Co-circulation of multiple reassortant H6 subtype avian influenza viruses in wild birds in eastern China, 2016-2017.

abstract：BACKGROUND:Echovirus 6 (E6) infections are associated with aseptic meningitis and acute flaccid paralysis (AFP). But some infections, sometimes most of them, are asymptomatic. The mechanism of E6 virulence is unknown. Analyses of the molecular evolution of asymptomatic E6 may help understand why the infections show dif...

journal_title：Virology journal

authors： Sun H,Huang X,Lin K,Huang K,Chu J,Yang Z,Ma S

更新日期：2017-07-25 00:00:00

abstract：AIM:To evaluate the efficacy and safety of Entecavir (ETV) plus adefovir (ADV) for chronic hepatitis B (CHB) patients after multiple nucleos(t)ide analogue (NAs) failure treatment. METHODS:Hepatitis B e antigen (HBeAg)-positive patients who had a suboptimal response or developed resistance to two or more previous NAs ...

journal_title：Virology journal

authors： Xu XH,Li GL,Qin Y,Li Q,He FQ,Li JY,Pan QR,Deng JY

更新日期：2013-05-25 00:00:00

abstract：BACKGROUND/AIM:Hepatitis C virus (HCV) has been the subject of intense research and clinical investigation as its major role in human disease has emerged. HCV circulates in vivo as a complex population of different but closely related viral variants, commonly referred to as a quasispecies. The extent to which recombina...

journal_title：Virology journal

authors： Moreno MP,Casane D,López L,Cristina J

更新日期：2006-10-24 00:00:00

abstract：BACKGROUND:The context and purpose of the study included 1) bacterial expression of viral protein 6 (VP6) of porcine rotavirus (PRV) and generation of rabbit polyclonal antiserum to the VP6 protein; 3) establishment of a discrimination ELISA to distinguish PRV from a panel of other porcine viruses. RESULTS:The VP6 gen...

journal_title：Virology journal

authors： Zhu J,Yang Q,Cao L,Dou X,Zhao J,Zhu W,Ding F,Bu RE,Suo S,Ren Y,Li G,Ren X

更新日期：2013-03-22 00:00:00

abstract：BACKGROUND:Host serine proteases are essential for the influenza virus life cycle because the viral haemagglutinin is synthesized as a precursor which requires proteolytic maturation. Therefore, we studied the activity and expression of serine proteases in lungs from mice infected with influenza and evaluated the effec...

journal_title：Virology journal

authors： Bahgat MM,Błazejewska P,Schughart K

更新日期：2011-01-20 00:00:00

abstract：BACKGROUND:Mumps virus is a negative-sense, single stranded RNA virus consisting of a ribonucleocapsid core enveloped by a lipid membrane derived from host cell, which causes mumps disease preventable by vaccination. Since virus lipid envelope and glycosylation pattern are not encoded by the virus but dependent on the ...

journal_title：Virology journal

authors： Brgles M,Bonta M,Šantak M,Jagušić M,Forčić D,Halassy B,Allmaier G,Marchetti-Deschmann M

更新日期：2016-01-14 00:00:00

abstract：:Vaccinia virus protein A33 (A33VACV) plays an important role in protection against orthopoxviruses, and hence is included in experimental multi-subunit smallpox vaccines. In this study we show that single-dose vaccination with recombinant Sindbis virus expressing A33VACV, is sufficient to protect mice against lethal c...

journal_title：Virology journal

authors： Paran N,Lustig S,Zvi A,Erez N,Israely T,Melamed S,Politi B,Ben-Nathan D,Schneider P,Lachmi B,Israeli O,Stein D,Levin R,Olshevsky U

更新日期：2013-07-10 00:00:00

abstract：BACKGROUND:Although prophylactic vaccines have been developed against HPV6, HPV11, HPV16 and HPV18 there is the clear unmet medical need in order to justify the development of drugs targeting human papillomavirus replication. The native host cells of HPVs are human primary keratinocytes which can be cultivated in raft ...

journal_title：Virology journal

authors： Isok-Paas H,Männik A,Ustav E,Ustav M

更新日期：2015-04-14 00:00:00

abstract：BACKGROUND:RNA viruses are characterized by high rate of mutations mainly due to the lack of proofreading repair activities associated with its RNA-dependent RNA-polymerase (RdRp). In case of arboviruses, this phenomenon has lead to the existence of mixed population of genomic variants within the host called quasi-spec...

journal_title：Virology journal

authors： Jain J,Mathur K,Shrinet J,Bhatnagar RK,Sunil S

更新日期：2016-06-02 00:00:00

abstract：BACKGROUND:The COVID-19 causing coronavirus is an enveloped RNA virus that utilizes an enzyme RNA dependent RNA polymerase for its replication. Favipiravir (FVP) triphosphate, a purine nucleoside analog, inhibits that enzyme. We have conducted this systematic review and meta-analysis on efficacy and safety of the drug ...

