The duck hepatitis virus 5'-UTR possesses HCV-like IRES activity that is independent of eIF4F complex and modulated by downstream coding sequences.

abstract：BACKGROUND:Oral malignancy is a major global health problem. Besides the main risk factors of tobacco, smoking and alcohol, infection by human papillomavirus (HPV) and genetic alterations are likely to play an important role in these lesions. The purpose of this study was to compare the efficacy of HC-II assay and PCR ...

journal_title：Virology journal

authors： Chaudhary AK,Pandya S,Mehrotra R,Bharti AC,Singh M,Singh M

更新日期：2010-09-23 00:00:00

abstract：BACKGROUND:Ticks are implicated as hosts to a wide range of animal and human pathogens. The full range of microbes harbored by ticks has not yet been fully explored. METHODS:As part of a viral surveillance and discovery project in arthropods, we used unbiased high-throughput sequencing to examine viromes of ticks coll...

journal_title：Virology journal

authors： Tokarz R,Sameroff S,Leon MS,Jain K,Lipkin WI

更新日期：2014-02-11 00:00:00

abstract：:Cyclooxygenases (COXs) play a significant role in many different viral infections with respect to replication and pathogenesis. Here we investigated the role of COXs in the mouse hepatitis coronavirus (MHV) infection cycle. Blocking COX activity by different inhibitors or by RNA interference affected MHV infection in ...

journal_title：Virology journal

authors： Raaben M,Einerhand AW,Taminiau LJ,van Houdt M,Bouma J,Raatgeep RH,Büller HA,de Haan CA,Rossen JW

更新日期：2007-06-07 00:00:00

abstract：BACKGROUND:hyaluronic acid (HA), a non-sulphated glycosaminoglycan, is present in synovial fluid, vitreous humour serum and many connective tissues. Pharmaceutical preparations of HA are used in clinical practice for wound healing, joint pain, kerato-conjunctivitis, asthma, mouth care, oesophageal-reflux, and gastritis...

journal_title：Virology journal

authors： Cermelli C,Cuoghi A,Scuri M,Bettua C,Neglia RG,Ardizzoni A,Blasi E,Iannitti T,Palmieri B

更新日期：2011-03-25 00:00:00

abstract：BACKGROUND:Cytomegalovirus (CMV) congenital infection is the major viral cause of well-documented birth defects in human. Because CMV is species-specific, the main obstacle to developing animal models for congenital infection is the difference in placental architecture, which preludes virus transmission across the plac...

journal_title：Virology journal

authors： Loh HS,Mohd-Lila MA,Abdul-Rahman SO,Kiew LJ

更新日期：2006-06-01 00:00:00

abstract：:Adenovirus has a wide tissue tropism. The virus attaches to the surface of cells via the fiber protein knob binding to the Coxsackie and Adenovirus receptor known as CAR. Virus entry inside cells is facilitated by integrins αVβ3 and αVβ5. Mice platelets are shown to be the predominant Ad binding blood cell type and th...

journal_title：Virology journal

authors： Gupalo E,Buriachkovskaia L,Othman M

更新日期：2011-09-30 00:00:00

abstract：BACKGROUND:The ESCRT (endosomal sorting complex required for transport) machinery functions to sort cellular receptors into the lumen of the multivesicular body (MVB) prior to lysosomal degradation. ESCRT components can also be recruited by enveloped viruses to sites of viral assembly where they have been proposed to m...

journal_title：Virology journal

authors： Valiathan RR,Resh MD

更新日期：2008-02-11 00:00:00

abstract：BACKGROUND:Since avian-origin H3N2 canine influenza virus (CIV) was first identified in South Korea in 2008, the novel influenza virus has been reported in several countries in Asia. Reverse zoonotic transmission of pandemic H1N1 (2009) influenza virus (pH1N1) has been observed in a broad range of animal species. Viral...

journal_title：Virology journal

authors： Na W,Lyoo KS,Song EJ,Hong M,Yeom M,Moon H,Kang BK,Kim DJ,Kim JK,Song D

更新日期：2015-09-04 00:00:00

abstract：OBJECTIVE:To determine HIV-1 RNA load during the third trimester of pregnancy and evaluate its effect on in utero and intra-partum/postpartum transmissions in a breastfeeding population. DESIGN:A nested case-control study within a PMTCT cohort of antiretroviral therapy naive pregnant women and their infants. METHODS:...

journal_title：Virology journal

authors： Duri K,Gumbo FZ,Kristiansen KI,Kurewa NE,Mapingure MP,Rusakaniko S,Chirenje MZ,Muller F,Stray-Pedersen B

更新日期：2010-08-02 00:00:00

abstract：BACKGROUND:Chronic hepatitis C virus (HCV) genotype (GT) 3 infection with advanced liver disease has emerged as a challenging to treat by direct-acting antivirals (DAAs), but the efficacy of DAAs in Chinese HCV-GT3 patients is rarely reported. This study aimed to analyze the efficacy of sofosbuvir (SOF)-based regimens ...

