当前位置： SCI文献检索 > Virology Journal期刊下所有文献 > The altered gut virome community in rhesus monkeys is correlated with the gut bacterial microbiome and associated metabolites.

The altered gut virome community in rhesus monkeys is correlated with the gut bacterial microbiome and associated metabolites.

Abstract：

BACKGROUND:The gut microbiome is closely associated with the health of the host; although the interaction between the bacterial microbiome and the whole virome has rarely been studied, it is likely of medical importance. Examination of the interactions between the gut bacterial microbiome and virome of rhesus monkey would significantly contribute to revealing the gut microbiome composition. METHODS:Here, we conducted a metagenomic analysis of the gut microbiome of rhesus monkeys in a longitudinal cohort treated with an antibiotic cocktail, and we documented the interactions between the bacterial microbiome and virome. The depletion of viral populations was confirmed at the species level by real-time PCR. We also detected changes in the gut metabolome by GC-MS and LC-MS. RESULTS:A majority of bacteria were depleted after treatment with antibiotics, and the Shannon diversity index decreased from 2.95 to 0.22. Furthermore, the abundance-based coverage estimator (ACE) decreased from 104.47 to 33.84, and the abundance of eukaryotic viruses also changed substantially. In the annotation, 6 families of DNA viruses and 1 bacteriophage family were present in the normal monkeys but absent after gut bacterial microbiome depletion. Intriguingly, we discovered that changes in the gut bacterial microbiome composition may promote changes in the gut virome composition, and tryptophan, arginine, and quinone may play roles in the interaction between the bacterial microbiome and virome. CONCLUSION:Our results indicated that the clearly altered composition of the virome was correlated with depletion in the bacterial community and that metabolites produced by bacteria possibly play important roles in the interaction.

journal_name

Virol J

journal_title

Virology journal

authors

Li H,Li H,Wang J,Guo L,Fan H,Zheng H,Yang Z,Huang X,Chu M,Yang F,He Z,Li N,Yang J,Wu Q,Shi H,Liu L

doi

10.1186/s12985-019-1211-z

subject

Has Abstract

pub_date

2019-08-19 00:00:00

pages

105

issue

1

issn

1743-422X

pii

10.1186/s12985-019-1211-z

journal_volume

16

pub_type

杂志文章

相关文献

Virology Journal文献大全
  • Epidemics of enterovirus infection in Chungnam Korea, 2008 and 2009.

    abstract：: Previously, we explored the epidemic pattern and molecular characterization of enteroviruses isolated in Chungnam, Korea from 2005 to 2006. The present study extended these observations to 2008 and 2009. In this study, enteroviruses showed similar seasonal prevalent pattern from summer to fall and age distribution to...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-8-297

    authors： Baek K,Yeo S,Lee B,Park K,Song J,Yu J,Rheem I,Kim J,Hwang S,Choi Y,Cheon D,Park J

    更新日期：2011-06-13 00:00:00

  • Oral vaccination with a recombinant Salmonella vaccine vector provokes systemic HIV-1 subtype C Gag-specific CD4+ Th1 and Th2 cell immune responses in mice.

    abstract：BACKGROUND:Recombinant Salmonella vaccine vectors may potentially be used to induce specific CD4+ T cell responses against foreign viral antigens. Such immune responses are required features of vaccines against pathogens such as human immunodeficiency virus type 1 (HIV-1). The aim of this study was to investigate the i...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-6-87

    authors： Chin'ombe N,Bourn WR,Williamson AL,Shephard EG

    更新日期：2009-06-25 00:00:00

  • The full genome sequence of three strains of Jamestown Canyon virus and their pathogenesis in mice or monkeys.

    abstract：BACKGROUND:Jamestown Canyon virus (JCV), family Bunyaviridae, is a mosquito-borne pathogen endemic in the United States and Canada that can cause encephalitis in humans and is considered an emerging threat to public health. The virus is genetically similar to Inkoo virus circulating in Europe, suggesting that much of t...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-8-136

    authors： Bennett RS,Nelson JT,Gresko AK,Murphy BR,Whitehead SS

    更新日期：2011-03-24 00:00:00

  • Controlled release delivery of penciclovir via a silicone (MED-4750) polymer: kinetics of drug delivery and efficacy in preventing primary feline herpesvirus infection in culture.

