Abstract:
:Papillomaviruses (PVs) are associated with the development of neoplasias and have been found in several different species, most of them in humans and other mammals. We identified, cloned and sequenced PV DNA from pigmented papilloma-like lesions of a diamond python (Morelia spilota spilota). This represents the first complete PV genome discovered in a Squamata host (MsPV1). It consists of 7048 nt and contains the characteristic open reading (ORF) frames E6, E7, E1, E2, L1 and L2. The L1 ORF sequence showed the highest percentage of sequence identities to human PV5 (57.9%) and Caribbean manatee (Trichechus manatus) PV1 (55.4%), thus, establishing a new clade. According to phylogenetic analysis, the MsPV1 genome clusters with PVs of mammalian rather than sauropsid hosts.
journal_name
Virol Jjournal_title
Virology journalauthors
Lange CE,Favrot C,Ackermann M,Gull J,Vetsch E,Tobler Kdoi
10.1186/1743-422X-8-436subject
Has Abstractpub_date
2011-09-12 00:00:00pages
436issn
1743-422Xpii
1743-422X-8-436journal_volume
8pub_type
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