Simultaneous alteration of residues 279 and 284 of the VP2 major capsid protein of a very virulent Infectious Bursal Disease Virus (vvIBDV) strain did not lead to attenuation in chickens.

abstract：BACKGROUND:R849 is a neurovirulent γ₁34.5 gene-deficient form of herpes simplex virus type 1 (HSV-1) and has LacZ genes at the deleted sites of the γ₁34.5 gene. HF is a spontaneously occurring, fusogenic HSV-1 strain. The purpose of this work was to generate a virus that has the syncytial character of HF, while preserv...

journal_title：Virology journal

authors： Takaoka H,Takahashi G,Ogawa F,Imai T,Iwai S,Yura Y

更新日期：2011-06-10 00:00:00

abstract：BACKGROUND:The effect of antiviral therapy in chronic hepatitis B (CHB) on reducing the risk of long-term complications (LTCs) remains unclear so far. To study whether long-term nucleos(t)ide analogues therapy can reduce the risk of long-term complications. METHODS:We searched MEDLINE, EMBASE, OVID, the Cochrane Centr...

journal_title：Virology journal

authors： Zhang QQ,An X,Liu YH,Li SY,Zhong Q,Wang J,Hu HD,Zhang DZ,Ren H,Hu P

更新日期：2011-02-15 00:00:00

abstract：:Vaccinia virus protein A33 (A33VACV) plays an important role in protection against orthopoxviruses, and hence is included in experimental multi-subunit smallpox vaccines. In this study we show that single-dose vaccination with recombinant Sindbis virus expressing A33VACV, is sufficient to protect mice against lethal c...

journal_title：Virology journal

authors： Paran N,Lustig S,Zvi A,Erez N,Israely T,Melamed S,Politi B,Ben-Nathan D,Schneider P,Lachmi B,Israeli O,Stein D,Levin R,Olshevsky U

更新日期：2013-07-10 00:00:00

abstract：BACKGROUND:Human respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) are two of the most frequent respiratory pathogens that circulate worldwide. Infection with either virus can lead to hospitalization of young children, immunocompromised people and the elderly.A better understanding of the epidemiologi...

journal_title：Virology journal

authors： Sastre P,Ruiz T,Schildgen O,Schildgen V,Vela C,Rueda P

更新日期：2012-07-02 00:00:00

abstract：:The NanoSight LM10 with Nanoparticle tracking analysis (NTA) software was evaluated for the quantification of latex particles, adenovirus 5, and influenza virus. The inter-day variability was determined by measuring the same sample over several consecutive days and the method's accuracy was demonstrated by using known...

journal_title：Virology journal

authors： Kramberger P,Ciringer M,Štrancar A,Peterka M

更新日期：2012-11-12 00:00:00

abstract：:Dengue virus (DENV) is a mosquito-borne virus that has four serotypes. Collection of serum from patients is time- and labor- consuming, and presents a high injury risk for infants and children. The genomic and serological diagnosis of imported dengue fever from a urine sample was used as a non-invasive diagnostic meth...

journal_title：Virology journal

authors： Ma X,Zhen W,Yang P,Sun X,Nie W,Zhang L,Xu H,Hu K

更新日期：2014-03-25 00:00:00

abstract：BACKGROUND:The family Mesoniviridae (order Nidovirales) comprises of a group of positive-sense, single-stranded RNA ([+]ssRNA) viruses isolated from mosquitoes. FINDINGS:Thirteen novel insect-specific virus isolates were obtained from mosquitoes collected in Indonesia, Thailand and the USA. By electron microscopy, the...

journal_title：Virology journal

authors： Vasilakis N,Guzman H,Firth C,Forrester NL,Widen SG,Wood TG,Rossi SL,Ghedin E,Popov V,Blasdell KR,Walker PJ,Tesh RB

