The full genome sequence of three strains of Jamestown Canyon virus and their pathogenesis in mice or monkeys.

abstract：BACKGROUND:The avian influenza virus (AIV) causes frequent disease with high morbidity and mortality. RNA interference (RNAi) has been shown to provide an effective antiviral defense in animals, and several studies have focused on harnessing small interfering RNAs (siRNAs) to inhibit viral infections. In addition, sing...

journal_title：Virology journal

authors： Wang S,Zhang P,He F,Wang JG,Sun JZ,Li ZL,Yi B,Xi J,Mao YP,Hou Q,Yuan DL,Zhang ZD,Liu WQ

更新日期：2014-11-29 00:00:00

abstract：BACKGROUND:Rodent borne hantaviruses are emerging viruses infecting humans through inhalation. They cause hemorrhagic fever with renal syndrome and hemorrhagic cardiopulmonary syndrome. Recently, hantaviruses have been detected in other small mammals such as Soricomorpha (shrews, moles) and Chiroptera (bats), suggested...

journal_title：Virology journal

authors： Lwande OW,Mohamed N,Bucht G,Ahlm C,Olsson G,Evander M

更新日期：2020-12-29 00:00:00

abstract：BACKGROUND:Yearly influenza virus mutations potentially affect the performance of molecular assays, if nucleic acid changes involve the sequences in the assay. Because individual patient viral loads depend on variables such as duration of illness, specimen type, age, and immunosuppression, we examined seasonal populati...

journal_title：Virology journal

authors： Rand KH,Pieretti M,Arcenas R,Beal SG,Houck H,Boslet E,Lednicky JA

更新日期：2017-07-14 00:00:00

abstract：BACKGROUND:It is becoming progressively more understandable that genetic variability of viruses is a major challenge in translating the laboratory findings to clinic. Genetic variability is the underlying cause of variant viral proteins which are not targetable by host immunological machinery. METHODS:500 patients wer...

journal_title：Virology journal

authors： Kanwal S,Mahmood T

更新日期：2014-09-30 00:00:00

abstract：BACKGROUND:Integrase (IN) is an essential protein for HIV replication that catalyzes insertion of the reverse-transcribed viral genome into the host chromosome during the early steps of viral infection. Highly active anti-retroviral therapy is a HIV/AIDS treatment method that combines three or more antiviral drugs ofte...

journal_title：Virology journal

authors： Park KH,Kim M,Bae SE,Lee HJ,Kim KC,Choi BS,Kim YB

更新日期：2021-01-13 00:00:00

abstract：BACKGROUND:Chronic viral hepatitis B remains a global public health concern. Currently, several drugs, such as lamivudine and telbivudine, are recommended for treatment of patients with chronic hepatitis B. However, there are no conclusive results on the comparison of the efficacy of lamivudine (LAM) and telbivudine (L...

journal_title：Virology journal

authors： Zhao S,Tang L,Fan X,Chen L,Zhou R,Dai X

更新日期：2010-09-03 00:00:00

abstract：BACKGROUND:One requisite of quantitative reverse transcription PCR (qRT-PCR) is to normalise the data with an internal reference gene that is invariant regardless of treatment, such as virus infection. Several studies have found variability in the expression of commonly used housekeeping genes, such as beta-actin (ACTB...

journal_title：Virology journal

authors： Kuchipudi SV,Tellabati M,Nelli RK,White GA,Perez BB,Sebastian S,Slomka MJ,Brookes SM,Brown IH,Dunham SP,Chang KC

更新日期：2012-10-08 00:00:00

abstract：:HIV expressed in genital secretions provides the inoculum from which transmitting variants are selected, both in sexual transmission and mother-to-infant transmission during partuition. Characterization of HIV levels and genotypes found in vaginal secretions and the impact of anti-retroviral therapy (ART) on this viru...

journal_title：Virology journal

authors： Randolph TC,Kissinger PJ,Clark RA,Lacour N,Amedee AM

更新日期：2008-07-29 00:00:00

abstract：:Here we report the case of a 54-year old, immunocompetent German patient with primary varicella whose Varicella-Zoster Virus (VZV)-specific T-cell responses could be detected early in infection and before the onset of seroconversion. This case demonstrates that the detection of VZV-specific T-cells may under certain c...

journal_title：Virology journal

authors： Baiker A,Haase R,Eberle J,Vizoso Pinto MG,Pfrepper KI,Petrich A,Deml L,Campe H,Nitschko H,Jaeger G

更新日期：2010-03-06 00:00:00

abstract：BACKGROUND:The effect of antiviral therapy in chronic hepatitis B (CHB) on reducing the risk of long-term complications (LTCs) remains unclear so far. To study whether long-term nucleos(t)ide analogues therapy can reduce the risk of long-term complications. METHODS:We searched MEDLINE, EMBASE, OVID, the Cochrane Centr...

