Full-length Ebola glycoprotein accumulates in the endoplasmic reticulum.

abstract：BACKGROUND:Respiratory syncytial virus (RSV), human Rhinovirus (HRV) and human Metapneumo Virus (HMPV) are important viral pathogens causing acute respiratory tract infections in the hospitalized patients. Sensitive and accurate detection of RSV, HRV and HMPV is necessary for clinical diagnosis and treatment. RESULTS:...

journal_title：Virology journal

authors： Feng ZS,Zhao L,Wang J,Qiu FZ,Zhao MC,Wang L,Duan SX,Zhang RQ,Chen C,Qi JJ,Fan T,Li GX,Ma XJ

更新日期：2018-10-30 00:00:00

abstract：BACKGROUND:Chikungunya virus (CHIKV) is transmitted via mosquito bite and potentially by aerosol, causing chikungunya fever and arthritic disease in humans. There are currently no licensed vaccines or antiviral therapeutics to protect against CHIKV infection in humans. Animal models recapitulating human disease, especi...

journal_title：Virology journal

authors： Cirimotich CM,Vela EM,Garver J,Barnewall RE,Miller BD,Meister GT,Rogers JV

更新日期：2017-07-20 00:00:00

abstract：BACKGROUND:The viral genome of hepatitis C virus constitutes a 9.6-kb single-stranded positive-sense RNA which encodes altogether 11 viral proteins. In order to study the humoral immune responses against different HCV proteins in patients suffering from chronic HCV infection, we produced three structural (core, E1 and ...

journal_title：Virology journal

authors： Sillanpää M,Melén K,Porkka P,Fagerlund R,Nevalainen K,Lappalainen M,Julkunen I

更新日期：2009-06-23 00:00:00

abstract：BACKGROUND:Although prophylactic vaccines have been developed against HPV6, HPV11, HPV16 and HPV18 there is the clear unmet medical need in order to justify the development of drugs targeting human papillomavirus replication. The native host cells of HPVs are human primary keratinocytes which can be cultivated in raft ...

journal_title：Virology journal

authors： Isok-Paas H,Männik A,Ustav E,Ustav M

更新日期：2015-04-14 00:00:00

abstract：:One coronavirus strain was isolated from brain tissues of ten piglets with evident clinical manifestations of vomiting, diarrhea and dyskinesia in Jilin province in China. Antigenic and genomic characterizations of the virus (isolate PHEV-JLsp09) were based on multiplex PCR and negative staining electron microscopy an...

journal_title：Virology journal

authors： Gao W,Zhao K,Zhao C,Du C,Ren W,Song D,Lu H,Chen K,Li Z,Lan Y,Xie S,He W,Gao F

更新日期：2011-03-21 00:00:00

abstract：BACKGROUND:The emergence of influenza viruses resistant to anti-influenza drugs is a threat to global public health. The Korea Centers for Disease Control and Prevention operates the Korea Influenza and Respiratory Viruses Surveillance System (KINRESS) to monitor epidemics of influenza and Severe Acute Respiratory Infe...

journal_title：Virology journal

authors： Kim HM,Lee N,Kim MS,Kang C,Chung YS

更新日期：2020-07-06 00:00:00

abstract：BACKGROUND:In adenoviruses, primary host cell recognition is generally performed by the head domains of their homo-trimeric fibre proteins. This first interaction is reversible. A secondary, irreversible interaction subsequently takes place via other adenovirus capsid proteins and leads to a productive infection. Altho...

journal_title：Virology journal

authors： Nguyen TH,Vidovszky MZ,Ballmann MZ,Sanz-Gaitero M,Singh AK,Harrach B,Benkő M,van Raaij MJ

更新日期：2015-05-22 00:00:00

abstract：:The suitability of V4 vaccine coated on cracked local grain (maize) and its husks and used for oral vaccination of chickens was assessed. Seventy-two (72) birds aged three (3) weeks and above were divided into six groups of twelve (12) birds per group. The birds were bled to determine their prevaccination HI antibody ...

journal_title：Virology journal

authors： Olabode AO,Ndako JA,Echeonwu GO,Nwankiti OO,Chukwuedo AA

更新日期：2010-03-23 00:00:00

abstract：:Modified vaccinia virus Ankara (MVA) has become a promising vaccine vector due to its immunogenicity and its proven safety in humans. As a general approach for stringent and rapid selection of recombinant MVA, we assessed marker rescue of the essential viral D4R gene in an engineered deletion mutant that is fully repl...

journal_title：Virology journal

authors： Ricci PS,Schäfer B,Kreil TR,Falkner FG,Holzer GW

更新日期：2011-12-12 00:00:00

abstract：BACKGROUND:Otitis media (OM) affects ≥80% of children before the age of three. OM can arise following co-infection with influenza A virus (IAV) and the bacterium Streptococcus pneumoniae. We have previously shown that H3 IAV strains (such as Udorn/72) induced a higher rate of bacterial OM than H1 strains (such as PR8/3...

