Abstract:
BACKGROUND:The implementation of phage therapy is re-emerging with the increase in widespread antibiotic-resistant bacteria. METHODS:Staphylococcus phage JD007 was characterized and its complete genome sequence analysed. RESULTS:Staphylococcus phage JD007 was classified as belonging to the Myoviridae family based on its morphology, as observed by transmission electron microscopy. Its lytic activity was stable between pH 5-11 and below 42 °C; moreover, an absorbance curve showed that nearly 90% of the viral particles had adsorbed to its host after a 20 min co-incubation. The complete genome size is 141,836 bp, making JD007 one of the largest Staphylococcus phages of Myoviridae. No identifiable resistance or virulence genes were found in the JD007 genome. JD007 was able to lyse 95% of S. aureus isolates, including the prevalent ST239-MRSA and ST59-MRSA strains isolated from different hospitals in Shanghai, China, and inhibition assays showed that JD007 could inhibit S. aureus growth at a multiplicity of infection of 0.1. CONCLUSIONS:The results suggested that Staphylococcus phage JD007 can potentially be used in phage therapy or for the detection of S. aureus.
journal_name
Virol Jjournal_title
Virology journalauthors
Cui Z,Feng T,Gu F,Li Q,Dong K,Zhang Y,Zhu Y,Han L,Qin J,Guo Xdoi
10.1186/s12985-017-0701-0subject
Has Abstractpub_date
2017-02-08 00:00:00pages
26issue
1issn
1743-422Xpii
10.1186/s12985-017-0701-0journal_volume
14pub_type
杂志文章相关文献
Virology Journal文献大全abstract:BACKGROUND:The influenza RNA dependent RNA polymerase synthesizes viral RNA in the nucleus as functional viral ribonucleoprotein (vRNP) complexes with RNA and nucleoprotein (NP). The N-terminus of NP contains an unconventional nuclear localization signal (NLS) important for initial vRNP nuclear localization but which a...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-11-155
更新日期:2014-08-31 00:00:00
abstract::We describe an improvement of an earlier reported real-time RT-PCR assay for the detection of enterovirus RNA, based on the 5' exonuclease digestion of a dual-labeled fluorogenic probe by Taq DNA polymerase. A different extraction method, real-time RT-PCR instrument and primer set were evaluated. Our data show that th...
journal_title:Virology journal
pub_type: 杂志文章,评审
doi:10.1186/1743-422X-6-95
更新日期:2009-07-07 00:00:00
abstract:BACKGROUND:Aleutian mink disease virus (AMDV) is the cause of a chronic immune complex disease, Aleutian disease (AD), which is common in mink-producing countries. In 2005, implementation of an AMDV eradication programme in Finland created a need for an automated high-throughput assay. The aim of this study was to vali...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-11-141
更新日期:2014-08-08 00:00:00
abstract::During the outbreak of SARS in 2002/3, a prototype virus was isolated from a patient in Frankfurt/Germany (strain Frankfurt-1). As opposed to all other SARS-Coronavirus strains, Frankfurt-1 has a 45-nucleotide deletion in the transmembrane domain of its ORF 7b protein. When over-expressed in HEK 293 cells, the full-le...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-6-131
更新日期:2009-08-24 00:00:00
abstract::The original version of the acknowledgement unfortunately contained a mistake. ...