更新日期：2014-05-20 00:00:00

abstract：BACKGROUND:Host serine proteases are essential for the influenza virus life cycle because the viral haemagglutinin is synthesized as a precursor which requires proteolytic maturation. Therefore, we studied the activity and expression of serine proteases in lungs from mice infected with influenza and evaluated the effec...

journal_title：Virology journal

authors： Bahgat MM,Błazejewska P,Schughart K

更新日期：2011-01-20 00:00:00

abstract：BACKGROUND:The reovirus M1 genome segment encodes the mu2 protein, a structurally minor component of the viral core, which has been identified as a transcriptase cofactor, nucleoside and RNA triphosphatase, and microtubule-binding protein. The mu2 protein is the most poorly understood of the reovirus structural protein...

journal_title：Virology journal

authors： Yin P,Keirstead ND,Broering TJ,Arnold MM,Parker JS,Nibert ML,Coombs KM

更新日期：2004-09-23 00:00:00

abstract：BACKGROUND:Human herpes virus 8 (HHV-8) is the etiologic agent associated with development of classical, AIDS-related, iatrogenic, and endemic Kaposi's sarcoma (KS). Several studies provide strong evidence that HHV-8 can be transmitted by blood transfusion. We evaluated the seroprevalence and potential risk factors of ...

journal_title：Virology journal

authors： Wang X,He B,Zhang Z,Liu T,Wang H,Li X,Zhang Q,Lan K,Lu X,Wen H

更新日期：2010-03-17 00:00:00

abstract：BACKGROUND:Human enterovirus (EV) and parechovirus (HPeV) are significant causes of encephalitis and meningitis in children. The aim of this study was to determine the prevalence, type and viral RNA concentration of EV and HPeV in cerebrospinal fluid (CSF) samples in an unselected cohort of patients <18 years admitted ...

journal_title：Virology journal

authors： Vollbach S,Müller A,Drexler JF,Simon A,Drosten C,Eis-Hübinger AM,Panning M

更新日期：2015-11-25 00:00:00

abstract：BACKGROUND:Classical swine fever (CSF) is one of the most important viral diseases of pigs. Clinical signs may vary from almost inapparent infection to a hemorrhagic fever like illness. Among the host factors leading to different disease courses are age, breed, and immune status. The aim of this study was to compare ho...

journal_title：Virology journal

authors： Petrov A,Blohm U,Beer M,Pietschmann J,Blome S

更新日期：2014-07-29 00:00:00

abstract：BACKGROUND:Human cytomegalovirus infection is associated with a variety of pathological conditions including retinitis, pneumonia, hepatitis and encephalitis that may be transmitted congenitally, horizontally and parenterally and occurs both as a primary infection and as reactivation in immunocompromised individuals. C...

journal_title：Virology journal

authors： Burbelo PD,Issa AT,Ching KH,Exner M,Drew WL,Alter HJ,Iadarola MJ

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:An extensive outbreak of equine influenza occurred across multiple countries in South America during 2012. The epidemic was first reported in Chile then spread to Brazil, Uruguay and Argentina, where both vaccinated and unvaccinated animals were affected. In Brazil, infections were widespread within 3months ...

journal_title：Virology journal

authors： Alves Beuttemmüller E,Woodward A,Rash A,Dos Santos Ferraz LE,Fernandes Alfieri A,Alfieri AA,Elton D

更新日期：2016-03-19 00:00:00

abstract：BACKGROUND:Sheeppox (SPP) and goatpox (GTP) caused by sheeppox virus (SPPV) and goatpox virus (GTPV), respectively of the genus Capripoxvirus in the family Poxviridae, are severely afflicting small ruminants' production systems in Africa and Asia. In endemic areas, SPP and GTP are controlled using vaccination with live...

journal_title：Virology journal

authors： Chibssa TR,Grabherr R,Loitsch A,Settypalli TBK,Tuppurainen E,Nwankpa N,Tounkara K,Madani H,Omani A,Diop M,Cattoli G,Diallo A,Lamien CE

