Entecavir plus adefovir rescue therapy for chronic hepatitis B patients after multiple treatment failures in real-life practice.

abstract：BACKGROUND:A serological method to simultaneously detect antibodies against infectious laryngotracheitis virus (ILTV) and infectious bronchitis virus (IBV) is imperative for the differential diagnosis and evaluation of antibodies titers after vaccination. METHOD:The microspheres coated with purified recombinant glycop...

journal_title：Virology journal

authors： Wang H,Cong F,Guan J,Xiao L,Zhu Y,Lian Y,Huang R,Chen M,Guo P

更新日期：2018-09-21 00:00:00

abstract：BACKGROUND:Recently, a new subset of CD4(+)T helper cell termed Follicular helper T cells (Tfh), which play a pivotal role in B cell activation and differentiation in lymphoid structures, has been reported to participate in some certain autoimmune diseases. But whether Tfh cells are involved in the pathogenesis of VMC ...

journal_title：Virology journal

authors： Yang F,Mo WH,Tan BP,Wei XM,Wang H

更新日期：2015-02-11 00:00:00

abstract：BACKGROUND:Hepatitis C virus roots a chronic liver disease. Currently approved treatment strategy includes administration of alpha interferon and ribavirin combined therapy for 24-48 weeks. One of the predictor of sustained virological response is an early virological response to treatment characterized as rapid respon...

journal_title：Virology journal

authors： Akram M,Idrees M,Hussain A,Afzal S,Ilyas M,Zafar S,Aftab M,Badar S,Khubaib B

更新日期：2011-05-23 00:00:00

abstract：BACKGROUND:Classical swine fever (CSF) is one of the most important viral diseases of pigs. Clinical signs may vary from almost inapparent infection to a hemorrhagic fever like illness. Among the host factors leading to different disease courses are age, breed, and immune status. The aim of this study was to compare ho...

journal_title：Virology journal

authors： Petrov A,Blohm U,Beer M,Pietschmann J,Blome S

更新日期：2014-07-29 00:00:00

abstract：BACKGROUND:Infection by any one of 15 high risk human papillomavirus (hrHPV) types causes most invasive cervical cancers. Their oncogenic genome is encapsidated by L1 (major) and L2 (minor) coat proteins. Current HPV prophylactic vaccines are composed of L1 virus-like particles (VLP) that elicit type restricted immunit...

journal_title：Virology journal

authors： Wu WH,Alkutkar T,Karanam B,Roden RB,Ketner G,Ibeanu OA

更新日期：2015-09-11 00:00:00

abstract：BACKGROUND:Longitudinal mark-recapture studies of rodents in two sites in the Mbaracayú Biosphere Reserve in the Interior Atlantic Forest of eastern Paraguay have revealed a complex and intriguing pattern of hantaviruses harbored by rodents in this area. Full-length sequencing and phylogenetic analyses were conducted f...

journal_title：Virology journal

authors： Chu YK,Owen RD,Jonsson CB

更新日期：2011-08-12 00:00:00

abstract：BACKGROUND:Avian hepatitis E virus (aHEV) has been associated with hepatitis-splenomegaly syndrome (HSS) in chickens along with asymptomatic subclinical infection in many cases. So far, four genotypes have been described, which cause infection in chickens, specifically in broiler breeders and layer chickens. In the pre...

journal_title：Virology journal

authors： Iqbal T,Rashid U,Idrees M,Afroz A,Kamili S,Purdy MA

更新日期：2019-11-21 00:00:00

abstract：BACKGROUND:A vaccine against all four dengue virus (DENV) serotypes includes the formulation of one genotype of each serotype. Although genetic similarities among genotypes within a serotype are higher as compared to those among serotypes, differences in the immunogenicity of the included genotypes would be a critical ...

journal_title：Virology journal

authors： Azami NAM,Moi ML,Ami Y,Suzaki Y,Lim CK,Taniguchi S,Saijo M,Takasaki T,Kurane I

更新日期：2018-03-27 00:00:00

abstract：BACKGROUND:Endometrial cancer (EC) is one of the most common gynecological malignancies globally. Although progress has been made in surgical and other adjuvant therapies, there is still a great need to develop new approaches to further reduce the incidence and mortality of EC. Oncolytic virotherapy offers a novel prom...

journal_title：Virology journal

authors： Lin Y,Wang W,Wan J,Yang Y,Fu W,Pan D,Cai L,Cheng T,Huang X,Wang Y

更新日期：2018-04-10 00:00:00

abstract：BACKGROUND:The reovirus M1 genome segment encodes the mu2 protein, a structurally minor component of the viral core, which has been identified as a transcriptase cofactor, nucleoside and RNA triphosphatase, and microtubule-binding protein. The mu2 protein is the most poorly understood of the reovirus structural protein...

