Evidence of recombination in quasispecies populations of a Hepatitis C Virus patient undergoing anti-viral therapy.

abstract：BACKGROUND:Hepatitis C virus (HCV) encodes several proteins that interfere with the host cell antiviral response. Previously, the serine protease NS3/4A was shown to inhibit IFN-beta gene expression by blocking dsRNA-activated retinoic acid-inducible gene I (RIG-I) and Toll-like receptor 3 (TLR3)-mediated signaling pat...

journal_title：Virology journal

authors： Kaukinen P,Sillanpää M,Kotenko S,Lin R,Hiscott J,Melén K,Julkunen I

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Controversy remains as to whether antiviral agents contribute to renal dysfunction in patients with chronic hepatitis B virus (HBV) infection. Thus, the aim of study was to analyze the changes in renal function of chronic hepatitis B (CHB) patients in response to anti-HBV therapy and the association with tre...

journal_title：Virology journal

authors： Zhang Y,Zhang WL,Pang XW,Wang LX,Wei X,Huang CX,Bai XF,Han S,Liu LN,Lian JQ

更新日期：2017-03-09 00:00:00

abstract：BACKGROUND:Bovine viral diarrhea virus (BVDV) infections continue to cause significantly losses in the deer population. Better isolation and identification of BVDV from sika deer may contribute significantly to the development of prophylactic therapeutic, and diagnostic reagents as well as help in prevention and contro...

journal_title：Virology journal

authors： Gao Y,Wang S,Du R,Wang Q,Sun C,Wang N,Zhang P,Zhang L

更新日期：2011-02-25 00:00:00

abstract：:The Filoviridae family comprises of Ebola and Marburg viruses, which are known to cause lethal hemorrhagic fever. However, there is no effective anti-viral therapy or licensed vaccines currently available for these human pathogens. The envelope glycoprotein (GP) of Ebola virus, which mediates entry into target cells, ...

journal_title：Virology journal

authors： Bhattacharyya S,Hope TJ

更新日期：2011-01-12 00:00:00

abstract：BACKGROUND:In China, more than 20 million patients with chronic hepatitis B need antiviral treatment. Side effects of antiviral treatment such as renal complications can be problematic, particularly in an aging population. METHODS:The data were retrospectively extracted from the hospital medical charts of five centers...

journal_title：Virology journal

authors： Gu J,Yu G,Zhang X,Zhang S,Cai H,Ye C,Yang Y,Li D,Tong Z,Shen H,Chen H,Ding F,Lai X,Liu J,Xu M,Wu W

更新日期：2021-01-13 00:00:00

abstract：BACKGROUND:Andes virus (ANDV), a rodent-borne Hantavirus, is the major etiological agent of Hantavirus cardiopulmonary syndrome (HCPS) in South America, which is mainly characterized by a vascular leakage with high rate of fatal outcomes for infected patients. Currently, neither specific therapy nor vaccines are availa...

journal_title：Virology journal

authors： Marsac D,García S,Fournet A,Aguirre A,Pino K,Ferres M,Kalergis AM,Lopez-Lastra M,Veas F

更新日期：2011-05-13 00:00:00

abstract：BACKGROUND:Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by SFTS bunyavirus (SFTSV), a tick borne bunyavirus. However, Immunohistochemistry of SFTS patients are not well studied. METHODS:We obtained multiple of tissues from a fatal case with SFTS, including blood, lungs, k...

journal_title：Virology journal

authors： Li S,Li Y,Wang Q,Yu X,Liu M,Xie H,Qian L,Ye L,Yang Z,Zhang J,Zhu H,Zhang W

更新日期：2018-05-30 00:00:00

abstract：BACKGROUND:The gut microbiome is closely associated with the health of the host; although the interaction between the bacterial microbiome and the whole virome has rarely been studied, it is likely of medical importance. Examination of the interactions between the gut bacterial microbiome and virome of rhesus monkey wo...

journal_title：Virology journal

authors： Li H,Li H,Wang J,Guo L,Fan H,Zheng H,Yang Z,Huang X,Chu M,Yang F,He Z,Li N,Yang J,Wu Q,Shi H,Liu L

更新日期：2019-08-19 00:00:00

abstract：BACKGROUND:Persistent infection of human papillomavirus (HPV) types 16 and 18 causes cervical cancer. To better understand immune responses to the prophylactic vaccine, HPV 16/18 L1 virus-like particles (HPV-VLPs), we investigated B cell epitopes of HPV16 L1-derived peptides. METHODS:Sera from mice immunized with HPV-...

journal_title：Virology journal

authors： Fukui A,Matsueda S,Kawano K,Tsuda N,Komatsu N,Shichijo S,Sasada T,Hattori S,Ushijima K,Itoh K,Kamura T

