Intracytoplasmic stable expression of IgG1 antibody targeting NS3 helicase inhibits replication of highly efficient hepatitis C Virus 2a clone.

abstract：BACKGROUND:There are over 100 known human adenovirus (HAdV) types, which are able to cause a broad variety of different self-limiting but also lethal diseases especially in immunocompromised patients. Only limited information about the pathogenesis and biology of the majority of these virus types is available. In the p...

journal_title：Virology journal

authors： Mese K,Bunz O,Schellhorn S,Volkwein W,Jung D,Gao J,Zhang W,Baiker A,Ehrhardt A

更新日期：2020-04-09 00:00:00

abstract：BACKGROUND:The mechanisms through which the avian influenza virus H5N1 modulate the host's innate immune defense during invasion, remains incompletely understood. RIG-I as a pattern recognition receptor plays an important role in mediating innate immune response induced by influenza virus. So, modulating RIG-I might be...

journal_title：Virology journal

authors： Mi Z,Ma Y,Tong Y

更新日期：2012-08-03 00:00:00

abstract：BACKGROUND:Finding new biomarkers for the early detection of cervical cancer is an essential requirement in this field. In this study, we aimed to evaluate the expression level of potential biomarkers in progression of cervical cancer in patients with cervical cancer compared to normal subjects. METHODS:The expression...

journal_title：Virology journal

authors： Farzanehpour M,Mozhgani SH,Jalilvand S,Faghihloo E,Akhavan S,Salimi V,Azad TM

更新日期：2019-10-07 00:00:00

abstract：BACKGROUND:Recently, human leukocyte antigen (HLA) class-II gene polymorphisms have been reported to be related to Hepatitis C virus (HCV) infection and chronicity. The objective of this study was to explore the relationship of HLA-DP rs9277535 and HLA-DQ rs7453920 with the outcomes of HCV infection. METHODS:The rs927...

journal_title：Virology journal

authors： Huang P,Fan H,Tian T,Liao P,Li J,Yu R,Xia X,Feng Y,Wang J,Liu Y,Zhang Y,Yue M

更新日期：2017-12-06 00:00:00

abstract：BACKGROUND:Lassa hemorrhagic fever (LHF) is a neglected tropical disease with significant impact on the health care system, society, and economy of Western and Central African nations where it is endemic. With a high rate of infection that may lead to morbidity and mortality, understanding how the virus interacts with ...

journal_title：Virology journal

authors： Branco LM,Grove JN,Moses LM,Goba A,Fullah M,Momoh M,Schoepp RJ,Bausch DG,Garry RF

更新日期：2010-11-09 00:00:00

abstract：BACKGROUND:HIV infection of cells varies greatly between individuals, with multiple steps in the replication cycle potentially contributing to the variability. Although entry and post-entry variability of HIV infection levels in cells has been demonstrated, variability in HIV binding has not been examined. In this stud...

journal_title：Virology journal

authors： Anzinger JJ,Olinger GG,Spear GT

更新日期：2008-08-15 00:00:00

abstract：BACKGROUND:During October 2010, Egypt reported an outbreak of acute hemorrhagic conjunctivitis (AHC). A total of 1831 cases were reported from three governorates; 1703 cases in El Daqahliya, 92 cases in Port Said, and 36 in Damietta. The purpose of this study was to identify and characterize the causative agent associa...

journal_title：Virology journal

authors： Ayoub EA,Shafik CF,Gaynor AM,Mohareb EW,Amin MA,Yassin AS,El-Refaey S,Genedy M,Kandeel A

更新日期：2013-03-25 00:00:00

abstract：BACKGROUND:hyaluronic acid (HA), a non-sulphated glycosaminoglycan, is present in synovial fluid, vitreous humour serum and many connective tissues. Pharmaceutical preparations of HA are used in clinical practice for wound healing, joint pain, kerato-conjunctivitis, asthma, mouth care, oesophageal-reflux, and gastritis...

journal_title：Virology journal

authors： Cermelli C,Cuoghi A,Scuri M,Bettua C,Neglia RG,Ardizzoni A,Blasi E,Iannitti T,Palmieri B

更新日期：2011-03-25 00:00:00

abstract：BACKGROUND:Bovine leukemia virus (BLV), which is closely related to human T-cell leukemia virus, is the etiological agent of enzootic bovine leukosis, a disease characterized by a highly prolonged course involving persistent lymphocytosis and B-cell lymphoma. The bovine major histocompatibility complex class II region ...

journal_title：Virology journal

authors： Bai L,Takeshima SN,Sato M,Davis WC,Wada S,Kohara J,Aida Y

更新日期：2019-12-16 00:00:00

abstract：:In order to improve the presentation and immunogenicity of single epitopes, virus-like particles (VLPs) are being used as platforms for the display of foreing epitopes on their surface. The rotavirus major capsid protein VP6 has the ability to self-assemble into empty non-infectious VLPs. In the present study, we anal...