journal_title：Virology journal

authors： Yin P,Keirstead ND,Broering TJ,Arnold MM,Parker JS,Nibert ML,Coombs KM

更新日期：2004-09-23 00:00:00

abstract：:The study was carried out to investigate the effects of inoculating three cowpea cultivars: "OLO II", "OLOYIN" and IT86D-719 with three unrelated viruses: Cowpea aphid-borne mosaic virus (CABMV), genus Potyvirus, Cowpea mottle virus (CMeV), genus Carmovirus and Southern bean mosaic virus (SBMV), genus Sobemovirus sing...

journal_title：Virology journal

authors： Kareem KT,Taiwo MA

更新日期：2007-02-08 00:00:00

abstract：BACKGROUND:The epidemic pattern of respiratory syncytial virus (RSV) is quite different in regions of Europe (biennial epidemics in alternating cycles of approximately 9 and 15 months) than in the Western Hemisphere (annual epidemics). In order to determine if these differences are accounted for by the circulation of d...

journal_title：Virology journal

authors： Mlinaric-Galinovic G,Vojnovic G,Cepin-Bogovic J,Bace A,Bozikov J,Welliver RC,Wahn U,Cebalo L

更新日期：2009-09-07 00:00:00

abstract：BACKGROUND:The mechanisms through which the avian influenza virus H5N1 modulate the host's innate immune defense during invasion, remains incompletely understood. RIG-I as a pattern recognition receptor plays an important role in mediating innate immune response induced by influenza virus. So, modulating RIG-I might be...

journal_title：Virology journal

authors： Mi Z,Ma Y,Tong Y

更新日期：2012-08-03 00:00:00

abstract：BACKGROUND:West Nile virus (WNV) is an emerging zoonotic pathogen which is harmful to human and animal health. Effective vaccination in susceptible hosts should protect against WNV infection and significantly reduce viral transmission between animals and from animals to humans. A versatile vaccine suitable for differen...

journal_title：Virology journal

authors： Wang J,Yang J,Ge J,Hua R,Liu R,Li X,Wang X,Shao Y,Sun E,Wu D,Qin C,Wen Z,Bu Z

更新日期：2016-06-24 00:00:00

abstract：:Duck hepatitis virus (DHV-1) is a worldwide distributed picornavirus that causes acute and fatal disease in young ducklings. Recently, the complete genome of DHV-1 has been determined and comparative sequence analysis has shown that possesses the typical picornavirus organization but exhibits several unique features. ...

journal_title：Virology journal

authors： Liu G,Yángüez E,Chen Z,Li C

更新日期：2011-03-31 00:00:00

abstract：BACKGROUND:Entry of Ebolavirus to the target cells is mediated by the viral glycoprotein GP. The native GP exists as a homotrimer on the virions and contains two subunits, a surface subunit (GP1) that is involved in receptor binding and a transmembrane subunit (GP2) that mediates the virus-host membrane fusion. Previou...

journal_title：Virology journal

authors： Manicassamy B,Rong L

更新日期：2009-06-08 00:00:00

abstract：BACKGROUND:RNA viruses are characterized by high rate of mutations mainly due to the lack of proofreading repair activities associated with its RNA-dependent RNA-polymerase (RdRp). In case of arboviruses, this phenomenon has lead to the existence of mixed population of genomic variants within the host called quasi-spec...

journal_title：Virology journal

authors： Jain J,Mathur K,Shrinet J,Bhatnagar RK,Sunil S

更新日期：2016-06-02 00:00:00

abstract：BACKGROUND:Hepatitis C virus (HCV) infection is a major public health problem with more than 170 million cases of chronic infections worldwide. There is no protective vaccine currently available for HCV, therefore the development of novel strategy to prevent chronic infection is important. We reported earlier that a re...

journal_title：Virology journal

authors： Chandra PK,Hazari S,Poat B,Gunduz F,Prabhu R,Liu G,Burioni R,Clementi M,Garry RF,Dash S

更新日期：2010-06-07 00:00:00

abstract：BACKGROUND:Both regulatory T cells (Tregs) and PD-1/PD-L1 pathway were critically involved in HCV viral persistence. However, the association between them was not well investigated. Herein, we aimed to investigate the distributional profiles of Tregs subsets and association between PD-1 expression on these subsets and ...

journal_title：Virology journal

authors： Shen T,Zheng J,Liang H,Xu C,Chen X,Zhang T,Xu Q,Lu F

更新日期：2011-06-07 00:00:00

abstract：BACKGROUND:Porcine circovirus type 2 (PCV2), the causative agent of postweaning multisystemic wasting syndrome (PMWS), is a serious economic problem in the swine industry. Different genotypes (PCV2a, PCV2b and PCV2d) of the virus are present in the clinical cases in China, and it is necessary to elucidate the pathogeni...