更新日期：2012-09-14 00:00:00

abstract：BACKGROUND:Zika virus (ZIKV) is a major human pathogen and member of the Flavivirus genus. Previous studies have identified neutralizing antibodies from Zika patients that bind to quaternary epitopes across neighboring envelope (E) proteins, called E dimer epitopes (EDE). An asparagine-linked glycan on the "glycan loop...

journal_title：Virology journal

authors： Henderson EA,Tam CC,Cheng LW,Ngono AE,Nguyen AV,Shresta S,McGee M,Padgett H,Grill LK,Martchenko Shilman M

更新日期：2020-03-31 00:00:00

abstract：BACKGROUND:Brevicoryne brassicae virus (BrBV) is a positive-strand genomic RNA virus which is unassigned tentative member of the genus Iflavirus. BrBv was first identified and characterized in the late 90's in the cabbage aphid in the United Kingdom (UK) (J Gen Virol 88:2590-2595, 2007) and was fully sequenced, using r...

journal_title：Virology journal

authors： Luria N,Reingold V,Lachman O,Sela N,Dombrovsky A

更新日期：2016-03-22 00:00:00

abstract：BACKGROUND:Influenza A virus evolution in humans is driven at least in part by mutations allowing the virus to escape antibody neutralization. Little is known about the evolution of influenza in birds, a major reservoir of influenza A. METHODS:Neutralizing polyclonal antiserum was raised in chicken against reassortant...

journal_title：Virology journal

authors： Thangavel RR,Reed A,Norcross EW,Dixon SN,Marquart ME,Stray SJ

更新日期：2011-04-18 00:00:00

abstract：:Adenovirus has a wide tissue tropism. The virus attaches to the surface of cells via the fiber protein knob binding to the Coxsackie and Adenovirus receptor known as CAR. Virus entry inside cells is facilitated by integrins αVβ3 and αVβ5. Mice platelets are shown to be the predominant Ad binding blood cell type and th...

journal_title：Virology journal

authors： Gupalo E,Buriachkovskaia L,Othman M

更新日期：2011-09-30 00:00:00

abstract：:Information on the replication of viral haemorrhagic fever viruses is not readily available and has never been analysed in a comparative approach. Here, we compared the cell culture growth characteristics of haemorrhagic fever viruses (HFV), of the Arenaviridae, Filoviridae, Bunyaviridae, and Flavivridae virus familie...

journal_title：Virology journal

authors： Weidmann M,Sall AA,Manuguerra JC,Koivogui L,Adjami A,Traoré FF,Hedlund KO,Lindegren G,Mirazimi A

更新日期：2011-02-24 00:00:00

abstract：BACKGROUND:Human pegivirus-1 (HPgV-1) is a member of the Flaviviridae family whose genomic organization and mode of cellular entry is similar to that of hepatitis C virus (HCV). The E2 glycoprotein of HPgV-1 is the principle mediator in the virus-cell interaction and as such harbors most of HPgV-1's antigenic determina...

journal_title：Virology journal

authors： Vitrenko Y,Kostenko I,Kulebyakina K,Sorochynska K

更新日期：2017-08-31 00:00:00

abstract：:Human cytomegalovirus (HCMV), a member of the Betaherpesvirinae sub-family of Herpesviridae family, is a widespread pathogen that infects a majority of the world's population by early adulthood. In individuals whose immune systems are immature or weakened, HCMV is a significant pathogen causing morbidity and mortality...

journal_title：Virology journal

authors： Tomtishen JP 3rd

更新日期：2012-01-17 00:00:00

abstract：BACKGROUND:Cell culture adaptation of very virulent infectious bursal disease virus (vvIBDV) was shown to be mainly associated with the VP2 capsid protein residues 253, 279, and 284. The single mutation A284T proved critical for cell culture tropism, but did not confer efficient virus replication, which at least requir...

journal_title：Virology journal

authors： Ben Abdeljelil N,Khabouchi N,Kassar S,Miled K,Boubaker S,Ghram A,Mardassi H

更新日期：2014-11-25 00:00:00

abstract：BACKGROUND:Human respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) are two of the most frequent respiratory pathogens that circulate worldwide. Infection with either virus can lead to hospitalization of young children, immunocompromised people and the elderly.A better understanding of the epidemiologi...

journal_title：Virology journal

authors： Sastre P,Ruiz T,Schildgen O,Schildgen V,Vela C,Rueda P

更新日期：2012-07-02 00:00:00

abstract：BACKGROUND:During the last two decades, structural biology analyses have shown that viruses infecting hosts far apart in evolution share similar architectural features, prompting a new virus classification based on structural lineages. Until recently, only a few prokaryotic viruses had been described for one of the lin...

journal_title：Virology journal

authors： San Martín C,van Raaij MJ

更新日期：2018-11-23 00:00:00

abstract：BACKGROUND:HIV-1 entry into cells is a multifaceted process involving target cell CD4 and the chemokine receptors, CXCR4 or CCR5. The lipid composition of the host cell plays a significant role in the HIV fusion process as it orchestrates the appropriate disposition of CD4 and co-receptors required for HIV-1 envelope g...