journal_title：Virology journal

authors： Tao YC,Deng R,Wang ML,Lv DD,Yuan M,Wang YH,Chen EQ,Tang H

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:During the last two decades, structural biology analyses have shown that viruses infecting hosts far apart in evolution share similar architectural features, prompting a new virus classification based on structural lineages. Until recently, only a few prokaryotic viruses had been described for one of the lin...

journal_title：Virology journal

authors： San Martín C,van Raaij MJ

更新日期：2018-11-23 00:00:00

abstract：BACKGROUND:In adenoviruses, primary host cell recognition is generally performed by the head domains of their homo-trimeric fibre proteins. This first interaction is reversible. A secondary, irreversible interaction subsequently takes place via other adenovirus capsid proteins and leads to a productive infection. Altho...

journal_title：Virology journal

authors： Nguyen TH,Vidovszky MZ,Ballmann MZ,Sanz-Gaitero M,Singh AK,Harrach B,Benkő M,van Raaij MJ

更新日期：2015-05-22 00:00:00

abstract：BACKGROUND:The Epstein-Barr virus (EBV) is associated with lymphoid malignancies, including Burkitt's lymphoma (BL), and can transform human B cells in vitro. EBV-harboring cell lines are widely used to investigate lymphocyte transformation and oncogenesis. Qualitative EBV gene expression has been extensively described...

journal_title：Virology journal

authors： Bernasconi M,Berger C,Sigrist JA,Bonanomi A,Sobek J,Niggli FK,Nadal D

更新日期：2006-06-06 00:00:00

abstract：BACKGROUND:The Urabe AM9 vaccine strain of mumps virus contains two variants of V protein: VWT (of HN-A1081 viral population) and VGly (of HN-G1081). The V protein is a promoting factor of viral replication by blocking the IFN antiviral pathway. FINDINGS:We studied the relationship between V protein variants and IFN-α...

journal_title：Virology journal

authors： Rosas-Murrieta NH,Santos-López G,Reyes-Leyva J,Jurado FS,Herrera-Camacho I

更新日期：2011-05-13 00:00:00

abstract：BACKGROUND:Hepatitis C virus (HCV) is a major cause of chronic hepatitis and hepatocellular carcinoma (HCC) and different HCV genotypes show characteristic variations in their pathological properties. Insulin resistance (IR) occurs early in HCV infection and may synergize with viral hepatitis in HCC development. Egypt ...

journal_title：Virology journal

authors： Mohamed AA,Loutfy SA,Craik JD,Hashem AG,Siam I

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Using a murine model of parainfluenza virus infection (mPIV1 or Sendai virus; SeV), we compared the inflammatory responses to lethal and sub-lethal infections in inbred DBA/2 mice. METHODS:Mice were intranasally inoculated with either 1.6×10(3) or 1.6×10(5) infectious units (IU) of SeV or diluent control. C...

journal_title：Virology journal

authors： Suryadevara M,Bonville CA,Rosenberg HF,Domachowske JB

更新日期：2013-12-21 00:00:00

abstract：BACKGROUND:Human cytomegalovirus infection is associated with a variety of pathological conditions including retinitis, pneumonia, hepatitis and encephalitis that may be transmitted congenitally, horizontally and parenterally and occurs both as a primary infection and as reactivation in immunocompromised individuals. C...

journal_title：Virology journal

authors： Burbelo PD,Issa AT,Ching KH,Exner M,Drew WL,Alter HJ,Iadarola MJ

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Preeclampsia is a major health problem. Although, the pathophysiology of preeclampsia is not fully understood, there are recent studies on association between infections and preeclampsia. OBJECTIVE:The aim of the present study was to investigate the association between maternal seropositivity of rubella, He...

journal_title：Virology journal

authors： Alshareef SA,Eltom AM,Nasr AM,Hamdan HZ,Adam I

更新日期：2017-07-26 00:00:00

abstract：BACKGROUND:Double-stranded RNA (dsRNA) and its mimic, polyinosinic acid: polycytidylic acid [Poly (I:C)], are recognized by toll-like receptor 3 (TLR3) and induce interferon (IFN)-β in many cell types. Poly (I:C) is the most potent IFN inducer. In in vivo mouse studies, intraperitoneal injection of Poly (I:C) elicited ...

journal_title：Virology journal

authors： Li YG,Siripanyaphinyo U,Tumkosit U,Noranate N,A-Nuegoonpipat A,Pan Y,Kameoka M,Kurosu T,Ikuta K,Takeda N,Anantapreecha S

更新日期：2012-06-14 00:00:00

abstract：:Vaccinia virus protein A33 (A33VACV) plays an important role in protection against orthopoxviruses, and hence is included in experimental multi-subunit smallpox vaccines. In this study we show that single-dose vaccination with recombinant Sindbis virus expressing A33VACV, is sufficient to protect mice against lethal c...

journal_title：Virology journal

authors： Paran N,Lustig S,Zvi A,Erez N,Israely T,Melamed S,Politi B,Ben-Nathan D,Schneider P,Lachmi B,Israeli O,Stein D,Levin R,Olshevsky U