    abstract：BACKGROUND:Herpesviruses are ubiquitous pathogens that infect and cause recurrent disease in multiple animal species. Feline herpesvirus-1 (FHV-1), a member of the alphaherpesvirus family, causes respiratory illness and conjunctivitis, and approximately 80% of domestic cats are latently infected. Oral administration of...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-11-34

    authors： Semenkow SL,Johnson NM,Maggs DJ,Margulies BJ

    更新日期：2014-02-22 00:00:00

  • Isolation of mixed subtypes of influenza A virus from a bald eagle (Haliaeetus leucocephalus).

    abstract：:From April 2007 to March 2008, cloacal swabs were obtained from 246 casualty raptors recovered by various wildlife rehabilitation centers in the United States. The swabs were placed in a virus transport medium and transported to the laboratory on ice packs. At the laboratory, the samples were pooled with each pool con...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-7-174

    authors： Goyal SM,Jindal N,Chander Y,Ramakrishnan MA,Redig PT,Sreevatsan S

    更新日期：2010-07-28 00:00:00

  • Genetic diversity and C2-like subgenogroup strains of enterovirus 71, Taiwan, 2008.

    abstract：BACKGROUND:Human enterovirus 71 (EV-71) is known of having caused numerous outbreaks of hand-foot-mouth disease, and other clinical manifestations globally. In 2008, 989 EV-71 strains were isolated in Taiwan. RESULTS:In this study, the genetic and antigenic properties of these strains were analyzed and the genetic div...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-7-277

    authors： Huang YP,Lin TL,Hsu LC,Chen YJ,Tseng YH,Hsu CC,Fan WB,Yang JY,Chang FY,Wu HS

    更新日期：2010-10-20 00:00:00

  • Serum levels of preS antigen (HBpreSAg) in chronic hepatitis B virus infected patients.

    abstract：BACKGROUND:Hepatitis B virus (HBV) infection is a serious health problem worldwide. Treatment recommendation and response are mainly indicated by viral load, e antigen (HBeAg) seroconversion, and ALT levels. The S antigen (HBsAg) seroconversion is much less frequent. Since HBeAg can be negative in the presence of high ...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-4-93

    authors： Lian M,Zhou X,Wei L,Qiu S,Zhou T,Li L,Gu X,Luo M,Zheng X

    更新日期：2007-09-24 00:00:00

  • De novo transcriptomic assembly and mRNA expression patterns of Botryosphaeria dothidea infection with mycoviruses chrysovirus 1 (BdCV1) and partitivirus 1 (BdPV1).

    abstract：BACKGROUND:Pear ring rot, caused by Botryosphaeria species, is responsible for substantial economic losses by causing severe recession of pear tree growth in China. Mycovirus-mediated hypovirulence in plant pathogenic fungi is a crucial biological method to control fungal diseases. METHODS:We conducted a large-scale a...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/s12985-018-1033-4

    authors： Wang L,Luo H,Hu W,Yang Y,Hong N,Wang G,Wang A,Wang L

    更新日期：2018-08-13 00:00:00

  • Difference in cytokine production and cell cycle progression induced by Epstein-Barr virus Lmp1 deletion variants in Kmh2, a Hodgkin lymphoma cell line.

    abstract：BACKGROUND:Epstein-Barr virus (EBV) is associated with 20-40% of Hodgkin's Lymphoma (HL) cases. EBV-encoded latent membrane protein 1 (LMP1) is a well-known oncogenic protein and two C-terminal deletion variants, del30-LMP1 and del69-LMP1, have been described in animal models to be more tumorigenic than the wild-type f...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-11-94

    authors： Sueur C,Lupo J,Mas P,Morand P,Boyer V

    更新日期：2014-05-19 00:00:00

  • Dissecting the role of putative CD81 binding regions of E2 in mediating HCV entry: putative CD81 binding region 1 is not involved in CD81 binding.