更新日期：2018-04-02 00:00:00

abstract：BACKGROUND:The genus Orbivirus includes several species that infect livestock - including Bluetongue virus (BTV) and African horse sickness virus (AHSV). These viruses have linear dsRNA genomes divided into ten segments, all of which have previously been assumed to be monocistronic. RESULTS:Bioinformatic evidence is p...

journal_title：Virology journal

authors： Firth AE

更新日期：2008-04-14 00:00:00

abstract：BACKGROUND:Double-stranded RNA (dsRNA) and its mimic, polyinosinic acid: polycytidylic acid [Poly (I:C)], are recognized by toll-like receptor 3 (TLR3) and induce interferon (IFN)-β in many cell types. Poly (I:C) is the most potent IFN inducer. In in vivo mouse studies, intraperitoneal injection of Poly (I:C) elicited ...

journal_title：Virology journal

authors： Li YG,Siripanyaphinyo U,Tumkosit U,Noranate N,A-Nuegoonpipat A,Pan Y,Kameoka M,Kurosu T,Ikuta K,Takeda N,Anantapreecha S

更新日期：2012-06-14 00:00:00

abstract：BACKGROUND:Human cytomegalovirus (HCMV) is a betaherpesvirus that causes severe disease in situations where the immune system is immature or compromised. HCMV immediate early (IE) gene expression is stimulated by the virion phosphoprotein pp71, encoded by open reading frame (ORF) UL82, and this transactivation activity...

journal_title：Virology journal

authors： Nicholson IP,Sutherland JS,Chaudry TN,Blewett EL,Barry PA,Nicholl MJ,Preston CM

更新日期：2009-05-27 00:00:00

abstract：:One coronavirus strain was isolated from brain tissues of ten piglets with evident clinical manifestations of vomiting, diarrhea and dyskinesia in Jilin province in China. Antigenic and genomic characterizations of the virus (isolate PHEV-JLsp09) were based on multiplex PCR and negative staining electron microscopy an...

journal_title：Virology journal

authors： Gao W,Zhao K,Zhao C,Du C,Ren W,Song D,Lu H,Chen K,Li Z,Lan Y,Xie S,He W,Gao F

更新日期：2011-03-21 00:00:00

abstract：AIM:To investigate the enhancement of humoral immunity when CpG ODN (cytidine phosphate guanosine oligodeoxynucleotides) and aluminium adjuvants are complexed with the HCV (Hepatitis C virus) recombinant immunogen in mice. METHODS:After immunizing Balb/c mice with the recombination HCV antigen adjuvanted with pUCpGs10...

journal_title：Virology journal

authors： Zhan N,Xiu BS,Wang GH,Chen K,Bai GZ,Song XG,Zhu CX,Dai ZH,Yang XQ,Zhang HQ

更新日期：2011-11-04 00:00:00

abstract：BACKGROUND:During the last two decades, structural biology analyses have shown that viruses infecting hosts far apart in evolution share similar architectural features, prompting a new virus classification based on structural lineages. Until recently, only a few prokaryotic viruses had been described for one of the lin...

journal_title：Virology journal

authors： San Martín C,van Raaij MJ

更新日期：2018-11-23 00:00:00

abstract：BACKGROUND:The mint family (Lamiaceae) produces a wide variety of constituents with medicinal properties. Several family members have been reported to have antiviral activity, including lemon balm (Melissa officinalis L.), sage (Salvia spp.), peppermint (Mentha×piperita L.), hyssop (Hyssopus officinalis L.), basil (Oci...

journal_title：Virology journal

authors： Oh C,Price J,Brindley MA,Widrlechner MP,Qu L,McCoy JA,Murphy P,Hauck C,Maury W

更新日期：2011-04-23 00:00:00

abstract：BACKGROUND:Enteroviruses (EVs) are the leading cause of aseptic meningitis, which is the most frequent central nervous system infection worldwide. We aimed to characterize the EVs involved in an aseptic meningitis outbreak in Korea in 2008. In Korea, Echovirus type 30 (E30) and E6 have been associated with outbreaks an...

