A novel fusogenic herpes simplex virus for oncolytic virotherapy of squamous cell carcinoma.

abstract：BACKGROUND:The pattern recognition receptors (PPRs) are the earliest phase of the host defense against pathogens in genital epithelium, and toll-like receptors (TLRs) are best characterized PPRs mediating innate immune responses. Herpes simplex virus type 2 (HSV-2), a member of herpesviridae family, causes one of the m...

journal_title：Virology journal

authors： Lv X,Wang H,Su A,Xu S,Chu Y

更新日期：2018-11-12 00:00:00

abstract：BACKGROUND:Respiratory syncytial virus (RSV) is the leading viral pathogen associated with bronchiolitis and lower respiratory tract disease in infants and young children worldwide. The respiratory epithelium is the primary initiator of pulmonary inflammation in RSV infections, which cause significant perturbations of ...

journal_title：Virology journal

authors： Zhao D,Peng D,Li L,Zhang Q,Zhang C

更新日期：2008-10-06 00:00:00

abstract：AIM:To investigate the enhancement of humoral immunity when CpG ODN (cytidine phosphate guanosine oligodeoxynucleotides) and aluminium adjuvants are complexed with the HCV (Hepatitis C virus) recombinant immunogen in mice. METHODS:After immunizing Balb/c mice with the recombination HCV antigen adjuvanted with pUCpGs10...

journal_title：Virology journal

authors： Zhan N,Xiu BS,Wang GH,Chen K,Bai GZ,Song XG,Zhu CX,Dai ZH,Yang XQ,Zhang HQ

更新日期：2011-11-04 00:00:00

abstract：BACKGROUND:Open reading frame 58 (ORF58) of varicella-zoster virus (VZV) lies at the 3'end of the Unique long (UL) region and its functional is unknown. In order to clarify whether ORF58 is essential for the growth of VZV, we constructed a deletion mutant of ORF58 (pOka-BACDelta58) from the Oka parental genome cloned i...

journal_title：Virology journal

authors： Yoshii H,Sadaoka K,Matsuura M,Nagaike K,Takahashi M,Yamanishi K,Mori Y

更新日期：2008-04-30 00:00:00

abstract：BACKGROUND:The UL54 protein of Duck Enteritis Virus (DEV) is a homolog of herpes simplex virus-1 (HSV-1) immediate-early infectious cell protein 27 (ICP27), a multifunctional protein essential for viral infection. Nonetheless, there is little information on the UL54 protein of DEV. METHODS:The UL54 gene was cloned int...

journal_title：Virology journal

authors： Liu C,Cheng A,Wang M,Chen S,Jia R,Zhu D,Liu M,Sun K,Yang Q,Chen X

更新日期：2015-11-25 00:00:00

abstract：BACKGROUND:Human caliciviruses (HuCV) are emerging enteric pathogens that are a common cause of diarrhea in humans worldwide. Due to the paucity of information on the molecular characterization of HuCV circulating in Mexico, the aim of this work was to investigate the diversity and molecular epidemiology of the HuCV in...

journal_title：Virology journal

authors： Gómez-Santiago F,Ribas-Aparicio RM,García-Lozano H

更新日期：2012-02-23 00:00:00

abstract：BACKGROUND:The Unique Long 26 (UL26) and UL26.5 proteins of herpes simplex virus are known to function during the assembly of the viruses. However, for duck enteritis virus (DEV), which is an unassigned member of the family Herpesviridae, little information is available about the function of the two proteins. In this s...

journal_title：Virology journal

authors： Liu X,Han Z,Shao Y,Yu D,Li H,Wang Y,Kong X,Liu S

更新日期：2010-09-13 00:00:00

abstract：BACKGROUND:Jamestown Canyon virus (JCV), family Bunyaviridae, is a mosquito-borne pathogen endemic in the United States and Canada that can cause encephalitis in humans and is considered an emerging threat to public health. The virus is genetically similar to Inkoo virus circulating in Europe, suggesting that much of t...

journal_title：Virology journal

authors： Bennett RS,Nelson JT,Gresko AK,Murphy BR,Whitehead SS

更新日期：2011-03-24 00:00:00

abstract：BACKGROUND:Dengue fever is perhaps the most important viral re-emergent disease especially in tropical and sub-tropical countries, affecting about 50 million people around the world yearly. In Colombia, dengue virus was first detected in 1971 and still remains as a major public health issue. Although four viral serotyp...

journal_title：Virology journal

authors： Méndez JA,Usme-Ciro JA,Domingo C,Rey GJ,Sánchez JA,Tenorio A,Gallego-Gomez JC

更新日期：2012-03-09 00:00:00

abstract：BACKGROUND:Recently, human leukocyte antigen (HLA) class-II gene polymorphisms have been reported to be related to Hepatitis C virus (HCV) infection and chronicity. The objective of this study was to explore the relationship of HLA-DP rs9277535 and HLA-DQ rs7453920 with the outcomes of HCV infection. METHODS:The rs927...