journal_title：Virology journal

authors： Zhang QQ,An X,Liu YH,Li SY,Zhong Q,Wang J,Hu HD,Zhang DZ,Ren H,Hu P

更新日期：2011-02-15 00:00:00

abstract：BACKGROUND:Open reading frame 58 (ORF58) of varicella-zoster virus (VZV) lies at the 3'end of the Unique long (UL) region and its functional is unknown. In order to clarify whether ORF58 is essential for the growth of VZV, we constructed a deletion mutant of ORF58 (pOka-BACDelta58) from the Oka parental genome cloned i...

journal_title：Virology journal

authors： Yoshii H,Sadaoka K,Matsuura M,Nagaike K,Takahashi M,Yamanishi K,Mori Y

更新日期：2008-04-30 00:00:00

abstract：BACKGROUND:Respiratory syncytial virus (RSV) is the leading viral pathogen associated with bronchiolitis and lower respiratory tract disease in infants and young children worldwide. The respiratory epithelium is the primary initiator of pulmonary inflammation in RSV infections, which cause significant perturbations of ...

journal_title：Virology journal

authors： Zhao D,Peng D,Li L,Zhang Q,Zhang C

更新日期：2008-10-06 00:00:00

abstract：BACKGROUND:Construction of conditionally-replicative Adenovirus (CRAd) is complex and time-consuming. While homologous recombination (HR) using a two-plasmid system in bacteria is commonly used to generate CRAds, alternative methods may be required when HR fails. Previously, in vitro ligation has been suggested to faci...

journal_title：Virology journal

authors： Haviv YS

更新日期：2009-02-07 00:00:00

abstract：BACKGROUND:Cell culture adaptation of very virulent infectious bursal disease virus (vvIBDV) was shown to be mainly associated with the VP2 capsid protein residues 253, 279, and 284. The single mutation A284T proved critical for cell culture tropism, but did not confer efficient virus replication, which at least requir...

journal_title：Virology journal

authors： Ben Abdeljelil N,Khabouchi N,Kassar S,Miled K,Boubaker S,Ghram A,Mardassi H

更新日期：2014-11-25 00:00:00

abstract：BACKGROUND:Influenza A virus evolution in humans is driven at least in part by mutations allowing the virus to escape antibody neutralization. Little is known about the evolution of influenza in birds, a major reservoir of influenza A. METHODS:Neutralizing polyclonal antiserum was raised in chicken against reassortant...

journal_title：Virology journal

authors： Thangavel RR,Reed A,Norcross EW,Dixon SN,Marquart ME,Stray SJ

更新日期：2011-04-18 00:00:00

abstract：:Hairpin RNAs have been used to confer resistance to viruses in plants through RNA silencing. However, it has not been demonstrated that RNA silencing was effective against inoculation by aphids of non-persistently transmitted viruses, the major route of plant virus spread in nature. As a proof-of-principle strategy, w...

journal_title：Virology journal

authors： Vargas M,Martínez-García B,Díaz-Ruíz JR,Tenllado F

更新日期：2008-03-19 00:00:00

abstract：BACKGROUND:Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by SFTS bunyavirus (SFTSV), a tick borne bunyavirus. However, Immunohistochemistry of SFTS patients are not well studied. METHODS:We obtained multiple of tissues from a fatal case with SFTS, including blood, lungs, k...

journal_title：Virology journal

authors： Li S,Li Y,Wang Q,Yu X,Liu M,Xie H,Qian L,Ye L,Yang Z,Zhang J,Zhu H,Zhang W

更新日期：2018-05-30 00:00:00

abstract：BACKGROUND:Reporting new cases of enterovirus (EV)-D68-associated acute flaccid myelitis (AFM) is essential to understand how the virus causes neurological damage and to characterize EV-D68 strains associated with AFM. CASE PRESENTATION:A previously healthy 4-year-old boy presented with sudden weakness and limited mob...

journal_title：Virology journal

authors： Esposito S,Chidini G,Cinnante C,Napolitano L,Giannini A,Terranova L,Niesters H,Principi N,Calderini E

更新日期：2017-01-11 00:00:00

abstract：BACKGROUND:Foot-and-mouth disease (FMD) is a highly contagious disease of livestock which causes severe economic loss in cloven-hoofed animals. Vaccination is still a major strategy in developing countries to control FMD. Currently, inactivated vaccine of FMDV has been used in many countries with limited success and sa...

journal_title：Virology journal

authors： Cao Y,Lu Z,Sun P,Fu Y,Tian F,Hao X,Bao H,Liu X,Liu Z

更新日期：2011-02-23 00:00:00

abstract：BACKGROUND:Crimean-Congo Hemorrhagic Fever virus (CCHFV), a member of the genus Nairovirus, family Bunyaviridae, is a tick-borne pathogen causing severe disease in humans. To better understand the CCHFV life cycle and explore potential intervention strategies, we studied the biosynthesis and intracellular targeting of ...

