Abstract:
BACKGROUND:Human papillomavirus (HPV) bivalent and quadrivalent vaccines have been widely implemented in worldwide organized immunization programs. A nonavalent HPV vaccine is now available in several countries. The objective was to describe the fraction of squamous non-invasive high-grade cervical intraepithelial lesions attributable to genotypes targeted by bi-quadrivalent vaccines and by nonavalent vaccine according to age and diagnosis in women living in the city of Vigo (Galicia, Spain). METHODS:Cervical scrapings (2009-2014) of women with histological diagnosis of cervical intraepithelial neoplasia grade 2 (CIN2, n = 145) and grade 3-carcinoma in situ (CIN3-CIS, n = 244) were tested with Linear Array HPV Genotyping test (Roche diagnostics, Mannheim, Germany). Hierarchical estimation of the fraction attributable to HPV 16/18 or HPV 31/33/45/52/58 detected alone or in combination was calculated. Absolute additional fraction attributable to genotypes targeted by nonavalent vaccine compared to genotypes targeted by bi-quadrivalent vaccines was calculated as the increment of attributable cases with respect to all studied cases. Age group 1, 2 and 3 included women 18 to 34, 35-44 and ≥45 years old, respectively. EPIDAT 3.1 was used. RESULTS:Fraction attributable to genotypes targeted by bi-quadrivalent vaccines was 59% CIN2 vs. 69% CIN3-CIS (p < 0.001). It was 63/51/50% of CIN2 and 78/66/45% of CIN3-CIS in age group 1, 2, 3, respectively. Fraction attributable to genotypes targeted by nonavalent vaccine was 86% CIN2 and 86% CIN3-CIS. It was 87/91/75% of CIN2 and 90/86/76% of CIN3-CIS in age group 1, 2, 3, respectively. Fraction attributable to genotypes targeted by these vaccines tended to decrease as age increased (p-trend <0.05). Globally, absolute additional attributable fraction was 16%, 26% and 29% in age group 1, 2 and 3, respectively (p < 0.005). CONCLUSIONS:Absolute additional fraction of CIN2 and CIN3-CIS attributable to genotypes targeted by nonavalent vaccine was observed in women of any age, especially in those over 35 years old.
journal_name
Virol Jjournal_title
Virology journalauthors
Perez S,Iñarrea A,Pérez-Tanoira R,Gil M,López-Díez E,Valenzuela O,Porto M,Alberte-Lista L,Peteiro-Cancelo MA,Treinta A,Carballo R,Reboredo MC,Alvarez-Argüelles ME,Purriños MJdoi
10.1186/s12985-017-0879-1subject
Has Abstractpub_date
2017-11-06 00:00:00pages
214issue
1issn
1743-422Xpii
10.1186/s12985-017-0879-1journal_volume
14pub_type
杂志文章相关文献
Virology Journal文献大全abstract:BACKGROUND:Nipah virus (NiV) is a zoonotic virus belonging to the henipavirus genus in the family Paramyxoviridae. Since NiV was first identified in 1999, outbreaks have continued to occur in humans in Bangladesh and India on an almost annual basis with case fatality rates reported between 40% and 100%. METHODS:Ferret...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-237
更新日期:2013-07-16 00:00:00
abstract::Human cytomegalovirus (HCMV), a member of the Betaherpesvirinae sub-family of Herpesviridae family, is a widespread pathogen that infects a majority of the world's population by early adulthood. In individuals whose immune systems are immature or weakened, HCMV is a significant pathogen causing morbidity and mortality...