journal_title：Virology journal

authors： Huang P,Fan H,Tian T,Liao P,Li J,Yu R,Xia X,Feng Y,Wang J,Liu Y,Zhang Y,Yue M

更新日期：2017-12-06 00:00:00

abstract：BACKGROUND:The diseases caused by Rice black streaked dwarf virus (RBSDV) and Southern rice black streaked dwarf virus (SRBSDV) have been occurring epidemically in China and southeastern Asia in recent years. A sensitive, reliable and quantitative method is required to detect and distinguish for RBSDV and SRBSDV in ric...

journal_title：Virology journal

authors： Zhang P,Mar TT,Liu W,Li L,Wang X

更新日期：2013-01-18 00:00:00

abstract：:Most viruses take advantage of endocytic pathways to gain entry into host cells and initiate infections. Understanding of virus entry via endocytosis is critically important for the design of antiviral strategies. Virus entry via endocytosis is a complex process involving hundreds of cellular proteins. The entire proc...

journal_title：Virology journal

authors： Barrow E,Nicola AV,Liu J

更新日期：2013-06-05 00:00:00

abstract：BACKGROUND:Influenza A virus genomes are comprised of 8 negative strand single-stranded RNA segments and are thought to encode 11 proteins, which are all translated from mRNAs complementary to the genomic strands. Although human, swine and avian influenza A viruses are very similar, cross-species infections are usually...

journal_title：Virology journal

authors： Clifford M,Twigg J,Upton C

更新日期：2009-11-16 00:00:00

abstract：:The Filoviridae family comprises of Ebola and Marburg viruses, which are known to cause lethal hemorrhagic fever. However, there is no effective anti-viral therapy or licensed vaccines currently available for these human pathogens. The envelope glycoprotein (GP) of Ebola virus, which mediates entry into target cells, ...

journal_title：Virology journal

authors： Bhattacharyya S,Hope TJ

更新日期：2011-01-12 00:00:00

abstract：BACKGROUND:Cervical cancer is a major public health problem worldwide. While Romania has the highest incidence of cervical cancer in Europe, the prevalence of HPV has not been evaluated. We report the first data on HPV prevalence and type distribution in Northeast Romania. METHODS:HPV prevalence and genotype distribut...

journal_title：Virology journal

authors： Ursu RG,Onofriescu M,Nemescu D,Iancu LS

更新日期：2011-12-22 00:00:00

abstract：BACKGROUND:The Epstein-Barr virus (EBV) is associated with lymphoid malignancies, including Burkitt's lymphoma (BL), and can transform human B cells in vitro. EBV-harboring cell lines are widely used to investigate lymphocyte transformation and oncogenesis. Qualitative EBV gene expression has been extensively described...

journal_title：Virology journal

authors： Bernasconi M,Berger C,Sigrist JA,Bonanomi A,Sobek J,Niggli FK,Nadal D

更新日期：2006-06-06 00:00:00

abstract：BACKGROUND:The Capripoxvirus, Lumpy skin disease virus (LSDV) has a restricted host-range and is being investigated as a novel HIV-1 vaccine vector. LSDV does not complete its replication cycle in non-ruminant hosts. METHODS:The safety of LSDV was tested at doses of 104 and 106 plaque forming units in two strains of i...

journal_title：Virology journal

authors： Shen YJ,Shephard E,Douglass N,Johnston N,Adams C,Williamson C,Williamson AL

更新日期：2011-05-30 00:00:00

abstract：BACKGROUND:The binding of viral-specific antibodies to cell-surface antigens usually results in down modulation of the antigen through redistribution of antigens into patches that subsequently may be internalized by endocytosis or may form caps that can be expelled to the extracellular space. Here, by use of confocal-l...

journal_title：Virology journal

authors： Sarmiento RE,Tirado RG,Valverde LE,Gómez-Garcia B

更新日期：2007-07-03 00:00:00

abstract：BACKGROUND:Nuclear factor-kappaB (NF-κB) is an inducible transcription factor that plays a key role in inflammation and immune responses, as well as in the regulation of cell proliferation and survival. Previous studies by our group and others have demonstrated that porcine reproductive and respiratory syndrome virus (...

journal_title：Virology journal

authors： Fang Y,Fang L,Wang Y,Lei Y,Luo R,Wang D,Chen H,Xiao S

更新日期：2012-04-30 00:00:00

abstract：BACKGROUND:Human pegivirus-1 (HPgV-1) is a member of the Flaviviridae family whose genomic organization and mode of cellular entry is similar to that of hepatitis C virus (HCV). The E2 glycoprotein of HPgV-1 is the principle mediator in the virus-cell interaction and as such harbors most of HPgV-1's antigenic determina...

journal_title：Virology journal

authors： Vitrenko Y,Kostenko I,Kulebyakina K,Sorochynska K

更新日期：2017-08-31 00:00:00

abstract：BACKGROUND:Public health risks associated to infection by human coronaviruses remain considerable and vaccination is a key option for preventing the resurgence of severe acute respiratory syndrome coronavirus (SARS-CoV). We have previously reported that antibodies elicited by a SARS-CoV vaccine candidate based on recom...

