Abstract:
:The triple-gene-block protein 2 (TGBp2) of Bamboo mosaic virus (BaMV) is a transmembrane protein which was proposed to be involved in viral RNA binding during virus transport. Here, we report on the RNA-binding properties of TGBp2. Using tyrosine fluorescence spectroscopy and UV-crosslinking assays, the TGBp2 solubilized with Triton X-100 was found to interact with viral RNA in a non-specific manner. These results raise the possibility that TGBp2 facilitates intracellular delivery of viral RNA through non-specific protein-RNA interaction.
journal_name
Virol Jjournal_title
Virology journalauthors
Hsu HT,Tseng YH,Chou YL,Su SH,Hsu YH,Chang BYdoi
10.1186/1743-422X-6-50subject
Has Abstractpub_date
2009-05-07 00:00:00pages
50issn
1743-422Xpii
1743-422X-6-50journal_volume
6pub_type
杂志文章相关文献
Virology Journal文献大全abstract:BACKGROUND:Human enterovirus (EV) and parechovirus (HPeV) are significant causes of encephalitis and meningitis in children. The aim of this study was to determine the prevalence, type and viral RNA concentration of EV and HPeV in cerebrospinal fluid (CSF) samples in an unselected cohort of patients <18 years admitted ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-015-0427-9
更新日期:2015-11-25 00:00:00
abstract:BACKGROUND:Human noroviruses (NoVs) are the main cause of gastroenteritis worldwide. The most commonly detected NoV strains belong to the genetically diverse GII.4 genotype, with new pandemic variants emerging periodically. Despite extensive efforts, NoV investigation has been hampered by the lack of an effective in vi...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-016-0538-y
更新日期:2016-05-21 00:00:00
abstract:BACKGROUND:Avian influenza virus (AIV) is classified into two pathotypes, low pathogenic (LP) and high pathogenic (HP), based on virulence in chickens.Differences in pathogenicity between HPAIV and LPAIV might eventually be related to specific characteristics of strains, tissue tropism and host responses. METHODS:To s...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-9-61
更新日期:2012-03-06 00:00:00
abstract::An 80-year-old man with no history of an immune-compromising disorder was diagnosed with progressive multifocal leukoencephalopathy (PML). He presented with dysphagia and left-sided weakness; magnetic resonance imaging demonstrated marked signal abnormality in the subcortical white matter of the left frontal lobe and ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-256
更新日期:2010-09-28 00:00:00
abstract:BACKGROUND:PCR-based detection and identification of viruses assumes a known, relatively stable genome. Unfortunately, high mutation rates may lead to extensive changes in viral nucleic acid sequences making dedicated PCR primer use problematic. Furthermore, in bioterrorism, viral consensus sequences can be genetically...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-4-65
更新日期:2007-06-28 00:00:00
abstract:BACKGROUND:Influenza A virus poses a continuous threat to global public health. Design of novel universal drugs and vaccine requires a careful analysis of different strains of Influenza A viral genome from diverse hosts and subtypes. We performed a systematic in silico analysis of Influenza A viral segments of all avai...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-44
更新日期:2011-01-27 00:00:00
abstract::RNA recombination is one of the two major factors that create RNA genome variability. Assessing its incidence in plant RNA viruses helps understand the formation of new isolates and evaluate the effectiveness of crop protection strategies. To search for recombination in Soybean mosaic virus (SMV), the causal agent of ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-5-143
更新日期:2008-11-26 00:00:00
abstract:BACKGROUND:Recently, a new subset of CD4(+)T helper cell termed Follicular helper T cells (Tfh), which play a pivotal role in B cell activation and differentiation in lymphoid structures, has been reported to participate in some certain autoimmune diseases. But whether Tfh cells are involved in the pathogenesis of VMC ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-015-0257-9
更新日期:2015-02-11 00:00:00
abstract:BACKGROUND:Zika virus (ZIKV) is a major human pathogen and member of the Flavivirus genus. Previous studies have identified neutralizing antibodies from Zika patients that bind to quaternary epitopes across neighboring envelope (E) proteins, called E dimer epitopes (EDE). An asparagine-linked glycan on the "glycan loop...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-020-01313-1
更新日期:2020-03-31 00:00:00
abstract:BACKGROUND:Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by SFTS bunyavirus (SFTSV), a tick borne bunyavirus. However, Immunohistochemistry of SFTS patients are not well studied. METHODS:We obtained multiple of tissues from a fatal case with SFTS, including blood, lungs, k...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-018-1006-7
更新日期:2018-05-30 00:00:00
abstract:BACKGROUND:The mechanisms through which the avian influenza virus H5N1 modulate the host's innate immune defense during invasion, remains incompletely understood. RIG-I as a pattern recognition receptor plays an important role in mediating innate immune response induced by influenza virus. So, modulating RIG-I might be...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-9-145
更新日期:2012-08-03 00:00:00
abstract:BACKGROUND:Understanding how an organism replicates and assembles a multi-segmented genome with fidelity previously measured at 100% presents a model system for exploring questions involving genome assortment and RNA/protein interactions in general. The virus family Reoviridae, containing nine genera and more than 200 ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-3-1
更新日期:2006-01-03 00:00:00
abstract:BACKGROUND:Hepatitis B virus (HBV) genotype F (HBV/F) is considered to be indigenous to the Americas, but its emergence and spread in the continent remain unknown. Previously, only two HBV/F complete genome sequences from Brazil were available, limiting the contribution of Brazilian isolates to the phylogenetic studies...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-236
更新日期:2013-07-16 00:00:00
abstract:BACKGROUND:Citrus sudden death (CSD), a disease that rapidly kills orange trees, is an emerging threat to the Brazilian citrus industry. Although the causal agent of CSD has not been definitively determined, based on the disease's distribution and symptomatology it is suspected that the agent may be a new strain of Cit...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-5-9
更新日期:2008-01-16 00:00:00