journal_title：Virology journal

authors： Short KR,Habets MN,Payne J,Reading PC,Diavatopoulos DA,Wijburg OL

更新日期：2013-04-23 00:00:00

abstract：BACKGROUND:The VP2 outer capsid protein Bluetongue Virus (BTV) is responsible for receptor binding, haemagglutination and eliciting host-specific immunity. However, the assembly of this outer capsid protein on the transcriptionally active viral core would block transcription of the virus. Thus assembly of the outer cap...

journal_title：Virology journal

authors： Bhattacharya B,Noad RJ,Roy P

更新日期：2007-01-15 00:00:00

abstract：BACKGROUND:The BK Polyomavirus (BKPyV) and JC polyomavirus (JCPyV) infections are widespread in human population and have been associated with severe kidney and brain disorders, respectively. The viruses remain latent primarily in reno-urinary tract, reactivating only in case of a compromised immune system. The seroepi...

journal_title：Virology journal

authors： Hussain I,Tasneem F,Umer M,Pervaiz A,Raza M,Arshad MI,Shahzad N

更新日期：2017-04-24 00:00:00

abstract：BACKGROUND:Highly-pathogenic avian influenza (HPAI) H5N1 and Newcastle disease (ND) viruses are the two most important poultry viruses in the world, with the ability to cause classic central nervous system dysfunction in poultry and migratory birds. To elucidate the mechanisms of neurovirulence caused by these viruses,...

journal_title：Virology journal

authors： Balasubramaniam VR,Wai TH,Omar AR,Othman I,Hassan SS

更新日期：2012-02-23 00:00:00

abstract：BACKGROUND:The use of sequence independent methods combined with next generation sequencing for identification purposes in clinical samples appears promising and exciting results have been achieved to understand unexplained infections. One sequence independent method, Virus Discovery based on cDNA Amplified Fragment Le...

journal_title：Virology journal

authors： Shaukat S,Angez M,Alam MM,Jebbink MF,Deijs M,Canuti M,Sharif S,de Vries M,Khurshid A,Mahmood T,van der Hoek L,Zaidi SS

更新日期：2014-08-12 00:00:00

abstract：BACKGROUND:In China, more than 20 million patients with chronic hepatitis B need antiviral treatment. Side effects of antiviral treatment such as renal complications can be problematic, particularly in an aging population. METHODS:The data were retrospectively extracted from the hospital medical charts of five centers...

journal_title：Virology journal

authors： Gu J,Yu G,Zhang X,Zhang S,Cai H,Ye C,Yang Y,Li D,Tong Z,Shen H,Chen H,Ding F,Lai X,Liu J,Xu M,Wu W

更新日期：2021-01-13 00:00:00

abstract：BACKGROUND:The influenza RNA dependent RNA polymerase synthesizes viral RNA in the nucleus as functional viral ribonucleoprotein (vRNP) complexes with RNA and nucleoprotein (NP). The N-terminus of NP contains an unconventional nuclear localization signal (NLS) important for initial vRNP nuclear localization but which a...

journal_title：Virology journal

authors： Sanchez A,Guerrero-Juarez CF,Ramirez J,Newcomb LL

更新日期：2014-08-31 00:00:00

abstract：:Measles, caused by measles virus (MeV), is a common infection in children. MeV is a member of the genus Morbillivirus and is most closely related to rinderpest virus (RPV), which is a pathogen of cattle. MeV is thought to have evolved in an environment where cattle and humans lived in close proximity. Understanding th...

journal_title：Virology journal

authors： Furuse Y,Suzuki A,Oshitani H

更新日期：2010-03-04 00:00:00

abstract：:Adenovirus has a wide tissue tropism. The virus attaches to the surface of cells via the fiber protein knob binding to the Coxsackie and Adenovirus receptor known as CAR. Virus entry inside cells is facilitated by integrins αVβ3 and αVβ5. Mice platelets are shown to be the predominant Ad binding blood cell type and th...

journal_title：Virology journal

authors： Gupalo E,Buriachkovskaia L,Othman M

更新日期：2011-09-30 00:00:00

abstract：BACKGROUND:Human herpesviruses have been hypothesized as environmental triggers in the development of autoimmune thyroid diseases (AITD), and in particular active human herpesvirus 6A (HHV-6A) infection was detected in thyrocytes of Hashimoto's thyroiditis (HT) patients, who also show specific anti-viral immune respons...

journal_title：Virology journal

authors： Caselli E,D'Accolti M,Soffritti I,Zatelli MC,Rossi R,Degli Uberti E,Di Luca D

更新日期：2017-01-11 00:00:00

abstract：BACKGROUND:The influenza virus is still one of the most important respiratory risks affecting humans which require effective treatments. In this case, traditional medications are of interest. HESA-A is an active natural biological compound from herbal-marine origin. Previous studies have reported that the therapeutic p...

journal_title：Virology journal

authors： Mehrbod P,Ideris A,Omar AR,Hair-Bejo M,Tan SW,Kheiri MT,Tabatabaian M

更新日期：2012-02-16 00:00:00

abstract：BACKGROUND:Progressive multifocal leukoencephalopathy (PML) onset, caused by Polyomavirus JC (JCPyV) in patients affected by immune-mediated diseases during biological treatment, raised concerns about the safety profile of these agents. Therefore, the aims of this study were the JCPyV reactivation monitoring and the no...