journal_title：Virology journal

authors： Yip MS,Leung NH,Cheung CY,Li PH,Lee HH,Daëron M,Peiris JS,Bruzzone R,Jaume M

更新日期：2014-05-06 00:00:00

abstract：:Intracellular influenza virus nucleoprotein (NP) is characterized by a high efficiency of homo-polymers formation, however their antigenic structure is still incompletely known. Herein, we report that RNase-resistant intracellular NP homo-polymers have a highly ordered conformational antigenic epitope, which depends o...

journal_title：Virology journal

authors： Prokudina EN,Semenova N,Chumakov V,Stitz L

更新日期：2008-02-29 00:00:00

abstract：BACKGROUND:Bovine viral diarrhea virus (BVDV) infections continue to cause significantly losses in the deer population. Better isolation and identification of BVDV from sika deer may contribute significantly to the development of prophylactic therapeutic, and diagnostic reagents as well as help in prevention and contro...

journal_title：Virology journal

authors： Gao Y,Wang S,Du R,Wang Q,Sun C,Wang N,Zhang P,Zhang L

更新日期：2011-02-25 00:00:00

abstract：BACKGROUND:Human T-cell Leukemia Virus type 1 (HTLV-1) is the etiological agent of tropical spastic paraparesis/HTLV-associated myelopathy (HAM/TSP) that can be identified in around 0.25%-3.8% of the infected population. Disease progression can be monitored by the proviral load and may depend on genetic factors, howeve...

journal_title：Virology journal

authors： Mota-Miranda AC,Barreto FK,Amarante MF,Batista E,Monteiro-Cunha JP,Farre L,Galvão-Castro B,Alcantara LC

更新日期：2013-03-06 00:00:00

abstract：BACKGROUND:Longitudinal mark-recapture studies of rodents in two sites in the Mbaracayú Biosphere Reserve in the Interior Atlantic Forest of eastern Paraguay have revealed a complex and intriguing pattern of hantaviruses harbored by rodents in this area. Full-length sequencing and phylogenetic analyses were conducted f...

journal_title：Virology journal

authors： Chu YK,Owen RD,Jonsson CB

更新日期：2011-08-12 00:00:00

abstract：:The I5L gene is one of approximately 90 genes that are conserved throughout the chordopoxvirus family, and hence are presumed to play vital roles in the poxvirus life cycle. Previous work had indicated that the VP13 protein, a component of the virion membrane, was encoded by the I5L gene, but no additional studies had...

journal_title：Virology journal

authors： Unger B,Nichols RJ,Stanitsa ES,Traktman P

更新日期：2008-12-15 00:00:00

abstract：BACKGROUND:Otitis media (OM) affects ≥80% of children before the age of three. OM can arise following co-infection with influenza A virus (IAV) and the bacterium Streptococcus pneumoniae. We have previously shown that H3 IAV strains (such as Udorn/72) induced a higher rate of bacterial OM than H1 strains (such as PR8/3...

journal_title：Virology journal

authors： Short KR,Habets MN,Payne J,Reading PC,Diavatopoulos DA,Wijburg OL

更新日期：2013-04-23 00:00:00

abstract：BACKGROUND:An HIV cure has not yet been achieved because latent viral reservoirs persist, particularly in resting CD4+ T lymphocytes. In vitro, it is difficult to infect resting CD4+ T cells with HIV-1, but infections readily occur in vivo. Endothelial cells (EC) line the lymphatic vessels in the lymphoid tissues and r...

journal_title：Virology journal

authors： Schilthuis M,Verkaik S,Walhof M,Philipose A,Harlow O,Kamp D,Kim BR,Shen A

更新日期：2018-10-03 00:00:00

abstract：BACKGROUND:The amino terminus of the tobacco etch virus (TEV) capsid protein is located on the external surface of infectious TEV particles, as proposed by previous studies and an in silico model. The epsilon amino groups on the exposed lysine residues are available for chemical conjugation to any given protein, and ca...

journal_title：Virology journal

authors： Manuel-Cabrera CA,Márquez-Aguirre A,Rodolfo HG,Ortiz-Lazareno PC,Chavez-Calvillo G,Carrillo-Tripp M,Silva-Rosales L,Gutiérrez-Ortega A

更新日期：2012-03-27 00:00:00

abstract：BACKGROUND:Cotton blue disease (CBD), an important global cotton crop pathology responsible for major economic losses, is prevalent in the major cotton-producing states of Brazil. Typical CBD symptoms include stunting due to internodal shortening, leaf rolling, intense green foliage, and yellowing veins. Atypical CBD s...

journal_title：Virology journal

authors： Silva TF,Corrêa RL,Castilho Y,Silvie P,Bélot JL,Vaslin MF

更新日期：2008-10-20 00:00:00