Novel snake papillomavirus does not cluster with other non-mammalian papillomaviruses.

Abstract:

:Papillomaviruses (PVs) are associated with the development of neoplasias and have been found in several different species, most of them in humans and other mammals. We identified, cloned and sequenced PV DNA from pigmented papilloma-like lesions of a diamond python (Morelia spilota spilota). This represents the first complete PV genome discovered in a Squamata host (MsPV1). It consists of 7048 nt and contains the characteristic open reading (ORF) frames E6, E7, E1, E2, L1 and L2. The L1 ORF sequence showed the highest percentage of sequence identities to human PV5 (57.9%) and Caribbean manatee (Trichechus manatus) PV1 (55.4%), thus, establishing a new clade. According to phylogenetic analysis, the MsPV1 genome clusters with PVs of mammalian rather than sauropsid hosts.

journal_name

Virol J

journal_title

Virology journal

authors

Lange CE,Favrot C,Ackermann M,Gull J,Vetsch E,Tobler K

doi

10.1186/1743-422X-8-436

subject

Has Abstract

pub_date

2011-09-12 00:00:00

pages

436

issn

1743-422X

pii

1743-422X-8-436

journal_volume

8

pub_type

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