, we explored the epidemic pattern and molecular characterization of enteroviruses isolated in Chungnam, Korea from 2005 to 2006. The present study extended these observations to 2008 and 2009. In this study, enteroviruses showed similar seasonal prevalent pattern from summer to fall and age distribution to...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-297
更新日期:2011-06-13 00:00:00
abstract:BACKGROUND:Japanese encephalitis virus (JEV) is a mosquito-borne flavivirus that causes acute viral encephalitis in humans. Pigs are important amplifier hosts of JEV. Emerging evidence indicates that host microRNAs (miRNAs) play key roles in modulating viral infection and pathogenesis. However, mechanistic studies deli...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-016-0562-y
更新日期:2016-06-21 00:00:00
abstract:BACKGROUND:Tembusu virus is a newly emerging flavivirus that caused egg-drop syndrome in ducks in China. TMUV envelope protein is a major structural protein locates at the surface of tembusu virus particle. During tembusu virus infection, envelope protein plays a pivotal role in induction of neutralizing antibody. Howe...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-018-1052-1
更新日期:2018-09-17 00:00:00
abstract:BACKGROUND:Respiratory syncytial virus (RSV), human Rhinovirus (HRV) and human Metapneumo Virus (HMPV) are important viral pathogens causing acute respiratory tract infections in the hospitalized patients. Sensitive and accurate detection of RSV, HRV and HMPV is necessary for clinical diagnosis and treatment. RESULTS:...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-018-1061-0
更新日期:2018-10-30 00:00:00
abstract:BACKGROUND:The COVID-19 causing coronavirus is an enveloped RNA virus that utilizes an enzyme RNA dependent RNA polymerase for its replication. Favipiravir (FVP) triphosphate, a purine nucleoside analog, inhibits that enzyme. We have conducted this systematic review and meta-analysis on efficacy and safety of the drug ...
journal_title:Virology journal
pub_type: 杂志文章,meta分析
doi:10.1186/s12985-020-01412-z
更新日期:2020-09-24 00:00:00
abstract:BACKGROUND:The family Mesoniviridae (order Nidovirales) comprises of a group of positive-sense, single-stranded RNA ([+]ssRNA) viruses isolated from mosquitoes. FINDINGS:Thirteen novel insect-specific virus isolates were obtained from mosquitoes collected in Indonesia, Thailand and the USA. By electron microscopy, the...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-11-97
更新日期:2014-05-20 00:00:00
abstract:BACKGROUND:Newcastle Disease (ND) is a highly contagious and economically devastating disease of poultry. At present, limited molecular epidemiological data are available regarding the causes of ND outbreaks in vaccinated commercial poultry farms. Knowing the genomic characteristics of Newcastle disease virus (NDV) inf...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-330
更新日期:2013-11-09 00:00:00
abstract:BACKGROUND:SEN virus is a blood-borne, circular ssDNA virus and possessing nine genotypes (A to I). Among nine genotypes, SENV-D and SENV-H genotypes have the strong link with patients with unknown (none-A to E) hepatitis infections. Infection with blood-borne viruses is the second important cause of death in thalassem...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-1
更新日期:2010-01-02 00:00:00
abstract:BACKGROUND:The highly pathogenic porcine reproductive and respiratory syndrome virus (PRRSV) emerging in China exhibits high fatality to pigs. However, the mechanism related to the increased pathogenicity of the virus remains unclear. In the present study, the differences in tissue tropism between the highly pathogenic...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-9-203
更新日期:2012-09-17 00:00:00
abstract:BACKGROUND:Early in infection, the genome of the influenza A virus, consisting of eight complexes of RNA and proteins (termed viral ribonucleoproteins; vRNPs), enters the nucleus of infected cells for replication. Incoming vRNPs are imported into the nucleus of infected cells using at least two nuclear localization seq...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-6-68
更新日期:2009-06-02 00:00:00
abstract:BACKGROUND:Influenza virus infections are responsible for significant morbidity worldwide and therefore it remains a high priority to develop more broadly protective vaccines. Adjuvation of current seasonal influenza vaccines has the potential to achieve this goal. METHODS:To assess the immune potentiating properties ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-015-0435-9
更新日期:2015-12-08 00:00:00
abstract:BACKGROUND:Longitudinal mark-recapture studies of rodents in two sites in the Mbaracayú Biosphere Reserve in the Interior Atlantic Forest of eastern Paraguay have revealed a complex and intriguing pattern of hantaviruses harbored by rodents in this area. Full-length sequencing and phylogenetic analyses were conducted f...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-399
更新日期:2011-08-12 00:00:00
abstract:BACKGROUND:Infection with hepatitis B virus (HBV) is major public health concern. The limitations of available antiviral drugs require development of novel approaches to inhibit HBV replication. This study was conducted to identify functional elements and new siRNA target sites within the highly conserved regions of th...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-216
更新日期:2010-09-08 00:00:00
abstract:BACKGROUND:T4 phage is a model species that has contributed broadly to our understanding of molecular biology. T4 DNA replication and packaging share various mechanisms with human double-stranded DNA viruses such as herpes virus. The literature indicates that T4-like phage genomes have permuted terminal sequences, and ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-194
更新日期:2011-04-27 00:00:00
abstract:BACKGROUND:Sequence and structural elements in the 3'-untranslated region (UTR) of Japanese encephalitis virus (JEV) are known to regulate translation and replication. We previously reported an abundant accumulation of small subgenomic flaviviral RNA (sfRNA) which is collinear with the highly conserved regions of the 3...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-492
更新日期:2011-11-01 00:00:00