    abstract：BACKGROUND:Hepatitis C virus (HCV) encodes two transmembrane glycoproteins E1 and E2 which form a heterodimer. E1 is believed to mediate fusion while E2 has been shown to bind cellular receptors including CD81. In this study, alanine substitutions in E2 were generated within putative CD81 binding regions to define resi...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-5-46

    authors： Rothwangl KB,Manicassamy B,Uprichard SL,Rong L

    更新日期：2008-03-20 00:00:00

  • A loop-mediated isothermal amplification assay for the visual detection of duck circovirus.

    abstract：BACKGROUND:Duck circovirus (DuCV) infection in farmed ducks is associated with growth problems or retardation syndromes. Rapid identification of DuCV infected ducks is essential to control DuCV effectively. Therefore, this study aims to develop of an assay for DuCV to be highly specific, sensitive, and simple without a...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-11-76

    authors： Xie L,Xie Z,Zhao G,Liu J,Pang Y,Deng X,Xie Z,Fan Q,Luo S

    更新日期：2014-04-29 00:00:00

  • Vomiting and wasting disease associated with hemagglutinating encephalomyelitis viruses infection in piglets in Jilin, China.

    abstract：:One coronavirus strain was isolated from brain tissues of ten piglets with evident clinical manifestations of vomiting, diarrhea and dyskinesia in Jilin province in China. Antigenic and genomic characterizations of the virus (isolate PHEV-JLsp09) were based on multiplex PCR and negative staining electron microscopy an...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-8-130

    authors： Gao W,Zhao K,Zhao C,Du C,Ren W,Song D,Lu H,Chen K,Li Z,Lan Y,Xie S,He W,Gao F

    更新日期：2011-03-21 00:00:00

  • Kinetics of antibody-induced modulation of respiratory syncytial virus antigens in a human epithelial cell line.

    abstract：BACKGROUND:The binding of viral-specific antibodies to cell-surface antigens usually results in down modulation of the antigen through redistribution of antigens into patches that subsequently may be internalized by endocytosis or may form caps that can be expelled to the extracellular space. Here, by use of confocal-l...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-4-68

    authors： Sarmiento RE,Tirado RG,Valverde LE,Gómez-Garcia B

    更新日期：2007-07-03 00:00:00

  • Mouse macrophage innate immune response to Chikungunya virus infection.

    abstract：BACKGROUND:Infection with Chikungunya alphavirus (CHIKV) can cause severe arthralgia and chronic arthritis in humans with persistence of the virus in perivascular macrophages of the synovial membrane by mechanisms largely ill-characterized. FINDINGS:We herein analysed the innate immune response (cytokine and programme...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-9-313

    authors： Kumar S,Jaffar-Bandjee MC,Giry C,Connen de Kerillis L,Merits A,Gasque P,Hoarau JJ

    更新日期：2012-12-19 00:00:00

  • No observed effect of homologous recombination on influenza C virus evolution.

    abstract：:The occurrence of homologous recombination in influenza viruses has been under some debate recently. To determine the extent of homologous recombination in influenza C virus, recombination analyses of all available gene sequences of influenza C virus were carried out. No recombination signal was found. With the previo...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-7-227

    authors： Han GZ,Boni MF,Li SS

    更新日期：2010-09-14 00:00:00

  • Long-term nucleos(t)ide analogues therapy for adults with chronic hepatitis B reduces the risk of long-term complications: a meta-analysis.

    abstract：BACKGROUND:The effect of antiviral therapy in chronic hepatitis B (CHB) on reducing the risk of long-term complications (LTCs) remains unclear so far. To study whether long-term nucleos(t)ide analogues therapy can reduce the risk of long-term complications. METHODS:We searched MEDLINE, EMBASE, OVID, the Cochrane Centr...

    journal_title：Virology journal

    pub_type： 杂志文章,meta分析,评审

    doi：10.1186/1743-422X-8-72

    authors： Zhang QQ,An X,Liu YH,Li SY,Zhong Q,Wang J,Hu HD,Zhang DZ,Ren H,Hu P

    更新日期：2011-02-15 00:00:00

  • Investigation of the immunogenicity of Zika glycan loop.

    abstract：BACKGROUND:Zika virus (ZIKV) is a major human pathogen and member of the Flavivirus genus. Previous studies have identified neutralizing antibodies from Zika patients that bind to quaternary epitopes across neighboring envelope (E) proteins, called E dimer epitopes (EDE). An asparagine-linked glycan on the "glycan loop...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/s12985-020-01313-1

    authors： Henderson EA,Tam CC,Cheng LW,Ngono AE,Nguyen AV,Shresta S,McGee M,Padgett H,Grill LK,Martchenko Shilman M