journal_title：Virology journal

authors： Guo LJ,Lu YH,Huang LP,Wei YW,Wu HL,Liu CM

更新日期：2011-06-10 00:00:00

abstract：:Much of the worlds' population is in active or imminent danger from established infectious pathogens, while sporadic and pandemic infections by these and emerging agents threaten everyone. RNA polymerases (RNApol) generate enormous genetic and consequent antigenic heterogeneity permitting both viruses and cellular pat...

journal_title：Virology journal

authors： Sallie R

更新日期：2005-08-22 00:00:00

abstract：BACKGROUND:HIV-1 subtype B' isolates have been predominantly circulating in China. Their intra- and inter-subtype neutralization sensitivity to autologous and heterologous plasmas has not been well studied. RESULTS:Twelve HIV-1 B' clinical isolates obtained from patients were tested for their intra- and inter-subtype ...

journal_title：Virology journal

authors： OuYang Y,Sun J,Huang Y,Lu L,Xu W,Hu X,Hong K,Jiang S,Shao Y,Ma L

更新日期：2013-01-05 00:00:00

abstract：BACKGROUND:The mint family (Lamiaceae) produces a wide variety of constituents with medicinal properties. Several family members have been reported to have antiviral activity, including lemon balm (Melissa officinalis L.), sage (Salvia spp.), peppermint (Mentha×piperita L.), hyssop (Hyssopus officinalis L.), basil (Oci...

journal_title：Virology journal

authors： Oh C,Price J,Brindley MA,Widrlechner MP,Qu L,McCoy JA,Murphy P,Hauck C,Maury W

更新日期：2011-04-23 00:00:00

abstract：BACKGROUND:Torque teno virus is a small chronically persisting circular negative ssDNA virus reaching near 100% prevalence. It is reported to be a marker for immune function in immunocompromised patients. The possibility of vertical maternal-fetal transmission remains controversial but incidence rate of TTV DNA in chil...

journal_title：Virology journal

authors： Tyschik EA,Rasskazova AS,Degtyareva AV,Rebrikov DV,Sukhikh GT

更新日期：2018-05-30 00:00:00

abstract：BACKGROUND:Sequence and structural elements in the 3'-untranslated region (UTR) of Japanese encephalitis virus (JEV) are known to regulate translation and replication. We previously reported an abundant accumulation of small subgenomic flaviviral RNA (sfRNA) which is collinear with the highly conserved regions of the 3...

journal_title：Virology journal

authors： Fan YH,Nadar M,Chen CC,Weng CC,Lin YT,Chang RY

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Classical swine fever (CSF) caused by virulent strains of Classical swine fever virus (CSFV) is a haemorrhagic disease of pigs, characterized by disseminated intravascular coagulation, thrombocytopoenia and immunosuppression, and the swine endothelial vascular cell is one of the CSFV target cells. In this re...

journal_title：Virology journal

authors： Tang QH,Zhang YM,Fan L,Tong G,He L,Dai C

更新日期：2010-01-11 00:00:00

abstract：BACKGROUND:Crimean-Congo Hemorrhagic Fever virus (CCHFV), a member of the genus Nairovirus, family Bunyaviridae, is a tick-borne pathogen causing severe disease in humans. To better understand the CCHFV life cycle and explore potential intervention strategies, we studied the biosynthesis and intracellular targeting of ...

journal_title：Virology journal

authors： Haferkamp S,Fernando L,Schwarz TF,Feldmann H,Flick R

更新日期：2005-04-25 00:00:00

abstract：BACKGROUND:The effect of antiviral therapy in chronic hepatitis B (CHB) on reducing the risk of long-term complications (LTCs) remains unclear so far. To study whether long-term nucleos(t)ide analogues therapy can reduce the risk of long-term complications. METHODS:We searched MEDLINE, EMBASE, OVID, the Cochrane Centr...

journal_title：Virology journal

authors： Zhang QQ,An X,Liu YH,Li SY,Zhong Q,Wang J,Hu HD,Zhang DZ,Ren H,Hu P

更新日期：2011-02-15 00:00:00

abstract：:Information on the replication of viral haemorrhagic fever viruses is not readily available and has never been analysed in a comparative approach. Here, we compared the cell culture growth characteristics of haemorrhagic fever viruses (HFV), of the Arenaviridae, Filoviridae, Bunyaviridae, and Flavivridae virus familie...

journal_title：Virology journal

authors： Weidmann M,Sall AA,Manuguerra JC,Koivogui L,Adjami A,Traoré FF,Hedlund KO,Lindegren G,Mirazimi A

更新日期：2011-02-24 00:00:00

abstract：BACKGROUND:The incidence of dengue, an infectious disease caused by dengue virus (DENV), has dramatically increased around the world in recent decades and is becoming a severe public health threat. However, there is currently no specific treatment for dengue fever, and licensed vaccine against dengue is not available. ...

journal_title：Virology journal

authors： Zhang S,Liang M,Gu W,Li C,Miao F,Wang X,Jin C,Zhang L,Zhang F,Zhang Q,Jiang L,Li M,Li D

更新日期：2011-06-30 00:00:00