abstract:BACKGROUND:The Hepatitis B Virus X protein (HBx) plays a major role in hepatocellular carcinoma (HCC) development, however, its contribution to tumor invasion and metastasis has not been established so far. Heat shock protein 90 alpha (HSP90alpha) isoform is an ATP-dependent molecular chaperone that maintains the activ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-45
更新日期:2010-02-20 00:00:00
abstract::HIV expressed in genital secretions provides the inoculum from which transmitting variants are selected, both in sexual transmission and mother-to-infant transmission during partuition. Characterization of HIV levels and genotypes found in vaginal secretions and the impact of anti-retroviral therapy (ART) on this viru...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-5-87
更新日期:2008-07-29 00:00:00
abstract:BACKGROUND:Farmington virus (FARV) is a rhabdovirus that was isolated from a wild bird during an outbreak of epizootic eastern equine encephalitis on a pheasant farm in Connecticut, USA. FINDINGS:Analysis of the nearly complete genome sequence of the prototype CT AN 114 strain indicates that it encodes the five canoni...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-219
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:The human polyomavirus BK expresses a 66 amino-acid peptide referred to as agnoprotein. Though mutants lacking agnoprotein are severely reduced in producing infectious virions, the exact function of this peptide remains incompletely understood. To elucidate the function of agnoprotein, we searched for novel ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-014-0220-1
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:PHYVV and PepGMV are plant viruses reported in Mexico and Southern US as causal agents of an important pepper disease known as "rizado amarillo". Mixed infections with PHYVV and PepGMV have been reported in several hosts over a wide geographic area. Previous work suggested that these viruses might interact a...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-104
更新日期:2011-03-08 00:00:00
abstract:BACKGROUND:Human papillomavirus (HPV) bivalent and quadrivalent vaccines have been widely implemented in worldwide organized immunization programs. A nonavalent HPV vaccine is now available in several countries. The objective was to describe the fraction of squamous non-invasive high-grade cervical intraepithelial lesi...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-017-0879-1
更新日期:2017-11-06 00:00:00
abstract::The NanoSight LM10 with Nanoparticle tracking analysis (NTA) software was evaluated for the quantification of latex particles, adenovirus 5, and influenza virus. The inter-day variability was determined by measuring the same sample over several consecutive days and the method's accuracy was demonstrated by using known...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-9-265
更新日期:2012-11-12 00:00:00
abstract:BACKGROUND:Torque Teno Virus (TTV) was the first single stranded circular DNA virus to be discovered that infects humans. Although there have been numerous reports regarding the prevalence of TTV from other countries of South Asia, there is severe lack of information regarding its prevalence in Pakistan. Thus the prese...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-9-320
更新日期:2012-12-28 00:00:00
abstract:BACKGROUND:Classical swine fever (CSF) caused by virulent strains of Classical swine fever virus (CSFV) is a haemorrhagic disease of pigs, characterized by disseminated intravascular coagulation, thrombocytopoenia and immunosuppression, and the swine endothelial vascular cell is one of the CSFV target cells. In this re...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-4
更新日期:2010-01-11 00:00:00
abstract:BACKGROUND:Progressive multifocal leukoencephalopathy (PML) onset, caused by Polyomavirus JC (JCPyV) in patients affected by immune-mediated diseases during biological treatment, raised concerns about the safety profile of these agents. Therefore, the aims of this study were the JCPyV reactivation monitoring and the no...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-298
更新日期:2013-09-30 00:00:00
abstract:BACKGROUND:Rodent borne hantaviruses are emerging viruses infecting humans through inhalation. They cause hemorrhagic fever with renal syndrome and hemorrhagic cardiopulmonary syndrome. Recently, hantaviruses have been detected in other small mammals such as Soricomorpha (shrews, moles) and Chiroptera (bats), suggested...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-020-01477-w
更新日期:2020-12-29 00:00:00
abstract::Earlier, we detected viral RNAs packaged in the porcine adenovirus (PAdV) -3 virions. Using Southern blot analysis, we further demonstrated that the viral RNAs were predominantly packaged in CsCl purified mature capsids (containing viral genome) than empty/intermediate capsids. Some of the packaged viral RNAs appear t...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-6-16
更新日期:2009-02-05 00:00:00
abstract:BACKGROUND:Dengue fever is perhaps the most important viral re-emergent disease especially in tropical and sub-tropical countries, affecting about 50 million people around the world yearly. In Colombia, dengue virus was first detected in 1971 and still remains as a major public health issue. Although four viral serotyp...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-9-64
更新日期:2012-03-09 00:00:00
abstract:BACKGROUND:Foot-and-mouth disease (FMD) is a highly contagious disease of livestock which causes severe economic loss in cloven-hoofed animals. Vaccination is still a major strategy in developing countries to control FMD. Currently, inactivated vaccine of FMDV has been used in many countries with limited success and sa...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-77
更新日期:2011-02-23 00:00:00
abstract:BACKGROUND:The VP2 outer capsid protein Bluetongue Virus (BTV) is responsible for receptor binding, haemagglutination and eliciting host-specific immunity. However, the assembly of this outer capsid protein on the transcriptionally active viral core would block transcription of the virus. Thus assembly of the outer cap...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-4-7
更新日期:2007-01-15 00:00:00
abstract:BACKGROUND:Hepatitis C virus (HCV) Core protein regulates multiple signaling pathways and alters cellular genes expression responsible for HCV induced pathogenesis leading to hepatocellular carcinoma (HCC). Prevalence of HCV genotype 3a associated HCC is higher in Pakistan as compare to the rest of world; however the m...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-522
更新日期:2011-11-23 00:00:00