    更新日期：2020-03-31 00:00:00

  • Identification of a novel linear B-cell epitope in the UL26 and UL26.5 proteins of Duck Enteritis Virus.

    abstract：BACKGROUND:The Unique Long 26 (UL26) and UL26.5 proteins of herpes simplex virus are known to function during the assembly of the viruses. However, for duck enteritis virus (DEV), which is an unassigned member of the family Herpesviridae, little information is available about the function of the two proteins. In this s...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-7-223

    authors： Liu X,Han Z,Shao Y,Yu D,Li H,Wang Y,Kong X,Liu S

    更新日期：2010-09-13 00:00:00

  • Evidence of recombination in quasispecies populations of a Hepatitis C Virus patient undergoing anti-viral therapy.

    abstract：BACKGROUND/AIM:Hepatitis C virus (HCV) has been the subject of intense research and clinical investigation as its major role in human disease has emerged. HCV circulates in vivo as a complex population of different but closely related viral variants, commonly referred to as a quasispecies. The extent to which recombina...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-3-87

    authors： Moreno MP,Casane D,López L,Cristina J

    更新日期：2006-10-24 00:00:00

  • Geminivirus mixed infection on pepper plants: synergistic interaction between PHYVV and PepGMV.

    abstract：BACKGROUND:PHYVV and PepGMV are plant viruses reported in Mexico and Southern US as causal agents of an important pepper disease known as "rizado amarillo". Mixed infections with PHYVV and PepGMV have been reported in several hosts over a wide geographic area. Previous work suggested that these viruses might interact a...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-8-104

    authors： Rentería-Canett I,Xoconostle-Cázares B,Ruiz-Medrano R,Rivera-Bustamante RF

    更新日期：2011-03-08 00:00:00

  • Hepatitis C virus core, NS3, NS4B and NS5A are the major immunogenic proteins in humoral immunity in chronic HCV infection.

    abstract：BACKGROUND:The viral genome of hepatitis C virus constitutes a 9.6-kb single-stranded positive-sense RNA which encodes altogether 11 viral proteins. In order to study the humoral immune responses against different HCV proteins in patients suffering from chronic HCV infection, we produced three structural (core, E1 and ...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-6-84

    authors： Sillanpää M,Melén K,Porkka P,Fagerlund R,Nevalainen K,Lappalainen M,Julkunen I

    更新日期：2009-06-23 00:00:00

  • Occurrence of genetic modifications in core, 5'UTR and NS5b of HCV associated with viral response to treatment.

    abstract：BACKGROUND:It is becoming progressively more understandable that genetic variability of viruses is a major challenge in translating the laboratory findings to clinic. Genetic variability is the underlying cause of variant viral proteins which are not targetable by host immunological machinery. METHODS:500 patients wer...

    journal_title：Virology journal

    pub_type： 临床试验,杂志文章

    doi：10.1186/1743-422X-11-171

    authors： Kanwal S,Mahmood T

    更新日期：2014-09-30 00:00:00

  • Monitoring HIV DNA and cellular activation markers in HIV-infected humanized mice under cART.

    abstract：BACKGROUND:The major obstacle to cure of HIV type-1 infection is the presence of the HIV reservoir, hidden from the immune system and insensitive to combined antiretroviral therapy (cART). Eradication approaches have been hindered by the difficulty for accurately monitoring its size in vivo, especially in the lymphoid ...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/s12985-018-1101-9

    authors： Rochat MA,Schlaepfer E,Kuster SP,Li D,Audige A,Ivic S,Fahrny A,Speck RF

    更新日期：2018-12-17 00:00:00

  • Screening and identification of B-cell epitopes within envelope protein of tembusu virus.

    abstract：BACKGROUND:Tembusu virus is a newly emerging flavivirus that caused egg-drop syndrome in ducks in China. TMUV envelope protein is a major structural protein locates at the surface of tembusu virus particle. During tembusu virus infection, envelope protein plays a pivotal role in induction of neutralizing antibody. Howe...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/s12985-018-1052-1

    authors： Zhao D,Han K,Huang X,Zhang L,Wang H,Liu N,Tian Y,Liu Q,Yang J,Liu Y,Li Y

