Abstract:
:The replication of porcine endogenous retrovirus (PERV) in human cell lines suggests a potential infectious risk in xenotransplantation. PERV isolated from human cells following cocultivation with porcine peripheral blood mononuclear cells is a recombinant of PERV-A and PERV-C. We describe two different recombinant PERV-AC sequences in the cellular DNA of some transmitting miniature swine. This is the first evidence of PERV-AC recombinant virus in porcine genomic DNA that may have resulted from autoinfection following exogenous viral recombination. Infectious risk in xenotransplantation will be defined by the activity of PERV loci in vivo.
journal_name
Virol Jjournal_title
Virology journalauthors
Martin SI,Wilkinson R,Fishman JAdoi
10.1186/1743-422X-3-91subject
Has Abstractpub_date
2006-11-02 00:00:00pages
91issn
1743-422Xpii
1743-422X-3-91journal_volume
3pub_type
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