Abstract:
:Cyclooxygenases (COXs) play a significant role in many different viral infections with respect to replication and pathogenesis. Here we investigated the role of COXs in the mouse hepatitis coronavirus (MHV) infection cycle. Blocking COX activity by different inhibitors or by RNA interference affected MHV infection in different cells. The COX inhibitors reduced MHV infection at a post-binding step, but early in the replication cycle. Both viral RNA and viral protein synthesis were affected with subsequent loss of progeny virus production. Thus, COX activity appears to be required for efficient MHV replication, providing a potential target for anti-coronaviral therapy.
journal_name
Virol Jjournal_title
Virology journalauthors
Raaben M,Einerhand AW,Taminiau LJ,van Houdt M,Bouma J,Raatgeep RH,Büller HA,de Haan CA,Rossen JWdoi
10.1186/1743-422X-4-55subject
Has Abstractpub_date
2007-06-07 00:00:00pages
55issn
1743-422Xpii
1743-422X-4-55journal_volume
4pub_type
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