更新日期：2013-07-10 00:00:00

abstract：BACKGROUND:Influenza virus infections are responsible for significant morbidity worldwide and therefore it remains a high priority to develop more broadly protective vaccines. Adjuvation of current seasonal influenza vaccines has the potential to achieve this goal. METHODS:To assess the immune potentiating properties ...

journal_title：Virology journal

authors： Cox F,Saeland E,Baart M,Koldijk M,Tolboom J,Dekking L,Koudstaal W,Lövgren Bengtsson K,Goudsmit J,Radošević K

更新日期：2015-12-08 00:00:00

abstract：:One coronavirus strain was isolated from brain tissues of ten piglets with evident clinical manifestations of vomiting, diarrhea and dyskinesia in Jilin province in China. Antigenic and genomic characterizations of the virus (isolate PHEV-JLsp09) were based on multiplex PCR and negative staining electron microscopy an...

journal_title：Virology journal

authors： Gao W,Zhao K,Zhao C,Du C,Ren W,Song D,Lu H,Chen K,Li Z,Lan Y,Xie S,He W,Gao F

更新日期：2011-03-21 00:00:00

abstract：BACKGROUND:An extensive outbreak of equine influenza occurred across multiple countries in South America during 2012. The epidemic was first reported in Chile then spread to Brazil, Uruguay and Argentina, where both vaccinated and unvaccinated animals were affected. In Brazil, infections were widespread within 3months ...

journal_title：Virology journal

authors： Alves Beuttemmüller E,Woodward A,Rash A,Dos Santos Ferraz LE,Fernandes Alfieri A,Alfieri AA,Elton D

更新日期：2016-03-19 00:00:00

abstract：BACKGROUND:The human polyomavirus BK expresses a 66 amino-acid peptide referred to as agnoprotein. Though mutants lacking agnoprotein are severely reduced in producing infectious virions, the exact function of this peptide remains incompletely understood. To elucidate the function of agnoprotein, we searched for novel ...

journal_title：Virology journal

authors： Gerits N,Johannessen M,Tümmler C,Walquist M,Kostenko S,Snapkov I,van Loon B,Ferrari E,Hübscher U,Moens U

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Construction of conditionally-replicative Adenovirus (CRAd) is complex and time-consuming. While homologous recombination (HR) using a two-plasmid system in bacteria is commonly used to generate CRAds, alternative methods may be required when HR fails. Previously, in vitro ligation has been suggested to faci...

journal_title：Virology journal

authors： Haviv YS

更新日期：2009-02-07 00:00:00

abstract：BACKGROUND:Human noroviruses (NoVs) are the main cause of gastroenteritis worldwide. The most commonly detected NoV strains belong to the genetically diverse GII.4 genotype, with new pandemic variants emerging periodically. Despite extensive efforts, NoV investigation has been hampered by the lack of an effective in vi...

journal_title：Virology journal

authors： Carmona-Vicente N,Allen DJ,Rodríguez-Díaz J,Iturriza-Gómara M,Buesa J

更新日期：2016-05-21 00:00:00

abstract：BACKGROUND:Infection with hepatitis B virus (HBV) is major public health concern. The limitations of available antiviral drugs require development of novel approaches to inhibit HBV replication. This study was conducted to identify functional elements and new siRNA target sites within the highly conserved regions of th...

journal_title：Virology journal

authors： Panjaworayan N,Payungporn S,Poovorawan Y,Brown CM

更新日期：2010-09-08 00:00:00

abstract：BACKGROUND:Brevicoryne brassicae virus (BrBV) is a positive-strand genomic RNA virus which is unassigned tentative member of the genus Iflavirus. BrBv was first identified and characterized in the late 90's in the cabbage aphid in the United Kingdom (UK) (J Gen Virol 88:2590-2595, 2007) and was fully sequenced, using r...

journal_title：Virology journal

authors： Luria N,Reingold V,Lachman O,Sela N,Dombrovsky A

更新日期：2016-03-22 00:00:00

abstract：:Information on the replication of viral haemorrhagic fever viruses is not readily available and has never been analysed in a comparative approach. Here, we compared the cell culture growth characteristics of haemorrhagic fever viruses (HFV), of the Arenaviridae, Filoviridae, Bunyaviridae, and Flavivridae virus familie...

journal_title：Virology journal

authors： Weidmann M,Sall AA,Manuguerra JC,Koivogui L,Adjami A,Traoré FF,Hedlund KO,Lindegren G,Mirazimi A

更新日期：2011-02-24 00:00:00

abstract：BACKGROUND:Classical swine fever (CSF) caused by virulent strains of Classical swine fever virus (CSFV) is a haemorrhagic disease of pigs, characterized by disseminated intravascular coagulation, thrombocytopoenia and immunosuppression, and the swine endothelial vascular cell is one of the CSFV target cells. In this re...

journal_title：Virology journal

authors： Tang QH,Zhang YM,Fan L,Tong G,He L,Dai C

更新日期：2010-01-11 00:00:00