journal_title:Virology journal
pub_type: 杂志文章,评审
doi:10.1186/1743-422X-9-22
更新日期:2012-01-17 00:00:00
abstract::In order to improve the presentation and immunogenicity of single epitopes, virus-like particles (VLPs) are being used as platforms for the display of foreing epitopes on their surface. The rotavirus major capsid protein VP6 has the ability to self-assemble into empty non-infectious VLPs. In the present study, we anal...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-6-192
更新日期:2009-11-06 00:00:00
abstract:BACKGROUND:The UL54 protein of Duck Enteritis Virus (DEV) is a homolog of herpes simplex virus-1 (HSV-1) immediate-early infectious cell protein 27 (ICP27), a multifunctional protein essential for viral infection. Nonetheless, there is little information on the UL54 protein of DEV. METHODS:The UL54 gene was cloned int...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-015-0424-z
更新日期:2015-11-25 00:00:00
abstract:BACKGROUND:The BK Polyomavirus (BKPyV) and JC polyomavirus (JCPyV) infections are widespread in human population and have been associated with severe kidney and brain disorders, respectively. The viruses remain latent primarily in reno-urinary tract, reactivating only in case of a compromised immune system. The seroepi...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-017-0752-2
更新日期:2017-04-24 00:00:00
abstract:BACKGROUND:Mumps virus is a negative-sense, single stranded RNA virus consisting of a ribonucleocapsid core enveloped by a lipid membrane derived from host cell, which causes mumps disease preventable by vaccination. Since virus lipid envelope and glycosylation pattern are not encoded by the virus but dependent on the ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-016-0463-0
更新日期:2016-01-14 00:00:00
abstract:BACKGROUND:Japanese encephalitis virus (JEV) is a mosquito-borne flavivirus that causes acute viral encephalitis in humans. Pigs are important amplifier hosts of JEV. Emerging evidence indicates that host microRNAs (miRNAs) play key roles in modulating viral infection and pathogenesis. However, mechanistic studies deli...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-016-0562-y
更新日期:2016-06-21 00:00:00
abstract::A tenuivirus, referred to here as JKI 29327, was isolated from a black medic (Medicago lupulina) plant collected in Austria. The virus was mechanically transmitted to Nicotiana benthamiana, M. lupulina, M. sativa, Pisum sativum and Vicia faba. The complete genome was determined by high throughput sequencing. The genom...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-019-1195-8
更新日期:2019-07-05 00:00:00
abstract:BACKGROUND:Farmington virus (FARV) is a rhabdovirus that was isolated from a wild bird during an outbreak of epizootic eastern equine encephalitis on a pheasant farm in Connecticut, USA. FINDINGS:Analysis of the nearly complete genome sequence of the prototype CT AN 114 strain indicates that it encodes the five canoni...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-219
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:T4 phage is a model species that has contributed broadly to our understanding of molecular biology. T4 DNA replication and packaging share various mechanisms with human double-stranded DNA viruses such as herpes virus. The literature indicates that T4-like phage genomes have permuted terminal sequences, and ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-194
更新日期:2011-04-27 00:00:00
abstract:BACKGROUND:Astroviruses (AstVs) have been reported to infect and cause gastroenteritis in most animal species. Human AstVs were regarded the causative agent of viral diarrhea in children. In dogs, little is known about the epidemiology and clinical significance of AstV infection. FINDINGS:In this study, we collected a...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-017-0823-4
更新日期:2017-08-17 00:00:00
abstract::Members of the genus Cypovirus (family Reoviridae) are common pathogens of insects. These viruses have linear dsRNA genomes divided into 10-11 segments, which have generally been assumed to be monocistronic. Here, bioinformatic evidence is presented for a short overlapping coding sequence (CDS) in the cypovirus genome...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-5-62
更新日期:2008-05-20 00:00:00
abstract:BACKGROUND:Infection with hepatitis B virus (HBV) is major public health concern. The limitations of available antiviral drugs require development of novel approaches to inhibit HBV replication. This study was conducted to identify functional elements and new siRNA target sites within the highly conserved regions of th...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-216
更新日期:2010-09-08 00:00:00
abstract:BACKGROUND:According to international guidelines, HPV DNA tests represent a valid alternative to Pap Test for primary cervical cancer screening, provided that they guarantee balanced clinical sensitivity and specificity for cervical intraepithelial neoplasia grade 2 or more severe lesions. The aim of this study was to ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-018-0965-z
更新日期:2018-03-20 00:00:00
abstract:BACKGROUND:The human polyomavirus BK expresses a 66 amino-acid peptide referred to as agnoprotein. Though mutants lacking agnoprotein are severely reduced in producing infectious virions, the exact function of this peptide remains incompletely understood. To elucidate the function of agnoprotein, we searched for novel ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-014-0220-1
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Torquetenovirus (TTV) belongs to Anelloviridae family, infects nearly all people indefinitely without causing overt disease establishing a fine and successful interaction with the host. Increasing evidence have shown some human viruses exploit extracellular vesicles thereby helping viral persistence in the h...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-018-1055-y
更新日期:2018-09-20 00:00:00
abstract:BACKGROUND:Infectious salmon anemia virus (ISAV) is an important fish pathogen that causes high mortality in farmed Atlantic salmon. The ISAV genome consists of eight single-stranded, negative-sense RNA segments. The six largest segments contain one open reading frame (ORF) each, and encode three polymerase proteins, n...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-017-0702-z
更新日期:2017-02-15 00:00:00
abstract:BACKGROUND:Pseudorabies virus (PRV) of the family Herpesviridae is the causative agent of Aujeszky's disease. Attenuation of PRV by serial passaging in vitro is a well-established method; however, the dynamic variations occurring on viral genome during this process have not been characterized. METHODS:Genome sequencin...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/s12985-018-1102-8
更新日期:2018-12-29 00:00:00
abstract:BACKGROUND:Xenotransplantation using pig cells, tissues and organs may help to overcome the shortage of human tissues and organs for the treatment of tissue and organ failure. Progress in the prevention of immunological rejection using genetically modified pigs and new, more effective, immunosuppression regimens will a...