journal_title：Virology journal

authors： Shrestha DB,Budhathoki P,Khadka S,Shah PB,Pokharel N,Rashmi P

更新日期：2020-09-24 00:00:00

abstract：BACKGROUND:Human cytomegalovirus (HCMV) is a betaherpesvirus that causes severe disease in situations where the immune system is immature or compromised. HCMV immediate early (IE) gene expression is stimulated by the virion phosphoprotein pp71, encoded by open reading frame (ORF) UL82, and this transactivation activity...

journal_title：Virology journal

authors： Nicholson IP,Sutherland JS,Chaudry TN,Blewett EL,Barry PA,Nicholl MJ,Preston CM

更新日期：2009-05-27 00:00:00

abstract：:The triple-gene-block protein 2 (TGBp2) of Bamboo mosaic virus (BaMV) is a transmembrane protein which was proposed to be involved in viral RNA binding during virus transport. Here, we report on the RNA-binding properties of TGBp2. Using tyrosine fluorescence spectroscopy and UV-crosslinking assays, the TGBp2 solubili...

journal_title：Virology journal

authors： Hsu HT,Tseng YH,Chou YL,Su SH,Hsu YH,Chang BY

更新日期：2009-05-07 00:00:00

abstract：BACKGROUND:The human immunodeficiency virus type 1(HIV-1) is a complex retrovirus and the causative agent of acquired immunodeficiency syndrome (AIDS). The HIV-1 Vpu protein is an oligomeric integral membrane protein essential for particle release, viral load and CD4 degradation. In silico models show Vpu to form penta...

journal_title：Virology journal

authors： Hussain A,Das SR,Tanwar C,Jameel S

更新日期：2007-08-29 00:00:00

abstract：BACKGROUND:A serological method to simultaneously detect antibodies against infectious laryngotracheitis virus (ILTV) and infectious bronchitis virus (IBV) is imperative for the differential diagnosis and evaluation of antibodies titers after vaccination. METHOD:The microspheres coated with purified recombinant glycop...

journal_title：Virology journal

authors： Wang H,Cong F,Guan J,Xiao L,Zhu Y,Lian Y,Huang R,Chen M,Guo P

更新日期：2018-09-21 00:00:00

abstract：:Intracellular influenza virus nucleoprotein (NP) is characterized by a high efficiency of homo-polymers formation, however their antigenic structure is still incompletely known. Herein, we report that RNase-resistant intracellular NP homo-polymers have a highly ordered conformational antigenic epitope, which depends o...

journal_title：Virology journal

authors： Prokudina EN,Semenova N,Chumakov V,Stitz L

更新日期：2008-02-29 00:00:00

abstract：BACKGROUND:Containment of influenza A H1N1 virus spread was implemented successfully in Xiamen, with large-scale inoculation to reduce morbidity. To identify beneficial elements and to guide decision-making in epidemic containment, we analyzed the epidemiologic parameters and evaluated the control measures. METHOD:We ...

journal_title：Virology journal

authors： Shen J,Niu J

更新日期：2012-01-17 00:00:00

abstract：BACKGROUND:Hepatitis B virus (HBV) infection is a serious health problem worldwide. Treatment recommendation and response are mainly indicated by viral load, e antigen (HBeAg) seroconversion, and ALT levels. The S antigen (HBsAg) seroconversion is much less frequent. Since HBeAg can be negative in the presence of high ...

journal_title：Virology journal

authors： Lian M,Zhou X,Wei L,Qiu S,Zhou T,Li L,Gu X,Luo M,Zheng X

更新日期：2007-09-24 00:00:00

abstract：:Lytic bacteriophage 0305phi8-36 forms visually observed aggregates during plaque formation. Aggregates intrinsically lower propagation potential. In the present study, the following observations indicate that lost propagation potential is regained with time: (1) Aggregates sometimes concentrate at the edge of clear pl...

journal_title：Virology journal

authors： Serwer P,Hayes SJ,Lieman K

更新日期：2007-12-04 00:00:00

abstract：BACKGROUND:Human T-cell Leukemia Virus type 1 (HTLV-1) is the etiological agent of tropical spastic paraparesis/HTLV-associated myelopathy (HAM/TSP) that can be identified in around 0.25%-3.8% of the infected population. Disease progression can be monitored by the proviral load and may depend on genetic factors, howeve...

journal_title：Virology journal

authors： Mota-Miranda AC,Barreto FK,Amarante MF,Batista E,Monteiro-Cunha JP,Farre L,Galvão-Castro B,Alcantara LC

更新日期：2013-03-06 00:00:00

abstract：BACKGROUND:Genome-wide RNAi screening has been widely used to identify host proteins involved in replication and infection of different viruses, and numerous host factors are implicated in the replication cycles of these viruses, demonstrating the power of this approach. However, discrepancies on target identification ...

journal_title：Virology journal

authors： Cheng H,Koning K,O'Hearn A,Wang M,Rumschlag-Booms E,Varhegyi E,Rong L

更新日期：2015-11-24 00:00:00

abstract：BACKGROUND:Most of the non-B HIV-1 subtypes are predominant in Sub-Saharan Africa and India although they have been found worldwide. In the last decade, immigration from these areas has increased considerably in Spain. The objective of this study was to evaluate the prevalence of non-B subtypes circulating in a cohort ...