journal_title：Virology journal

authors： Peralta A,Molinari P,Taboga O

更新日期：2009-11-06 00:00:00

abstract：BACKGROUND:PCR-based detection and identification of viruses assumes a known, relatively stable genome. Unfortunately, high mutation rates may lead to extensive changes in viral nucleic acid sequences making dedicated PCR primer use problematic. Furthermore, in bioterrorism, viral consensus sequences can be genetically...

journal_title：Virology journal

authors： Clem AL,Sims J,Telang S,Eaton JW,Chesney J

更新日期：2007-06-28 00:00:00

abstract：BACKGROUND:The implementation of phage therapy is re-emerging with the increase in widespread antibiotic-resistant bacteria. METHODS:Staphylococcus phage JD007 was characterized and its complete genome sequence analysed. RESULTS:Staphylococcus phage JD007 was classified as belonging to the Myoviridae family based on ...

journal_title：Virology journal

authors： Cui Z,Feng T,Gu F,Li Q,Dong K,Zhang Y,Zhu Y,Han L,Qin J,Guo X

更新日期：2017-02-08 00:00:00

abstract：BACKGROUND:A vaccine against all four dengue virus (DENV) serotypes includes the formulation of one genotype of each serotype. Although genetic similarities among genotypes within a serotype are higher as compared to those among serotypes, differences in the immunogenicity of the included genotypes would be a critical ...

journal_title：Virology journal

authors： Azami NAM,Moi ML,Ami Y,Suzaki Y,Lim CK,Taniguchi S,Saijo M,Takasaki T,Kurane I

更新日期：2018-03-27 00:00:00

abstract：BACKGROUND:Due to the high prevalence of viral infections having no specific treatment and the constant appearance of resistant viral strains, the development of novel antiviral agents is essential. The aim of this study was to evaluate the antiviral activity against bovine viral diarrhea virus, herpes simplex virus ty...

journal_title：Virology journal

authors： Visintini Jaime MF,Redko F,Muschietti LV,Campos RH,Martino VS,Cavallaro LV

更新日期：2013-07-27 00:00:00

abstract：BACKGROUND:Torque teno virus is a small chronically persisting circular negative ssDNA virus reaching near 100% prevalence. It is reported to be a marker for immune function in immunocompromised patients. The possibility of vertical maternal-fetal transmission remains controversial but incidence rate of TTV DNA in chil...

journal_title：Virology journal

authors： Tyschik EA,Rasskazova AS,Degtyareva AV,Rebrikov DV,Sukhikh GT

更新日期：2018-05-30 00:00:00

abstract：BACKGROUND:Human papillomavirus (HPV)-associated malignancy remain a main cause of cancer in men and women. Cancer immunotherapy has represented great potential as a new promising cancer therapeutic approach. Here, we report Mesenchymal stem cells (MSCs) as a carrier for the delivery of oncolytic Newcastle disease viru...

journal_title：Virology journal

authors： Keshavarz M,Ebrahimzadeh MS,Miri SM,Dianat-Moghadam H,Ghorbanhosseini SS,Mohebbi SR,Keyvani H,Ghaemi A

更新日期：2020-05-05 00:00:00

abstract：:We report the presence of three new O1 ElTor vibriophages named AS1, AS2 and AS3, isolated from the sewage and pond waters of the outskirts of Kolkata. A few phages, named AS4, with hexagonal heads and abnormally long tails with typical curly projections were also found in the water samples. ...

journal_title：Virology journal

authors： Sen A,Ghosh AN

更新日期：2005-04-11 00:00:00

abstract：BACKGROUND:The recent 2009 (H1N1) influenza A pandemic saw a rapid spread of the virus to essentially all parts of the world. In the course of its evolution, the virus acquired many mutations, some of which have been investigated in the context of increased severity due to high occurrences in fatal cases. For example, ...

journal_title：Virology journal

authors： Lee RT,Santos CL,de Paiva TM,Cui L,Sirota FL,Eisenhaber F,Maurer-Stroh S

更新日期：2010-11-01 00:00:00

abstract：:While improved drug regimens have greatly enhanced outcomes for patients with chronic viral infection, antiviral therapy is still not ideal due to drug toxicities, treatment costs, primary drug failure and emergent resistance. New antiviral agents, alternative treatment strategies and a better understanding of viral p...

journal_title：Virology journal

authors： Sallie R

更新日期：2007-03-13 00:00:00

abstract：BACKGROUND:Astroviruses (AstVs) have been reported to infect and cause gastroenteritis in most animal species. Human AstVs were regarded the causative agent of viral diarrhea in children. In dogs, little is known about the epidemiology and clinical significance of AstV infection. FINDINGS:In this study, we collected a...

journal_title：Virology journal

authors： Zhou H,Liu L,Li R,Qin Y,Fang Q,Balasubramaniam VR,Wang G,Wei Z,Ouyang K,Huang W,Chen Y