    更新日期：2018-09-17 00:00:00

  • Characterization of hepatitis B virus (HBV) genotypes in patients from Rondônia, Brazil.

    abstract：BACKGROUND:Hepatitis B virus (HBV) can be classified into nine genotypes (A-I) defined by sequence divergence of more than 8% based on the complete genome. This study aims to identify the genotypic distribution of HBV in 40 HBsAg-positive patients from Rondônia, Brazil. A fragment of 1306 bp partially comprising surfac...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-7-315

    authors： Santos AO,Alvarado-Mora MV,Botelho L,Vieira DS,Pinho JR,Carrilho FJ,Honda ER,Salcedo JM

    更新日期：2010-11-12 00:00:00

  • The dual role of tetraspanin CD63 in HIV-1 replication.

    abstract：BACKGROUND:Previously, we showed that the tetraspanin membrane protein CD63 mediates both early and post-integration stages of the HIV-1 replication cycle. The temporal roles of CD63 were discerned using monoclonal antibodies and small interfering RNAs (siRNAs) to block CD63 function, and determining which of the seque...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-11-23

    authors： Li G,Endsley MA,Somasunderam A,Gbota SL,Mbaka MI,Murray JL,Ferguson MR

    更新日期：2014-02-08 00:00:00

  • Lineage shift in Indian strains of Dengue virus serotype-3 (Genotype III), evidenced by detection of lineage IV strains in clinical cases from Kerala.

    abstract：BACKGROUND:Local epidemiology of Dengue is defined by the genetic diversity of the circulating Dengue virus (DENV) strains. This important information is not available for the virus strains from most parts of the Indian subcontinent. The present study focused on the genetic diversity of the serotype 3 DENV strains (DEN...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-10-37

    authors： Manakkadan A,Joseph I,Prasanna RR,Kunju RI,Kailas L,Sreekumar E

    更新日期：2013-01-29 00:00:00

  • Satisfactory virological response and fibrosis improvement of sofosbuvir-based regimens for Chinese patients with hepatitis C virus genotype 3 infection: results of a real-world cohort study.

    abstract：BACKGROUND:Chronic hepatitis C virus (HCV) genotype (GT) 3 infection with advanced liver disease has emerged as a challenging to treat by direct-acting antivirals (DAAs), but the efficacy of DAAs in Chinese HCV-GT3 patients is rarely reported. This study aimed to analyze the efficacy of sofosbuvir (SOF)-based regimens ...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/s12985-018-1066-8

    authors： Tao YC,Deng R,Wang ML,Lv DD,Yuan M,Wang YH,Chen EQ,Tang H

    更新日期：2018-10-01 00:00:00

  • Comparative study between the Hybrid Capture II test and PCR based assay for the detection of human papillomavirus DNA in oral submucous fibrosis and oral squamous cell carcinoma.

    abstract：BACKGROUND:Oral malignancy is a major global health problem. Besides the main risk factors of tobacco, smoking and alcohol, infection by human papillomavirus (HPV) and genetic alterations are likely to play an important role in these lesions. The purpose of this study was to compare the efficacy of HC-II assay and PCR ...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/1743-422X-7-253

    authors： Chaudhary AK,Pandya S,Mehrotra R,Bharti AC,Singh M,Singh M

    更新日期：2010-09-23 00:00:00

  • Specific and quantitative detection of Human polyomaviruses BKPyV and JCPyV in the healthy Pakistani population.

    abstract：BACKGROUND:The BK Polyomavirus (BKPyV) and JC polyomavirus (JCPyV) infections are widespread in human population and have been associated with severe kidney and brain disorders, respectively. The viruses remain latent primarily in reno-urinary tract, reactivating only in case of a compromised immune system. The seroepi...

    journal_title：Virology journal

    pub_type： 杂志文章

    doi：10.1186/s12985-017-0752-2

    authors： Hussain I,Tasneem F,Umer M,Pervaiz A,Raza M,Arshad MI,Shahzad N

    更新日期：2017-04-24 00:00:00