journal_title:Virology journal
pub_type: 杂志文章,评审
doi:10.1186/s12985-018-1088-2
更新日期:2018-11-08 00:00:00
abstract:BACKGROUND:Panicum streak virus (PanSV; Family Geminiviridae; Genus Mastrevirus) is a close relative of Maize streak virus (MSV), the most serious viral threat to maize production in Africa. PanSV and MSV have the same leafhopper vector species, largely overlapping natural host ranges and similar geographical distribut...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-6-194
更新日期:2009-11-10 00:00:00
abstract:BACKGROUND:Duck circovirus (DuCV) infection in farmed ducks is associated with growth problems or retardation syndromes. Rapid identification of DuCV infected ducks is essential to control DuCV effectively. Therefore, this study aims to develop of an assay for DuCV to be highly specific, sensitive, and simple without a...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-11-76
更新日期:2014-04-29 00:00:00
abstract::The original version of the acknowledgement unfortunately contained a mistake. ...
journal_title:Virology journal
pub_type: 已发布勘误
doi:10.1186/s12985-020-01439-2
更新日期:2020-11-09 00:00:00
abstract::We report the presence of three new O1 ElTor vibriophages named AS1, AS2 and AS3, isolated from the sewage and pond waters of the outskirts of Kolkata. A few phages, named AS4, with hexagonal heads and abnormally long tails with typical curly projections were also found in the water samples. ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-2-28
更新日期:2005-04-11 00:00:00
abstract:BACKGROUND:Hepatitis C virus (HCV) Core protein regulates multiple signaling pathways and alters cellular genes expression responsible for HCV induced pathogenesis leading to hepatocellular carcinoma (HCC). Prevalence of HCV genotype 3a associated HCC is higher in Pakistan as compare to the rest of world; however the m...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-8-522
更新日期:2011-11-23 00:00:00
abstract:BACKGROUND:An extensive outbreak of equine influenza occurred across multiple countries in South America during 2012. The epidemic was first reported in Chile then spread to Brazil, Uruguay and Argentina, where both vaccinated and unvaccinated animals were affected. In Brazil, infections were widespread within 3months ...
journal_title:Virology journal
pub_type: 历史文章,杂志文章
doi:10.1186/s12985-016-0503-9
更新日期:2016-03-19 00:00:00
abstract:BACKGROUND:Aleutian mink disease virus (AMDV) is the cause of a chronic immune complex disease, Aleutian disease (AD), which is common in mink-producing countries. In 2005, implementation of an AMDV eradication programme in Finland created a need for an automated high-throughput assay. The aim of this study was to vali...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-11-141
更新日期:2014-08-08 00:00:00
abstract::HIV expressed in genital secretions provides the inoculum from which transmitting variants are selected, both in sexual transmission and mother-to-infant transmission during partuition. Characterization of HIV levels and genotypes found in vaginal secretions and the impact of anti-retroviral therapy (ART) on this viru...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-5-87
更新日期:2008-07-29 00:00:00
abstract:BACKGROUND:The genus Orbivirus includes several species that infect livestock - including Bluetongue virus (BTV) and African horse sickness virus (AHSV). These viruses have linear dsRNA genomes divided into ten segments, all of which have previously been assumed to be monocistronic. RESULTS:Bioinformatic evidence is p...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-5-48
更新日期:2008-04-14 00:00:00
abstract:BACKGROUND:Subviral particles of hepatitis B virus (HBV) composed of L protein deletion variants with the 48 N-terminal amino acids of preS joined to the N-terminus of S protein (1-48preS/S) induced broadly neutralizing antibodies after immunization of mice with a Semliki Forest virus vector. A practical limitation for...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-10-63
更新日期:2013-02-25 00:00:00
abstract:BACKGROUND:Co-circulation of multiple dengue virus serotypes has been reported from many parts of the world including India, however concurrent infection with more than one serotype of dengue viruses in the same individual is rarely documented. An outbreak of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) occ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-5-1
更新日期:2008-01-09 00:00:00