journal_title：Virology journal

authors： de Felipe B,Pérez-Romero P,Abad-Fernández M,Fernandez-Cuenca F,Martinez-Fernandez FJ,Trastoy M,Mata Rdel C,López-Cortés LF,Leal M,Viciana P,Vallejo A

更新日期：2011-08-26 00:00:00

abstract：BACKGROUND:Subviral particles of hepatitis B virus (HBV) composed of L protein deletion variants with the 48 N-terminal amino acids of preS joined to the N-terminus of S protein (1-48preS/S) induced broadly neutralizing antibodies after immunization of mice with a Semliki Forest virus vector. A practical limitation for...

journal_title：Virology journal

authors： Niedre-Otomere B,Bogdanova A,Bruvere R,Ose V,Gerlich WH,Pumpens P,Glebe D,Kozlovska T

更新日期：2013-02-25 00:00:00

abstract：BACKGROUND:More than a decade after the outbreak of human coronaviruses (HCoVs) SARS in Guangdong province and Hong Kong SAR of China in 2002, there is still no reoccurrence, but the evolution and recombination of the coronaviruses in this region are still unknown. Therefore, surveillance on the prevalence and the viru...

journal_title：Virology journal

authors： Liu P,Shi L,Zhang W,He J,Liu C,Zhao C,Kong SK,Loo JFC,Gu D,Hu L

更新日期：2017-11-22 00:00:00

abstract：BACKGROUND:To understand the prevalence and characteristics of human cytomegalovirus (HCMV) infection in children in the Weifang area, and to provide information for its prevention and treatment. METHODS:A comprehensive survey was performed from 2009 to 2012 in 7582 children from birth to 6 years of age hospitalized i...

journal_title：Virology journal

authors： Sun X,Liu Z,Wang B,Shi L,Liang R,Li L,Qian D,Song X

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:The amino terminus of the tobacco etch virus (TEV) capsid protein is located on the external surface of infectious TEV particles, as proposed by previous studies and an in silico model. The epsilon amino groups on the exposed lysine residues are available for chemical conjugation to any given protein, and ca...

journal_title：Virology journal

authors： Manuel-Cabrera CA,Márquez-Aguirre A,Rodolfo HG,Ortiz-Lazareno PC,Chavez-Calvillo G,Carrillo-Tripp M,Silva-Rosales L,Gutiérrez-Ortega A

更新日期：2012-03-27 00:00:00

abstract：BACKGROUND:Chikungunya virus (CHIKV) is a mosquito-borne, arthrogenic Alphavirus that causes large epidemics in Africa, South-East Asia and India. Recently, CHIKV has been transmitted to humans in Southern Europe by invading and now established Asian tiger mosquitoes. To study the processing of envelope proteins E1 and...

journal_title：Virology journal

authors： Metz SW,Geertsema C,Martina BE,Andrade P,Heldens JG,van Oers MM,Goldbach RW,Vlak JM,Pijlman GP

更新日期：2011-07-15 00:00:00

abstract：:Herpes simplex virus (HSV) infection is one of the most common viral sexually transmitted diseases worldwide. The first time infection of the mother may lead to severe illness in pregnancy and may be associated with virus transmission from mother to foetus/newborn. Since the incidence of this sexually transmitted infe...

journal_title：Virology journal

authors： Anzivino E,Fioriti D,Mischitelli M,Bellizzi A,Barucca V,Chiarini F,Pietropaolo V

更新日期：2009-04-06 00:00:00

abstract：BACKGROUND:SEN virus is a blood-borne, circular ssDNA virus and possessing nine genotypes (A to I). Among nine genotypes, SENV-D and SENV-H genotypes have the strong link with patients with unknown (none-A to E) hepatitis infections. Infection with blood-borne viruses is the second important cause of death in thalassem...

journal_title：Virology journal

authors： Karimi-Rastehkenari A,Bouzari M

更新日期：2010-01-02 00:00:00

abstract：:During the outbreak of SARS in 2002/3, a prototype virus was isolated from a patient in Frankfurt/Germany (strain Frankfurt-1). As opposed to all other SARS-Coronavirus strains, Frankfurt-1 has a 45-nucleotide deletion in the transmembrane domain of its ORF 7b protein. When over-expressed in HEK 293 cells, the full-le...

journal_title：Virology journal

authors： Pfefferle S,Krähling V,Ditt V,Grywna K,Mühlberger E,Drosten C

更新日期：2009-08-24 00:00:00

abstract：BACKGROUND:Human papillomaviruses (HPVs), a group of non-enveloped small viruses with double-stranded circular DNA which lead to multiple skin diseases such as benign warts, are commonly seen in clinics. The current HPV detection systems aim mainly at mucosal HPVs, however, an efficient clinical approach for cutaneous ...

journal_title：Virology journal

authors： Wang Y,Ge G,Mao R,Wang Z,Sun YZ,Du YG,Gao XH,Qi RQ,Chen HD

更新日期：2020-07-09 00:00:00