Abstract:
BACKGROUND:Otitis media (OM) affects ≥80% of children before the age of three. OM can arise following co-infection with influenza A virus (IAV) and the bacterium Streptococcus pneumoniae. We have previously shown that H3 IAV strains (such as Udorn/72) induced a higher rate of bacterial OM than H1 strains (such as PR8/34). This was associated with more efficient replication of H3 strains in the middle ear. FINDINGS:Here, we assess if the increased replication of IAV strains such as Udorn/72 in the middle ear is dependent upon the binding of the viral HA to α2,6-linked sialic acid. Using murine and in vitro models, the present study shows that recognition of α2,6-linked sialic acid was not required to facilitate bacterial OM. CONCLUSIONS:Taken together, these data suggest that other features of the HA mediate bacterial OM.
journal_name
Virol Jjournal_title
Virology journalauthors
Short KR,Habets MN,Payne J,Reading PC,Diavatopoulos DA,Wijburg OLdoi
10.1186/1743-422X-10-128subject
Has Abstractpub_date
2013-04-23 00:00:00pages
128issn
1743-422Xpii
1743-422X-10-128journal_volume
10pub_type
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