journal_title：Virology journal

authors： Ablan S,Rawat SS,Viard M,Wang JM,Puri A,Blumenthal R

更新日期：2006-12-22 00:00:00

abstract：:Viral diseases constitute obstacles to pepper production in the world. In Nigeria, pepper plants are primarily affected by pepper veinal mottle virus (PVMV), Cucumber mosaic virus (CMV), Pepper leaf curl Virus (TLCV), Tobacco mosaic virus (TMV), Pepper mottle virus (PMV) and a host of other viruses. The experiment was...

journal_title：Virology journal

authors： Arogundade O,Balogun OS,Kareem KT

更新日期：2012-04-11 00:00:00

abstract：BACKGROUND:Most of the non-B HIV-1 subtypes are predominant in Sub-Saharan Africa and India although they have been found worldwide. In the last decade, immigration from these areas has increased considerably in Spain. The objective of this study was to evaluate the prevalence of non-B subtypes circulating in a cohort ...

journal_title：Virology journal

authors： de Felipe B,Pérez-Romero P,Abad-Fernández M,Fernandez-Cuenca F,Martinez-Fernandez FJ,Trastoy M,Mata Rdel C,López-Cortés LF,Leal M,Viciana P,Vallejo A

更新日期：2011-08-26 00:00:00

abstract：BACKGROUND:Xenotransplantation using pig cells, tissues and organs may help to overcome the shortage of human tissues and organs for the treatment of tissue and organ failure. Progress in the prevention of immunological rejection using genetically modified pigs and new, more effective, immunosuppression regimens will a...

journal_title：Virology journal

authors： Denner J

更新日期：2018-11-08 00:00:00

abstract：BACKGROUND:Acute gastroenteritis caused by bacteria, virus and parasite is an important cause of childhood morbidity and mortality in developing countries. Rotavirus and norovirus have been recognized as the most common pathogens causing acute gastroenteritis among children. However, there is still no valuable data abo...

journal_title：Virology journal

authors： Sai L,Sun J,Shao L,Chen S,Liu H,Ma L

更新日期：2013-10-08 00:00:00

abstract：BACKGROUND:An extensive outbreak of equine influenza occurred across multiple countries in South America during 2012. The epidemic was first reported in Chile then spread to Brazil, Uruguay and Argentina, where both vaccinated and unvaccinated animals were affected. In Brazil, infections were widespread within 3months ...

journal_title：Virology journal

authors： Alves Beuttemmüller E,Woodward A,Rash A,Dos Santos Ferraz LE,Fernandes Alfieri A,Alfieri AA,Elton D

更新日期：2016-03-19 00:00:00

abstract：:Remarkable progress has been made during the past ten years in elucidating the structure of the bacteriophage T4 tail by a combination of three-dimensional image reconstruction from electron micrographs and X-ray crystallography of the components. Partial and complete structures of nine out of twenty tail structural p...

journal_title：Virology journal

authors： Leiman PG,Arisaka F,van Raaij MJ,Kostyuchenko VA,Aksyuk AA,Kanamaru S,Rossmann MG

更新日期：2010-12-03 00:00:00

abstract：BACKGROUND:To understand the prevalence and characteristics of human cytomegalovirus (HCMV) infection in children in the Weifang area, and to provide information for its prevention and treatment. METHODS:A comprehensive survey was performed from 2009 to 2012 in 7582 children from birth to 6 years of age hospitalized i...

journal_title：Virology journal

authors： Sun X,Liu Z,Wang B,Shi L,Liang R,Li L,Qian D,Song X

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Torque Teno Virus (TTV) was the first single stranded circular DNA virus to be discovered that infects humans. Although there have been numerous reports regarding the prevalence of TTV from other countries of South Asia, there is severe lack of information regarding its prevalence in Pakistan. Thus the prese...

journal_title：Virology journal

authors： Hussain T,Manzoor S,Waheed Y,Tariq H,Hanif K

更新日期：2012-12-28 00:00:00

abstract：BACKGROUND:Nonstructural glycoprotein 4 (NSP4) encoded by rotavirus is the only viral protein currently believed to function as an enterotoxin. NSP4 is synthesized as an intracellular transmembrane glycoprotein and as such is essential for virus assembly. Infection of polarized Caco-2 cells with rotavirus also results ...

journal_title：Virology journal

authors： Didsbury A,Wang C,Verdon D,Sewell MA,McIntosh JD,Taylor JA

更新日期：2011-12-20 00:00:00

abstract：:Hairpin RNAs have been used to confer resistance to viruses in plants through RNA silencing. However, it has not been demonstrated that RNA silencing was effective against inoculation by aphids of non-persistently transmitted viruses, the major route of plant virus spread in nature. As a proof-of-principle strategy, w...

journal_title：Virology journal

authors： Vargas M,Martínez-García B,Díaz-Ruíz JR,Tenllado F

更新日期：2008-03-19 00:00:00