journal_title:Virology journal
pub_type: 已发布勘误
doi:10.1186/s12985-020-01439-2
更新日期:2020-11-09 00:00:00
abstract:BACKGROUND:Human cytomegalovirus UL114 encodes a uracil-DNA glycosylase homolog that is highly conserved in all characterized herpesviruses that infect mammals. Previous studies demonstrated that the deletion of this nonessential gene delays significantly the onset of viral DNA synthesis and results in a prolonged repl...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-2-55
更新日期:2005-07-15 00:00:00
abstract:BACKGROUND:Norovirus (NoV) has been recognized as the leading cause of both outbreaks and sporadic cases of acute gastroenteritis in children and adults worldwide. Stool samples collected from outpatients with clinical symptoms of acute gastroenteritis in all age groups at the First People's Hospital in Huzhou, Huzhou,...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-015-0370-9
更新日期:2015-09-11 00:00:00
abstract::Six major Hepatitis C virus (HCV) genotypes and hundreds of subtypes have been identified globally. All these genotypes are generally studied for epidemiology, their vaccine development and clinical management. This article comments the frequency distribution of various HCV genotypes circulate in different areas/distr...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-203
更新日期:2010-08-26 00:00:00
abstract:BACKGROUND:Finding new biomarkers for the early detection of cervical cancer is an essential requirement in this field. In this study, we aimed to evaluate the expression level of potential biomarkers in progression of cervical cancer in patients with cervical cancer compared to normal subjects. METHODS:The expression...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-019-1220-y
更新日期:2019-10-07 00:00:00
abstract::Guards of Cyprian honey bee colonies, Apis mellifera cypria, display a great defensive behaviour against hornets' attacks. The deformed wing virus (DWV) and the kakugo virus (KV) genomes are very similar, but unlike KV, the presence of DWV is not related to honey bees' aggressiveness. This discrepancy is further discu...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-3-61
更新日期:2006-08-30 00:00:00
abstract:BACKGROUND:The avian influenza virus (AIV) causes frequent disease with high morbidity and mortality. RNA interference (RNAi) has been shown to provide an effective antiviral defense in animals, and several studies have focused on harnessing small interfering RNAs (siRNAs) to inhibit viral infections. In addition, sing...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-014-0208-x
更新日期:2014-11-29 00:00:00
abstract:BACKGROUND:To assess the potential effects of telbivudine (LdT) and entecavir (ETV) on renal function in patients with chronic hepatitis B (CHB), we performed a meta-analysis of the relevant data available on these agents to evaluate their effects on the estimated glomerular filtration rate (eGFR) during treatment. ME...
journal_title:Virology journal
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12985-016-0522-6
更新日期:2016-04-09 00:00:00
abstract:: Previously, we explored the epidemic pattern and molecular characterization of enteroviruses isolated in Chungnam, Korea from 2005 to 2006. The present study extended these observations to 2008 and 2009. In this study, enteroviruses showed similar seasonal prevalent pattern from summer to fall and age distribution to...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-297
更新日期:2011-06-13 00:00:00
abstract:BACKGROUND:Human papillomaviruses (HPVs), a group of non-enveloped small viruses with double-stranded circular DNA which lead to multiple skin diseases such as benign warts, are commonly seen in clinics. The current HPV detection systems aim mainly at mucosal HPVs, however, an efficient clinical approach for cutaneous ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-020-01373-3
更新日期:2020-07-09 00:00:00
abstract:BACKGROUND:Rotavirus (RV) is the main cause of severe gastroenteritis in children. An effective vaccination regime against RV can substantially reduce morbidity and mortality. Previous studies have demonstrated the efficacy of virus-like particles formed by RV VP2 and VP6 (VLP2/6), as well as that of recombinant adenov...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-3
更新日期:2011-01-05 00:00:00
abstract:BACKGROUND:The epidemic pattern of respiratory syncytial virus (RSV) is quite different in regions of Europe (biennial epidemics in alternating cycles of approximately 9 and 15 months) than in the Western Hemisphere (annual epidemics). In order to determine if these differences are accounted for by the circulation of d...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-6-133
更新日期:2009-09-07 00:00:00
abstract:BACKGROUND:H5N1 highly pathogenic avian influenza virus (HPAIV) is continuously circulating in many Asian countries and threatening poultry industry and human population. Vaccination is the best strategy to control H5N1 HPAIV infection in poultry and transmission to human population. The aim of this study is to identif...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-9-97
更新日期:2012-05-23 00:00:00
abstract:BACKGROUND:Rhabdoviridae is one of the most ecologically diverse families of RNA viruses which can infect a wide range of vertebrates and invertebrates. Bats, among mammals, are pointed to harbor a significantly higher proportion of unknown or emerging viruses with zoonotic potential. Herein, we report the isolation of...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-018-0949-z
更新日期:2018-02-17 00:00:00
abstract:BACKGROUND:During October 2010, Egypt reported an outbreak of acute hemorrhagic conjunctivitis (AHC). A total of 1831 cases were reported from three governorates; 1703 cases in El Daqahliya, 92 cases in Port Said, and 36 in Damietta. The purpose of this study was to identify and characterize the causative agent associa...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-96
更新日期:2013-03-25 00:00:00
abstract:BACKGROUND:Containment of influenza A H1N1 virus spread was implemented successfully in Xiamen, with large-scale inoculation to reduce morbidity. To identify beneficial elements and to guide decision-making in epidemic containment, we analyzed the epidemiologic parameters and evaluated the control measures. METHOD:We ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-9-20
更新日期:2012-01-17 00:00:00
abstract:BACKGROUND:An extensive outbreak of equine influenza occurred across multiple countries in South America during 2012. The epidemic was first reported in Chile then spread to Brazil, Uruguay and Argentina, where both vaccinated and unvaccinated animals were affected. In Brazil, infections were widespread within 3months ...