journal_title：Virology journal

authors： Haferkamp S,Fernando L,Schwarz TF,Feldmann H,Flick R

更新日期：2005-04-25 00:00:00

abstract：BACKGROUND:Porcine circovirus type-2b (PCV2b) is recognized as the etiological agent of the various clinical manifestations of porcine circovirus-associated disease (PCVAD). Previous studies have demonstrated effectiveness of chimeric PCV1-2 vaccines against PCV2b challenge. In this study, the efficacy of inactivated a...

journal_title：Virology journal

authors： Li J,Yu T,Wang X,Zhou J,Gao R,Zhang F,Gao X,Gao S,Liu X

更新日期：2015-07-30 00:00:00

abstract：:The Filoviridae family comprises of Ebola and Marburg viruses, which are known to cause lethal hemorrhagic fever. However, there is no effective anti-viral therapy or licensed vaccines currently available for these human pathogens. The envelope glycoprotein (GP) of Ebola virus, which mediates entry into target cells, ...

journal_title：Virology journal

authors： Bhattacharyya S,Hope TJ

更新日期：2011-01-12 00:00:00

abstract：BACKGROUND:Hepatitis C virus roots a chronic liver disease. Currently approved treatment strategy includes administration of alpha interferon and ribavirin combined therapy for 24-48 weeks. One of the predictor of sustained virological response is an early virological response to treatment characterized as rapid respon...

journal_title：Virology journal

authors： Akram M,Idrees M,Hussain A,Afzal S,Ilyas M,Zafar S,Aftab M,Badar S,Khubaib B

更新日期：2011-05-23 00:00:00

abstract：BACKGROUND:Subviral particles of hepatitis B virus (HBV) composed of L protein deletion variants with the 48 N-terminal amino acids of preS joined to the N-terminus of S protein (1-48preS/S) induced broadly neutralizing antibodies after immunization of mice with a Semliki Forest virus vector. A practical limitation for...

journal_title：Virology journal

authors： Niedre-Otomere B,Bogdanova A,Bruvere R,Ose V,Gerlich WH,Pumpens P,Glebe D,Kozlovska T

更新日期：2013-02-25 00:00:00

abstract：:Dengue virus (DENV) is a mosquito-borne virus that has four serotypes. Collection of serum from patients is time- and labor- consuming, and presents a high injury risk for infants and children. The genomic and serological diagnosis of imported dengue fever from a urine sample was used as a non-invasive diagnostic meth...

journal_title：Virology journal

authors： Ma X,Zhen W,Yang P,Sun X,Nie W,Zhang L,Xu H,Hu K

更新日期：2014-03-25 00:00:00

abstract：BACKGROUND:In China, more than 20 million patients with chronic hepatitis B need antiviral treatment. Side effects of antiviral treatment such as renal complications can be problematic, particularly in an aging population. METHODS:The data were retrospectively extracted from the hospital medical charts of five centers...

journal_title：Virology journal

authors： Gu J,Yu G,Zhang X,Zhang S,Cai H,Ye C,Yang Y,Li D,Tong Z,Shen H,Chen H,Ding F,Lai X,Liu J,Xu M,Wu W

更新日期：2021-01-13 00:00:00

abstract：BACKGROUND:RNA viruses are characterized by high rate of mutations mainly due to the lack of proofreading repair activities associated with its RNA-dependent RNA-polymerase (RdRp). In case of arboviruses, this phenomenon has lead to the existence of mixed population of genomic variants within the host called quasi-spec...

journal_title：Virology journal

authors： Jain J,Mathur K,Shrinet J,Bhatnagar RK,Sunil S

更新日期：2016-06-02 00:00:00

abstract：:Members of the genus Cypovirus (family Reoviridae) are common pathogens of insects. These viruses have linear dsRNA genomes divided into 10-11 segments, which have generally been assumed to be monocistronic. Here, bioinformatic evidence is presented for a short overlapping coding sequence (CDS) in the cypovirus genome...

journal_title：Virology journal

authors： Firth AE,Atkins JF

更新日期：2008-05-20 00:00:00

abstract：BACKGROUND:Human respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) are two of the most frequent respiratory pathogens that circulate worldwide. Infection with either virus can lead to hospitalization of young children, immunocompromised people and the elderly.A better understanding of the epidemiologi...

journal_title：Virology journal

authors： Sastre P,Ruiz T,Schildgen O,Schildgen V,Vela C,Rueda P

更新日期：2012-07-02 00:00:00

abstract：BACKGROUND:A serological method to simultaneously detect antibodies against infectious laryngotracheitis virus (ILTV) and infectious bronchitis virus (IBV) is imperative for the differential diagnosis and evaluation of antibodies titers after vaccination. METHOD:The microspheres coated with purified recombinant glycop...

journal_title：Virology journal

authors： Wang H,Cong F,Guan J,Xiao L,Zhu Y,Lian Y,Huang R,Chen M,Guo P

更新日期：2018-09-21 00:00:00