更新日期：2017-08-17 00:00:00

abstract：BACKGROUND:Resonant microwave absorption has been proposed in the literature to excite the vibrational states of microorganisms in an attempt to destroy them. But it is extremely difficult to transfer microwave excitation energy to the vibrational energy of microorganisms due to severe absorption of water in this spect...

journal_title：Virology journal

authors： Tsen KT,Tsen SW,Chang CL,Hung CF,Wu TC,Kiang JG

更新日期：2007-06-05 00:00:00

abstract：BACKGROUND:Papillomaviruses (PVs) infecting artiodactyls are very diverse, and only second in number to PVs infecting primates. PVs associated to lesions in economically important ruminant species have been isolated from cattle and sheep. METHODS:Potential PV DNA from teat lesions of a Damascus goat was isolated, clon...

journal_title：Virology journal

authors： Willemsen A,van den Boom A,Dietz J,Bilge Dagalp S,Dogan F,Bravo IG,Ehrhardt A,Ehrke-Schulz E

更新日期：2020-10-30 00:00:00

abstract：:Lytic bacteriophage 0305phi8-36 forms visually observed aggregates during plaque formation. Aggregates intrinsically lower propagation potential. In the present study, the following observations indicate that lost propagation potential is regained with time: (1) Aggregates sometimes concentrate at the edge of clear pl...

journal_title：Virology journal

authors： Serwer P,Hayes SJ,Lieman K

更新日期：2007-12-04 00:00:00

abstract：BACKGROUND:Cell culture adaptation of very virulent infectious bursal disease virus (vvIBDV) was shown to be mainly associated with the VP2 capsid protein residues 253, 279, and 284. The single mutation A284T proved critical for cell culture tropism, but did not confer efficient virus replication, which at least requir...

journal_title：Virology journal

authors： Ben Abdeljelil N,Khabouchi N,Kassar S,Miled K,Boubaker S,Ghram A,Mardassi H

更新日期：2014-11-25 00:00:00

abstract：BACKGROUND:Endometrial cancer (EC) is one of the most common gynecological malignancies globally. Although progress has been made in surgical and other adjuvant therapies, there is still a great need to develop new approaches to further reduce the incidence and mortality of EC. Oncolytic virotherapy offers a novel prom...

journal_title：Virology journal

authors： Lin Y,Wang W,Wan J,Yang Y,Fu W,Pan D,Cai L,Cheng T,Huang X,Wang Y

更新日期：2018-04-10 00:00:00

abstract：BACKGROUND:Papillomaviruses (PVs) establish a persistent infection in the proliferating basal cells of the epithelium. The viral genome is replicated and maintained as a low-copy nuclear plasmid in basal keratinocytes. Bovine and human papillomaviruses (BPV and HPV) are known to utilize two viral proteins; E1, a DNA he...

journal_title：Virology journal

authors： Pittayakhajonwut D,Angeletti PC

更新日期：2010-06-10 00:00:00

abstract：BACKGROUND:RNA viruses are characterized by high rate of mutations mainly due to the lack of proofreading repair activities associated with its RNA-dependent RNA-polymerase (RdRp). In case of arboviruses, this phenomenon has lead to the existence of mixed population of genomic variants within the host called quasi-spec...

journal_title：Virology journal

authors： Jain J,Mathur K,Shrinet J,Bhatnagar RK,Sunil S

更新日期：2016-06-02 00:00:00

abstract：BACKGROUND:Foot-and-mouth disease (FMD) is an extremely contagious viral disease of cattle, pigs, sheep, goats, and many cloven-hoofed wild animals. FMDV serotypes O and Asia 1 have circulated separately in China during the last fifty years, and eliminating infected animals and vaccination are the main policies to prev...

journal_title：Virology journal

authors： Wu L,Jiang T,Lu ZJ,Yang YM,Sun P,Liang Z,Li D,Fu YF,Cao YM,Liu XT,Liu ZX

更新日期：2011-04-23 00:00:00

abstract：BACKGROUND:The deciphering of cellular networks to determine susceptibility to infection by HIV or the related simian immunodeficiency virus (SIV) is a major challenge in infection biology. RESULTS:Here, we have compared gene expression profiles of a human CD4+ T cell line at 24 h after infection with a cell line of t...

journal_title：Virology journal

authors： He FQ,Sauermann U,Beer C,Winkelmann S,Yu Z,Sopper S,Zeng AP,Wirth M

更新日期：2014-08-27 00:00:00

abstract：BACKGROUND:Mumps virus (MuV) is a highly infectious paramyxovirus closely related to measles virus (MeV). Despite the availability of a mumps vaccine, outbreaks continue to occur and no treatment options are available. Vitamin A and other naturally occurring retinoids inhibit the replication of MeV in vitro. METHODS:A...

journal_title：Virology journal

authors： Soye KJ,Trottier C,Di Lenardo TZ,Restori KH,Reichman L,Miller WH Jr,Ward BJ

更新日期：2013-11-14 00:00:00