journal_title:Virology journal
pub_type: 历史文章,杂志文章
doi:10.1186/s12985-016-0503-9
更新日期:2016-03-19 00:00:00
abstract::Papillomaviruses (PVs) are associated with the development of neoplasias and have been found in several different species, most of them in humans and other mammals. We identified, cloned and sequenced PV DNA from pigmented papilloma-like lesions of a diamond python (Morelia spilota spilota). This represents the first ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-436
更新日期:2011-09-12 00:00:00
abstract:BACKGROUND:The addition of N-linked glycans to proteins is normally a cotranslational process that occurs during translocation of the nascent protein to the endoplasmic reticulum. Here, we report on an exception to this rule occurring on the hepatitis B virus (HBV) large L envelope protein that is a subject to co-plus ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-4-45
更新日期:2007-05-30 00:00:00
abstract::The replication of porcine endogenous retrovirus (PERV) in human cell lines suggests a potential infectious risk in xenotransplantation. PERV isolated from human cells following cocultivation with porcine peripheral blood mononuclear cells is a recombinant of PERV-A and PERV-C. We describe two different recombinant PE...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-3-91
更新日期:2006-11-02 00:00:00
abstract::Dengue virus (DENV) is a mosquito-borne virus that has four serotypes. Collection of serum from patients is time- and labor- consuming, and presents a high injury risk for infants and children. The genomic and serological diagnosis of imported dengue fever from a urine sample was used as a non-invasive diagnostic meth...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-11-56
更新日期:2014-03-25 00:00:00
abstract:AIM:To investigate the enhancement of humoral immunity when CpG ODN (cytidine phosphate guanosine oligodeoxynucleotides) and aluminium adjuvants are complexed with the HCV (Hepatitis C virus) recombinant immunogen in mice. METHODS:After immunizing Balb/c mice with the recombination HCV antigen adjuvanted with pUCpGs10...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-507
更新日期:2011-11-04 00:00:00
abstract::Vaccinia virus protein A33 (A33VACV) plays an important role in protection against orthopoxviruses, and hence is included in experimental multi-subunit smallpox vaccines. In this study we show that single-dose vaccination with recombinant Sindbis virus expressing A33VACV, is sufficient to protect mice against lethal c...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-229
更新日期:2013-07-10 00:00:00
abstract:BACKGROUND:Avian influenza virus (AIV) is classified into two pathotypes, low pathogenic (LP) and high pathogenic (HP), based on virulence in chickens.Differences in pathogenicity between HPAIV and LPAIV might eventually be related to specific characteristics of strains, tissue tropism and host responses. METHODS:To s...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-9-61
更新日期:2012-03-06 00:00:00
abstract:BACKGROUND:Chronic HCV is one of the major causes of morbidity and mortality in the present day world. The assessment of disease progression not only provides useful information for diagnosis and therapeutic supervision judgment but also for monitoring disease. Different invasive and non invasive methods are applied to...
journal_title:Virology journal
pub_type: 杂志文章,评审
doi:10.1186/1743-422X-8-53
更新日期:2011-02-08 00:00:00
abstract:BACKGROUND:Enzootic nasal tumor virus (ENTV) is a betaretrovirus of sheep (ENTV-1) and goats (ENTV-2) associated with neoplastic transformation of epithelial cells of the ethmoid turbinate. Confirmation of the role of ENTV in the pathogenesis of enzootic nasal adenocarcinoma (ENA) has yet to be resolved due to the inab...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-017-0795-4
更新日期:2017-07-26 00:00:00