journal_title：Virology journal

authors： Bellizzi A,Anzivino E,Rodio DM,Cioccolo S,Scrivo R,Morreale M,Pontecorvo S,Ferrari F,Di Nardo G,Nencioni L,Carluccio S,Valesini G,Francia A,Cucchiara S,Palamara AT,Pietropaolo V

更新日期：2013-09-30 00:00:00

abstract：:Fatal influenza A virus infection is a major threat to public health throughout the world. Lung macrophages and neutrophils have critical roles for both the pathogenesis and viral clearance of fatal viral infections. These are complicated by the interaction of innate immunity and adaptive immunity against viral infect...

journal_title：Virology journal

authors： Lv J,Hua Y,Wang D,Liu A,An J,Li A,Wang Y,Wang X,Jia N,Jiang Q

更新日期：2014-03-26 00:00:00

abstract：BACKGROUND:Multi-resistant Achromobacter xylosoxidans has been recognized as an emerging pathogen causing nosocomially acquired infections during the last years. Phages as natural opponents could be an alternative to fight such infections. Bacteriophages against this opportunistic pathogen were isolated in a recent stu...

journal_title：Virology journal

authors： Wittmann J,Dreiseikelmann B,Rohde M,Meier-Kolthoff JP,Bunk B,Rohde C

更新日期：2014-01-27 00:00:00

abstract：BACKGROUND:Pseudorabies virus (PRV) of the family Herpesviridae is the causative agent of Aujeszky's disease. Attenuation of PRV by serial passaging in vitro is a well-established method; however, the dynamic variations occurring on viral genome during this process have not been characterized. METHODS:Genome sequencin...

journal_title：Virology journal

authors： Ye C,Wu J,Tong W,Shan T,Cheng X,Xu J,Liang C,Zheng H,Li G,Tong G

更新日期：2018-12-29 00:00:00

abstract：BACKGROUND:Human papillomavirus (HPV) E6 and E7 oncoproteins play a crucial role in HPV-related diseases, such as cervical cancer, and can be used as ideal targets for therapeutic vaccines. Human leukocyte antigen (HLA) participates in the immune response to block HPV infection and invasion by its target/recognition fu...

journal_title：Virology journal

authors： He J,Yang Y,Chen Z,Liu Y,Bao S,Zhao Y,Ding X

更新日期：2019-05-28 00:00:00

abstract：BACKGROUND:Since its emergence in March 2009, the pandemic 2009 H1N1 influenza A virus has posed a serious threat to public health. To trace the evolutionary path of these new pathogens, we performed a selection-pressure analysis of a large number of hemagglutinin (HA) and neuraminidase (NA) gene sequences of H1N1 infl...

journal_title：Virology journal

authors： Li W,Shi W,Qiao H,Ho SY,Luo A,Zhang Y,Zhu C

更新日期：2011-04-21 00:00:00

abstract：BACKGROUND:Panicum streak virus (PanSV; Family Geminiviridae; Genus Mastrevirus) is a close relative of Maize streak virus (MSV), the most serious viral threat to maize production in Africa. PanSV and MSV have the same leafhopper vector species, largely overlapping natural host ranges and similar geographical distribut...

journal_title：Virology journal

authors： Varsani A,Monjane AL,Donaldson L,Oluwafemi S,Zinga I,Komba EK,Plakoutene D,Mandakombo N,Mboukoulida J,Semballa S,Briddon RW,Markham PG,Lett JM,Lefeuvre P,Rybicki EP,Martin DP

更新日期：2009-11-10 00:00:00

abstract：:Hepatitis C virus (HCV) infection is a worldwide public health burden and it is estimated that 185 million people are or have previously been infected worldwide. There is no effective vaccine for prevention of HCV infection; however, a number of drugs are available for the treatment of infection. The availability of d...

journal_title：Virology journal

authors： Jardim ACG,Shimizu JF,Rahal P,Harris M

更新日期：2018-02-13 00:00:00

abstract：BACKGROUND:Throughout the history of human influenza pandemics, pigs have been considered the most likely "mixing vessel" for reassortment between human and avian influenza viruses (AIVs). However, the replication efficiencies of influenza viruses from various hosts, as well as the expression of sialic acid (Sia) recep...

journal_title：Virology journal

authors： Van Poucke SG,Nicholls JM,Nauwynck HJ,Van Reeth K

更新日期：2010-02-16 00:00:00

abstract：BACKGROUND:To explore the relationship between enteroviruses and hospitalized children with hand, foot and mouth disease (HFMD) complicated with nervous system disease. 234 hospitalized HFMD patients treated in Shengjing Hospital, Liaoning Province were analyzed retrospectively. Based on the presence and severity of ne...

journal_title：Virology journal

authors： Xu W,Liu CF,Yan L,Li JJ,Wang LJ,Qi Y,Cheng RB,Xiong XY

更新日期：2012-01-09 00:00:00