journal_title：Virology journal

authors： Kim HJ,Kang B,Hwang S,Hong J,Kim K,Cheon DS

更新日期：2012-02-15 00:00:00

abstract：:Ten potential reference genes were compared for their use in experiments investigating cellular mRNA expression of virus infected cells. Human cell lines were infected with Cytomegalovirus, Human Herpesvirus-6, Camelpox virus, SARS coronavirus or Yellow fever virus. The expression levels of these genes and the viral r...

journal_title：Virology journal

authors： Radonić A,Thulke S,Bae HG,Müller MA,Siegert W,Nitsche A

更新日期：2005-02-10 00:00:00

abstract：BACKGROUND:Reporting new cases of enterovirus (EV)-D68-associated acute flaccid myelitis (AFM) is essential to understand how the virus causes neurological damage and to characterize EV-D68 strains associated with AFM. CASE PRESENTATION:A previously healthy 4-year-old boy presented with sudden weakness and limited mob...

journal_title：Virology journal

authors： Esposito S,Chidini G,Cinnante C,Napolitano L,Giannini A,Terranova L,Niesters H,Principi N,Calderini E

更新日期：2017-01-11 00:00:00

abstract：BACKGROUND:Rotavirus (RV) is the main cause of severe gastroenteritis in children. An effective vaccination regime against RV can substantially reduce morbidity and mortality. Previous studies have demonstrated the efficacy of virus-like particles formed by RV VP2 and VP6 (VLP2/6), as well as that of recombinant adenov...

journal_title：Virology journal

authors： Zhou H,Guo L,Wang M,Qu J,Zhao Z,Wang J,Hung T

更新日期：2011-01-05 00:00:00

abstract：BACKGROUND:Integrase (IN) is an essential protein for HIV replication that catalyzes insertion of the reverse-transcribed viral genome into the host chromosome during the early steps of viral infection. Highly active anti-retroviral therapy is a HIV/AIDS treatment method that combines three or more antiviral drugs ofte...

journal_title：Virology journal

authors： Park KH,Kim M,Bae SE,Lee HJ,Kim KC,Choi BS,Kim YB

更新日期：2021-01-13 00:00:00

abstract：BACKGROUND:During October 2010, Egypt reported an outbreak of acute hemorrhagic conjunctivitis (AHC). A total of 1831 cases were reported from three governorates; 1703 cases in El Daqahliya, 92 cases in Port Said, and 36 in Damietta. The purpose of this study was to identify and characterize the causative agent associa...

journal_title：Virology journal

authors： Ayoub EA,Shafik CF,Gaynor AM,Mohareb EW,Amin MA,Yassin AS,El-Refaey S,Genedy M,Kandeel A

更新日期：2013-03-25 00:00:00

abstract：BACKGROUND:Due to potential advantages, human adenoviral vectors have been evaluated pre-clinically as recombinant vaccine vectors against several cancers and infectious diseases, including human immunodeficiency virus (HIV) infection. The V3 loop of HIV-1 glycoprotein 120 (gp120) contains important neutralizing epitop...

journal_title：Virology journal

authors： Gu L,Krendelchtchikova V,Krendelchtchikov A,Oster RA,Fujihashi K,Matthews QL

更新日期：2014-06-16 00:00:00

abstract：BACKGROUND:Herpesviruses are ubiquitous pathogens that infect and cause recurrent disease in multiple animal species. Feline herpesvirus-1 (FHV-1), a member of the alphaherpesvirus family, causes respiratory illness and conjunctivitis, and approximately 80% of domestic cats are latently infected. Oral administration of...

journal_title：Virology journal

authors： Semenkow SL,Johnson NM,Maggs DJ,Margulies BJ

更新日期：2014-02-22 00:00:00